Comparing BPHYT_RS02735 FitnessBrowser__BFirm:BPHYT_RS02735 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8fdbA Crystal structure of nagb-ii phosphosugar isomerase from shewanella denitrificans os217 in complex with glucitolamine-6-phosphate at 3.06 a resolution. (see paper)
35% identity, 100% coverage: 1:334/335 of query aligns to 6:331/332 of 8fdbA
8fdbB Crystal structure of nagb-ii phosphosugar isomerase from shewanella denitrificans os217 in complex with glucitolamine-6-phosphate at 3.06 a resolution. (see paper)
35% identity, 100% coverage: 1:334/335 of query aligns to 7:332/333 of 8fdbB
8eymA Crystal structure of nagb-ii phosphosugar isomerase from shewanella denitrificans os217 in complex with glucitolamine-6-phosphate and n- acetylglucosamine-6-phosphate at 2.31 a resolution (see paper)
35% identity, 96% coverage: 1:323/335 of query aligns to 5:319/319 of 8eymA
4amvA E.Coli glucosamine-6p synthase in complex with fructose-6p (see paper)
31% identity, 74% coverage: 82:330/335 of query aligns to 339:603/608 of 4amvA
Sites not aligning to the query:
1jxaA Glucosamine 6-phosphate synthase with glucose 6-phosphate (see paper)
31% identity, 74% coverage: 82:330/335 of query aligns to 339:603/608 of 1jxaA
Sites not aligning to the query:
1mosA Isomerase domain of glucosamine 6-phosphate synthase complexed with 2- amino-2-deoxyglucitol 6-phosphate (see paper)
30% identity, 74% coverage: 82:330/335 of query aligns to 98:362/367 of 1mosA
Sites not aligning to the query:
1morA Isomerase domain of glucosamine 6-phosphate synthase complexed with glucose 6-phosphate (see paper)
30% identity, 74% coverage: 82:330/335 of query aligns to 97:361/366 of 1morA
Sites not aligning to the query:
1moqA Isomerase domain of glucosamine 6-phosphate synthase complexed with glucosamine 6-phosphate (see paper)
30% identity, 74% coverage: 82:330/335 of query aligns to 97:361/366 of 1moqA
Sites not aligning to the query:
2j6hA E. Coli glucosamine-6-p synthase in complex with glucose-6p and 5-oxo- l-norleucine (see paper)
30% identity, 74% coverage: 82:330/335 of query aligns to 339:603/608 of 2j6hA
Sites not aligning to the query:
2zj4A Isomerase domain of human glucose:fructose-6-phosphate amidotransferase (see paper)
25% identity, 99% coverage: 1:330/335 of query aligns to 9:360/365 of 2zj4A
2zj3A Isomerase domain of human glucose:fructose-6-phosphate amidotransferase (see paper)
25% identity, 99% coverage: 1:330/335 of query aligns to 9:360/365 of 2zj3A
6svmA Crystal structure of human gfat-1 in complex with glucose-6-phosphate, l-glu, and udp-galnac (see paper)
25% identity, 99% coverage: 1:330/335 of query aligns to 304:655/660 of 6svmA
Sites not aligning to the query:
6r4eA Crystal structure of human gfat-1 in complex with glucose-6-phosphate and l-glu (see paper)
25% identity, 99% coverage: 1:330/335 of query aligns to 307:658/663 of 6r4eA
Sites not aligning to the query:
Q06210 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1; D-fructose-6-phosphate amidotransferase 1; Glutamine:fructose-6-phosphate amidotransferase 1; GFAT 1; GFAT1; Hexosephosphate aminotransferase 1; EC 2.6.1.16 from Homo sapiens (Human) (see paper)
25% identity, 99% coverage: 1:330/335 of query aligns to 343:694/699 of Q06210
7dnrA Crystal structure of zn-bound sis domain of glucosamine-6-p synthase from e. Coli
30% identity, 73% coverage: 82:326/335 of query aligns to 97:357/357 of 7dnrA
6r4gA Crystal structure of human gfat-1 in complex with udp-glcnac (see paper)
25% identity, 98% coverage: 1:328/335 of query aligns to 303:652/652 of 6r4gA
Sites not aligning to the query:
P14742 Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; GFAT; D-fructose-6-phosphate amidotransferase; Hexosephosphate aminotransferase; EC 2.6.1.16 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
26% identity, 84% coverage: 48:330/335 of query aligns to 406:712/717 of P14742
Sites not aligning to the query:
2pocB The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from candida albicans (see paper)
28% identity, 84% coverage: 41:323/335 of query aligns to 54:352/352 of 2pocB
Sites not aligning to the query:
2v4mA The isomerase domain of human glutamine-fructose-6-phosphate transaminase 1 (gfpt1) in complex with fructose 6-phosphate
24% identity, 96% coverage: 1:323/335 of query aligns to 8:352/352 of 2v4mA
2puwB The crystal structure of isomerase domain of glucosamine-6-phosphate synthase from candida albicans (see paper)
26% identity, 84% coverage: 41:323/335 of query aligns to 54:331/331 of 2puwB
>BPHYT_RS02735 FitnessBrowser__BFirm:BPHYT_RS02735
MLKEALASAETVAAQLTDTSRVEALAAKLAQQPRHVALTVARGSSDHAASYFASLTMSRL
GVPVASLPMSVATLQQAPLQVRDQLALAFSQSGKSPDLVGTMEALRKAGALTVAAVNVSG
SPLADACEFELPLVAGPELSVAATKSYIAMLSISAQLVAHWQKDAELLAALKTLPEALCT
AGKLDWSVAVEELRGIERMIVIGRGLGLAIAQEAALKLKETSGIQAEAFSSAEVRHGPME
LIDRDYPLLVFAPRGPEQAGLLQLARDMKARGARVLLAASVDVPEATLPLATTAHAALDP
IAAILSFYVMAAGLAAARGRNPDAPRHLNKVTETH
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory