Comparing BPHYT_RS10100 BPHYT_RS10100 dihydroxy-acid dehydratase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 12 hits to proteins with known functional sites (download)
P9WKJ5 Dihydroxy-acid dehydratase; DAD; EC 4.2.1.9 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
40% identity, 98% coverage: 5:611/620 of query aligns to 20:573/575 of P9WKJ5
6ovtA Crystal structure of ilvd from mycobacterium tuberculosis (see paper)
40% identity, 98% coverage: 5:611/620 of query aligns to 7:560/562 of 6ovtA
Q9LIR4 Dihydroxy-acid dehydratase, chloroplastic; AthDHAD; DAD; EC 4.2.1.9 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
36% identity, 98% coverage: 4:613/620 of query aligns to 56:607/608 of Q9LIR4
8hs0A The mutant structure of dhad v178w
36% identity, 98% coverage: 4:613/620 of query aligns to 18:569/570 of 8hs0A
B5ZZ34 L-arabinonate dehydratase; ArDHT; D-fuconate dehydratase; Galactonate dehydratase; L-arabonate dehydratase; EC 4.2.1.25; EC 4.2.1.67; EC 4.2.1.6 from Rhizobium leguminosarum bv. trifolii (strain WSM2304) (see 2 papers)
34% identity, 95% coverage: 33:618/620 of query aligns to 43:567/579 of B5ZZ34
5j85A Ser480ala mutant of l-arabinonate dehydratase (see paper)
33% identity, 95% coverage: 33:618/620 of query aligns to 40:564/576 of 5j85A
8ej0A Crystal structure of fe-s cluster-dependent dehydratase from paralcaligenes ureilyticus in complex with mg
33% identity, 90% coverage: 19:577/620 of query aligns to 19:526/568 of 8ej0A
8epzA Crystal structure of fe-s cluster-dependent dehydratase from paralcaligenes ureilyticus in complex with mn
33% identity, 90% coverage: 19:577/620 of query aligns to 20:527/569 of 8epzA
Q1JUQ1 L-arabonate dehydratase; L-arabinonate dehydratase; EC 4.2.1.25 from Azospirillum brasilense (see paper)
33% identity, 92% coverage: 2:571/620 of query aligns to 6:529/583 of Q1JUQ1
7m3kA Crystal structure of galactonate dehydratase from brucella melitensis biovar abortus 2308
28% identity, 90% coverage: 33:588/620 of query aligns to 37:559/587 of 7m3kA
Q9A9Z2 D-xylonate dehydratase; XyDHT; Gluconate dehydratase; EC 4.2.1.82; EC 4.2.1.39 from Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus) (see 2 papers)
31% identity, 87% coverage: 33:573/620 of query aligns to 48:547/595 of Q9A9Z2
5oynA Crystal structure of d-xylonate dehydratase in holo-form (see paper)
31% identity, 87% coverage: 33:573/620 of query aligns to 42:541/589 of 5oynA
>BPHYT_RS10100 BPHYT_RS10100 dihydroxy-acid dehydratase
MPDYRSKTSTHGRNMAGARALWRATGMKDGDFGKPIIAVVNSFTQFVPGHVHLRDLGALV
AKEIEAAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
NCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVKSPTDGQVIAKIDLIDAMIKAGDSRVS
DAEVAEIERSACPTCGSCSGMFTANSMNCLTEAIGLALPGNGTIVATHAWRKGLFEQAGR
LVVDLCRRYYQEDDASVLPRSIASKQAFENAMALDVAMGGSTNTVLHLLAAAQEGGVDFT
MSDIDRISRKVPCLCKVAPATDKFHIEDVHRAGGIPGILGELARAELLDLSCGNVHSGTL
GNAIAKWDVAGGAGEEAQKFFRAAPGGIPTTVAFSQEATFAALDTDRNTGCIRSKQSAYS
KDGGLAVLYGNLAEKGCIVKTAGVDESQWIFSGRARVFESQDDAVEAILGDKVVAGDVVV
IRYEGPKGGPGMQEMLYPTSYLKSKGLGKSCALFTDGRFSGGSSGLVIGHASPEAAEGGT
IGLVEEGDVIEIDIPNRKMHLVVSDAELARRREAMEARGDKAWQPANRERVVSQALQAYA
ALATSADRGAVRDLSQLKRK
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory