SitesBLAST
Comparing BPHYT_RS10500 FitnessBrowser__BFirm:BPHYT_RS10500 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
44% identity, 96% coverage: 2:574/600 of query aligns to 12:576/582 of 3ea4A
- active site: Y32 (= Y22), G34 (= G24), G35 (= G25), A36 (= A26), S37 (≠ I27), E58 (= E57), T81 (= T80), F120 (= F119), Q121 (= Q120), E122 (= E121), K170 (= K169), M265 (= M271), V292 (= V298), V399 (= V402), G425 (= G428), M427 (= M430), D452 (= D455), N479 (= N482), H481 (≠ G484), L482 (≠ D485), M484 (= M487), V485 (≠ I488), W488 (= W491), H557 (≠ E555)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (= D296), R291 (= R297), W488 (= W491), S567 (≠ P565)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R159), G221 (= G225), G222 (= G226), G223 (= G227), T245 (= T251), L246 (= L252), M247 (= M253), L263 (= L269), G264 (= G270), M265 (= M271), H266 (= H272), G285 (= G291), R287 (= R293), D289 (= D295), R291 (= R297), D309 (= D317), I310 (= I318), G327 (= G335), D328 (= D336), V329 (≠ A337), M404 (= M407), G422 (= G425)
- binding magnesium ion: D452 (= D455), N479 (= N482), H481 (≠ G484)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V402), G400 (= G403), Q401 (= Q404), H402 (= H405), M427 (= M430), G451 (= G454), D452 (= D455), G453 (= G456), S454 (= S457), N479 (= N482), H481 (≠ G484), L482 (≠ D485), G483 (= G486), M484 (= M487), V485 (≠ I488)
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
44% identity, 96% coverage: 2:574/600 of query aligns to 12:576/582 of 3e9yA
- active site: Y32 (= Y22), G34 (= G24), G35 (= G25), A36 (= A26), S37 (≠ I27), E58 (= E57), T81 (= T80), F120 (= F119), Q121 (= Q120), E122 (= E121), K170 (= K169), M265 (= M271), V292 (= V298), V399 (= V402), G425 (= G428), M427 (= M430), D452 (= D455), N479 (= N482), H481 (≠ G484), L482 (≠ D485), M484 (= M487), V485 (≠ I488), W488 (= W491), H557 (≠ E555)
- binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (= D296), R291 (= R297), W488 (= W491), S567 (≠ P565)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R159), G221 (= G225), G222 (= G226), G223 (= G227), T245 (= T251), L246 (= L252), M247 (= M253), L263 (= L269), G285 (= G291), R287 (= R293), D289 (= D295), R291 (= R297), D309 (= D317), I310 (= I318), G327 (= G335), D328 (= D336), V329 (≠ A337), M404 (= M407), G422 (= G425)
- binding magnesium ion: D452 (= D455), N479 (= N482), H481 (≠ G484)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V402), G400 (= G403), Q401 (= Q404), H402 (= H405), M427 (= M430), G451 (= G454), G453 (= G456), S454 (= S457), N479 (= N482), H481 (≠ G484), L482 (≠ D485), G483 (= G486), M484 (= M487), V485 (≠ I488)
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
44% identity, 95% coverage: 3:574/600 of query aligns to 14:577/585 of 5k2oA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E57), T82 (= T80), F121 (= F119), Q122 (= Q120), E123 (= E121), K171 (= K169), M266 (= M271), V293 (= V298), V400 (= V402), G426 (= G428), M428 (= M430), D453 (= D455), N480 (= N482), H482 (≠ G484), L483 (≠ D485), M485 (= M487), V486 (≠ I488), W489 (= W491), H558 (≠ E555)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (= M271), R292 (= R297), W489 (= W491), S568 (≠ P565)
- binding flavin-adenine dinucleotide: R161 (= R159), G222 (= G225), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), G286 (= G291), R288 (= R293), D290 (= D295), V293 (= V298), D310 (= D317), I311 (= I318), D329 (= D336), V330 (≠ A337), Q404 (= Q406), M405 (= M407), G423 (= G425)
- binding magnesium ion: D453 (= D455), N480 (= N482), H482 (≠ G484)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V402), G401 (= G403), Q402 (= Q404), H403 (= H405), M428 (= M430), D453 (= D455), G454 (= G456), S455 (= S457), N480 (= N482), H482 (≠ G484), L483 (≠ D485), G484 (= G486), M485 (= M487), V486 (≠ I488)
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
44% identity, 95% coverage: 3:574/600 of query aligns to 99:662/670 of P17597
- A122 (= A26) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ L28) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E57) binding
- S186 (= S99) binding
- P197 (= P110) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ A112) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q120) binding
- K220 (= K133) binding
- R246 (= R159) binding ; binding
- K256 (= K169) binding
- G308 (= G226) binding
- TL 331:332 (= TL 251:252) binding
- C340 (≠ V260) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (= LGMH 269:272) binding
- GVRFD 371:375 (≠ GARFD 291:295) binding
- DR 376:377 (= DR 296:297) binding
- DI 395:396 (= DI 317:318) binding
- DV 414:415 (≠ DA 336:337) binding
- QH 487:488 (= QH 404:405) binding
- GG 508:509 (≠ GS 425:426) binding
- GAM 511:513 (≠ GTM 428:430) binding
- D538 (= D455) binding
- DGS 538:540 (= DGS 455:457) binding
- N565 (= N482) binding
- NQHLGM 565:570 (≠ NLGDGM 482:487) binding
- H567 (≠ G484) binding
- W574 (= W491) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (≠ P565) binding ; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
44% identity, 95% coverage: 3:574/600 of query aligns to 14:577/583 of 5k3sA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E57), T82 (= T80), F121 (= F119), Q122 (= Q120), E123 (= E121), K171 (= K169), M266 (= M271), V293 (= V298), V400 (= V402), G426 (= G428), M428 (= M430), D453 (= D455), N480 (= N482), H482 (≠ G484), L483 (≠ D485), M485 (= M487), V486 (≠ I488), W489 (= W491), H558 (≠ E555)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R297), M485 (= M487), W489 (= W491), G569 (= G566)
- binding flavin-adenine dinucleotide: R161 (= R159), G222 (= G225), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), M266 (= M271), G286 (= G291), R288 (= R293), D290 (= D295), V293 (= V298), D310 (= D317), I311 (= I318), D329 (= D336), V330 (≠ A337), M405 (= M407), G423 (= G425)
- binding magnesium ion: D453 (= D455), N480 (= N482), H482 (≠ G484)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V402), G401 (= G403), Q402 (= Q404), H403 (= H405), G426 (= G428), M428 (= M430), D453 (= D455), G454 (= G456), S455 (= S457), N480 (= N482), H482 (≠ G484), L483 (≠ D485), G484 (= G486), M485 (= M487), V486 (≠ I488)
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
44% identity, 95% coverage: 3:574/600 of query aligns to 14:577/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V402), G401 (= G403), Q402 (= Q404), H403 (= H405), G426 (= G428), M428 (= M430), G452 (= G454), D453 (= D455), G454 (= G456), S455 (= S457), M458 (= M460), N480 (= N482), H482 (≠ G484), L483 (≠ D485), G484 (= G486), M485 (= M487), V486 (≠ I488)
- binding flavin-adenine dinucleotide: R161 (= R159), G222 (= G225), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), M266 (= M271), H267 (= H272), G286 (= G291), V287 (≠ A292), R288 (= R293), D290 (= D295), R292 (= R297), V293 (= V298), D310 (= D317), I311 (= I318), D329 (= D336), V330 (≠ A337), M405 (= M407), G423 (= G425)
- binding magnesium ion: F370 (≠ Y372), D453 (= D455), M458 (= M460), Q461 (≠ G463), N480 (= N482), H482 (≠ G484), K533 (≠ L530)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (= M271), R292 (= R297), M485 (= M487), W489 (= W491), S568 (≠ P565)
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
44% identity, 95% coverage: 3:574/600 of query aligns to 14:577/582 of 5wj1A
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E57), T82 (= T80), F121 (= F119), Q122 (= Q120), E123 (= E121), K171 (= K169), M266 (= M271), V293 (= V298), V400 (= V402), G426 (= G428), M428 (= M430), D453 (= D455), N480 (= N482), H482 (≠ G484), L483 (≠ D485), M485 (= M487), V486 (≠ I488), W489 (= W491), H558 (≠ E555)
- binding flavin-adenine dinucleotide: R161 (= R159), G222 (= G225), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), M263 (= M268), L264 (= L269), G286 (= G291), R288 (= R293), V293 (= V298), D310 (= D317), I311 (= I318), D329 (= D336), V330 (≠ A337), M405 (= M407), G423 (= G425), G424 (≠ S426)
- binding magnesium ion: D453 (= D455), N480 (= N482), H482 (≠ G484)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (= M271), D291 (= D296), R292 (= R297), M485 (= M487), W489 (= W491), S568 (≠ P565)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V402), G401 (= G403), Q402 (= Q404), H403 (= H405), M428 (= M430), D453 (= D455), G454 (= G456), S455 (= S457), M458 (= M460), N480 (= N482), H482 (≠ G484), L483 (≠ D485), G484 (= G486), M485 (= M487), V486 (≠ I488)
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
44% identity, 95% coverage: 3:574/600 of query aligns to 14:577/582 of 5k6tA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E57), T82 (= T80), F121 (= F119), Q122 (= Q120), E123 (= E121), K171 (= K169), M266 (= M271), V293 (= V298), V400 (= V402), G426 (= G428), M428 (= M430), D453 (= D455), N480 (= N482), H482 (≠ G484), L483 (≠ D485), M485 (= M487), V486 (≠ I488), W489 (= W491), H558 (≠ E555)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (= H272), R292 (= R297), M485 (= M487), W489 (= W491), S568 (≠ P565)
- binding flavin-adenine dinucleotide: R161 (= R159), G222 (= G225), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), G286 (= G291), R288 (= R293), D290 (= D295), R292 (= R297), V293 (= V298), D310 (= D317), I311 (= I318), D329 (= D336), V330 (≠ A337), Q404 (= Q406), M405 (= M407), G423 (= G425)
- binding magnesium ion: D453 (= D455), N480 (= N482), H482 (≠ G484)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V402), G401 (= G403), Q402 (= Q404), H403 (= H405), G426 (= G428), M428 (= M430), G452 (= G454), G454 (= G456), S455 (= S457), N480 (= N482), H482 (≠ G484), L483 (≠ D485), G484 (= G486)
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
44% identity, 95% coverage: 3:574/600 of query aligns to 14:577/582 of 5k6rA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E57), T82 (= T80), F121 (= F119), Q122 (= Q120), E123 (= E121), K171 (= K169), M266 (= M271), V293 (= V298), V400 (= V402), G426 (= G428), M428 (= M430), D453 (= D455), N480 (= N482), H482 (≠ G484), L483 (≠ D485), M485 (= M487), V486 (≠ I488), W489 (= W491), H558 (≠ E555)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (= R297), W489 (= W491), S568 (≠ P565)
- binding flavin-adenine dinucleotide: R161 (= R159), G222 (= G225), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), M266 (= M271), G286 (= G291), R288 (= R293), R292 (= R297), V293 (= V298), D310 (= D317), I311 (= I318), G328 (= G335), D329 (= D336), V330 (≠ A337), M405 (= M407), G423 (= G425)
- binding magnesium ion: D453 (= D455), N480 (= N482), H482 (≠ G484)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V402), G401 (= G403), Q402 (= Q404), H403 (= H405), G426 (= G428), M428 (= M430), D453 (= D455), G454 (= G456), S455 (= S457), M458 (= M460), N480 (= N482), H482 (≠ G484), L483 (≠ D485), G484 (= G486), M485 (= M487), V486 (≠ I488)
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
44% identity, 95% coverage: 3:574/600 of query aligns to 14:577/582 of 1z8nA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E57), T82 (= T80), F121 (= F119), Q122 (= Q120), E123 (= E121), K171 (= K169), M266 (= M271), V293 (= V298), V400 (= V402), G426 (= G428), M428 (= M430), D453 (= D455), N480 (= N482), H482 (≠ G484), L483 (≠ D485), M485 (= M487), V486 (≠ I488), W489 (= W491), H558 (≠ E555)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K133), R161 (= R159), Y191 (= Y189), R194 (= R192), D291 (= D296), R292 (= R297), D312 (= D319), W489 (= W491), G569 (= G566)
- binding flavin-adenine dinucleotide: R161 (= R159), G222 (= G225), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), G265 (= G270), M266 (= M271), H267 (= H272), G286 (= G291), V287 (≠ A292), R288 (= R293), D290 (= D295), R292 (= R297), V293 (= V298), D310 (= D317), I311 (= I318), D329 (= D336), V330 (≠ A337), M405 (= M407), G423 (= G425), G424 (≠ S426)
- binding magnesium ion: D453 (= D455), N480 (= N482)
- binding thiamine diphosphate: V400 (= V402), G401 (= G403), Q402 (= Q404), H403 (= H405), G426 (= G428), M428 (= M430), G452 (= G454), G454 (= G456), S455 (= S457), N480 (= N482), H482 (≠ G484), L483 (≠ D485), G484 (= G486), M485 (= M487), V486 (≠ I488)
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
44% identity, 95% coverage: 3:574/600 of query aligns to 14:577/582 of 1yi1A
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E57), T82 (= T80), F121 (= F119), Q122 (= Q120), E123 (= E121), K171 (= K169), M266 (= M271), V293 (= V298), V400 (= V402), G426 (= G428), M428 (= M430), D453 (= D455), N480 (= N482), H482 (≠ G484), L483 (≠ D485), M485 (= M487), V486 (≠ I488), W489 (= W491), H558 (≠ E555)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (= D296), R292 (= R297), W489 (= W491), S568 (≠ P565)
- binding flavin-adenine dinucleotide: R161 (= R159), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), M263 (= M268), L264 (= L269), G265 (= G270), M266 (= M271), H267 (= H272), G286 (= G291), V287 (≠ A292), R288 (= R293), D290 (= D295), V293 (= V298), D310 (= D317), I311 (= I318), D329 (= D336), V330 (≠ A337), M405 (= M407), G423 (= G425), G424 (≠ S426)
- binding magnesium ion: D453 (= D455), N480 (= N482), H482 (≠ G484)
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
44% identity, 95% coverage: 3:574/600 of query aligns to 14:577/582 of 1yi0A
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E57), T82 (= T80), F121 (= F119), Q122 (= Q120), E123 (= E121), K171 (= K169), M266 (= M271), V293 (= V298), V400 (= V402), G426 (= G428), M428 (= M430), D453 (= D455), N480 (= N482), H482 (≠ G484), L483 (≠ D485), M485 (= M487), V486 (≠ I488), W489 (= W491), H558 (≠ E555)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D296), R292 (= R297), W489 (= W491), S568 (≠ P565)
- binding flavin-adenine dinucleotide: R161 (= R159), G222 (= G225), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), G265 (= G270), M266 (= M271), H267 (= H272), G286 (= G291), V287 (≠ A292), R288 (= R293), D290 (= D295), R292 (= R297), V293 (= V298), D310 (= D317), I311 (= I318), G328 (= G335), D329 (= D336), V330 (≠ A337), M405 (= M407), G423 (= G425), G424 (≠ S426)
- binding magnesium ion: D453 (= D455), N480 (= N482), H482 (≠ G484)
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
44% identity, 95% coverage: 3:574/600 of query aligns to 14:577/582 of 1yhzA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E57), T82 (= T80), F121 (= F119), Q122 (= Q120), E123 (= E121), K171 (= K169), M266 (= M271), V293 (= V298), V400 (= V402), G426 (= G428), M428 (= M430), D453 (= D455), N480 (= N482), H482 (≠ G484), L483 (≠ D485), M485 (= M487), V486 (≠ I488), W489 (= W491), H558 (≠ E555)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (= D296), R292 (= R297), M485 (= M487), W489 (= W491), S568 (≠ P565)
- binding flavin-adenine dinucleotide: R161 (= R159), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), M266 (= M271), H267 (= H272), G286 (= G291), V287 (≠ A292), R288 (= R293), D290 (= D295), V293 (= V298), D310 (= D317), I311 (= I318), D329 (= D336), V330 (≠ A337), Q404 (= Q406), M405 (= M407), G423 (= G425), G424 (≠ S426)
- binding magnesium ion: D453 (= D455), N480 (= N482), H482 (≠ G484)
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
44% identity, 95% coverage: 3:574/600 of query aligns to 14:577/582 of 1yhyA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E57), T82 (= T80), F121 (= F119), Q122 (= Q120), E123 (= E121), K171 (= K169), M266 (= M271), V293 (= V298), V400 (= V402), G426 (= G428), M428 (= M430), D453 (= D455), N480 (= N482), H482 (≠ G484), L483 (≠ D485), M485 (= M487), V486 (≠ I488), W489 (= W491), H558 (≠ E555)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D296), R292 (= R297), V486 (≠ I488), W489 (= W491), S568 (≠ P565)
- binding flavin-adenine dinucleotide: R161 (= R159), G222 (= G225), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), G265 (= G270), M266 (= M271), H267 (= H272), G286 (= G291), V287 (≠ A292), R288 (= R293), D290 (= D295), V293 (= V298), D310 (= D317), I311 (= I318), D329 (= D336), V330 (≠ A337), Q404 (= Q406), M405 (= M407), G423 (= G425), G424 (≠ S426)
- binding magnesium ion: D453 (= D455), N480 (= N482), H482 (≠ G484)
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl (see paper)
44% identity, 95% coverage: 3:574/600 of query aligns to 14:577/582 of 1ybhA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E57), T82 (= T80), F121 (= F119), Q122 (= Q120), E123 (= E121), K171 (= K169), M266 (= M271), V293 (= V298), V400 (= V402), G426 (= G428), M428 (= M430), D453 (= D455), N480 (= N482), H482 (≠ G484), L483 (≠ D485), M485 (= M487), V486 (≠ I488), W489 (= W491), H558 (≠ E555)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: M266 (= M271), D291 (= D296), R292 (= R297), M485 (= M487), W489 (= W491), S568 (≠ P565)
- binding flavin-adenine dinucleotide: R161 (= R159), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), M266 (= M271), H267 (= H272), G286 (= G291), V287 (≠ A292), R288 (= R293), D290 (= D295), V293 (= V298), D310 (= D317), I311 (= I318), D329 (= D336), V330 (≠ A337), Q404 (= Q406), M405 (= M407), G423 (= G425), G424 (≠ S426)
- binding magnesium ion: D453 (= D455), N480 (= N482), H482 (≠ G484)
6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
42% identity, 96% coverage: 1:573/600 of query aligns to 14:579/601 of 6deqA
- active site: Y35 (= Y22), G37 (= G24), G38 (= G25), A39 (= A26), I40 (= I27), E61 (= E57), T84 (= T80), F123 (= F119), Q124 (= Q120), E125 (= E121), K173 (= K169), K232 (≠ E236), M268 (= M271), V295 (= V298), V411 (= V402), L436 (≠ M427), G437 (= G428), M439 (= M430), D464 (= D455), N491 (= N482), E493 (≠ G484), Q494 (≠ D485), M496 (= M487), V497 (≠ I488), W500 (= W491), L522 (≠ A515), N527 (≠ G520), V528 (≠ F521)
- binding flavin-adenine dinucleotide: R163 (= R159), G221 (= G225), A222 (≠ G226), G223 (= G227), N226 (≠ T230), T248 (= T251), L249 (= L252), Q250 (≠ M253), L266 (= L269), G288 (= G291), A289 (= A292), R290 (= R293), D292 (= D295), R294 (= R297), V295 (= V298), E321 (≠ D317), I322 (= I318), D340 (= D336), V341 (≠ A337), M416 (= M407), G434 (= G425)
- binding magnesium ion: D464 (= D455), N491 (= N482), E493 (≠ G484)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (= M271), R294 (= R297), M496 (= M487), V497 (≠ I488), W500 (= W491), A571 (≠ P565)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (= V402), G412 (= G403), Q413 (= Q404), H414 (= H405), M439 (= M430), G463 (= G454), D464 (= D455), A465 (≠ G456), S466 (= S457), N491 (= N482), E493 (≠ G484), Q494 (≠ D485), G495 (= G486), M496 (= M487), V497 (≠ I488)
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium (see paper)
43% identity, 95% coverage: 3:574/600 of query aligns to 14:577/582 of 7tzzA
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: M266 (= M271), R292 (= R297), W489 (= W491), S568 (≠ P565)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V402), G401 (= G403), Q402 (= Q404), H403 (= H405), G426 (= G428), M428 (= M430), G452 (= G454), D453 (= D455), G454 (= G456), S455 (= S457), L483 (≠ D485), G484 (= G486), M485 (= M487), V486 (≠ I488)
- binding flavin-adenine dinucleotide: R161 (= R159), G222 (= G225), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), M263 (= M268), L264 (= L269), M266 (= M271), H267 (= H272), G286 (= G291), R288 (= R293), V293 (= V298), D310 (= D317), I311 (= I318), D329 (= D336), V330 (≠ A337), M405 (= M407), G423 (= G425)
- binding magnesium ion: A37 (= A26), T82 (= T80), S83 (= S81), Q122 (= Q120), Y381 (≠ F383), D453 (= D455), M458 (= M460), Q461 (≠ G463), N480 (= N482), H482 (≠ G484), K533 (≠ L530)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
42% identity, 96% coverage: 1:573/600 of query aligns to 10:571/593 of 6deoA
- active site: Y31 (= Y22), G33 (= G24), G34 (= G25), A35 (= A26), I36 (= I27), E57 (= E57), T80 (= T80), F119 (= F119), Q120 (= Q120), E121 (= E121), K169 (= K169), K224 (≠ E236), M260 (= M271), V287 (= V298), V403 (= V402), L428 (≠ M427), G429 (= G428), M431 (= M430), D456 (= D455), N483 (= N482), E485 (≠ G484), Q486 (≠ D485), M488 (= M487), V489 (≠ I488), W492 (= W491), L514 (≠ A515), N519 (≠ G520), V520 (≠ F521)
- binding flavin-adenine dinucleotide: R159 (= R159), G213 (= G225), A214 (≠ G226), G215 (= G227), N218 (≠ T230), T240 (= T251), L241 (= L252), Q242 (≠ M253), L258 (= L269), G280 (= G291), A281 (= A292), R282 (= R293), D284 (= D295), R286 (= R297), V287 (= V298), E313 (≠ D317), I314 (= I318), N318 (≠ E322), D332 (= D336), V333 (≠ A337), M408 (= M407), G426 (= G425)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (= M271), D285 (= D296), R286 (= R297), M488 (= M487), W492 (= W491)
- binding magnesium ion: D456 (= D455), N483 (= N482), E485 (≠ G484)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (= V402), G404 (= G403), Q405 (= Q404), H406 (= H405), G429 (= G428), M431 (= M430), G455 (= G454), D456 (= D455), A457 (≠ G456), S458 (= S457), M461 (= M460), N483 (= N482), E485 (≠ G484), Q486 (≠ D485), G487 (= G486), M488 (= M487), V489 (≠ I488)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
44% identity, 98% coverage: 1:589/600 of query aligns to 8:590/596 of 1t9dA
- active site: Y29 (= Y22), G31 (= G24), G32 (= G25), A33 (= A26), I34 (= I27), E55 (= E57), T78 (= T80), F117 (= F119), Q118 (= Q120), E119 (= E121), K167 (= K169), R227 (≠ A235), M263 (= M271), V290 (= V298), V406 (= V402), L431 (≠ M427), G432 (= G428), M434 (= M430), D459 (= D455), N486 (= N482), E488 (≠ G484), Q489 (≠ D485), M491 (= M487), V492 (≠ I488), W495 (= W491), L517 (≠ A515), G522 (= G520), L523 (≠ F521), K556 (≠ E555)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G25), A33 (= A26), V107 (= V109), P108 (= P110), F117 (= F119), K167 (= K169), M263 (= M271), D288 (= D296), R289 (= R297), W495 (= W491)
- binding flavin-adenine dinucleotide: R157 (= R159), G216 (= G225), A217 (≠ G226), G218 (= G227), N221 (≠ T230), T243 (= T251), L244 (= L252), Q245 (≠ M253), M260 (= M268), L261 (= L269), H264 (= H272), G283 (= G291), A284 (= A292), R285 (= R293), D287 (= D295), R289 (= R297), V290 (= V298), E316 (≠ D317), V317 (≠ I318), N321 (≠ E322), G334 (= G335), D335 (= D336), A336 (= A337), Q410 (= Q406), M411 (= M407), G429 (= G425), G430 (≠ S426)
- binding magnesium ion: D459 (= D455), N486 (= N482), E488 (≠ G484)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E57), P81 (= P83), Q118 (= Q120), G432 (= G428), M434 (= M430), M464 (= M460)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
44% identity, 98% coverage: 1:589/600 of query aligns to 9:591/597 of 1t9aA
- active site: Y30 (= Y22), G32 (= G24), G33 (= G25), A34 (= A26), I35 (= I27), E56 (= E57), T79 (= T80), F118 (= F119), Q119 (= Q120), E120 (= E121), K168 (= K169), R228 (≠ A235), M264 (= M271), V291 (= V298), V407 (= V402), L432 (≠ M427), G433 (= G428), M435 (= M430), D460 (= D455), N487 (= N482), E489 (≠ G484), Q490 (≠ D485), M492 (= M487), V493 (≠ I488), W496 (= W491), L518 (≠ A515), G523 (= G520), L524 (≠ F521), K557 (≠ E555)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G25), V108 (= V109), P109 (= P110), F118 (= F119), K168 (= K169), M264 (= M271), D289 (= D296), R290 (= R297), M492 (= M487), V493 (≠ I488), W496 (= W491)
- binding flavin-adenine dinucleotide: R158 (= R159), G217 (= G225), A218 (≠ G226), G219 (= G227), N222 (≠ T230), T244 (= T251), L245 (= L252), Q246 (≠ M253), L262 (= L269), M264 (= M271), H265 (= H272), G284 (= G291), A285 (= A292), R286 (= R293), D288 (= D295), R290 (= R297), V291 (= V298), E317 (≠ D317), V318 (≠ I318), N322 (≠ E322), G335 (= G335), D336 (= D336), A337 (= A337), Q411 (= Q406), M412 (= M407), G430 (= G425), G431 (≠ S426)
- binding magnesium ion: D460 (= D455), N487 (= N482), E489 (≠ G484)
- binding propyl trihydrogen diphosphate: V407 (= V402), G408 (= G403), Q409 (= Q404), H410 (= H405), M435 (= M430), G459 (= G454), D460 (= D455), A461 (≠ G456), S462 (= S457), N487 (= N482), E489 (≠ G484), Q490 (≠ D485), G491 (= G486), M492 (= M487)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G428), M435 (= M430), M465 (= M460)
Query Sequence
>BPHYT_RS10500 FitnessBrowser__BFirm:BPHYT_RS10500
MSGADIILRVLSEQGVDTVFGYSGGAILPTYDAVFRFNEMHAQTPERQIKLVVPANEQAA
GFMAAGYARASGKVGVFMVTSGPGATNAVTPIADCNGDSIPVVLICGQVPRAMIGTDAFQ
EAPVFNIMSACAKQVFLVTDPAKLEQTLRTAFEVARTGRPGPVVVDVPKDIQNWTGTYQG
QGTLEFRGYSDRLRMVAKGARLDEGKRNDFFGLLAQSKRPLLYAGGGIITAGATAELRRF
AERFGIPVVTTLMGLGAISVRHELGLGMLGMHGAACANYAVEDCDFLIAVGARFDDRVAG
GRPDAFAPRARHVAHIDIDEAEINKVKRAHWAHVGDAKESLLSLMKHGPAVQPRLDWLDR
IKELKRVYGMNYDRNSPAIQPQFVVEKLSALTGGRAIVTTGVGQHQMWAAQFFDFVEPRS
FLTSGSMGTMGFGLPAAIGAQLARPDALVIDIDGDGSIRMNIGDLETATTYGVPVKVLLL
NNLGDGMIRQWQRLFYEGRLCVSDKSLHRKDFVMAAQADGFEFARRVATLNELEDQLKAF
IEFDGPAFLEVMVDENADVFPMVGPGQSYANMVTGPFIPSRAEPEARGKGAERQAAADMF
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory