SitesBLAST
Comparing Ac3H11_701 FitnessBrowser__acidovorax_3H11:Ac3H11_701 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1cevA Arginase from bacillus caldovelox, native structure at ph 5.6 (see paper)
44% identity, 82% coverage: 61:362/368 of query aligns to 2:299/299 of 1cevA
- active site: H99 (= H156), D122 (= D183), H124 (= H185), D126 (= D187), H139 (= H200), D226 (= D289), D228 (= D291), E271 (= E334)
- binding manganese (ii) ion: H99 (= H156), D122 (= D183), D122 (= D183), H124 (= H185), D126 (= D187), D226 (= D289), D226 (= D289), D228 (= D291)
P53608 Arginase; EC 3.5.3.1 from Bacillus caldovelox (see paper)
44% identity, 82% coverage: 61:362/368 of query aligns to 2:299/299 of P53608
5cevA Arginase from bacillus caldevelox, l-lysine complex (see paper)
44% identity, 82% coverage: 61:362/368 of query aligns to 1:298/298 of 5cevA
- active site: H98 (= H156), D121 (= D183), H123 (= H185), D125 (= D187), H138 (= H200), D225 (= D289), D227 (= D291), E270 (= E334)
- binding guanidine: H251 (≠ Q315), E255 (= E319)
- binding lysine: S134 (= S196), H138 (= H200), E270 (= E334)
- binding manganese (ii) ion: H98 (= H156), D121 (= D183), D121 (= D183), H123 (= H185), D125 (= D187), D225 (= D289), D225 (= D289), D227 (= D291)
4cevA Arginase from bacillus caldevelox, l-ornithine complex (see paper)
44% identity, 82% coverage: 61:362/368 of query aligns to 1:298/298 of 4cevA
- active site: H98 (= H156), D121 (= D183), H123 (= H185), D125 (= D187), H138 (= H200), D225 (= D289), D227 (= D291), E270 (= E334)
- binding guanidine: H251 (≠ Q315), E255 (= E319)
- binding manganese (ii) ion: H98 (= H156), D121 (= D183), D121 (= D183), H123 (= H185), D125 (= D187), D225 (= D289), D225 (= D289), D227 (= D291)
- binding L-ornithine: H123 (= H185), D125 (= D187), S134 (= S196), H138 (= H200), D177 (= D242)
3cevA Arginase from bacillus caldevelox, complexed with l-arginine (see paper)
44% identity, 82% coverage: 61:362/368 of query aligns to 1:298/298 of 3cevA
- active site: H98 (= H156), D121 (= D183), H123 (= H185), D125 (= D187), H138 (= H200), D225 (= D289), D227 (= D291), E270 (= E334)
- binding arginine: H123 (= H185), D125 (= D187), S134 (= S196), H138 (= H200), D225 (= D289), H251 (≠ Q315), E255 (= E319), E270 (= E334), E295 (≠ K359), L297 (≠ T361)
- binding manganese (ii) ion: H98 (= H156), D121 (= D183), D125 (= D187), D225 (= D289)
2cevB Arginase from bacillus caldevelox, native structure at ph 8.5 (see paper)
44% identity, 82% coverage: 61:362/368 of query aligns to 1:298/298 of 2cevB
- active site: H98 (= H156), D121 (= D183), H123 (= H185), D125 (= D187), H138 (= H200), D225 (= D289), D227 (= D291), E270 (= E334)
- binding guanidine: H251 (≠ Q315), E255 (= E319)
- binding manganese (ii) ion: H98 (= H156), D121 (= D183), D121 (= D183), H123 (= H185), D125 (= D187), D225 (= D289), D225 (= D289), D227 (= D291)
6nfpD 1.7 angstrom resolution crystal structure of arginase from bacillus subtilis subsp. Subtilis str. 168
42% identity, 82% coverage: 61:362/368 of query aligns to 4:289/289 of 6nfpD
6dktA Crystal structure of arginase from bacillus subtilis
42% identity, 82% coverage: 61:362/368 of query aligns to 1:283/283 of 6dktA
6nfpA 1.7 angstrom resolution crystal structure of arginase from bacillus subtilis subsp. Subtilis str. 168
41% identity, 82% coverage: 61:362/368 of query aligns to 1:292/292 of 6nfpA
6nbkA Crystal structure of arginase from bacillus cereus
42% identity, 82% coverage: 61:360/368 of query aligns to 1:287/289 of 6nbkA
2ef5A Crystal structure of the arginase from thermus thermophilus
45% identity, 81% coverage: 61:359/368 of query aligns to 1:270/273 of 2ef5A
- active site: H80 (= H156), D102 (= D183), H104 (= H185), D106 (= D187), H118 (= H200), D200 (= D289), D202 (= D291), E245 (= E334)
- binding lysine: P9 (= P69), D15 (≠ S80), M16 (= M81), S19 (≠ E84)
- binding manganese (ii) ion: H80 (= H156), D102 (= D183), D102 (= D183), H104 (= H185), D106 (= D187), D200 (= D289), D200 (= D289), D202 (= D291)
6dktE Crystal structure of arginase from bacillus subtilis
39% identity, 82% coverage: 61:362/368 of query aligns to 1:268/268 of 6dktE
P78540 Arginase-2, mitochondrial; Arginase II; Kidney-type arginase; Non-hepatic arginase; Type II arginase; EC 3.5.3.1 from Homo sapiens (Human) (see paper)
38% identity, 82% coverage: 58:360/368 of query aligns to 21:326/354 of P78540
6ss2AAA of arginase-2 in complex with the inhibitory human antigen-binding fragment fab c0021158' (see paper)
38% identity, 81% coverage: 63:360/368 of query aligns to 5:305/320 of 6ss2AAA
6q39A Complex of arginase 2 with example 49 (see paper)
38% identity, 81% coverage: 63:360/368 of query aligns to 3:303/306 of 6q39A
- active site: H97 (= H156), D120 (= D183), H122 (= H185), D124 (= D187), H137 (= H200), D228 (= D289), D230 (= D291), E273 (= E334)
- binding 3-[(3~{S},4~{R})-4-azanyl-4-carboxy-1-[[(2~{S})-piperidin-2-yl]methyl]pyrrolidin-3-yl]propyl-tris(oxidanyl)boranuide: H97 (= H156), D120 (= D183), H122 (= H185), D124 (= D187), N126 (= N189), S133 (= S196), H137 (= H200), D177 (≠ S240), D179 (= D242), D228 (= D289), T242 (= T303), E273 (= E334)
- binding manganese (ii) ion: H97 (= H156), D120 (= D183), D120 (= D183), H122 (= H185), D124 (= D187), D228 (= D289), D228 (= D289), D230 (= D291)
6q37A Complex of arginase 2 with example 23 (see paper)
38% identity, 81% coverage: 63:360/368 of query aligns to 3:303/306 of 6q37A
- active site: H97 (= H156), D120 (= D183), H122 (= H185), D124 (= D187), H137 (= H200), D228 (= D289), D230 (= D291), E273 (= E334)
- binding 3-[(3~{S},4~{R})-4-azanyl-4-carboxy-pyrrolidin-3-yl]propyl-tris(oxidanyl)boranuide: H97 (= H156), D120 (= D183), H122 (= H185), D124 (= D187), N126 (= N189), S133 (= S196), H137 (= H200), G138 (= G201), D179 (= D242), D228 (= D289)
- binding manganese (ii) ion: H97 (= H156), D120 (= D183), D120 (= D183), H122 (= H185), D124 (= D187), D228 (= D289), D228 (= D289), D230 (= D291)
4ixvA Crystal structure of human arginase-2 complexed with inhibitor 2d: {(5r)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4- yl]pentyl}(trihydroxy)borate(1-) (see paper)
38% identity, 81% coverage: 63:360/368 of query aligns to 3:303/306 of 4ixvA
- active site: H97 (= H156), D120 (= D183), H122 (= H185), D124 (= D187), H137 (= H200), D228 (= D289), D230 (= D291), E273 (= E334)
- binding manganese (ii) ion: H97 (= H156), D120 (= D183), D120 (= D183), H122 (= H185), D124 (= D187), D228 (= D289), D228 (= D289), D230 (= D291)
- binding {(5R)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-): D120 (= D183), H122 (= H185), D124 (= D187), S132 (≠ P195), S133 (= S196), H137 (= H200), G138 (= G201), D179 (= D242), D228 (= D289), E273 (= E334)
4ixuA Crystal structure of human arginase-2 complexed with inhibitor 11d: {(5r)-5-amino-5-carboxy-5-[(3-endo)-8-(3,4-dichlorobenzyl)-8- azabicyclo[3.2.1]oct-3-yl]pentyl}(trihydroxy)borate(1-) (see paper)
38% identity, 81% coverage: 63:360/368 of query aligns to 3:303/306 of 4ixuA
- active site: H97 (= H156), D120 (= D183), H122 (= H185), D124 (= D187), H137 (= H200), D228 (= D289), D230 (= D291), E273 (= E334)
- binding {(5R)-5-amino-5-carboxy-5-[(3-endo)-8-(3,4-dichlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]pentyl}(trihydroxy)borate(1-): D120 (= D183), H122 (= H185), D124 (= D187), N126 (= N189), S133 (= S196), H137 (= H200), G138 (= G201), D179 (= D242), D228 (= D289)
- binding manganese (ii) ion: H97 (= H156), D120 (= D183), D120 (= D183), H122 (= H185), D124 (= D187), D228 (= D289), D228 (= D289), D230 (= D291)
4ie3A Crystal structure of human arginase-2 complexed with inhbitor 1o (see paper)
38% identity, 81% coverage: 63:360/368 of query aligns to 3:303/306 of 4ie3A
- active site: H97 (= H156), D120 (= D183), H122 (= H185), D124 (= D187), H137 (= H200), D228 (= D289), D230 (= D291), E273 (= E334)
- binding [(5R)-5-amino-5-carboxy-7-(4-hydroxypiperidin-1-yl)heptyl](trihydroxy)borate(1-): D120 (= D183), H122 (= H185), D124 (= D187), N126 (= N189), S133 (= S196), H137 (= H200), D179 (= D242), D228 (= D289)
- binding manganese (ii) ion: H97 (= H156), D120 (= D183), D120 (= D183), H122 (= H185), D124 (= D187), D228 (= D289), D228 (= D289), D230 (= D291)
4ie2A Crystal structure of human arginase-2 complexed with inhibitor 1h (see paper)
38% identity, 81% coverage: 63:360/368 of query aligns to 3:303/306 of 4ie2A
- active site: H97 (= H156), D120 (= D183), H122 (= H185), D124 (= D187), H137 (= H200), D228 (= D289), D230 (= D291), E273 (= E334)
- binding [(5R)-5-amino-5-carboxy-8-hydroxyoctyl](trihydroxy)borate(1-): H97 (= H156), D120 (= D183), H122 (= H185), D124 (= D187), S133 (= S196), H137 (= H200), G138 (= G201), D179 (= D242), D228 (= D289)
- binding manganese (ii) ion: H97 (= H156), D120 (= D183), D120 (= D183), H122 (= H185), D124 (= D187), D228 (= D289), D228 (= D289), D230 (= D291)
Query Sequence
>Ac3H11_701 FitnessBrowser__acidovorax_3H11:Ac3H11_701
VDTRTVHKGHGGLISPRTVHWHPKPRECPGATARAAAWPLPLSTPAQKALTMPPNTLRSA
QPTSLIGAPTDIGAGARGASMGPEALRVAGLQAALELHGLQVFDRGNLGGPSNPWLPPVN
GYRHLPEVAQWNRLVYDAVYAELQLGHLPILLGGDHSLGLGSISAVARHCAESGKKLRVL
WLDAHADFNTSELTPSGNVHGMPVACLCGFGPAELTQLAAMPGGGPALRPEQIRQIGIRS
VDAGEKRFVHEQGLEVFDMRAIDEVGMRQVMERALAGMDAHTHLHVSFDVDFLDPDIAPG
VGTTVPGGPTYREAQLCMEMIADSGRLASLDIVELNPALDVRNKTAVLAVDLVESLFGKS
TLMRTRPV
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory