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Comparing BPHYT_RS07235 BPHYT_RS07235 2-hydroxymuconic semialdehyde dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4u3wA X-ray crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase from burkholderia cenocepacia
88% identity, 97% coverage: 14:496/496 of query aligns to 3:485/485 of 4u3wA
4npiA 1.94 angstroms x-ray crystal structure of NAD- and intermediate- bound alpha-aminomuconate-epsilon-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
71% identity, 97% coverage: 15:495/496 of query aligns to 3:483/483 of 4npiA
- active site: N152 (= N164), K175 (= K187), E251 (= E263), C285 (= C297), E387 (= E399), E464 (= E476)
- binding (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid: R103 (= R115), L157 (= L169), W160 (= W172), E251 (= E263), C285 (= C297), Y445 (≠ F457), R447 (= R459), F453 (= F465)
- binding nicotinamide-adenine-dinucleotide: I148 (= I160), S149 (= S161), P150 (= P162), W151 (= W163), K175 (= K187), E178 (= E190), G208 (= G220), G213 (= G225), E214 (= E226), F227 (= F239), G229 (= G241), E230 (= E242), T233 (= T245), G253 (= G265), C285 (= C297), K335 (= K347), E387 (= E399), F389 (= F401)
4i2rA 2.15 angstroms x-ray crystal structure of NAD- and alternative substrate-bound 2-aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
71% identity, 97% coverage: 15:495/496 of query aligns to 3:483/483 of 4i2rA
- active site: N152 (= N164), K175 (= K187), E251 (= E263), C285 (= C297), E387 (= E399), E464 (= E476)
- binding (2E,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid: R103 (= R115), L157 (= L169), C285 (= C297), Y445 (≠ F457), R447 (= R459), F453 (= F465)
- binding nicotinamide-adenine-dinucleotide: I148 (= I160), S149 (= S161), W151 (= W163), N152 (= N164), K175 (= K187), E178 (= E190), G208 (= G220), F227 (= F239), T228 (= T240), G229 (= G241), E230 (= E242), T233 (= T245), E251 (= E263), L252 (= L264), G253 (= G265), C285 (= C297), E387 (= E399), F389 (= F401)
4i25A 2.00 angstroms x-ray crystal structure of NAD- and substrate-bound 2- aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
71% identity, 97% coverage: 15:495/496 of query aligns to 3:483/483 of 4i25A
- active site: N152 (= N164), K175 (= K187), E251 (= E263), C285 (= C297), E387 (= E399), E464 (= E476)
- binding (2E,4E)-2-amino-6-oxohexa-2,4-dienoic acid: R103 (= R115), L157 (= L169), C285 (= C297), Y445 (≠ F457), R447 (= R459), F453 (= F465)
- binding nicotinamide-adenine-dinucleotide: I148 (= I160), S149 (= S161), P150 (= P162), W151 (= W163), N152 (= N164), K175 (= K187), E178 (= E190), G208 (= G220), G213 (= G225), F227 (= F239), T228 (= T240), G229 (= G241), E230 (= E242), T233 (= T245), E251 (= E263), L252 (= L264), C285 (= C297), E387 (= E399), F389 (= F401)
5kllA Crystal structure of 2-hydroxymuconate-6-semialdehyde derived tautomeric intermediate in 2-aminomuconate 6-semialdehyde dehydrogenase n169d (see paper)
70% identity, 97% coverage: 15:495/496 of query aligns to 3:483/483 of 5kllA
- active site: D152 (≠ N164), K175 (= K187), E251 (= E263), C285 (= C297), E387 (= E399), E464 (= E476)
- binding (3~{E},5~{E})-6-oxidanyl-2-oxidanylidene-hexa-3,5-dienoic acid: R103 (= R115), D152 (≠ N164), L157 (= L169), W160 (= W172), C285 (= C297), Y445 (≠ F457), R447 (= R459), F453 (= F465)
5kj5B Crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase n169d in complex with NAD+ (see paper)
70% identity, 97% coverage: 15:495/496 of query aligns to 4:484/484 of 5kj5B
- active site: D153 (≠ N164), K176 (= K187), E252 (= E263), C286 (= C297), E388 (= E399), E465 (= E476)
- binding nicotinamide-adenine-dinucleotide: I149 (= I160), S150 (= S161), P151 (= P162), W152 (= W163), D153 (≠ N164), L158 (= L169), K176 (= K187), G209 (= G220), K210 (≠ P221), G214 (= G225), F228 (= F239), T229 (= T240), G230 (= G241), E231 (= E242), T234 (= T245), E252 (= E263), L253 (= L264), C286 (= C297), E388 (= E399), F390 (= F401), F454 (= F465)
4ou2A A 2.15 angstroms x-ray crystal structure of e268a 2-aminomuconate 6- semialdehyde dehydrogenase catalytic intermediate from pseudomonas fluorescens (see paper)
70% identity, 97% coverage: 15:495/496 of query aligns to 3:483/483 of 4ou2A
- active site: N152 (= N164), K175 (= K187), A251 (≠ E263), C285 (= C297), E387 (= E399), E464 (= E476)
- binding (2Z,4E)-2,6-dihydroxyhexa-2,4-dienoic acid: R103 (= R115), L157 (= L169), C285 (= C297), Y445 (≠ F457), R447 (= R459), F453 (= F465)
- binding nicotinamide-adenine-dinucleotide: I148 (= I160), S149 (= S161), P150 (= P162), W151 (= W163), N152 (= N164), K175 (= K187), G208 (= G220), G213 (= G225), E214 (= E226), F227 (= F239), T228 (= T240), G229 (= G241), E230 (= E242), T233 (= T245), A251 (≠ E263), L252 (= L264), G253 (= G265), C285 (= C297), E387 (= E399), F389 (= F401)
Q9H2A2 2-aminomuconic semialdehyde dehydrogenase; Aldehyde dehydrogenase 12; Aldehyde dehydrogenase family 8 member A1; EC 1.2.1.32 from Homo sapiens (Human) (see paper)
42% identity, 98% coverage: 7:494/496 of query aligns to 2:486/487 of Q9H2A2
- R109 (= R115) mutation to A: About 65-fold loss of catalytic efficiency.
- N155 (= N164) mutation to A: Complete loss of activity.
- R451 (= R459) mutation to A: Complete loss of activity.
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
40% identity, 97% coverage: 15:495/496 of query aligns to 17:490/491 of 5gtlA
- active site: N165 (= N164), K188 (= K187), E263 (= E263), C297 (= C297), E394 (= E399), E471 (= E476)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I160), P163 (= P162), K188 (= K187), A190 (≠ S189), E191 (= E190), Q192 (≠ E191), G221 (= G220), G225 (= G225), G241 (= G241), S242 (≠ E242), T245 (= T245), L264 (= L264), C297 (= C297), E394 (= E399), F396 (= F401)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
40% identity, 97% coverage: 15:495/496 of query aligns to 17:490/491 of 5gtkA
- active site: N165 (= N164), K188 (= K187), E263 (= E263), C297 (= C297), E394 (= E399), E471 (= E476)
- binding nicotinamide-adenine-dinucleotide: I161 (= I160), I162 (≠ S161), P163 (= P162), W164 (= W163), K188 (= K187), E191 (= E190), G221 (= G220), G225 (= G225), A226 (≠ E226), F239 (= F239), G241 (= G241), S242 (≠ E242), T245 (= T245), Y248 (≠ T248), L264 (= L264), C297 (= C297), Q344 (≠ H344), R347 (≠ K347), E394 (= E399), F396 (= F401)
2d4eC Crystal structure of the hpcc from thermus thermophilus hb8
42% identity, 96% coverage: 17:493/496 of query aligns to 29:503/515 of 2d4eC
- active site: N173 (= N164), K196 (= K187), E271 (= E263), C305 (= C297), E409 (= E399), E486 (= E476)
- binding nicotinamide-adenine-dinucleotide: I169 (= I160), T170 (≠ S161), P171 (= P162), W172 (= W163), K196 (= K187), A198 (≠ S189), G229 (= G220), G233 (= G225), A234 (≠ E226), T248 (= T240), G249 (= G241), E250 (= E242), T253 (= T245), E271 (= E263), L272 (= L264), C305 (= C297), E409 (= E399), F411 (= F401), F475 (= F465)
Q9HTJ1 NAD/NADP-dependent betaine aldehyde dehydrogenase; BADH; EC 1.2.1.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
39% identity, 97% coverage: 16:495/496 of query aligns to 8:483/490 of Q9HTJ1
- GAWN 150:153 (≠ SPWN 161:164) binding
- K162 (= K173) active site, Charge relay system
- KPSE 176:179 (= KPSE 187:190) binding
- G209 (= G220) binding
- GTST 230:233 (≠ ESRT 242:245) binding
- E252 (= E263) active site, Proton acceptor
- C286 (= C297) binding covalent; modified: Cysteine sulfenic acid (-SOH)
- E387 (= E399) binding
- E464 (= E476) active site, Charge relay system
4cazA Crystal structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa in complex with nadh
39% identity, 97% coverage: 16:495/496 of query aligns to 7:482/489 of 4cazA
- active site: N152 (= N164), K175 (= K187), E251 (= E263), C285 (= C297), E386 (= E399), E463 (= E476)
- binding [[(2R,3S,4R,5R)-5-[(3R)-3-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate: I148 (= I160), G149 (≠ S161), W151 (= W163), N152 (= N164), K175 (= K187), E178 (= E190), G208 (= G220), G212 (= G225), F226 (= F239), T227 (= T240), G228 (= G241), G229 (≠ E242), T232 (= T245), V236 (≠ I249), E251 (= E263), L252 (= L264), C285 (= C297), E386 (= E399), F388 (= F401)
2woxA Betaine aldehyde dehydrogenase from pseudomonas aeruginosa with NAD(p) h-catalytic thiol adduct. (see paper)
39% identity, 97% coverage: 16:495/496 of query aligns to 7:482/489 of 2woxA
- active site: N152 (= N164), K175 (= K187), E251 (= E263), C285 (= C297), E386 (= E399), E463 (= E476)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I148 (= I160), G149 (≠ S161), W151 (= W163), N152 (= N164), K175 (= K187), S177 (= S189), E178 (= E190), G208 (= G220), G212 (= G225), F226 (= F239), T227 (= T240), G228 (= G241), G229 (≠ E242), T232 (= T245), V236 (≠ I249), E251 (= E263), L252 (= L264), C285 (= C297), E386 (= E399), F388 (= F401)
2wmeA Crystallographic structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa (see paper)
39% identity, 97% coverage: 16:495/496 of query aligns to 7:482/489 of 2wmeA
- active site: N152 (= N164), K175 (= K187), E251 (= E263), C285 (= C297), E386 (= E399), E463 (= E476)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G149 (≠ S161), W151 (= W163), K175 (= K187), S177 (= S189), E178 (= E190), G208 (= G220), G212 (= G225), F226 (= F239), G228 (= G241), G229 (≠ E242), T232 (= T245), V236 (≠ I249)
P49189 4-trimethylaminobutyraldehyde dehydrogenase; TMABA-DH; TMABALDH; Aldehyde dehydrogenase E3 isozyme; Aldehyde dehydrogenase family 9 member A1; Formaldehyde dehydrogenase; Gamma-aminobutyraldehyde dehydrogenase; R-aminobutyraldehyde dehydrogenase; EC 1.2.1.47; EC 1.2.1.3; EC 1.2.1.46; EC 1.2.1.19 from Homo sapiens (Human) (see 2 papers)
39% identity, 93% coverage: 33:495/496 of query aligns to 32:487/494 of P49189
- C116 (≠ N119) to S: in allele ALDH9A1*2
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed; alternate
- 2 modified: N-acetylserine; in 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed
6vr6D Structure of aldh9a1 complexed with NAD+ in space group p1 (see paper)
39% identity, 93% coverage: 33:495/496 of query aligns to 31:486/493 of 6vr6D
- active site: N156 (= N164), E253 (= E263), C287 (= C297), E467 (= E476)
- binding nicotinamide-adenine-dinucleotide: I152 (= I160), G153 (≠ S161), W155 (= W163), K179 (= K187), A212 (≠ G220), G215 (= G225), Q216 (≠ E226), F229 (= F239), G231 (= G241), S232 (≠ E242), T235 (= T245), I239 (= I249)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
39% identity, 96% coverage: 18:495/496 of query aligns to 7:479/489 of 4o6rA
- active site: N150 (= N164), K173 (= K187), E248 (= E263), C282 (= C297), E383 (= E399), E460 (= E476)
- binding adenosine monophosphate: I146 (= I160), V147 (≠ S161), K173 (= K187), G206 (= G220), G210 (= G225), Q211 (≠ E226), F224 (= F239), G226 (= G241), S227 (≠ E242), T230 (= T245), R233 (≠ T248)
8skfA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (lattice translocation disorder)
39% identity, 96% coverage: 18:495/496 of query aligns to 17:490/497 of 8skfA
- binding calcium ion: T33 (≠ N32), I34 (≠ L33), D100 (= D100), V187 (≠ E191)
- binding nicotinamide-adenine-dinucleotide: I156 (= I160), G157 (≠ S161), A158 (≠ P162), W159 (= W163), K183 (= K187), E186 (= E190), G216 (= G220), G220 (= G225), T235 (= T240), G236 (= G241), G237 (≠ E242), S240 (≠ T245), K243 (≠ T248), E259 (= E263), C293 (= C297), F396 (= F401)
8vr1A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (ctp bound)
39% identity, 96% coverage: 18:495/496 of query aligns to 8:481/488 of 8vr1A
Query Sequence
>BPHYT_RS07235 BPHYT_RS07235 2-hydroxymuconic semialdehyde dehydrogenase
MTFTPAAAQRAQPLLRHYVDGEFIATATTFPNLSPVDGSVLAQVCEADAETVDAAVRAAA
AAQRAGWRNTTPAQRADWLHKIADGIQARFDEFVAAEVADTGRPLEQARKLDIARGIANF
RTFGDLIRTANSEFFETHAADGSELINYVTRKPLGVIGIISPWNLPLLLFTWKVAPALAM
GNCVVAKPSEETPGSATLLAEVMHDIGLPPGVFNLVHGHGPNAAGEFLTRHPDISAITFT
GESRTGSTIMKTVADGVKEISFELGGKNAAVVFADADFDAAVAGVLKSSFTNAGQVCLCS
ERVYVERSIFERFVAALKEKTEALRVGAPHDPETTMGPLISRGHREKVLSYFRLAVEEGA
TVVTGGHVPQFGDERDQGAFVMPTIWTGLADDARCVKEEIFGPVCHIAPFDTEDEVIGRV
NDSAYGLAASIWTTQLARGHRVARRIETGIVWVNAWFVRDLRTPFGGAKLSGIGREGGRH
SLDFYSELTNICVRIA
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory