SitesBLAST – Find functional sites

 

SitesBLAST

Comparing Ac3H11_650 FitnessBrowser__acidovorax_3H11:Ac3H11_650 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 6 hits to proteins with known functional sites (download)

2iiiA Crystal structure of the adenosylmethionine decarboxylase (aq_254) from aquifex aeolicus vf5
34% identity, 96% coverage: 3:126/129 of query aligns to 5:116/120 of 2iiiA

query
sites
2iiiA
G
 
G
L
 
L
H
 
H
L
 
I
T
 
L
A
 
A
D
 
D
L
 
L
Q
 
Y
G
 
G
C
 
V
R
 
D
C
 
A
A
x
D
S
 
K
A
 
-
W
 
-
L
 
I
L
x
D
D
 
R
A
 
V
T
 
E
A
x
D
L
 
I
G
 
R
G
 
E
A
 
L
C
 
L
T
x
E
D
 
G
A
 
A
V
 
V
R
 
K
A
 
Y
A
 
A
G
 
N
L
 
L
Q
 
T
A
x
K
V
 
I
G
 
S
Q
x
S
L
 
H
F
 
Y
Y
 
Y
E
 
Q
F
 
F
P
 
Q
A
 
-
T
 
-
A
 
-
R
 
-
G
 
-
P
 
P
G
 
H
G
 
G
V
 
A
T
|
T
A
 
G
T
 
V
V
 
V
L
 
L
L
 
L
A
 
A
E
 
-
S
|
S
H
 
H
L
 
I
C
 
S
V
 
I
H
|
H
T
 
T
W
 
W
P
 
P
E
 
E
Q
 
H
R
 
G
A
 
L
V
 
A
T
 
T
L
 
V
D
 
D
V
 
V
Y
 
Y
V
 
T
C
|
C
N
 
G
F
 
-
G
 
-
A
 
-
D
 
-
H
 
D
S
 
P
A
 
S
K
 
K
A
 
A
H
 
Y
A
 
R
L
 
A
M
 
M
D
 
D
A
 
Y
L
 
I
L
 
I
A
 
T
L
 
Q
F
 
L
Q
 
N
P
 
P
T
 
K
T
 
R
A
 
I
D
 
D
R
 
K
H
 
Q
A
 
V
L
 
H
Q
 
E
R
 
R
G
 
G
V
 
I
V
 
V
S
 
E
E
 
E

Q57763 S-adenosylmethionine decarboxylase proenzyme; AdoMetDC; SAMDC; EC 4.1.1.50 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
29% identity, 95% coverage: 3:125/129 of query aligns to 6:117/124 of Q57763

query
sites
Q57763
G
 
G
L
 
K
H
 
H
L
 
L
T
 
I
A
 
L
D
 
E
L
 
L
Q
 
W
G
 
G
C
 
C
R
 
D
C
 
P
A
 
K
S
 
A
A
 
-
W
 
-
L
 
L
L
 
D
D
 
D
A
 
I
T
 
E
A
 
G
L
 
I
G
 
E
G
 
K
A
 
M
C
 
L
T
 
V
D
 
D
A
 
S
V
 
V
R
 
K
A
 
A
A
 
C
G
 
G
L
 
A
Q
 
T
A
 
L
V
 
I
G
 
C
Q
 
V
L
 
R
F
 
T
Y
 
H
E
 
K
F
 
F
P
 
-
A
 
-
T
 
-
A
 
-
R
 
-
G
 
S
P
 
P
G
 
Q
G
 
G
V
 
A
T
 
T
A
 
G
T
 
V
V
 
A
L
 
V
L
 
L
A
 
A
E
 
E
S
|
S
H
 
H
L
 
I
C
 
A
V
 
I
H
 
H
T
 
T
W
 
Y
P
 
P
E
 
E
Q
 
Y
R
 
G
A
 
Y
V
 
A
T
 
A
L
 
L
D
 
D
V
 
V
Y
 
F
V
 
T
C
 
C
N
 
-
F
 
-
G
 
-
A
 
G
D
 
E
H
 
H
S
 
T
A
 
D
K
 
P
A
 
Y
H
 
K
A
 
A
L
 
L
M
 
-
D
 
E
A
 
V
L
 
I
L
 
R
A
 
E
L
 
F
F
 
L
Q
 
K
P
 
P
T
 
K
T
 
S
A
 
I
D
 
Q
R
 
I
H
 
I
A
 
D
L
 
L
Q
 
K
R
 
R
G
 
G
V
 
L
V
 
M
S
 
E

O34426 S-adenosylmethionine decarboxylase proenzyme; AdoMetDC; SAMDC; EC 4.1.1.50 from Bacillus subtilis (strain 168) (see paper)
31% identity, 74% coverage: 3:98/129 of query aligns to 5:98/126 of O34426

query
sites
O34426
G
 
G
L
 
R
H
 
H
L
 
V
T
 
I
A
 
S
D
 
E
L
 
L
Q
 
W
G
 
G
C
 
C
R
 
D
C
 
F
A
 
D
S
 
K
A
 
-
W
 
-
L
 
L
L
 
N
D
 
D
A
 
M
T
 
D
A
 
F
L
 
I
G
 
E
G
 
K
A
 
T
C
 
F
T
 
V
D
 
N
A
 
A
V
 
A
R
 
L
A
 
K
A
 
S
G
 
G
L
 
A
Q
 
E
A
 
V
V
 
R
G
 
E
Q
 
V
L
 
A
F
 
F
Y
 
H
E
 
K
F
 
F
P
 
-
A
 
-
T
 
-
A
 
-
R
 
-
G
 
A
P
 
P
G
 
Q
G
 
G
V
 
V
T
 
S
A
 
G
T
 
V
V
 
V
L
 
I
L
 
I
A
 
S
E
 
E
S
|
S
H
 
H
L
 
L
C
 
T
V
 
I
H
 
H
T
 
S
W
 
F
P
 
P
E
 
E
Q
 
H
R
 
G
A
 
Y
V
 
A
T
 
S
L
 
I
D
 
D
V
 
V
Y
 
Y
V
 
T
C
 
C
-
 
G
-
 
D
-
 
L
-
 
D
-
 
P
N
 
N
F
 
V
G
 
A
A
 
A
D
 
D
H
 
Y
S
 
I
A
 
A
K
 
E
A
 
A

Q9UWU1 Arginine decarboxylase proenzyme; ADC; ArgDC; Pyruvoyl-dependent arginine decarboxylase; EC 4.1.1.19 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
36% identity, 75% coverage: 20:116/129 of query aligns to 37:131/134 of Q9UWU1

query
sites
Q9UWU1
L
 
L
L
 
N
D
 
D
A
 
K
T
 
E
A
 
F
L
 
L
G
 
E
G
 
K
A
 
L
C
 
V
T
 
L
D
 
E
A
 
A
V
 
V
R
 
D
A
 
I
A
 
A
G
 
H
L
 
M
Q
 
K
A
 
L
V
 
V
G
 
-
Q
 
-
L
 
-
F
 
-
Y
 
-
E
 
E
F
 
I
P
 
K
A
 
A
T
 
W
A
 
S
R
 
F
G
 
G
-
 
G
-
 
K
P
 
K
G
 
G
G
 
G
V
 
V
T
 
S
A
 
V
T
 
I
V
 
A
L
 
L
L
 
V
A
 
E
E
 
E
S
|
S
H
 
H
L
 
I
C
 
A
V
 
L
H
 
H
T
 
T
W
 
W
P
 
N
E
 
E
Q
 
Y
R
 
N
A
 
Y
V
 
A
T
 
T
L
 
L
D
 
D
V
 
V
Y
 
Y
V
 
T
C
 
C
N
 
G
F
 
E
G
 
D
A
 
S
D
 
D
-
 
P
H
 
Q
S
 
S
A
 
A
K
 
F
A
 
A
H
 
H
A
 
I
L
 
V
M
 
N
D
 
A
A
 
L
L
 
N
L
 
P
A
 
K
L
 
R
F
 
Y
Q
 
Q
P
 
M
T
 
F
T
 
Y
A
 
A
D
 
D
R
 
R

Q9WZC3 S-adenosylmethionine decarboxylase proenzyme; AdoMetDC; SAMDC; EC 4.1.1.50 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
30% identity, 81% coverage: 3:107/129 of query aligns to 5:102/130 of Q9WZC3

query
sites
Q9WZC3
G
 
G
L
 
R
H
 
H
L
 
L
T
 
V
A
 
A
D
 
E
L
 
F
Q
 
-
G
 
-
C
 
Y
R
 
E
C
 
C
A
 
D
S
 
R
A
 
E
W
 
V
L
 
L
L
 
D
D
 
N
A
 
V
T
 
Q
A
 
L
L
 
I
G
 
E
G
 
Q
A
 
E
C
 
M
T
 
K
D
 
Q
A
 
A
V
 
A
R
 
Y
A
 
E
A
 
S
G
 
G
L
 
A
Q
 
T
A
 
I
V
 
V
G
 
T
Q
 
S
L
 
T
F
 
F
Y
 
H
E
 
R
F
 
F
P
 
L
A
 
-
T
 
-
A
 
-
R
 
-
G
 
-
P
 
P
G
 
Y
G
 
G
V
 
V
T
x
S
A
 
G
T
 
V
V
 
V
L
 
V
L
 
I
A
 
S
E
 
E
S
|
S
H
 
H
L
 
L
C
 
T
V
 
I
H
|
H
T
 
T
W
 
W
P
 
P
E
 
E
Q
 
Y
R
 
G
A
 
Y
V
 
A
T
 
A
L
 
I
D
 
D
V
 
L
Y
 
F
V
 
T
C
|
C
N
 
G
F
 
E
G
 
D
A
 
V
D
 
D
H
 
P
S
 
W
A
 
K
K
 
A
A
 
F
H
 
E
A
 
H
L
 
L
M
 
K
D
 
K
A
 
A
L
 
L
L
 
K
A
 
A

Q9UWY8 S-adenosylmethionine decarboxylase proenzyme; AdoMetDC; SAMDC; EC 4.1.1.50 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
52% identity, 24% coverage: 58:88/129 of query aligns to 61:91/124 of Q9UWY8

query
sites
Q9UWY8
G
 
G
V
 
V
T
 
S
A
 
V
T
 
V
V
 
A
L
 
I
L
 
I
A
 
L
E
 
E
S
|
S
H
 
H
L
 
I
C
 
T
V
 
I
H
 
H
T
 
T
W
 
W
P
 
P
E
 
E
Q
 
Y
R
 
R
A
 
F
V
 
A
T
 
T
L
 
V
D
 
D
V
 
V
Y
 
Y
V
 
S
C
 
C

Query Sequence

>Ac3H11_650 FitnessBrowser__acidovorax_3H11:Ac3H11_650
MQGLHLTADLQGCRCASAWLLDATALGGACTDAVRAAGLQAVGQLFYEFPATARGPGGVT
ATVLLAESHLCVHTWPEQRAVTLDVYVCNFGADHSAKAHALMDALLALFQPTTADRHALQ
RGVVSEVAA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory