Comparing BPHYT_RS02335 BPHYT_RS02335 fumarylacetoacetate hydrolase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 8 hits to proteins with known functional sites (download)
3lzkC The crystal structure of a probably aromatic amino acid degradation protein from sinorhizobium meliloti 1021
58% identity, 99% coverage: 1:324/327 of query aligns to 7:339/343 of 3lzkC
8gstC Crystal structure of l-2,4-diketo-3-deoxyrhamnonate hydrolase from sphingomonas sp. (Pyruvate bound-form) (see paper)
29% identity, 48% coverage: 109:265/327 of query aligns to 93:243/290 of 8gstC
Sites not aligning to the query:
8gsrA Crystal structure of l-2,4-diketo-3-deoxyrhamnonate hydrolase from sphingomonas sp. (Apo-form) (see paper)
29% identity, 48% coverage: 109:265/327 of query aligns to 93:243/290 of 8gsrA
4dbhA Crystal structure of cg1458 with inhibitor (see paper)
22% identity, 63% coverage: 65:271/327 of query aligns to 48:245/269 of 4dbhA
3r6oA Crystal structure of a probable 2-hydroxyhepta-2,4-diene-1, 7- dioateisomerase from mycobacterium abscessus (see paper)
23% identity, 72% coverage: 29:265/327 of query aligns to 19:226/265 of 3r6oA
6j5xB Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate (see paper)
26% identity, 64% coverage: 56:265/327 of query aligns to 44:242/280 of 6j5xB
6j5xA Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate (see paper)
26% identity, 64% coverage: 56:265/327 of query aligns to 44:242/280 of 6j5xA
6iymA Fumarylacetoacetate hydrolase (eafah) from psychrophilic exiguobacterium antarcticum (see paper)
23% identity, 61% coverage: 68:265/327 of query aligns to 57:240/277 of 6iymA
>BPHYT_RS02335 BPHYT_RS02335 fumarylacetoacetate hydrolase
MKLATLKDGTRDGQLIVVSRDLHTAAVADAIAPTLQRVLDDWAFYAPQLHDLYDALNQGR
ARNTFPFDAKECMAPLPRAFQWADGSSYVNHVELVRRARGAEMPPEFWTDPLMYQGGSDD
FIGPKDDVLCASEAFGIDFEAEVAVITGDVPMGVTPDQALRSVRLITLVNDVSLRNLIPA
DLAKGFGFFQSKPATSFAPMAVTPDELGEHWREGRVHRPMIVHWNNKKVGQPDAGTDMVF
HFGQLIAHAAKTRNLRAGAIVGSGTVSNKDAKRGYCCIAEKRCLETIEHGAPQTEFMKYG
DTVKIEMFDEAGKSIFGSIDQGIAPLD
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory