Comparing BPHYT_RS00250 FitnessBrowser__BFirm:BPHYT_RS00250 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7ovgA The c146a variant of an amidase from pyrococcus horikoshii with bound acetamide (see paper)
41% identity, 95% coverage: 8:276/283 of query aligns to 3:263/263 of 7ovgA
6ypaB The c146a variant of an amidase from pyrococcus horikoshii with bound glutaramide
41% identity, 95% coverage: 8:276/283 of query aligns to 9:269/269 of 6ypaB
3klcB Crystal structure of hyperthermophilic nitrilase (see paper)
41% identity, 95% coverage: 8:276/283 of query aligns to 1:261/261 of 3klcB
3klcA Crystal structure of hyperthermophilic nitrilase (see paper)
41% identity, 95% coverage: 8:276/283 of query aligns to 1:261/261 of 3klcA
Q9UYV8 Nitrilase; PaNit; EC 3.5.5.1 from Pyrococcus abyssi (strain GE5 / Orsay) (see paper)
41% identity, 95% coverage: 8:276/283 of query aligns to 2:262/262 of Q9UYV8
Q44185 N-carbamoyl-D-amino acid hydrolase; D-N-alpha-carbamilase; EC 3.5.1.77 from Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium radiobacter) (see paper)
31% identity, 97% coverage: 6:280/283 of query aligns to 3:304/304 of Q44185
Q9NQR4 Omega-amidase NIT2; Nitrilase homolog 2; EC 3.5.1.3 from Homo sapiens (Human) (see 2 papers)
33% identity, 89% coverage: 22:274/283 of query aligns to 17:269/276 of Q9NQR4
5h8jB Crystal structure of medicago truncatula n-carbamoylputrescine amidohydrolase (mtcpa) in complex with cadaverine (see paper)
32% identity, 97% coverage: 8:282/283 of query aligns to 10:292/297 of 5h8jB
5h8iC Crystal structure of medicago truncatula n-carbamoylputrescine amidohydrolase (mtcpa) in complex with n-(dihydroxymethyl)putrescine (see paper)
33% identity, 91% coverage: 25:282/283 of query aligns to 25:296/301 of 5h8iC
5h8lB Crystal structure of medicago truncatula n-carbamoylputrescine amidohydrolase (mtcpa) c158s mutant in complex with putrescine (see paper)
32% identity, 97% coverage: 8:282/283 of query aligns to 11:293/298 of 5h8lB
8hpcC Crystal structure of c171a mutant of n-carbamyl-d-amino acid amidohydrolase complexed with n-carbamyl-d-hydroxyphenylglycine
30% identity, 96% coverage: 6:277/283 of query aligns to 2:300/303 of 8hpcC
1uf8A Crystal structure of c171a/v236a mutant of n-carbamyl-d-amino acid amidohydrolase complexed with n-carbamyl-d-phenylalanine
30% identity, 96% coverage: 6:277/283 of query aligns to 2:300/303 of 1uf8A
1uf7A Crystal structure of c171a/v236a mutant of n-carbamyl-d-amino acid amidohydrolase complexed with n-carbamyl-d-valine
30% identity, 96% coverage: 6:277/283 of query aligns to 2:300/303 of 1uf7A
1uf5A Crystal structure of c171a/v236a mutant of n-carbamyl-d-amino acid amidohydrolase complexed with n-carbamyl-d-methionine
30% identity, 96% coverage: 6:277/283 of query aligns to 2:300/303 of 1uf5A
4iztA The e41q mutant of the amidase from nesterenkonia sp. An1 showing covalent addition of the acetamide moiety of fluoroacetamide at the active site cysteine
30% identity, 95% coverage: 6:274/283 of query aligns to 8:259/263 of 4iztA
4izuA The e41q mutant of the amidase from nesterenkonia sp. An1 showing the result of michael addition of acrylamide at the active site cysteine
31% identity, 95% coverage: 7:274/283 of query aligns to 1:250/254 of 4izuA
5nybA A c145a mutant of nesterenkonia an1 amidase bound to adipamide
30% identity, 95% coverage: 6:274/283 of query aligns to 7:258/262 of 5nybA
5ny7A A c145a mutant of nesterenkonia an1 amidase bound to nicotinamide
30% identity, 95% coverage: 6:274/283 of query aligns to 7:258/262 of 5ny7A
Sites not aligning to the query:
5nycA A c145a mutant of nesterenkonia an1 amidase bound to propionitrile
30% identity, 95% coverage: 6:274/283 of query aligns to 7:257/261 of 5nycA
4izsA The c145a mutant of the amidase from nesterenkonia sp. An1 in complex with butyramide
30% identity, 95% coverage: 6:274/283 of query aligns to 7:257/261 of 4izsA
>BPHYT_RS00250 FitnessBrowser__BFirm:BPHYT_RS00250
MLFSRKNVQIACVQMAPRIGEKDLNVRRAIDFVTRAADLGAELVVLPELANTGYVFDSRA
EAESLAEPVPDGSTTAAWSEVASALGVYIVAGIAEKADGALYNSAVLLGPDGYLGSYRKT
HLWGDEKKLFASGDRPSPIYDTPLGRIAIAICYDLWFPELFRLYALGGAQIVCVPTNWVP
MPNQSADRPAMANTLAMAAAHTNGLVVACADRVGVERGQPFEGQSLVVDQSGWPVGDVAS
RSLEEIVSASITLDARTSVGTHNDVLADRRADIYGRIPAFDGH
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory