SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing BPHYT_RS04435 FitnessBrowser__BFirm:BPHYT_RS04435 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
35% identity, 39% coverage: 388:638/646 of query aligns to 1:253/253 of 1g9xB

query
sites
1g9xB

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binding adenosine-5'-diphosphate: F14 (= F401), F17 (≠ L404), N39 (= N426), G40 (= G427), S41 (= S428), G42 (= G429), K43 (= K430), S44 (= S431), T45 (= T432)
binding magnesium ion: S44 (= S431), E176 (= E565)

1g6hA Crystal structure of the adp conformation of mj1267, an atp- binding cassette of an abc transporter (see paper)
35% identity, 39% coverage: 388:638/646 of query aligns to 1:253/254 of 1g6hA

query
sites
1g6hA

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binding adenosine-5'-diphosphate: F14 (= F401), F17 (≠ L404), N39 (= N426), G40 (= G427), S41 (= S428), G42 (= G429), K43 (= K430), S44 (= S431), T45 (= T432)

P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see paper)
34% identity, 40% coverage: 389:644/646 of query aligns to 2:245/501 of P04983

query
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P04983

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K43 (= K430) mutation to R: Loss of transport.

6mjpB Lptb(e163q)fgc from vibrio cholerae (see paper)
28% identity, 39% coverage: 391:640/646 of query aligns to 2:237/240 of 6mjpB

query
sites
6mjpB

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binding 6-cyclohexylhexyl beta-D-glucopyranoside: R90 (≠ G479), K91 (≠ E480)

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
28% identity, 39% coverage: 391:640/646 of query aligns to 2:237/240 of 6mjpA

query
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6mjpA

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C

D

E

R

K

V

A

S

Y

V

I

L

V

D

S

F

Q

G

G

Q

R

K

L

I

I

A

A

E

E

G

G

K

T

P

P

A

Q

D

D

I

V

Q

L

S

N

N

N

E

E

K

Q

V

V

I

K

E

Q

A

V

Y

Y

L

L

G

G

G

E

Q

Q

binding calcium ion: E111 (≠ R514), D115 (≠ E518)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
32% identity, 35% coverage: 400:626/646 of query aligns to 10:223/240 of 4ymuJ

query
sites
4ymuJ

Q

N

F
|
F

S

G

G

S

L
|
L

K

E

A
x
V

L

L

N

K

D

G

V

V

D

T

L

L

T

K

V

V

Q

N

R

K

G

G

T

E

I

V

H

V

G

V

L

I

I

I

G

G

P

P

N
x
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

M

L

M

L

N

R

V

C

L

I

T

N

G

L

I

L

Y
x
E

V

E

P

P

T

T

A

K

G

G

T

E

L

V

E

F

Y

I

R

D

G

G

A

V

S

K

L

I

A

N

-

N

G

G

K

K

T

V

S

N

A

I

Q

N

I

K

A

V

L

R

S

Q

G

K

I

V

A

G

R

M

T

V

F

F

Q

Q

N

H

V

F

Q

N

L

L

F

F

G

P

E

H

M

L

T

T

A

A

L

I

E

E

N

N

V

I

L

-

V

-

G

-

L

-

H

-

H

-

T

-

F

-

N

-

A

-

N

T

L

L

A

A

D

P

V

V

G

K

L

V

M

-

S

-

S

-

R

-

Y

K

R

K

R

M

E

N

E

K

R

K

A

E

A

A

R

E

E

E

R

L

A

A

F

V

G

D

M

L

L

L

R

A

F

K

V

V

G

G

L

L

D

L

N

D

V

K

A

K

A

D

E

Q

E

Y

A

P

R

I

N

K

L

L

P

S

Y

G

G

G

K

Q

Q

K

R

Q

L

R

L

L

E

A

I

I

A

A

R

R

A

A

L

L

A

A

L

M

D

Q

P

P

Q

E

L

V

L

M

L

L

L

F

D

D

E
|
E

P

P

A

T

A

S

G

A

L

L

T

D

A

P

P

E

D

M

I

V

K

K

E

E

L

V

V

L

A

N

I

V

I

M

R

K

K

Q

V

L

R

A

D

N

H

E

G

G

I

M

T

T

V

M

V

V

L

V

I

V

E

T

H
|
H

H

E

M

M

D

G

V

F

V

A

M

R

S

E

V

V

C

G

D

D

R

R

V

V

S

I

V

F

L

M

D

D

F

D

G

G

Q

V

K

I

I

V

A

E

E

E

G

G

K

T

P

P

A

E

D

E

I

I

binding adenosine-5'-triphosphate: F11 (= F401), L14 (= L404), V16 (≠ A406), S36 (≠ N426), G37 (= G427), S38 (= S428), G39 (= G429), K40 (= K430), S41 (= S431), T42 (= T432), E51 (≠ Y441), E162 (= E565), H194 (= H597)
binding magnesium ion: S41 (= S431), E162 (= E565)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
29% identity, 38% coverage: 391:638/646 of query aligns to 6:238/240 of 1ji0A

query
sites
1ji0A

I

V

L

L

Q

E

L

V

R

Q

G

S

I

L

L

H

M

V

Q

Y

F
x
Y

S

G

G

A

L
x
I

K

H

A
|
A

L

I

N

K

D

G

V

I

D

D

L

L

T

K

V

V

Q

P

R

R

G

G

T

Q

I

I

H

V

G

T

L

L

I

I

G

G

P

A

N
|
N

G
|
G

S
x
A

G
|
G

K
|
K

S
x
T

T
|
T

M

T

M

L

N

S

V

A

L

I

T

A

G

G

I

L

Y

V

V

R

P

A

T

Q

A

K

G

G

T

K

L

I

E

I

Y

F

R

N

G

G

A

Q

S

D

L

I

A

T

G

N

K

K

T

P

S

A

A

H

Q

V

I

I

A

N

L

R

S

M

G

G

I

I

A

A

R

L

T

V

F

P

Q
x
E

N

G

V

R

Q

R

L

I

F

F

G

P

E

E

M

L

T

T

A

V

L

Y

E

E

N

N

V

L

L

M

V

M

G

G

L

A

H

Y

H

N

T

R

F

-

N

-

A

-

N

-

L

-

A

-

D

-

V

-

G

-

L

-

M

-

S

-

S

-

R

-

Y

-

R

K

R

D

E

K

E

E

R

G

A

I

A

K

R

R

E

D

R

L

A

E

F

W

G

I

M

F

L

S

R

L

F

F

V

P

G

R

L

L

D

K

N

E

V

R

A

L

A

K

E

Q

E

L

A

G

R

G

N

T

L

L

P

S

Y

G

G

G

K

E

Q

Q

R

Q

L

M

L

L

E

A

I

I

A

G

R

R

A

A

L

L

A

M

L

S

D

R

P

P

Q

K

L

L

L

L

L

M

L

M

D
|
D

E
|
E

P

P

A

S

A

L

G

G

L

L

T

A

A

P

P

I

D

L

I

V

K

S

E

E

L

V

V

F

A

E

I

V

I

I

R

Q

K

K

V

I

R

N

D

Q

H

E

G

G

I

T

T

T

V

I

V

L

L

L

I

V

E

E

H

Q

H

N

M

A

D

L

V

G

V

A

M

L

S

K

V

V

C

A

D

H

R

Y

V

G

S

Y

V

V

L

L

D

E

F

T

G

G

Q

Q

K

I

I

V

A

L

E

E

G

G

K

K

P

A

A

S

D

E

I

L

Q

L

S

D

N

N

E

E

K

M

V

V

I

R

E

K

A

A

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y16 (≠ F401), I19 (≠ L404), A21 (= A406), N41 (= N426), G42 (= G427), A43 (≠ S428), G44 (= G429), K45 (= K430), T46 (≠ S431), T47 (= T432), E88 (≠ Q473), D164 (= D564), E165 (= E565)

Q5M244 Energy-coupling factor transporter ATP-binding protein EcfA2; ECF transporter A component EcfA2; EC 3.6.3.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
33% identity, 34% coverage: 405:626/646 of query aligns to 21:232/280 of Q5M244

query
sites
Q5M244

K

R

A

A

L

L

N

F

D

D

V

M

D

T

L

V

T

T

V

I

Q

K

R

D

G

G

T

S

I

Y

H

T

G

A

L

F

I

I

G

G

P

H

N

T

G

G

S

S

G

G

K

K

S

S

T

T

M

I

M

M

N

Q

V

L

L

L

T

N

G

G

I

L

Y

Y

V

L

P

P

T

T

A

S

G

G

T

Q

L

V

E

K

Y

V

R

D

G

D

A

T

S

I

L

I

A

N

G

S

K

Q

T

S

S

K

A

N

Q

K

I

E

-

I

-

K

-

P

-

I

-

R

A

K

L

K

S

V

G

G

I

L

A

V

R

F

T

Q

F

F

Q

P

N

E

V

S

Q
|
Q

L

L

F

F

G

A

E

E

M

-

T

T

A

V

L

L

E

E

N

D

V

I

L

A

V

F

G

G

L

P

H

Q

H

N

T

-

F

F

N

G

A

V

N

S

L

-

A

-

D

-

V

-

G

-

L

-

M

-

S

-

S

-

R

-

Y

-

R

-

R

K

E

E

E

E

R

-

A

-

A

A

R

E

E

Q

R

R

A

A

F

L

G

E

M

S

L

L

R

R

F

L

V

V

G

G

L

L

-

S

D

D

N

E

V

L

A

R

A

D

E

Q

E

N

A

P

R

F

N

D

L

L

P

S

Y

G

G

G

K

Q

Q

M

R

R

L

R

L

V

E

A

I

I

A

A

R

G

A

I

L

L

A

A

L

M

D

Q

P

P

Q

D

L

I

L

L

L

V

L

L

D

D

E
|
E

P

P

A

T

A

A

G

G

L

L

T

D

A

P

P

Q

D

G

I

R

K

K

E

E

L

L

V

M

A

S

I

L

I

F

R

K

K

Q

V

L

R

H

D

L

H

S

G

G

I

I

T

T

V

I

V

V

L

L

I

V

E

T

H

H

H

L

M

M

D

D

V

D

V

V

M

A

S

D

V

Y

C

A

D

T

R

A

V

V

S

N

V

V

L

M

D

E

F

K

G

G

Q

R

K

L

I

V

A

L

E

S

G

G

K

T

P

P

A

K

D

D

I

V

Q97 (= Q476) mutation to A: No effect on ATPase, 10-fold decrease in riboflavin uptake; when associated with A-90 in EcfA1.
E171 (= E565) mutation to Q: 10-fold decrease in ATPase and riboflavin uptake; when associated with Q-163 in EcfA1.

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
30% identity, 38% coverage: 392:638/646 of query aligns to 3:235/235 of 6mhzA

query
sites
6mhzA

L

L

Q

T

L

A

R

K

G

N

I

L

L

A

M

K

Q

A

F
x
Y

S

K

G

G

L

R

K

R

A

V

L

V

N

E

D

D

V

V

D

S

L

L

T

T

V

V

Q

N

R

S

G

G

T

E

I

I

H

V

G

G

L

L

I

L

G

G

P
|
P

N
|
N

G
|
G

S
x
A

G
|
G

K
|
K

S
x
T

T
|
T

M

T

M

F

N

Y

V

M

L

V

T

V

G

G

I

I

Y

V

V

P

P

R

T

D

A

A

G

G

T

N

L

I

E

I

Y

I

R

D

G

D

A

D

S

D

L

I

A

S

G

L

K

L

T

P

S

L

A

H

Q

A

I

R

A

A

L

R

S

R

G

G

I

I

A

G

R

Y

T

L

F

P

Q
|
Q

N

E

V

A

Q

S

L

I

F

F

G

R

E

R

M

L

T

S

A

V

L

Y

E

D

N

N

V

L

L

M

V

A

G

V

L

L

H

Q

H

-

T

-

F

I

N

R

A

D

N

D

L

L

A

-

D

-

V

-

G

-

L

-

M

-

S

-

S

S

R

A

Y

E

R

Q

R

R

E

E

E

D

R

R

A

A

A

N

R

E

E

-

R

-

A

-

F

-

G

-

M

L

L

M

R

E

F

E

V

F

G

H

L

I

D

E

N

H

V

L

A

R

A

D

E

S

E

M

A

G

R

Q

N
x
S

L

L

P
x
S

Y
x
G

G
|
G

K
x
E

Q

R

R

R

L

R

L

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

L

A

D

N

P

P

Q

K

L

F

L

I

L

L

L

L

D

D

E
|
E

P

P

A

F

A

A

G
|
G

L

V

T

D

A

P

P

I

D

S

I

V

K

I

E

D

L

I

V

K

A

R

I

I

I

I

R

E

K

H

V

L

R

R

D

D

H

S

G

G

I

L

T

G

V

V

V

L

L

I

I

T

E

D

H
|
H

H

N

M

V

D

R

V

E

V

T

M

L

S

A

V

V

C

C

D

E

R

R

V

A

S

Y

V

I

L

V

D

S

F

Q

G

G

Q

H

K

L

I

I

A

A

E

H

G

G

K

T

P

P

A

T

D

E

I

I

Q

L

S

Q

N

D

E

E

K

H

V

V

I

K

E

R

A

V

Y

Y

L

L

G

G

binding adp orthovanadate: Y12 (≠ F401), P36 (= P425), N37 (= N426), G38 (= G427), A39 (≠ S428), G40 (= G429), K41 (= K430), T42 (≠ S431), T43 (= T432), Q84 (= Q473), S136 (≠ N539), S138 (≠ P541), G139 (≠ Y542), G140 (= G543), E141 (≠ K544), E162 (= E565), G166 (= G569), H194 (= H597)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
30% identity, 38% coverage: 392:638/646 of query aligns to 3:235/238 of 6s8nB

query
sites
6s8nB

L

L

Q

T

L

A

R

K

G

N

I

L

L

A

M

K

Q

A

F

Y

S

K

G

G

L

R

K

R

A

V

L

V

N

E

D

D

V

V

D

S

L

L

T

T

V

V

Q

N

R

S

G

G

T

E

I

I

H

V

G

G

L

L

I

L

G

G

P

P

N

N

G

G

S

A

G

G

K

K

S

T

T

T

M

T

M

F

N

Y

V

M

L

V

T

V

G

G

I

I

Y

V

V

P

P

R

T

D

A

A

G

G

T

N

L

I

E

I

Y

I

R

D

G

D

A

D

S

D

L

I

A

S

G

L

K

L

T

P

S

L

A

H

Q

A

I

R

A

A

L

R

S

R

G

G

I

I

A

G

R

Y

T

L

F

P

Q

Q

N

E

V

A

Q

S

L

I

F

F

G
x
R

E

R

M

L

T

S

A

V

L

Y

E

D

N

N

V

L

L

M

V

A

G

V

L

L

H

Q

H

-

T

-

F

I

N

R

A

D

N

D

L

L

A

-

D

-

V

-

G

-

L

-

M

-

S

-

S

S

R

A

Y

E

R

Q

R

R

E

E

E

D

R

R

A

A

A

N

R

E

E

-

R

-

A

-

F

-

G

-

M

L

L

M

R

E

F

E

V

F

G

H

L

I

D

E

N

H

V

L

A

R

A

D

E

S

E
x
M

A
x
G

R
x
Q

N

S

L

L

P

S

Y

G

G

G

K

E

Q

R

R

R

L

R

L

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

L

A

D

N

P

P

Q

K

L

F

L

I

L

L

L

L

D

D

E

E

P

P

A

F

A

A

G

G

L

V

T

D

A

P

P

I

D

S

I

V

K

I

E

D

L

I

V

K

A

R

I

I

I

I

R

E

K

H

V

L

R

R

D

D

H

S

G

G

I

L

T

G

V

V

V

L

L

I

I

T

E

D

H

H

H

N

M

V

D

R

V

E

V

T

M

L

S

A

V

V

C

C

D

E

R

R

V

A

S

Y

V

I

L

V

D

S

F

Q

G

G

Q

H

K

L

I

I

A

A

E

H

G

G

K

T

P

P

A

T

D

E

I

I

Q

L

S

Q

N

D

E

E

K

H

V

V

I

K

E

R

A

V

Y

Y

L

L

G

G

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (≠ G479), M133 (≠ E536), G134 (≠ A537), Q135 (≠ R538)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
30% identity, 38% coverage: 392:638/646 of query aligns to 3:235/238 of 6s8gA

query
sites
6s8gA

L

L

Q

T

L

A

R

K

G

N

I

L

L

A

M

K

Q

A

F
x
Y

S

K

G

G

L
x
R

K

R

A
x
V

L

V

N

E

D

D

V

V

D

S

L

L

T

T

V

V

Q

N

R

S

G

G

T

E

I

I

H

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

S

A

G
|
G

K
|
K

S
x
T

T
|
T

M

T

M

F

N

Y

V

M

L

V

T

V

G

G

I

I

Y

V

V

P

P

R

T

D

A

A

G

G

T

N

L

I

E

I

Y

I

R

D

G

D

A

D

S

D

L

I

A

S

G

L

K

L

T

P

S

L

A

H

Q

A

I

R

A

A

L

R

S

R

G

G

I

I

A

G

R

Y

T

L

F

P

Q
|
Q

N

E

V

A

Q

S

L

I

F

F

G

R

E

R

M

L

T

S

A

V

L

Y

E

D

N

N

V

L

L

M

V

A

G

V

L

L

H

Q

H

-

T

-

F

I

N

R

A

D

N

D

L

L

A

-

D

-

V

-

G

-

L

-

M

-

S

-

S

S

R

A

Y

E

R

Q

R

R

E

E

E

D

R

R

A

A

A

N

R

E

E

-

R

-

A

-

F

-

G

-

M

L

L

M

R

E

F

E

V

F

G

H

L

I

D

E

N

H

V

L

A

R

A

D

E

S

E

M

A

G

R

Q

N
x
S

L

L

P
x
S

Y

G

G

G

K
x
E

Q

R

R

R

L

R

L

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

L

A

D

N

P

P

Q

K

L

F

L

I

L

L

L

L

D

D

E

E

P

P

A

F

A

A

G

G

L

V

T

D

A

P

P

I

D

S

I

V

K

I

E

D

L

I

V

K

A

R

I

I

I

I

R

E

K

H

V

L

R

R

D

D

H

S

G

G

I

L

T

G

V

V

V

L

L

I

I

T

E

D

H
|
H

H

N

M

V

D

R

V

E

V

T

M

L

S

A

V

V

C

C

D

E

R

R

V

A

S

Y

V

I

L

V

D

S

F

Q

G

G

Q

H

K

L

I

I

A

A

E

H

G

G

K

T

P

P

A

T

D

E

I

I

Q

L

S

Q

N

D

E

E

K

H

V

V

I

K

E

R

A

V

Y

Y

L

L

G

G

binding phosphoaminophosphonic acid-adenylate ester: Y12 (≠ F401), R15 (≠ L404), V17 (≠ A406), N37 (= N426), G38 (= G427), G40 (= G429), K41 (= K430), T42 (≠ S431), T43 (= T432), Q84 (= Q473), S136 (≠ N539), S138 (≠ P541), E141 (≠ K544), H194 (= H597)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
30% identity, 37% coverage: 391:631/646 of query aligns to 2:228/241 of 4u00A

query
sites
4u00A

I

I

L

I

Q

R

L

I

R

R

G

N

I

L

L

H

M

K

Q

W

F
|
F

S

G

G

P

L
|
L

K

H

A
x
V

L

L

N

K

D

G

V

I

D

H

L

L

T

E

V

V

Q

A

R

P

G

G

T

E

I

K

H

L

G

V

L

I

I

I

G

G

P

P

N
x
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

M

L

M

I

N

R

V

T

L

I

T

N

G

R

I

L

Y

E

V

D

P

F

T

Q

A

E

G

G

T

E

L

V

E

V

Y

V

R

D

G

G

A

L

S

S

L

V

A

K

G

D

K

D

T

R

S

A

A

L

Q

R

I

E

A

I

L

R

S

R

G

E

I

V

A

G

R

M

T

V

F

F

Q

Q

N

Q

V

F

Q

N

L

L

F

F

G

P

E

H

M

M

T

T

A

V

L

L

E

E

N

N

V

V

L

T

V

L

G

A

L

-

H

-

H

-

T

-

F

-

N

-

A

-

N

-

L

-

A

-

D

-

V

-

G

P

L

M

M

R

S

V

S

R

R

R

Y

W

R

P

R

R

E

E

E

K

R

-

A

-

A

A

R

E

E

K

R

K

A

A

F

L

G

E

M

L

L

L

R

E

F

R

V

V

G

G

L

I

D

L

N

D

V

Q

A

A

A

R

E

K

E

Y

A

P

R

A

N

Q

L

L

P

S

Y

G

G

G

K

Q

Q

Q

R

Q

L

R

L

V

E

A

I

I

A

A

R

R

A

A

L

L

A

A

L

M

D

E

P

P

Q

K

L

I

L

M

L

L

L

F

D

D

E

E

P

P

A

T

A

S

G

A

L

L

T

D

A

P

P

E

D

M

I

V

K

G

E

E

L

V

V

L

A

D

I

V

I

M

R

R

K

D

V

L

R

A

D

Q

H

G

G

G

I

M

T

T

V

M

V

V

L

V

I

V

E

T

H

H

H

E

M

M

D

G

V

F

V

A

M

R

S

E

V

V

C

A

D

D

R

R

V

V

S

V

V

F

L

M

D

D

F

G

G

G

Q

Q

K

I

I

V

A

E

E

E

G

G

K

R

P

P

A

E

D

E

I

I

Q

F

S

T

N

R

E

P

K

K

binding adenosine-5'-diphosphate: F12 (= F401), L15 (= L404), V17 (≠ A406), S37 (≠ N426), G38 (= G427), S39 (= S428), G40 (= G429), K41 (= K430), S42 (= S431), T43 (= T432)

6mbnA Lptb e163q in complex with atp (see paper)
30% identity, 38% coverage: 392:638/646 of query aligns to 4:236/241 of 6mbnA

query
sites
6mbnA

L

L

Q

T

L

A

R

K

G

N

I

L

L

A

M

K

Q

A

F
x
Y

S

K

G

G

L
x
R

K

R

A
x
V

L

V

N

E

D

D

V

V

D

S

L

L

T

T

V

V

Q

N

R

S

G

G

T

E

I

I

H

V

G

G

L

L

I

L

G

G

P
|
P

N
|
N

G
|
G

S
x
A

G
|
G

K
|
K

S
x
T

T
|
T

M

T

M

F

N

Y

V

M

L

V

T

V

G

G

I

I

Y

V

V

P

P

R

T

D

A

A

G

G

T

N

L

I

E

I

Y

I

R

D

G

D

A

D

S

D

L

I

A

S

G

L

K

L

T

P

S

L

A

H

Q

A

I

R

A

A

L

R

S

R

G

G

I

I

A

G

R

Y

T

L

F

P

Q
|
Q

N

E

V

A

Q

S

L

I

F

F

G

R

E

R

M

L

T

S

A

V

L

Y

E

D

N

N

V

L

L

M

V

A

G

V

L

L

H

Q

H

-

T

-

F

I

N

R

A

D

N

D

L

L

A

-

D

-

V

-

G

-

L

-

M

-

S

-

S

S

R

A

Y

E

R

Q

R

R

E

E

E

D

R

R

A

A

A

N

R

E

E

-

R

-

A

-

F

-

G

-

M

L

L

M

R

E

F

E

V

F

G

H

L

I

D

E

N

H

V

L

A

R

A

D

E

S

E

M

A

G

R

Q

N

S

L

L

P

S

Y

G

G

G

K

E

Q

R

R

R

L

R

L

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

L

A

D

N

P

P

Q

K

L

F

L

I

L

L

L

L

D

D

E

Q

P

P

A

F

A

A

G

G

L

V

T

D

A

P

P

I

D

S

I

V

K

I

E

D

L

I

V

K

A

R

I

I

I

I

R

E

K

H

V

L

R

R

D

D

H

S

G

G

I

L

T

G

V

V

V

L

L

I

I

T

E

D

H
|
H

H

N

M

V

D

R

V

E

V

T

M

L

S

A

V

V

C

C

D

E

R

R

V

A

S

Y

V

I

L

V

D

S

F

Q

G

G

Q

H

K

L

I

I

A

A

E

H

G

G

K

T

P

P

A

T

D

E

I

I

Q

L

S

Q

N

D

E

E

K

H

V

V

I

K

E

R

A

V

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y13 (≠ F401), R16 (≠ L404), V18 (≠ A406), P37 (= P425), N38 (= N426), G39 (= G427), A40 (≠ S428), G41 (= G429), K42 (= K430), T43 (≠ S431), T44 (= T432), Q85 (= Q473), H195 (= H597)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
30% identity, 38% coverage: 392:637/646 of query aligns to 3:234/234 of 6b89A

query
sites
6b89A

L

L

Q

T

L

A

R

K

G

N

I

L

L

A

M

K

Q

A

F
x
Y

S

K

G

G

L
x
R

K

R

A
x
V

L

V

N

E

D

D

V

V

D

S

L

L

T

T

V

V

Q

N

R

S

G

G

T

E

I

I

H

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

S
x
A

G
|
G

K
|
K

S
x
T

T
|
T

M

T

M

F

N

Y

V

M

L

V

T

V

G

G

I

I

Y

V

V

P

P

R

T

D

A

A

G

G

T

N

L

I

E

I

Y

I

R

D

G

D

A

D

S

D

L

I

A

S

G

L

K

L

T

P

S
x
L

A
x
H

Q

A

I

R

A

A

L

R

S

R

G

G

I

I

A

G

R
x
Y

T

L

F
x
P

Q
|
Q

N
x
E

V
x
A

Q
x
S

L

I

F
|
F

G
x
R

E
x
R

M
x
L

T

S

A

V

L

Y

E

D

N

N

V

L

L

M

V

A

G
x
V

L

L

H

Q

H

-

T

-

F

I

N

R

A

D

N

D

L

L

A

-

D

-

V

-

G

-

L

-

M

-

S

-

S

S

R

A

Y

E

R

Q

R

R

E

E

E

D

R

R

A

A

A

N

R

E

E

-

R

-

A

-

F

-

G

-

M

L

L

M

R

E

F

E

V

F

G

H

L

I

D

E

N

H

V

L

A

R

A

D

E

S

E

M

A

G

R
x
Q

N

S

L

L

P

S

Y

G

G

G

K

E

Q

R

R

R

L

R

L

V

E

E

I

I

A

A

R
|
R

A

A

L

L

A

A

L

A

D

N

P

P

Q

K

L

F

L

I

L

L

L

L

D

D

E

E

P

P

A

F

A

A

G

G

L

V

T

D

A

P

P

I

D

S

I

V

K

I

E

D

L

I

V

K

A

R

I

I

I

I

R

E

K

H

V

L

R

R

D

D

H

S

G

G

I

L

T

G

V

V

V

L

L

I

I

T

E

D

H

H

H

N

M

V

D

R

V

E

V

T

M

L

S

A

V

V

C

C

D

E

R

R

V

A

S

Y

V

I

L

V

D

S

F

Q

G

G

Q

H

K

L

I

I

A

A

E

H

G

G

K

T

P

P

A

T

D

E

I

I

Q

L

S

Q

N

D

E

E

K

H

V

V

I

K

E

R

A

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (≠ F401), R15 (≠ L404), V17 (≠ A406), N37 (= N426), G38 (= G427), A39 (≠ S428), G40 (= G429), K41 (= K430), T42 (≠ S431), T43 (= T432)
binding magnesium ion: T42 (≠ S431), Q84 (= Q473)
binding novobiocin: L71 (≠ S460), H72 (≠ A461), Y81 (≠ R470), P83 (≠ F472), E85 (≠ N474), A86 (≠ V475), S87 (≠ Q476), F89 (= F478), F89 (= F478), R90 (≠ G479), R91 (≠ E480), L92 (≠ M481), V101 (≠ G490), Q135 (≠ R538), R149 (= R552)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
30% identity, 38% coverage: 392:637/646 of query aligns to 3:234/234 of 4p31A

query
sites
4p31A

L

L

Q

T

L

A

R

K

G

N

I

L

L

A

M

K

Q

A

F
x
Y

S

K

G

G

L
x
R

K

R

A
x
V

L

V

N

E

D

D

V

V

D

S

L

L

T

T

V

V

Q

N

R

S

G

G

T

E

I

I

H

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

S
x
A

G
|
G

K
|
K

S
x
T

T
|
T

M

T

M

F

N

Y

V

M

L

V

T

V

G

G

I

I

Y

V

V

P

P

R

T

D

A

A

G

G

T

N

L

I

E

I

Y

I

R

D

G

D

A

D

S

D

L

I

A

S

G

L

K

L

T

P

S

L

A

H

Q

A

I

R

A

A

L

R

S

R

G

G

I

I

A

G

R

Y

T

L

F

P

Q
|
Q

N

E

V

A

Q

S

L

I

F

F

G

R

E

R

M

L

T

S

A

V

L

Y

E

D

N

N

V

L

L

M

V

A

G

V

L

L

H

Q

H

-

T

-

F

I

N

R

A

D

N

D

L

L

A

-

D

-

V

-

G

-

L

-

M

-

S

-

S

S

R

A

Y

E

R

Q

R

R

E

E

E

D

R

R

A

A

A

N

R

E

E

-

R

-

A

-

F

-

G

-

M

L

L

M

R

E

F

E

V

F

G

H

L

I

D

E

N

H

V

L

A

R

A

D

E

S

E

M

A

G

R

Q

N

S

L

L

P

S

Y

G

G

G

K

E

Q

R

R

R

L

R

L

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

L

A

D

N

P

P

Q

K

L

F

L

I

L

L

L

L

D

D

E

E

P

P

A

F

A

A

G

G

L

V

T

D

A

P

P

I

D

S

I

V

K

I

E

D

L

I

V

K

A

R

I

I

I

I

R

E

K

H

V

L

R

R

D

D

H

S

G

G

I

L

T

G

V

V

V

L

L

I

I

T

E

D

H

H

H

N

M

V

D

R

V

E

V

T

M

L

S

A

V

V

C

C

D

E

R

R

V

A

S

Y

V

I

L

V

D

S

F

Q

G

G

Q

H

K

L

I

I

A

A

E

H

G

G

K

T

P

P

A

T

D

E

I

I

Q

L

S

Q

N

D

E

E

K

H

V

V

I

K

E

R

A

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (≠ F401), R15 (≠ L404), V17 (≠ A406), N37 (= N426), G38 (= G427), A39 (≠ S428), G40 (= G429), K41 (= K430), T42 (≠ S431), T43 (= T432)
binding magnesium ion: T42 (≠ S431), Q84 (= Q473)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
29% identity, 38% coverage: 392:636/646 of query aligns to 3:233/233 of 6b8bA

query
sites
6b8bA

L

L

Q

T

L

A

R

K

G

N

I

L

L

A

M

K

Q

A

F
x
Y

S

K

G

G

L
x
R

K

R

A
x
V

L

V

N

E

D

D

V

V

D

S

L

L

T

T

V

V

Q

N

R

S

G

G

T

E

I

I

H

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

S
x
A

G
|
G

K
|
K

S
x
T

T
|
T

M

T

M

F

N

Y

V

M

L

V

T

V

G

G

I

I

Y

V

V

P

P

R

T

D

A

A

G

G

T

N

L

I

E

I

Y

I

R

D

G

D

A

D

S

D

L

I

A

S

G

L

K

L

T

P

S

L

A

H

Q

A

I

R

A

A

L

R

S

R

G

G

I

I

A

G

R

Y

T

L

F

P

Q

Q

N

E

V

A

Q

S

L

I

F
|
F

G
x
R

E
x
R

M

L

T

S

A

V

L

Y

E

D

N

N

V

L

L

M

V

A

G

V

L

L

H

Q

H

-

T

-

F

I

N

R

A

D

N

D

L

L

A

-

D

-

V

-

G

-

L

-

M

-

S

-

S

S

R

A

Y

E

R

Q

R

R

E

E

E

D

R

R

A

A

A

N

R

E

E

-

R

-

A

-

F

-

G

-

M

L

L

M

R

E

F

E

V

F

G

H

L

I

D

E

N

H

V

L

A

R

A

D

E

S

E

M

A

G

R

Q

N

S

L

L

P

S

Y

G

G

G

K

E

Q

R

R

R

L

R

L

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

L

A

D

N

P

P

Q

K

L

F

L

I

L

L

L

L

D

D

E

E

P

P

A

F

A

A

G

G

L

V

T

D

A

P

P

I

D

S

I

V

K

I

E

D

L

I

V

K

A

R

I

I

I

I

R

E

K

H

V

L

R

R

D

D

H

S

G

G

I

L

T

G

V

V

V

L

L

I

I

T

E

D

H

H

H

N

M

V

D

R

V

E

V

T

M

L

S

A

V

V

C

C

D

E

R

R

V

A

S

Y

V

I

L

V

D

S

F

Q

G

G

Q

H

K

L

I

I

A

A

E

H

G

G

K

T

P

P

A

T

D

E

I

I

Q

L

S

Q

N

D

E

E

K

H

V

V

I

K

E

R

A

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (≠ F401), R15 (≠ L404), V17 (≠ A406), N37 (= N426), G38 (= G427), A39 (≠ S428), G40 (= G429), K41 (= K430), T42 (≠ S431), T43 (= T432)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (= F478), R90 (≠ G479), R91 (≠ E480)

3c4jA Abc protein artp in complex with atp-gamma-s
30% identity, 37% coverage: 390:626/646 of query aligns to 5:225/242 of 3c4jA

query
sites
3c4jA

D

D

I

V

L

H

Q

Q

L

L

R

K

G

K

I

-

L

-

M

-

Q

S

F
|
F

S

G

G

S

L

L

K

E

A
x
V

L

L

N

K

D

G

V

I

D

N

L

V

T

H

V

I

Q

R

R

E

G

G

T

E

I

V

H

V

G

V

L

V

I

I

G

G

P
|
P

N
x
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

M

F

M

L

N

R

V

C

L

L

T

N

G

L

I

L

Y

E

V

D

P

F

T

D

A

E

G

G

T

E

L

I

E

I

Y

I

R

D

G

G

A

I

S

N

L

L

A

K

G

A

K

K

-

D

T

T

S

N

A

L

Q

N

I

K

A

V

L

R

S

E

G

E

I

V

A

G

R

M

T

V

F

F

Q

Q

N

R

V

F

Q

N

L

L

F

F

G

P

E

H

M

M

T

T

A

V

L

L

E

N

N

N

V

I

L

T

V

L

G

A

L

-

H

-

H

-

T

-

F

-

N

-

A

-

N

-

L

-

A

-

D

-

V

-

G

P

L

M

M

K

S

V

S

R

R

K

Y

W

R

P

R

R

E

E

E

K

R

-

A

-

A

A

R

E

E

A

R

K

A

A

F

M

G

E

M

L

L

L

R

D

F

K

V

V

G

G

L

L

D

K

N

D

V

K

A

A

A
x
H

E

A

E
x
Y

A

P

R

D

N

S

L

L

P

S

Y

G

G

G

K

Q

Q

A

R

Q

L

R

L

V

E

A

I

I

A

A

R

R

A

A

L

L

A

A

L

M

D

E

P

P

Q

K

L

I

L

M

L

L

L

F

D

D

E
|
E

P

P

A

T

A

S

G

A

L

L

T

D

A

P

P

E

D

M

I

V

K

G

E

E

L

V

V

L

A

S

I

V

I

M

R

K

K

Q

V

L

R

A

D

N

H

E

G

G

I

M

T

T

V

M

V

V

L

V

I

V

E

T

H

H

H

E

M

M

D

G

V

F

V

A

M

R

S

E

V

V

C

G

D

D

R

R

V

V

S

L

V

F

L

M

D

D

F

G

G

G

Q

Y

K

I

I

I

A

E

E

E

G

G

K

K

P

P

A

E

D

D

I

L

binding phosphothiophosphoric acid-adenylate ester: F13 (= F401), V18 (≠ A406), P37 (= P425), S38 (≠ N426), G39 (= G427), S40 (= S428), G41 (= G429), K42 (= K430), S43 (= S431), T44 (= T432), H133 (≠ A534), Y135 (≠ E536), E164 (= E565)

3c41J Abc protein artp in complex with amp-pnp/mg2+
30% identity, 37% coverage: 390:626/646 of query aligns to 5:225/242 of 3c41J

query
sites
3c41J

D

D

I

V

L

H

Q

Q

L

L

R

K

G

K

I

-

L

-

M

-

Q

S

F
|
F

S

G

G

S

L

L

K

E

A
x
V

L

L

N

K

D

G

V

I

D

N

L

V

T

H

V

I

Q

R

R

E

G

G

T

E

I

V

H

V

G

V

L

V

I

I

G

G

P
|
P

N
x
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

M

F

M

L

N
x
R

V

C

L

L

T

N

G

L

I

L

Y

E

V

D

P

F

T

D

A

E

G

G

T

E

L

I

E

I

Y

I

R

D

G

G

A

I

S

N

L

L

A

K

G

A

K

K

-

D

T

T

S

N

A

L

Q

N

I

K

A

V

L

R

S

E

G

E

I

V

A

G

R

M

T

V

F

F

Q

Q

N

R

V

F

Q

N

L

L

F

F

G

P

E

H

M

M

T

T

A

V

L

L

E

N

N

N

V

I

L

T

V

L

G

A

L

-

H

-

H

-

T

-

F

-

N

-

A

-

N

-

L

-

A

-

D

-

V

-

G

P

L

M

M

K

S

V

S

R

R

K

Y

W

R

P

R

R

E

E

E

K

R

-

A

-

A

A

R

E

E

A

R

K

A

A

F

M

G

E

M

L

L

L

R

D

F

K

V

V

G

G

L

L

D

K

N

D

V

K

A

A

A
x
H

E

A

E
x
Y

A

P

R

D

N

S

L

L

P

S

Y

G

G

G

K

Q

Q

A

R

Q

L

R

L

V

E

A

I

I

A

A

R

R

A

A

L

L

A

A

L

M

D

E

P

P

Q

K

L

I

L

M

L

L

L

F

D
|
D

E

E

P

P

A

T

A

S

G

A

L

L

T

D

A

P

P

E

D

M

I

V

K

G

E

E

L

V

V

L

A

S

I

V

I

M

R

K

K

Q

V

L

R

A

D

N

H

E

G

G

I

M

T

T

V

M

V

V

L

V

I

V

E

T

H

H

H

E

M

M

D

G

V

F

V

A

M

R

S

E

V

V

C

G

D

D

R

R

V

V

S

L

V

F

L

M

D

D

F

G

G

G

Q

Y

K

I

I