SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing BPHYT_RS03500 FitnessBrowser__BFirm:BPHYT_RS03500 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

Q9YHT2 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur subunit of complex II; Ip; EC 1.3.5.1 from Gallus gallus (Chicken) (see 2 papers)
29% identity, 23% coverage: 8:101/408 of query aligns to 180:279/290 of Q9YHT2

query
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Q9YHT2

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C196 (= C25) binding
C199 (= C28) binding
C202 (= C31) binding
C206 (= C35) binding
W211 (≠ I40) binding
C253 (= C75) binding
C259 (= C81) binding
C263 (= C85) binding

Sites not aligning to the query:

103 binding
108 binding
111 binding
123 binding

1yq3B Avian respiratory complex ii with oxaloacetate and ubiquinone (see paper)
29% identity, 23% coverage: 8:101/408 of query aligns to 137:236/242 of 1yq3B

query
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1yq3B

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binding fe3-s4 cluster: C163 (= C35), Y173 (≠ L45), P176 (= P48), C210 (= C75), T212 (= T77), I213 (≠ C78), M214 (≠ R79), N215 (= N80), C216 (= C81)
binding iron/sulfur cluster: C153 (= C25), I154 (≠ V26), L155 (≠ H27), C156 (= C28), A157 (≠ G29), C159 (= C31), A177 (≠ R49), C220 (= C85), P221 (= P86)
binding Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer: P164 (= P36), W168 (≠ I40), I213 (≠ C78)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 60, 61, 63, 65, 66, 67, 68, 80

6myqB Avian mitochondrial complex ii with ferulenol bound (see paper)
29% identity, 23% coverage: 8:101/408 of query aligns to 134:233/239 of 6myqB

query
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6myqB

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binding 4-oxidanyl-3-[(2~{E},6~{E})-3,7,11-trimethyldodeca-2,6,10-trienyl]chromen-2-one: W165 (≠ I40), I210 (≠ C78)
binding fe3-s4 cluster: C160 (= C35), Y170 (≠ L45), P173 (= P48), C207 (= C75), T209 (= T77), I210 (≠ C78), M211 (≠ R79), N212 (= N80), C213 (= C81)
binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), L152 (≠ H27), C153 (= C28), C156 (= C31), A174 (≠ R49), C217 (= C85), P218 (= P86)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 57, 58, 60, 62, 63, 65, 77

6mysB Avian mitochondrial complex ii with atpenin a5 bound, sidechain outside (see paper)
29% identity, 23% coverage: 8:101/408 of query aligns to 135:234/240 of 6mysB

query
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6mysB

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binding 3-[(2s,4s,5r)-5,6-dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1h)-pyridinone: P162 (= P36), W166 (≠ I40), H209 (≠ L76), I211 (≠ C78)
binding fe3-s4 cluster: C161 (= C35), Y171 (≠ L45), P174 (= P48), C208 (= C75), T210 (= T77), I211 (≠ C78), M212 (≠ R79), N213 (= N80), C214 (= C81)
binding iron/sulfur cluster: C151 (= C25), I152 (≠ V26), L153 (≠ H27), C154 (= C28), A155 (≠ G29), C157 (= C31), A175 (≠ R49), C218 (= C85)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 57, 58, 59, 61, 63, 64, 65, 66, 78

6myrB Avian mitochondrial complex ii with thiapronil bound (see paper)
29% identity, 23% coverage: 8:101/408 of query aligns to 135:234/240 of 6myrB

query
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6myrB

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binding fe3-s4 cluster: C161 (= C35), Y171 (≠ L45), P174 (= P48), C208 (= C75), H209 (≠ L76), T210 (= T77), I211 (≠ C78), M212 (≠ R79), N213 (= N80), C214 (= C81)
binding thiapronil: P162 (= P36), W166 (≠ I40), H209 (≠ L76), I211 (≠ C78)
binding iron/sulfur cluster: C151 (= C25), I152 (≠ V26), L153 (≠ H27), C154 (= C28), A155 (≠ G29), C157 (= C31), A175 (≠ R49), C218 (= C85)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 58, 59, 63, 64, 65, 66, 78

6mypB Avian mitochondrial complex ii with ttfa (thenoyltrifluoroacetone) bound (see paper)
29% identity, 23% coverage: 8:101/408 of query aligns to 135:234/240 of 6mypB

query
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6mypB

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binding fe3-s4 cluster: C161 (= C35), C208 (= C75), H209 (≠ L76), T210 (= T77), M212 (≠ R79), N213 (= N80), C214 (= C81)
binding iron/sulfur cluster: C151 (= C25), I152 (≠ V26), L153 (≠ H27), C154 (= C28), A155 (≠ G29), C157 (= C31), A175 (≠ R49), C218 (= C85)
binding 4,4,4-trifluoro-1-thien-2-ylbutane-1,3-dione: P162 (= P36), W166 (≠ I40), H209 (≠ L76)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 58, 59, 61, 63, 64, 65, 66, 78

6myoB Avian mitochondrial complex ii with flutolanyl bound (see paper)
29% identity, 23% coverage: 8:101/408 of query aligns to 135:234/240 of 6myoB

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6myoB

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binding fe3-s4 cluster: C161 (= C35), Y171 (≠ L45), P174 (= P48), C208 (= C75), T210 (= T77), I211 (≠ C78), M212 (≠ R79), N213 (= N80), C214 (= C81)
binding N-[3-(1-methylethoxy)phenyl]-2-(trifluoromethyl)benzamide: W166 (≠ I40), H209 (≠ L76), I211 (≠ C78)
binding iron/sulfur cluster: C151 (= C25), I152 (≠ V26), L153 (≠ H27), C154 (= C28), A155 (≠ G29), C157 (= C31), A175 (≠ R49), C218 (= C85)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 58, 59, 61, 63, 64, 65, 66, 78

2fbwB Avian respiratory complex ii with carboxin bound (see paper)
29% identity, 23% coverage: 8:101/408 of query aligns to 135:234/240 of 2fbwB

query
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2fbwB

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binding 2-methyl-n-phenyl-5,6-dihydro-1,4-oxathiine-3-carboxamide: P162 (= P36), W166 (≠ I40), H209 (≠ L76)
binding fe3-s4 cluster: C161 (= C35), Y171 (≠ L45), P174 (= P48), C208 (= C75), T210 (= T77), I211 (≠ C78), M212 (≠ R79), N213 (= N80), C214 (= C81)
binding iron/sulfur cluster: C151 (= C25), I152 (≠ V26), L153 (≠ H27), C154 (= C28), C157 (= C31), A175 (≠ R49), C218 (= C85), P219 (= P86)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 58, 59, 61, 63, 64, 65, 66, 78

5odqB Heterodisulfide reductase / [nife]-hydrogenase complex from methanothermococcus thermolithotrophicus soaked with bromoethanesulfonate. (see paper)
27% identity, 54% coverage: 168:388/408 of query aligns to 2:237/291 of 5odqB

query
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5odqB

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S

N

G
|
G

C
|
C

G

Y

A

G

T

S

V

L

K

F

E

E

Y

A

A

A

H

H

L

L

R

-

H

H

D

D

P

N

A

K

Y

E

A

A

-

L

-

N

-

F

-

V

-

N

-

E

-

K

-

L

-

D

-

K

-

V

-

G

-

K

-

E

-

Y

-

K

-

G

-

N

E

V

K

K

A

V

R

R

R

H

V

F

V

A

E

E

L

L

T

I

R

Y

D

N

-

D

-

I

-

G

V

V

A

D

E

K

I

I

L

A

P

E

E

K

F

V

E

E

E

R

A

P

L

L

-

N

V

I

S

N

V

V

T

G

R

V

R

H

R

Y

S
x
G

V
x
C

H
|
H

T

-

V

-

A

-

F

F

H

L

P

K

P

P

C

T

T

D

L

V

Q

K

H

H

-

L

G

G

Q

S

Q

A

I

E

R

R

-

P

G

V

K

M

V

L

E

D

H

E

L

I

L

V

T

E

A

A

L

T

G

G

V

A

E

K

V

S

R

V

L

P

P

Y

A

A

D

D

S

K

H

M

L

M

C
|
C

G

G

S

A

A
x
G

G

G

T

G

Y

V

S
x
R

L

A

T

R

Q

E

P

L

K

E

L

L

S

S

Y

L

A

D

L

M

R

T

D

N

Q

E

K

K

L

I

D

E

R

N

L

M

Q

I

A

K

Q

A

E

G

P

A

Q

D

V

C

I

T

V

V

S

-

A

-

N

N

V

V

G
x
C

C

P

I
x
F

A
x
C

H

H

L
|
L

Q

Q

binding Non-cubane [4Fe-4S]-cluster: G8 (= G174), C9 (= C175), C41 (= C207), C42 (= C208), C78 (≠ A247), G80 (= G249), C81 (= C250), G152 (≠ S300), C153 (≠ V301), H154 (= H302), C193 (= C342), C194 (= C343), C231 (≠ G382), F233 (≠ I384), C234 (≠ A385)
binding 2-bromanylethanesulfonic acid: G46 (≠ R212), G80 (= G249), H154 (= H302), G197 (≠ A346), R201 (≠ S350), F233 (≠ I384), L236 (= L387)

5odhH Heterodisulfide reductase / [nife]-hydrogenase complex from methanothermococcus thermolithotrophicus soaked with heterodisulfide for 3.5 minutes (see paper)
27% identity, 54% coverage: 168:388/408 of query aligns to 2:237/291 of 5odhH

query
sites
5odhH

K

K

M

Y

L

A

M

F

L

F

A

L

G
|
G

C
|
C

V

I

Q

M

P

P

S

N

M

R

M

Y

P

A

N

G

V

V

N

E

I

A

A

A

T

T

A

R

R

T

V

V

F

M

D

E

A

K

L

L

G

G

V

V

E

E

T

L

L

V

I

D

A

M

P

T

D

G

A

A

G

S

C
|
C

G

P

A
|
A

I
x
P

R
x
G

L

V

H

F

L

G

G

S

Y

F

N

D

D

Q

D

K

A

T

L

W

D

L

D

T

L

L

R

A

A

A

N

R

I

-

D

-

A

N

W

L

W

C

P

I

Y

A

I

E

E

E

Q

M

G

G

V

V

E

D

A

-

I

I

V

V

M

T

N

V

A
x
C

S

N

G
|
G

C
|
C

G

Y

A

G

T

S

V

L

K

F

E

E

Y

A

A

A

H

H

L

L

R

-

H

H

D

D

P

N

A

K

Y

E

A

A

-

L

-

N

-

F

-

V

-

N

-

E

-

K

-

L

-

D

-

K

-

V

-

G

-

K

-

E

-

Y

-

K

-

G

-

N

E

V

K

K

A

V

R

R

R

H

V

F

V

A

E

E

L

L

T

I

R

Y

D

N

-

D

-

I

-

G

V

V

A

D

E

K

I

I

L

A

P

E

E

K

F

V

E

E

E

R

A

P

L

L

-

N

V

I

S

N

V

V

T

G

R

V

R

H

R

Y

S

G

V
x
C

H
|
H

T

-

V

-

A

-

F

F

H

L

P

K

P

P

C

T

T

D

L

V

Q

K

H

H

-

L

G

G

Q

S

Q

A

I

E

R

R

-

P

G

V

K

M

V

L

E

D

H

E

L

I

L

V

T

E

A

A

L

T

G

G

V

A

E

K

V

S

R

V

L

P

P

Y

A

A

D

D

S

K

H

M

L

M

C
|
C

G

G

S

A

A
x
G

G
|
G

T

G

Y

V

S
x
R

L

A

T

R

Q

E

P

L

K

E

L

L

S

S

Y

L

A

D

L

M

R

T

D

N

Q

E

K

K

L

I

D

E

R

N

L

M

Q

I

A

K

Q

A

E

G

P

A

Q

D

V

C

I

T

V

V

S

-

A

-

N

N

V

V

G
x
C

C

P

I
x
F

A
x
C

H

H

L

L

Q

Q

binding Non-cubane [4Fe-4S]-cluster: G8 (= G174), C9 (= C175), C41 (= C207), C42 (= C208), C78 (≠ A247), G80 (= G249), C81 (= C250), C153 (≠ V301), H154 (= H302), C193 (= C342), C194 (= C343), C231 (≠ G382), F233 (≠ I384), C234 (≠ A385)
binding 1-thioethanesulfonic acid: A44 (= A210), P45 (≠ I211), G46 (≠ R212), G80 (= G249), H154 (= H302), G197 (≠ A346), G198 (= G347)
binding Coenzyme B: R201 (≠ S350), F233 (≠ I384)

Sites not aligning to the query:

binding Coenzyme B: 240

5odhB Heterodisulfide reductase / [nife]-hydrogenase complex from methanothermococcus thermolithotrophicus soaked with heterodisulfide for 3.5 minutes (see paper)
27% identity, 54% coverage: 168:388/408 of query aligns to 2:237/291 of 5odhB

query
sites
5odhB

K

K

M

Y

L

A

M

F

L

F

A

L

G
|
G

C
|
C

V
x
I

Q

M

P

P

S

N

M

R

M

Y

P

A

N

G

V

V

N

E

I

A

A

A

T

T

A

R

R

T

V

V

F

M

D

E

A

K

L

L

G

G

V

V

E

E

T

L

L

V

I

D

A

M

P

T

D

G

A

A

G

S

C
|
C

G

P

A

A

I
x
P

R
x
G

L

V

H

F

L

G

G

S

Y

F

N

D

D

Q

D

K

A

T

L

W

D

L

D

T

L

L

R

A

A

A

N

R

I

-

D

-

A

N

W

L

W

C

P

I

Y

A

I

E

E

E

Q

M

G

G

V

V

E

D

A

-

I

I

V

V

M

T

N

V

A
x
C

S

N

G
|
G

C
|
C

G

Y

A

G

T

S

V

L

K

F

E

E

Y

A

A

A

H

H

L

L

R

-

H

H

D

D

P

N

A

K

Y

E

A

A

-

L

-

N

-

F

-

V

-

N

-

E

-

K

-

L

-

D

-

K

-

V

-

G

-

K

-

E

-

Y

-

K

-

G

-

N

E

V

K

K

A

V

R

R

R

H

V

F

V

A

E

E

L

L

T

I

R

Y

D

N

-

D

-

I

-

G

V

V

A

D

E

K

I

I

L

A

P

E

E

K

F

V

E

E

E

R

A

P

L

L

-

N

V

I

S

N

V

V

T

G

R

V

R

H

R

Y

S
x
G

V
x
C

H
|
H

T

-

V

-

A

-

F

F

H

L

P

K

P

P

C

T

T

D

L

V

Q

K

H

H

-

L

G

G

Q

S

Q

A

I

E

R

R

-

P

G

V

K

M

V

L

E

D

H

E

L

I

L

V

T

E

A

A

L

T

G

G

V

A

E

K

V

S

R

V

L

P

P

Y

A

A

D

D

S

K

H

M

L

M

C
|
C

G

G

S

A

A

G

G

G

T

G

Y

V

S

R

L

A

T

R

Q

E

P

L

K

E

L

L

S

S

Y

L

A

D

L

M

R

T

D

N

Q

E

K

K

L

I

D

E

R

N

L

M

Q

I

A

K

Q

A

E

G

P

A

Q

D

V

C

I

T

V

V

S

-

A

-

N

N

V

V

G
x
C

C

P

I
x
F

A
x
C

H

H

L

L

Q

Q

binding Non-cubane [4Fe-4S]-cluster: G8 (= G174), C9 (= C175), I10 (≠ V176), C41 (= C207), C42 (= C208), C78 (≠ A247), G80 (= G249), C81 (= C250), G152 (≠ S300), C153 (≠ V301), H154 (= H302), C193 (= C342), C194 (= C343), C231 (≠ G382), F233 (≠ I384), C234 (≠ A385)
binding 1-thioethanesulfonic acid: P45 (≠ I211), G46 (≠ R212), G80 (= G249), F233 (≠ I384)

5odcB Heterodisulfide reductase / [nife]-hydrogenase complex from methanothermococcus thermolithotrophicus at 2.3 a resolution (see paper)
27% identity, 54% coverage: 168:388/408 of query aligns to 2:237/291 of 5odcB

query
sites
5odcB

K

K

M

Y

L

A

M

F

L

F

A

L

G
|
G

C
|
C

V
x
I

Q

M

P

P

S

N

M

R

M

Y

P

A

N

G

V

V

N

E

I

A

A

A

T

T

A

R

R

T

V

V

F

M

D

E

A

K

L

L

G

G

V

V

E

E

T

L

L

V

I

D

A

M

P

T

D

G

A

A

G

S

C
|
C

G

P

A

A

I

P

R

G

L

V

H

F

L

G

G

S

Y

F

N

D

D

Q

D

K

A

T

L

W

D

L

D

T

L

L

R

A

A

A

N

R

I

-

D

-

A

N

W

L

W

C

P

I

Y

A

I

E

E

E

Q

M

G

G

V

V

E

D

A

-

I

I

V

V

M

T

N

V

A
x
C

S
x
N

G
|
G

C
|
C

G

Y

A

G

T

S

V

L

K

F

E

E

Y

A

A

A

H

H

L

L

R

-

H

H

D

D

P

N

A

K

Y

E

A

A

-

L

-

N

-

F

-

V

-

N

-

E

-

K

-

L

-

D

-

K

-

V

-

G

-

K

-

E

-

Y

-

K

-

G

-

N

E

V

K

K

A

V

R

R

R

H

V

F

V

A

E

E

L

L

T

I

R

Y

D

N

-

D

-

I

-

G

V

V

A

D

E

K

I

I

L

A

P

E

E

K

F

V

E

E

E

R

A

P

L

L

-

N

V

I

S

N

V

V

T

G

R

V

R

H

R

Y

S
x
G

V
x
C

H

H

T

-

V

-

A

-

F

F

H

L

P

K

P

P

C

T

T

D

L

V

Q

K

H

H

-

L

G

G

Q

S

Q

A

I

E

R

R

-

P

G

V

K

M

V

L

E

D

H

E

L

I

L

V

T

E

A

A

L

T

G

G

V

A

E

K

V

S

R

V

L

P

P

Y

A

A

D

D

S

K

H

M

L

M

C
|
C

G

G

S

A

A
x
G

G

G

T

G

Y

V

S

R

L

A

T

R

Q

E

P

L

K

E

L

L

S

S

Y

L

A

D

L

M

R

T

D

N

Q

E

K

K

L

I

D

E

R

N

L

M

Q

I

A

K

Q

A

E

G

P

A

Q

D

V

C

I

T

V

V

S

-

A

-

N

N

V

V

G
x
C

C

P

I
x
F

A
x
C

H

H

L

L

Q

Q

binding Non-cubane [4Fe-4S]-cluster: G8 (= G174), C9 (= C175), I10 (≠ V176), C41 (= C207), C42 (= C208), C78 (≠ A247), N79 (≠ S248), G80 (= G249), C81 (= C250), G152 (≠ S300), C153 (≠ V301), C193 (= C342), C194 (= C343), G197 (≠ A346), C231 (≠ G382), F233 (≠ I384), C234 (≠ A385)

Q007T0 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur subunit of complex II; Ip; EC 1.3.5.1 from Sus scrofa (Pig) (see paper)
25% identity, 25% coverage: 2:101/408 of query aligns to 164:269/280 of Q007T0

query
sites
Q007T0

Q

Q

T

E

N

G

L

K

A

Q

D

Q

F

Y

I

L

R

Q

N

S

T

I

P

E

D

E

G

R

D

E

E

K

A

L

D

D

G

G

I

-

L

L

R

Y

N

E

C
|
C

V

I

H

L

C
|
C

G

A

F

C

C
|
C

T

S

A

T

T

S

C
|
C

P

P

T

S

Y

Y

Q

W

I
x
W

L

N

G

G

D

D

E

K

L

Y

D

L

G

G

P

P

R

A

G

V

R

L

I

M

Y

Q

L

A

I

Y

K

R

Q

W

M

M

V

I

E

D

G

S

A

R

P

D

V

D

T

F

R

T

S

E

T

E

Q

R

V

L

-

A

-

K

-

L

-

Q

-

D

-

P

-

F

H

S

L

L

D

Y

R

R

C
|
C

L

H

T

T

C

I

R

M

N

N

C
|
C

E

T

S

G

T

T

C
|
C

P

P

S

K

G

G

V

L

Q

N

Y

P

G

G

R

K

L

A

V

I

E

A

I

E

G

I

R

K

K

K

L

M

C186 (= C25) binding
C189 (= C28) binding
C192 (= C31) binding
C196 (= C35) binding
W201 (≠ I40) binding
C243 (= C75) binding
C249 (= C81) binding
C253 (= C85) binding

Sites not aligning to the query:

93 binding
98 binding
101 binding
113 binding

3sfeB Crystal structure of porcine mitochondrial respiratory complex ii bound with oxaloacetate and thiabendazole (see paper)
25% identity, 25% coverage: 2:101/408 of query aligns to 129:234/240 of 3sfeB

query
sites
3sfeB

Q

Q

T

E

N

G

L

K

A

Q

D

Q

F

Y

I

L

R

Q

N

S

T

I

P

E

D

E

G

R

D

E

E

K

A

L

D

D

G

G

I

-

L

L

R

Y

N

E

C
|
C

V
x
I

H
x
L

C
|
C

G
x
A

F

C

C
|
C

T

S

A

T

T

S

C
|
C

P

P

T

S

Y

Y

Q

W

I

W

L

N

G

G

D

D

E

K

L
x
Y

D

L

G

G

P
|
P

R
x
A

G

V

R

L

I

M

Y

Q

L

A

I

Y

K

R

Q

W

M

M

V

I

E

D

G

S

A

R

P

D

V

D

T

F

R

T

S

E

T

E

Q

R

V

L

-

A

-

K

-

L

-

Q

-

D

-

P

-

F

H

S

L

L

D

Y

R

R

C
|
C

L
x
H

T
|
T

C
x
I

R
x
M

N
|
N

C
|
C

E

T

S

G

T

T

C
|
C

P
|
P

S
x
K

G

G

V
x
L

Q

N

Y

P

G

G

R

K

L

A

V

I

E

A

I

E

G

I

R

K

K

K

L

M

binding fe3-s4 cluster: C161 (= C35), Y171 (≠ L45), P174 (= P48), C208 (= C75), T210 (= T77), I211 (≠ C78), M212 (≠ R79), N213 (= N80), C214 (= C81)
binding iron/sulfur cluster: C151 (= C25), I152 (≠ V26), L153 (≠ H27), C154 (= C28), A155 (≠ G29), C157 (= C31), A175 (≠ R49), C218 (= C85), P219 (= P86), K220 (≠ S87), L222 (≠ V89)
binding 2-(1,3-thiazol-4-yl)-1h-benzimidazole: H209 (≠ L76), I211 (≠ C78)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 58, 59, 61, 63, 64, 65, 66, 78

8gs8B Cryo-em structure of the human respiratory complex ii (see paper)
25% identity, 25% coverage: 2:101/408 of query aligns to 130:235/239 of 8gs8B

query
sites
8gs8B

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binding fe3-s4 cluster: C162 (= C35), Y172 (≠ L45), P175 (= P48), C209 (= C75), H210 (≠ L76), T211 (= T77), I212 (≠ C78), M213 (≠ R79), N214 (= N80), C215 (= C81)
binding iron/sulfur cluster: C152 (= C25), C155 (= C28), C158 (= C31), A176 (≠ R49), C219 (= C85)
binding ubiquinone-1: P163 (= P36), W167 (≠ I40), I212 (≠ C78)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 59, 60, 64, 65, 66, 67, 79

3sfdB Crystal structure of porcine mitochondrial respiratory complex ii bound with oxaloacetate and pentachlorophenol (see paper)
25% identity, 25% coverage: 2:101/408 of query aligns to 128:233/239 of 3sfdB

query
sites
3sfdB

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binding fe3-s4 cluster: C160 (= C35), Y170 (≠ L45), P173 (= P48), C207 (= C75), T209 (= T77), I210 (≠ C78), M211 (≠ R79), N212 (= N80), C213 (= C81)
binding pentachlorophenol: P161 (= P36), W165 (≠ I40), I210 (≠ C78)
binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), L152 (≠ H27), C153 (= C28), A154 (≠ G29), C156 (= C31), A174 (≠ R49), C217 (= C85), P218 (= P86), K219 (≠ S87)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 57, 58, 60, 62, 63, 64, 65, 77

3aegB Crystal structure of porcine heart mitochondrial complex ii bound with n-biphenyl-3-yl-2-iodo-benzamide
25% identity, 25% coverage: 2:101/408 of query aligns to 128:233/239 of 3aegB

query
sites
3aegB

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binding N-biphenyl-3-yl-2-iodobenzamide: S162 (≠ T37), W164 (≠ Q39), W165 (≠ I40), H208 (≠ L76)
binding fe3-s4 cluster: C160 (= C35), Y170 (≠ L45), P173 (= P48), C207 (= C75), I210 (≠ C78), M211 (≠ R79), C213 (= C81), I227 (≠ V95)
binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), L152 (≠ H27), C153 (= C28), A154 (≠ G29), C156 (= C31), A174 (≠ R49), C217 (= C85)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 57, 58, 60, 62, 63, 65, 75, 77

3aeeB Crystal structure of porcine heart mitochondrial complex ii bound with atpenin a5
25% identity, 25% coverage: 2:101/408 of query aligns to 128:233/239 of 3aeeB

query
sites
3aeeB

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binding 3-[(2s,4s,5r)-5,6-dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1h)-pyridinone: W165 (≠ I40), H208 (≠ L76), I210 (≠ C78)
binding fe3-s4 cluster: C160 (= C35), Y170 (≠ L45), P173 (= P48), C207 (= C75), T209 (= T77), I210 (≠ C78), M211 (≠ R79), N212 (= N80), C213 (= C81)
binding iron/sulfur cluster: C150 (= C25), L152 (≠ H27), C153 (= C28), C156 (= C31), A174 (≠ R49), C217 (= C85), P218 (= P86), L221 (≠ V89)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 57, 58, 60, 62, 63, 65, 77

3aedB Crystal structure of porcine heart mitochondrial complex ii bound with 2-iodo-n-phenyl-benzamide
25% identity, 25% coverage: 2:101/408 of query aligns to 128:233/239 of 3aedB

query
sites
3aedB

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binding 2-iodo-N-phenylbenzamide: P161 (= P36), W165 (≠ I40), H208 (≠ L76), I210 (≠ C78)
binding fe3-s4 cluster: C160 (= C35), Y170 (≠ L45), P173 (= P48), C207 (= C75), I210 (≠ C78), M211 (≠ R79), N212 (= N80), C213 (= C81)
binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), L152 (≠ H27), C153 (= C28), A154 (≠ G29), C156 (= C31), C217 (= C85), L221 (≠ V89)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 57, 58, 60, 62, 63, 65, 77

3aecB Crystal structure of porcine heart mitochondrial complex ii bound with 2-iodo-n-(1-methylethyl)-benzamid
25% identity, 25% coverage: 2:101/408 of query aligns to 128:233/239 of 3aecB

query
sites
3aecB

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binding 2-iodo-N-(1-methylethyl)benzamide: P161 (= P36), W165 (≠ I40), H208 (≠ L76)
binding fe3-s4 cluster: C160 (= C35), Y170 (≠ L45), P173 (= P48), C207 (= C75), I210 (≠ C78), M211 (≠ R79), N212 (= N80), C213 (= C81)
binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), L152 (≠ H27), C153 (= C28), C156 (= C31), A174 (≠ R49), C217 (= C85), P218 (= P86), L221 (≠ V89)

Sites not aligning to the query:

binding fe2/s2 (inorganic) cluster: 57, 58, 62, 63, 65, 75, 77

Query Sequence

>BPHYT_RS03500 FitnessBrowser__BFirm:BPHYT_RS03500
MQTNLADFIRNTPDGDEADGILRNCVHCGFCTATCPTYQILGDELDGPRGRIYLIKQMVE
GAPVTRSTQVHLDRCLTCRNCESTCPSGVQYGRLVEIGRKLTEEKVTRPLGQRLVRRMLA
SFVPNSALFTPTMRIGQHFRPLLPKKLRDKVPARQRPLEWPTAKHPRKMLMLAGCVQPSM
MPNVNIATARVFDALGVETLIAPDAGCCGAIRLHLGYNDDALDDLRANIDAWWPYIEQGV
EAIVMNASGCGATVKEYAHLLRHDPAYAEKARRVVELTRDVAEILPEFEEALVSVTRRRS
VHTVAFHPPCTLQHGQQIRGKVEHLLTALGVEVRLPADSHLCCGSAGTYSLTQPKLSYAL
RDQKLDRLQAQEPQVIVSANVGCIAHLQSGTSTPVAHWIELVEHMLSV

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory