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Comparing BPHYT_RS09890 FitnessBrowser__BFirm:BPHYT_RS09890 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8b7sA Crystal structure of the chloramphenicol-inactivating oxidoreductase from novosphingobium sp (see paper)
35% identity, 97% coverage: 2:538/553 of query aligns to 4:456/458 of 8b7sA
- binding flavin-adenine dinucleotide: G11 (= G9), G13 (= G11), S14 (= S12), A15 (= A13), E35 (= E33), A36 (= A34), W47 (= W60), P65 (= P78), G67 (= G80), V180 (≠ A218), A214 (= A253), G215 (= G254), A218 (≠ D257), T270 (≠ M335), Y391 (= Y472), A424 (= A506), I435 (= I517), N436 (= N518)
5nccA Structure of fatty acid photodecarboxylase in complex with fad and palmitic acid (see paper)
35% identity, 97% coverage: 2:536/553 of query aligns to 23:573/578 of 5nccA
- active site: R347 (≠ G322), L420 (≠ F386), I421 (≠ N387), S507 (≠ I471), A509 (≠ H473), G552 (= G515), Q553 (≠ N516)
- binding flavin-adenine dinucleotide: G30 (= G9), G32 (= G11), T33 (≠ S12), A34 (= A13), L53 (= L32), E54 (= E33), A55 (= A34), F74 (≠ Y54), W80 (= W60), A98 (≠ P78), G100 (= G80), G105 (= G85), S106 (= S86), N110 (= N90), A111 (= A91), T112 (≠ M92), L113 (≠ I93), V238 (≠ A218), A278 (= A253), H282 (≠ D257), L286 (= L261), N508 (≠ Y472), Q553 (≠ N516), T554 (≠ I517), G555 (≠ N518), V558 (≠ T521)
6yrvAAA structure of fap after illumination at 100k (see paper)
35% identity, 97% coverage: 2:536/553 of query aligns to 7:564/573 of 6yrvAAA
- binding carbon dioxide: R375 (≠ Y358), N499 (≠ Y472)
- binding flavin-adenine dinucleotide: G14 (= G9), G16 (= G11), T17 (≠ S12), A18 (= A13), L37 (= L32), E38 (= E33), A39 (= A34), F58 (≠ Y54), W64 (= W60), A82 (≠ P78), G89 (= G85), S90 (= S86), N94 (= N90), A95 (= A91), T96 (≠ M92), L97 (≠ I93), M191 (≠ N187), V222 (≠ A218), C264 (≠ S252), A265 (= A253), G266 (= G254), H269 (≠ D257), N499 (≠ Y472), A534 (= A506), Q544 (≠ N516), T545 (≠ I517), G546 (≠ N518)
- binding heptadecane: V377 (≠ N360), G379 (vs. gap), M380 (vs. gap), G386 (vs. gap), T389 (≠ L362), Y390 (≠ S363), F393 (≠ I366), T408 (≠ L383), Q410 (≠ A385)
A0A248QE08 Fatty acid photodecarboxylase, chloroplastic; CvFAP; EC 4.1.1.106 from Chlorella variabilis (Green alga) (see paper)
34% identity, 97% coverage: 2:536/553 of query aligns to 83:640/654 of A0A248QE08
- TA 93:94 (≠ SA 12:13) binding
- E114 (= E33) binding
- L162 (≠ V82) binding
- S166 (= S86) binding
- NATL 170:173 (≠ NAMI 90:93) binding
- V298 (≠ A218) binding
- C432 (≠ N338) binding
- R451 (≠ Y358) binding
- Y466 (≠ N373) binding
- Q486 (≠ A385) binding
- G622 (≠ N518) binding
4mjwA Crystal structure of choline oxidase in complex with the reaction product glycine betaine (see paper)
32% identity, 96% coverage: 3:532/553 of query aligns to 14:526/532 of 4mjwA
- active site: I333 (≠ S340), P377 (≠ F386), N378 (= N387), V464 (≠ I471), H466 (= H473), V509 (≠ G515), N510 (= N516)
- binding flavin-adenine dinucleotide: G20 (= G9), G22 (= G11), S23 (= S12), E44 (= E33), A45 (= A34), W71 (= W60), R89 (= R79), A90 (≠ G80), G95 (= G85), C96 (≠ S86), H99 (≠ I89), N100 (= N90), S101 (≠ A91), I103 (= I93), R231 (≠ L217), A232 (= A218), T269 (≠ A253), G270 (= G254), D273 (= D257), Y465 (= Y472), H466 (= H473), A500 (= A506), N510 (= N516), P511 (≠ I517), N512 (= N518), V515 (≠ T521)
2jbvA Crystal structure of choline oxidase reveals insights into the catalytic mechanism (see paper)
32% identity, 96% coverage: 3:532/553 of query aligns to 14:526/527 of 2jbvA
- active site: I333 (≠ S340), P377 (≠ F386), N378 (= N387), V464 (≠ I471), H466 (= H473), V509 (≠ G515), N510 (= N516)
- binding [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(4aS,10aR)-7,8-dimethyl-2,4-dioxo-1,3,4,4a,5,10a-hexahydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate: G22 (= G11), S23 (= S12), E44 (= E33), A45 (= A34), W71 (= W60), A90 (≠ G80), G95 (= G85), C96 (≠ S86), H99 (≠ I89), N100 (= N90), S101 (≠ A91), I103 (= I93), R231 (≠ L217), A232 (= A218), T269 (≠ A253), G270 (= G254), D273 (= D257), V464 (≠ I471), Y465 (= Y472), H466 (= H473), D499 (= D505), A500 (= A506), N510 (= N516), P511 (≠ I517), N512 (= N518), V515 (≠ T521)
3ljpA Crystal structure of choline oxidase v464a mutant (see paper)
32% identity, 96% coverage: 3:532/553 of query aligns to 14:526/530 of 3ljpA
- active site: I333 (≠ S340), P377 (≠ F386), N378 (= N387), A464 (≠ I471), H466 (= H473), V509 (≠ G515), N510 (= N516)
- binding dihydroflavine-adenine dinucleotide: G22 (= G11), S23 (= S12), E44 (= E33), A45 (= A34), W71 (= W60), R89 (= R79), A90 (≠ G80), G95 (= G85), C96 (≠ S86), H99 (≠ I89), N100 (= N90), S101 (≠ A91), I103 (= I93), A232 (= A218), T269 (≠ A253), D273 (= D257), Y465 (= Y472), H466 (= H473), D499 (= D505), A500 (= A506), N510 (= N516), P511 (≠ I517), N512 (= N518), V515 (≠ T521)
5oc1A Crystal structure of aryl-alcohol oxidase from pleurotus eryngii in complex with p-anisic acid (see paper)
30% identity, 97% coverage: 2:535/553 of query aligns to 1:564/565 of 5oc1A
- active site: V339 (≠ L321), N413 (≠ P388), A414 (≠ C389), I499 (= I471), H501 (= H473), A544 (≠ G515), H545 (≠ N516)
- binding 4-methoxybenzoic acid: Y91 (≠ A91), I356 (≠ V337), I390 (≠ P367), F396 (vs. gap), T412 (≠ N387), I499 (= I471), H501 (= H473), H545 (≠ N516)
- binding flavin-adenine dinucleotide: G8 (= G9), G10 (= G11), N11 (≠ S12), A12 (= A13), E32 (= E33), A33 (= A34), W60 (= W60), P78 (= P78), G80 (= G80), G85 (= G85), S86 (= S86), H90 (≠ N90), Y91 (≠ A91), V93 (≠ I93), V230 (≠ A218), S270 (= S252), A271 (= A253), G272 (= G254), F500 (≠ Y472), H545 (≠ N516), T546 (≠ I517), Q547 (≠ N518), I550 (≠ T521)
3t37A Crystal structure of pyridoxine 4-oxidase from mesorbium loti
31% identity, 95% coverage: 2:526/553 of query aligns to 1:498/509 of 3t37A
- active site: F360 (= F386), G361 (≠ N387), H444 (≠ I471), H446 (= H473), G487 (= G515), P488 (≠ N516)
- binding flavin-adenine dinucleotide: G8 (= G9), G10 (= G11), S11 (= S12), A12 (= A13), E32 (= E33), A33 (= A34), W58 (= W60), R77 (= R79), G78 (= G80), R79 (≠ K81), G83 (= G85), S84 (= S86), H88 (≠ N90), A89 (= A91), G91 (≠ I93), R217 (≠ L217), V218 (≠ A218), A251 (= A253), E255 (≠ D257), H445 (≠ Y472), A478 (= A506), P488 (≠ N516), I489 (= I517), H490 (≠ N518)
3fimB Crystal structure of aryl-alcohol-oxidase from pleurotus eryingii (see paper)
29% identity, 97% coverage: 2:535/553 of query aligns to 1:564/565 of 3fimB
- active site: V339 (≠ L321), N413 (≠ P388), A414 (≠ C389), I499 (= I471), H501 (= H473), A544 (≠ G515), H545 (≠ N516)
- binding flavin-adenine dinucleotide: G8 (= G9), N11 (≠ S12), A12 (= A13), E32 (= E33), A33 (= A34), W60 (= W60), P78 (= P78), G80 (= G80), G85 (= G85), S86 (= S86), H90 (≠ N90), Y91 (≠ A91), V93 (≠ I93), V230 (≠ A218), S270 (= S252), A271 (= A253), F500 (≠ Y472), H501 (= H473), H545 (≠ N516), T546 (≠ I517), Q547 (≠ N518), I550 (≠ T521)
4ha6A Crystal structure of pyridoxine 4-oxidase - pyridoxamine complex (see paper)
31% identity, 95% coverage: 2:526/553 of query aligns to 1:498/508 of 4ha6A
- active site: F360 (= F386), G361 (≠ N387), H444 (≠ I471), H446 (= H473), G487 (= G515), P488 (≠ N516)
- binding flavin-adenine dinucleotide: G8 (= G9), G10 (= G11), S11 (= S12), A12 (= A13), E32 (= E33), A33 (= A34), W58 (= W60), R77 (= R79), G78 (= G80), G83 (= G85), S84 (= S86), L87 (≠ I89), H88 (≠ N90), A89 (= A91), M90 (= M92), G91 (≠ I93), V218 (≠ A218), A251 (= A253), G252 (= G254), E255 (≠ D257), H445 (≠ Y472), A478 (= A506), P488 (≠ N516), I489 (= I517), H490 (≠ N518)
- binding 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol: A89 (= A91), S314 (≠ N338), H444 (≠ I471), H446 (= H473)
4yntA Crystal structure of aspergillus flavus fad glucose dehydrogenase (see paper)
30% identity, 97% coverage: 3:538/553 of query aligns to 5:569/570 of 4yntA
- active site: V342 (≠ T307), F413 (≠ Y379), W414 (≠ S380), N502 (≠ I471), H504 (= H473), G546 (= G515), H547 (≠ N516)
- binding dihydroflavine-adenine dinucleotide: G13 (= G11), T14 (≠ S12), S15 (≠ A13), E35 (= E33), A36 (= A34), F56 (≠ Y54), W62 (= W60), R80 (≠ P78), G82 (= G80), G87 (= G85), T88 (≠ S86), N92 (= N90), G93 (≠ A91), M94 (= M92), A95 (≠ I93), A234 (= A218), A274 (= A253), R278 (≠ D257), F503 (≠ Y472), A537 (= A506), H547 (≠ N516), L548 (≠ I517), V549 (≠ N518), L552 (≠ T521)
4ynuA Crystal structure of aspergillus flavus fadgdh in complex with d- glucono-1,5-lactone (see paper)
30% identity, 97% coverage: 3:538/553 of query aligns to 4:568/569 of 4ynuA
- active site: V341 (≠ T307), F412 (≠ Y379), W413 (≠ S380), N501 (≠ I471), H503 (= H473), G545 (= G515), H546 (≠ N516)
- binding flavin-adenine dinucleotide: G12 (= G11), T13 (≠ S12), S14 (≠ A13), E34 (= E33), A35 (= A34), Y51 (= Y53), F55 (≠ Y54), W61 (= W60), R79 (≠ P78), G81 (= G80), G86 (= G85), T87 (≠ S86), N91 (= N90), G92 (≠ A91), T232 (≠ L217), A233 (= A218), A273 (= A253), G274 (= G254), R277 (≠ D257), F502 (≠ Y472), A536 (= A506), H546 (≠ N516), L547 (≠ I517), V548 (≠ N518), L551 (≠ T521)
- binding D-glucono-1,5-lactone: Y51 (= Y53), E411 (≠ P378), A496 (≠ E466), N497 (≠ Q467), R499 (≠ G469), R499 (≠ G469), N501 (≠ I471), H503 (= H473), H546 (≠ N516)
7vzsA Fad-dpendent glucose dehydrogenase complexed with an inhibitor at ph7.56
30% identity, 97% coverage: 3:536/553 of query aligns to 4:566/566 of 7vzsA
- binding D-glucal: Y6 (= Y5), L22 (= L21), N25 (≠ S24), Y51 (= Y53), I349 (≠ L315), Q356 (≠ G322), E411 (≠ P378), E444 (= E418), W445 (≠ K419), K448 (≠ D422), R499 (≠ G469), N501 (≠ I471), H546 (≠ N516), K563 (≠ L533), A566 (= A536)
- binding flavin-adenine dinucleotide: G10 (= G9), G12 (= G11), T13 (≠ S12), S14 (≠ A13), E34 (= E33), A35 (= A34), Y51 (= Y53), F55 (≠ Y54), W61 (= W60), R79 (≠ P78), G81 (= G80), G86 (= G85), T87 (≠ S86), N91 (= N90), G92 (≠ A91), M93 (= M92), A94 (≠ I93), T232 (≠ L217), A233 (= A218), A273 (= A253), G274 (= G254), R277 (≠ D257), F502 (≠ Y472), A536 (= A506), H546 (≠ N516), L547 (≠ I517), V548 (≠ N518), L551 (≠ T521)
E4QP00 5-(hydroxymethyl)furfural oxidase; 5-hydroxymethylfurfural oxidase; HMFO; Thiol oxidase; EC 1.1.3.47; EC 1.8.3.- from Methylovorus sp. (strain MP688) (see paper)
30% identity, 97% coverage: 3:536/553 of query aligns to 6:531/531 of E4QP00
- V101 (≠ I89) mutation to H: Abolishes activity.
- M103 (≠ A91) mutation to A: 16-fold reduction in catalytic efficiency on vanillyl alcohol.
- V367 (vs. gap) mutation to K: 1.6-fold reduction in catalytic efficiency on vanillyl alcohol. Shows significantly improved activity on the aldehyde 5-formyl-2-furancarboxylate, which results in a better 5-hydroxymethylfurfural to 2,5-furandicarboxylate conversion.; mutation to R: 1.4-fold reduction in catalytic efficiency on vanillyl alcohol. Shows significantly improved activity on the aldehyde 5-formyl-2-furancarboxylate, which results in a better 5-hydroxymethylfurfural to 2,5-furandicarboxylate conversion. Displays a catalytic efficiency toward 5-formyl-2-furancarboxylate that is over 1000-fold higher than that for wild-type; when associated with F-466.
- W369 (≠ N387) mutation to A: 7.5-fold reduction in catalytic efficiency on vanillyl alcohol.
- V465 (≠ I471) mutation to A: 18-fold reduction in catalytic efficiency on vanillyl alcohol.
- W466 (≠ Y472) mutation to A: 39-fold reduction in catalytic efficiency on vanillyl alcohol. In contrast to wild-type, is active on secondary alcohols, such as (S)-1-phenylethanol, and is strictly enantionselective as this mutant has no activity on (R)-1-phenylethanol. Shows increased activity on the aldehyde 5-formyl-2-furancarboxylate.; mutation to F: 3.4-fold reduction in catalytic efficiency on vanillyl alcohol. In contrast to wild-type, is active on secondary alcohols, such as (S)-1-phenylethanol, and is strictly enantionselective as this mutant has no activity on (R)-1-phenylethanol. Shows increased activity on the aldehyde 5-formyl-2-furancarboxylate. Displays a catalytic efficiency toward 5-formyl-2-furancarboxylate that is over 1000-fold higher than that for wild-type; when associated with R-367.
- H467 (= H473) mutation to A: Abolishes activity.
- N511 (= N516) mutation to A: 53-fold reduction in catalytic efficiency on vanillyl alcohol.
4udqA Crystal structure of 5-hydroxymethylfurfural oxidase (hmfo) in the reduced state
30% identity, 96% coverage: 3:533/553 of query aligns to 2:524/525 of 4udqA
- active site: L331 (= L327), F364 (= F386), W365 (≠ N387), V461 (≠ I471), H463 (= H473), A506 (≠ G515), N507 (= N516)
- binding flavin-adenine dinucleotide: G8 (= G9), G10 (= G11), T11 (≠ S12), A12 (= A13), E32 (= E33), A33 (= A34), W64 (= W60), G88 (= G80), G93 (= G85), G94 (≠ S86), N98 (= N90), M99 (≠ A91), V101 (≠ I93), V229 (≠ A218), T261 (≠ S252), A262 (= A253), W462 (≠ Y472), H463 (= H473), A497 (= A506), N507 (= N516), T508 (≠ I517), N509 (= N518), T512 (= T521)
6ze6A Fad-dependent oxidoreductase from chaetomium thermophilum in complex with fragment 4-nitrocatechol (see paper)
28% identity, 97% coverage: 2:535/553 of query aligns to 1:581/585 of 6ze6A
- binding 4-nitrocatechol: I75 (≠ P78), L92 (≠ V95), Q306 (≠ H294), V360 (≠ P332), Y431 (≠ N387), L433 (≠ C389), N514 (≠ S468), S516 (= S470), N517 (≠ I471), H519 (= H473), G561 (= G515), S562 (≠ N516)
- binding dihydroflavine-adenine dinucleotide: G8 (= G9), G10 (= G11), I11 (≠ S12), S12 (≠ A13), E32 (= E33), A33 (= A34), W56 (vs. gap), A77 (≠ G80), G82 (= G85), G83 (≠ S86), N87 (= N90), A88 (= A91), V90 (≠ I93), L227 (= L217), V228 (≠ A218), A265 (= A253), A518 (≠ Y472), H519 (= H473), D551 (= D505), I552 (≠ A506), S562 (≠ N516), P563 (≠ I517), M564 (≠ N518)
6ze5A Fad-dependent oxidoreductase from chaetomium thermophilum in complex with fragment 2-(1h-indol-3-yl)-n-[(1-methyl-1h-pyrrol-2-yl) methyl]ethanamine (see paper)
28% identity, 97% coverage: 2:535/553 of query aligns to 1:581/585 of 6ze5A
- binding 2-(1H-indol-3-yl)-N-[(1-methyl-1H-pyrrol-2-yl)methyl]ethanamine: I75 (≠ P78), V90 (≠ I93), Y431 (≠ N387), N517 (≠ I471), D576 (= D530), K580 (≠ E534)
- binding dihydroflavine-adenine dinucleotide: G8 (= G9), G10 (= G11), I11 (≠ S12), S12 (≠ A13), E32 (= E33), A33 (= A34), W56 (vs. gap), A77 (≠ G80), G82 (= G85), G83 (≠ S86), N87 (= N90), A88 (= A91), V90 (≠ I93), L227 (= L217), V228 (≠ A218), A265 (= A253), A518 (≠ Y472), H519 (= H473), D551 (= D505), I552 (≠ A506), S562 (≠ N516), P563 (≠ I517), M564 (≠ N518)
Sites not aligning to the query:
6ze4A Fad-dependent oxidoreductase from chaetomium thermophilum in complex with fragment 4-oxo-n-[(1s)-1-(pyridin-3-yl)ethyl]-4-(thiophen-2-yl) butanamide (see paper)
28% identity, 97% coverage: 2:535/553 of query aligns to 1:581/585 of 6ze4A
- binding 4-oxo-N-[(1S)-1-(pyridin-3-yl)ethyl]-4-(thiophen-2-yl)butanamide: A88 (= A91), V90 (≠ I93), L354 (= L326), H421 (≠ E377), L429 (≠ A385), Y431 (≠ N387), N517 (≠ I471)
- binding dihydroflavine-adenine dinucleotide: G8 (= G9), G10 (= G11), I11 (≠ S12), S12 (≠ A13), E32 (= E33), A33 (= A34), W56 (vs. gap), A77 (≠ G80), G82 (= G85), G83 (≠ S86), N87 (= N90), A88 (= A91), V90 (≠ I93), L227 (= L217), V228 (≠ A218), A265 (= A253), A518 (≠ Y472), H519 (= H473), D551 (= D505), I552 (≠ A506), S562 (≠ N516), P563 (≠ I517), M564 (≠ N518)
6ze3A Fad-dependent oxidoreductase from chaetomium thermophilum in complex with fragment (4-methoxycarbonylphenyl)methylazanium (see paper)
28% identity, 97% coverage: 2:535/553 of query aligns to 1:581/585 of 6ze3A
- binding (4-methoxycarbonylphenyl)methylazanium: A88 (= A91), L354 (= L326), Y431 (≠ N387), N517 (≠ I471)
- binding dihydroflavine-adenine dinucleotide: G10 (= G11), I11 (≠ S12), S12 (≠ A13), E32 (= E33), A33 (= A34), W56 (vs. gap), G82 (= G85), G83 (≠ S86), I86 (= I89), N87 (= N90), A88 (= A91), V90 (≠ I93), L227 (= L217), V228 (≠ A218), A265 (= A253), A518 (≠ Y472), H519 (= H473), D551 (= D505), I552 (≠ A506), S562 (≠ N516), M564 (≠ N518)
Query Sequence
>BPHYT_RS09890 FitnessBrowser__BFirm:BPHYT_RS09890
MNYDYIIVGAGSAGCILANRLSASGQYSVLLLEAGGKDSSFWFKIPVGFTKTYYNETYNW
MYYSEPEKELDNRPIYCPRGKVQGGSGSINAMIYVRGQPHDFDDWAAAGNTGWAFRDVLP
YFRKLESHPLGNTDYHGADGPIRISPMKDAVHPICHVFLKGCDQAGYQRSDDFNGAQFEG
AGIYDVNTRNGQRSSSSFEYLHPVLSRKNLTVERDVLASRVLFDGKQHAIGVSVMQNGTT
RQFMATREVILSAGAVDSPKLLQLSGVGDSALLAKHRIAMVKELPAVGQNLQDHLCVSFY
YRANMKTLNDEMRPLLGKLKLGLQYLLTRKGPLAMSVNQSGGFFKGNDLQTQPNLQLYFN
PLSYRIPKSNKANLEPEPYSGFLLAFNPCRPTSRGSIEIASNRAEDSAKIRINALTTEKD
IDEVIQGCELVRKVMASPALKAITVEEISPGPQVNTREGFLQYFREQSGSIYHLCGSCAM
GDDPRSSVVDARLRVHGIAGLRVVDASIFPNITSGNINAPTMMVAEKGADMILEDAASEV
AYRPVTAEMAAAA
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory