Comparing BPHYT_RS08955 FitnessBrowser__BFirm:BPHYT_RS08955 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q5F8J4 NAD(+)-dependent homoserine dehydrogenase; NAD(+)-dependent HSD; NgHSD; EC 1.1.1.3 from Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) (see paper)
59% identity, 100% coverage: 1:443/443 of query aligns to 1:434/435 of Q5F8J4
6dzsA Mycobacterial homoserine dehydrogenase thra in complex with NADP
40% identity, 99% coverage: 2:440/443 of query aligns to 3:429/431 of 6dzsA
4pg7A Crystal structure of s. Aureus homoserine dehydrogenase at ph7.5 (see paper)
42% identity, 77% coverage: 1:340/443 of query aligns to 2:323/402 of 4pg7A
Sites not aligning to the query:
6a0sA Homoserine dehydrogenase from thermus thermophilus hb8 complexed with hse and NADPH (see paper)
35% identity, 74% coverage: 1:330/443 of query aligns to 1:312/331 of 6a0sA
2ejwA Homoserine dehydrogenase from thermus thermophilus hb8
35% identity, 74% coverage: 1:330/443 of query aligns to 1:312/331 of 2ejwA
6a0tB Homoserine dehydrogenase k99a mutant from thermus thermophilus hb8 complexed with hse and NADP+ (see paper)
35% identity, 74% coverage: 1:330/443 of query aligns to 1:312/332 of 6a0tB
7f4cA The crystal structure of the immature holo-enzyme of homoserine dehydrogenase complexed with NADP and 1,4-butandiol from the hyperthermophilic archaeon sulfurisphaera tokodaii. (see paper)
39% identity, 51% coverage: 96:322/443 of query aligns to 90:297/300 of 7f4cA
Sites not aligning to the query:
5x9dA Crystal structure of homoserine dehydrogenase in complex with l- cysteine and NAD (see paper)
38% identity, 51% coverage: 96:322/443 of query aligns to 90:299/302 of 5x9dA
Sites not aligning to the query:
4xb1A Hyperthermophilic archaeal homoserine dehydrogenase in complex with NADPH (see paper)
32% identity, 49% coverage: 103:321/443 of query aligns to 111:312/319 of 4xb1A
Sites not aligning to the query:
4xb2A Hyperthermophilic archaeal homoserine dehydrogenase mutant in complex with NADPH (see paper)
32% identity, 49% coverage: 103:321/443 of query aligns to 111:312/319 of 4xb2A
Sites not aligning to the query:
3jsaA Homoserine dehydrogenase from thermoplasma volcanium complexed with NAD
28% identity, 52% coverage: 1:231/443 of query aligns to 1:239/321 of 3jsaA
Sites not aligning to the query:
3ingA Crystal structure of homoserine dehydrogenase (np_394635.1) from thermoplasma acidophilum at 1.95 a resolution
30% identity, 31% coverage: 96:233/443 of query aligns to 102:238/319 of 3ingA
Sites not aligning to the query:
O94671 Probable homoserine dehydrogenase; HDH; EC 1.1.1.3 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
34% identity, 29% coverage: 95:222/443 of query aligns to 110:244/376 of O94671
P31116 Homoserine dehydrogenase; HDH; EC 1.1.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
29% identity, 49% coverage: 4:222/443 of query aligns to 6:236/359 of P31116
1tveA Homoserine dehydrogenase in complex with 4-(4-hydroxy-3- isopropylphenylthio)-2-isopropylphenol (see paper)
29% identity, 49% coverage: 4:222/443 of query aligns to 5:235/358 of 1tveA
1q7gA Homoserine dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-oxonorvaline (see paper)
29% identity, 49% coverage: 4:222/443 of query aligns to 5:235/358 of 1q7gA
Sites not aligning to the query:
1ebuD Homoserine dehydrogenase complex with NAD analogue and l-homoserine (see paper)
29% identity, 49% coverage: 4:222/443 of query aligns to 5:235/358 of 1ebuD
Sites not aligning to the query:
1ebfA Homoserine dehydrogenase from s. Cerevisiae complex with NAD+ (see paper)
29% identity, 49% coverage: 4:222/443 of query aligns to 5:235/358 of 1ebfA
O81852 Bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic; AK-HD 2; AK-HSDH 2; Beta-aspartyl phosphate homoserine 2; EC 2.7.2.4; EC 1.1.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
27% identity, 49% coverage: 102:318/443 of query aligns to 667:906/916 of O81852
Sites not aligning to the query:
3upyA Crystal structure of the brucella abortus enzyme catalyzing the first committed step of the methylerythritol 4-phosphate pathway. (see paper)
28% identity, 30% coverage: 2:133/443 of query aligns to 21:164/436 of 3upyA
Sites not aligning to the query:
>BPHYT_RS08955 FitnessBrowser__BFirm:BPHYT_RS08955
MEPIKVGLLGFGTVGSGTFTVLRRNQEEIKRRAGRGIEIARIAVRNPAKATAALGSEAST
VALTDDFNAVVDDPSIDIVAEMIGGTGVARDVVLRAIKNRKHVVTANKALLAVHGTEIFE
AARANGVMVSFEAAVAGGIPIIKALREGLTANRIQYIAGIINGTTNYILSEMRDRGLDFA
TALKAAQELGYAEADPTFDIEGVDAAHKATIMSAIAFGVPVQFDKAYVEGISKLAAIDIK
YAEELGYRIKLLGIARRTDKGIELRVHPTLIPEKRLLANVEGAMNAVVVHGDAVGTTLYY
GKGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPDSLSSTPILPIDEVTSGYYLR
LRVADVTGVLADITRILADTGISIDALLQKESEQVDANGKGETDIILITHETVEKNVNAA
IKTIEALKTVVSQVTKLRMEALN
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory