SitesBLAST
Comparing BPHYT_RS10835 FitnessBrowser__BFirm:BPHYT_RS10835 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
1t3qB Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
34% identity, 75% coverage: 26:787/1012 of query aligns to 11:748/786 of 1t3qB
- active site: Q224 (≠ M237), A259 (≠ Q273), E336 (≠ T348), V343 (≠ C355), R371 (= R383), E743 (= E782), S744 (≠ G783)
- binding pterin cytosine dinucleotide: G254 (≠ S268), F255 (= F269), R371 (= R383), S506 (≠ A527), G507 (= G528), Q508 (= Q529), H510 (= H531), T513 (≠ V534), Y545 (= Y570), S547 (= S572), G549 (≠ F574), A550 (= A575), C666 (≠ A705), I670 (≠ L709), I674 (≠ L713), V675 (≠ A714), Q678 (= Q717), K739 (= K778), G740 (= G779), M741 (≠ L780), G742 (= G781)
1ffvB Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava (see paper)
32% identity, 78% coverage: 29:814/1012 of query aligns to 12:786/797 of 1ffvB
- active site: Q231 (≠ N235), V266 (≠ Q273), P343 (≠ Y350), I349 (≠ G354), R378 (vs. gap), C379 (vs. gap), E751 (= E782), S752 (≠ G783)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): G260 (= G267), G261 (≠ S268), F262 (= F269), G263 (= G270), A376 (≠ V382), R378 (vs. gap), C379 (vs. gap), Q516 (≠ A527), G517 (= G528), Q518 (= Q529), H520 (= H531), T523 (≠ V534), Y556 (= Y570), G557 (≠ S571), S558 (= S572), S560 (≠ F574), T561 (≠ A575), C674 (≠ A705), I678 (≠ L709), I683 (≠ A714), Q686 (= Q717), K747 (= K778), G748 (= G779), V749 (≠ L780), A750 (≠ G781), E751 (= E782)
1ffuB Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
32% identity, 78% coverage: 29:814/1012 of query aligns to 12:786/797 of 1ffuB
- active site: Q231 (≠ N235), V266 (≠ Q273), P343 (≠ Y350), I349 (≠ G354), R378 (vs. gap), C379 (vs. gap), E751 (= E782), S752 (≠ G783)
- binding cytidine-5'-diphosphate: Q518 (= Q529), H520 (= H531), T523 (≠ V534), S558 (= S572), S560 (≠ F574), T561 (≠ A575), C674 (≠ A705), T676 (= T707), I678 (≠ L709), I683 (≠ A714), K747 (= K778), G748 (= G779), V749 (≠ L780), A750 (≠ G781)
P19913 Carbon monoxide dehydrogenase large chain; CO dehydrogenase subunit L; CO-DH L; EC 1.2.5.3 from Hydrogenophaga pseudoflava (Pseudomonas carboxydoflava) (see paper)
32% identity, 77% coverage: 37:814/1012 of query aligns to 26:792/803 of P19913
- R384 (vs. gap) modified: 4-hydroxyarginine
7dqxD Crystal structure of xanthine dehydrogenase family protein
31% identity, 78% coverage: 26:816/1012 of query aligns to 3:764/770 of 7dqxD
- binding pterin cytosine dinucleotide: G247 (= G267), S248 (= S268), F249 (= F269), R363 (= R383), V491 (≠ A527), G492 (= G528), Q493 (= Q529), G494 (= G530), V498 (= V534), S530 (≠ N569), W531 (≠ Y570), S532 (= S571), S533 (= S572), R534 (= R573), S535 (≠ F574), T536 (≠ A575), T658 (≠ L713), T659 (≠ A714), Q662 (= Q717), G725 (= G779), L726 (= L780), G727 (= G781), E728 (= E782)
1zxiB Reconstituted co dehydrogenase from oligotropha carboxidovorans (see paper)
30% identity, 77% coverage: 29:808/1012 of query aligns to 16:787/804 of 1zxiB
- active site: Q235 (≠ M237), V270 (≠ Q273), P347 (≠ Y350), I353 (≠ G354), R382 (vs. gap), C383 (vs. gap), E758 (= E782), S759 (≠ G783)
- binding copper (ii) ion: C383 (vs. gap), S384 (≠ G384), E758 (= E782)
- binding cu(i)-s-mo(vi)(=o)oh cluster: F266 (= F269), G267 (= G270), A380 (≠ V382), Y381 (≠ R383), R382 (vs. gap), C383 (vs. gap), Y563 (= Y570), G564 (≠ S571), E758 (= E782)
- binding pterin cytosine dinucleotide: G265 (≠ S268), F266 (= F269), R382 (vs. gap), Q523 (≠ A527), G524 (= G528), Q525 (= Q529), H527 (= H531), T530 (≠ V534), T562 (≠ N569), Y563 (= Y570), S565 (= S572), S567 (≠ F574), T568 (≠ A575), C681 (≠ A705), I685 (≠ L709), I689 (≠ L713), I690 (≠ A714), Q693 (= Q717), K754 (= K778), G755 (= G779), V756 (≠ L780), E758 (= E782)
P19919 Carbon monoxide dehydrogenase large chain; CO dehydrogenase subunit L; CO-DH L; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
30% identity, 77% coverage: 29:808/1012 of query aligns to 21:792/809 of P19919
- C388 (vs. gap) binding
- E763 (= E782) binding
1n62B Crystal structure of the mo,cu-co dehydrogenase (codh), n- butylisocyanide-bound state (see paper)
30% identity, 77% coverage: 29:808/1012 of query aligns to 16:787/804 of 1n62B
- active site: Q235 (≠ M237), V270 (≠ Q273), P347 (≠ Y350), I353 (≠ G354), R382 (vs. gap), C383 (vs. gap), E758 (= E782), S759 (≠ G783)
- binding cu(i)-s-mo(iv)(=o)o-nbic cluster: G267 (= G270), V379 (≠ L381), A380 (≠ V382), R382 (vs. gap), C383 (vs. gap), F385 (= F385), Y563 (= Y570), G564 (≠ S571), E758 (= E782)
- binding pterin cytosine dinucleotide: G265 (≠ S268), F266 (= F269), R382 (vs. gap), Q523 (≠ A527), G524 (= G528), Q525 (= Q529), H527 (= H531), T530 (≠ V534), T562 (≠ N569), Y563 (= Y570), G564 (≠ S571), S565 (= S572), S567 (≠ F574), T568 (≠ A575), C681 (≠ A705), I685 (≠ L709), I689 (≠ L713), I690 (≠ A714), Q693 (= Q717), K754 (= K778), G755 (= G779), V756 (≠ L780), G757 (= G781), E758 (= E782)
1n5wB Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
30% identity, 77% coverage: 29:808/1012 of query aligns to 16:787/804 of 1n5wB
- active site: Q235 (≠ M237), V270 (≠ Q273), P347 (≠ Y350), I353 (≠ G354), R382 (vs. gap), C383 (vs. gap), E758 (= E782), S759 (≠ G783)
- binding cu(i)-s-mo(vi)(=o)oh cluster: G267 (= G270), A380 (≠ V382), R382 (vs. gap), C383 (vs. gap), Y563 (= Y570), G564 (≠ S571), E758 (= E782)
- binding pterin cytosine dinucleotide: G265 (≠ S268), F266 (= F269), R382 (vs. gap), Q523 (≠ A527), G524 (= G528), Q525 (= Q529), H527 (= H531), T530 (≠ V534), T562 (≠ N569), Y563 (= Y570), S565 (= S572), S567 (≠ F574), T568 (≠ A575), C681 (≠ A705), I685 (≠ L709), I689 (≠ L713), I690 (≠ A714), Q693 (= Q717), K754 (= K778), G755 (= G779), V756 (≠ L780), E758 (= E782)
1n60B Crystal structure of the cu,mo-co dehydrogenase (codh); cyanide- inactivated form (see paper)
30% identity, 77% coverage: 29:808/1012 of query aligns to 15:786/803 of 1n60B
- active site: Q234 (≠ M237), V269 (≠ Q273), P346 (≠ Y350), I352 (≠ G354), R381 (vs. gap), C382 (vs. gap), E757 (= E782), S758 (≠ G783)
- binding pterin cytosine dinucleotide: G264 (≠ S268), F265 (= F269), R381 (vs. gap), Q522 (≠ A527), G523 (= G528), Q524 (= Q529), H526 (= H531), T529 (≠ V534), T561 (≠ N569), Y562 (= Y570), G563 (≠ S571), S564 (= S572), S566 (≠ F574), T567 (≠ A575), C680 (≠ A705), I684 (≠ L709), I688 (≠ L713), I689 (≠ A714), Q692 (= Q717), K753 (= K778), G754 (= G779), V755 (≠ L780), E757 (= E782)
- binding mo(vi)(=o)(oh)2 cluster: F265 (= F269), G266 (= G270), Y562 (= Y570), G563 (≠ S571), E757 (= E782)
1n63B Crystal structure of the cu,mo-co dehydrogenase (codh); carbon monoxide reduced state (see paper)
30% identity, 77% coverage: 29:808/1012 of query aligns to 17:788/805 of 1n63B
- active site: Q236 (≠ M237), V271 (≠ Q273), P348 (≠ Y350), I354 (≠ G354), R383 (vs. gap), C384 (vs. gap), E759 (= E782), S760 (≠ G783)
- binding cu(i)-s-mo(iv)(=o)oh cluster: G268 (= G270), A381 (≠ V382), R383 (vs. gap), C384 (vs. gap), Y564 (= Y570), G565 (≠ S571), E759 (= E782)
- binding pterin cytosine dinucleotide: G266 (≠ S268), F267 (= F269), R383 (vs. gap), Q524 (≠ A527), G525 (= G528), Q526 (= Q529), H528 (= H531), T531 (≠ V534), T563 (≠ N569), Y564 (= Y570), S566 (= S572), S568 (≠ F574), T569 (≠ A575), C682 (≠ A705), I686 (≠ L709), I690 (≠ L713), I691 (≠ A714), Q694 (= Q717), K755 (= K778), G756 (= G779), V757 (≠ L780), E759 (= E782)
1rm6A Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
28% identity, 77% coverage: 42:818/1012 of query aligns to 16:754/761 of 1rm6A
- active site: Q206 (≠ M237), T241 (≠ Q273), Y318 (= Y350), L322 (vs. gap), R350 (= R383), E718 (= E782), G719 (= G783)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): G235 (= G267), G236 (≠ S268), F237 (= F269), G238 (= G270), R350 (= R383), I473 (≠ A527), G474 (= G528), Q475 (= Q529), G476 (= G530), Y513 (= Y570), S514 (= S571), S515 (= S572), V517 (≠ F574), T518 (≠ A575), L646 (= L709), N647 (= N710), V651 (≠ A714), Q654 (= Q717), K714 (= K778), E715 (≠ G779), A716 (≠ L780), S717 (≠ G781), E718 (= E782)
4zohA Crystal structure of glyceraldehyde oxidoreductase (see paper)
27% identity, 77% coverage: 28:809/1012 of query aligns to 2:695/701 of 4zohA
- active site: Q186 (≠ F240), I219 (≠ Q273), V298 (vs. gap), S300 (vs. gap), M304 (≠ C355), R332 (= R383), E668 (= E782), A669 (≠ G783)
- binding pterin cytosine dinucleotide: G213 (= G267), A214 (≠ S268), F215 (= F269), R332 (= R383), H442 (≠ A527), G443 (= G528), Q444 (= Q529), D446 (≠ H531), W482 (≠ Y570), S484 (= S572), T486 (≠ F574), V487 (≠ A575), I594 (≠ L709), N595 (= N710), L598 (= L713), Q602 (= Q717), K664 (= K778), G665 (= G779), I666 (≠ L780), G667 (= G781), E668 (= E782)
O33819 4-hydroxybenzoyl-CoA reductase subunit alpha; 4-HBCR subunit alpha; EC 1.1.7.1 from Thauera aromatica (see paper)
28% identity, 77% coverage: 42:818/1012 of query aligns to 24:762/769 of O33819
7orcB Human aldehyde oxidase in complex with raloxifene (see paper)
25% identity, 78% coverage: 23:814/1012 of query aligns to 537:1274/1299 of 7orcB
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 43, 44, 228, 229, 230, 231, 232, 233, 234, 235, 236, 309, 310, 318, 319, 322, 323, 326, 328, 331, 332, 376, 403
- binding fe2/s2 (inorganic) cluster: 40, 41, 42, 44, 46, 47, 49, 69, 71, 111, 112, 114, 146, 148
- binding raloxifene: 417, 418, 419, 449, 451, 506, 507
Q06278 Aldehyde oxidase; Aldehyde oxidase 1; Azaheterocycle hydroxylase; EC 1.2.3.1; EC 1.17.3.- from Homo sapiens (Human) (see 3 papers)
25% identity, 78% coverage: 23:814/1012 of query aligns to 574:1311/1338 of Q06278
- R802 (≠ D264) to C: decreases homodimerization but nearly no effect on kinetic parameters; dbSNP:rs41309768
- AF 806:807 (≠ SF 268:269) binding
- R921 (= R383) to H: increases homodimerization; abolishes enzymatic activity on phenanthridine; decreases turnover number with benzaldehyde, phtalazine and chloroquinazolinone as substrate, while nearly no effect on the KM; dbSNP:rs56199635
- M1047 (≠ A527) binding
- GSVV 1088:1091 (≠ ARIV 594:597) binding
- N1135 (= N660) to S: increases homodimerization and turnover number with phenanthridine as substrate; nearly no effect on kinetic parameters with benzaldehyde, phtalazine and chloroquinazolinone as substrate; dbSNP:rs55754655
- Q1203 (= Q717) binding
- L1268 (= L780) binding
- G1269 (= G781) mutation to R: No effect on dimerization. Loss of oxidase activity.
- S1271 (≠ G783) to L: no effect on dimerization; no effect on oxidase activity; dbSNP:rs141786030
- H1297 (vs. gap) to R: increases homodimerization and turnover number with phenanthridine as substrate; nearly no effect on kinetic parameters with benzaldehyde, phtalazine and chloroquinazolinone as substrate; dbSNP:rs3731722
Sites not aligning to the query:
- 44 binding ; C→W: Disrupts protein stability.
- 49 binding
- 52 binding
- 74 binding
- 113 binding
- 114 binding
- 117 binding
- 149 binding
- 151 binding ; binding
- 264:271 binding
- 345 binding
- 354 binding
- 358 binding
- 367 binding
- 411 binding
8emtA Cryo-em analysis of the human aldehyde oxidase from liver (see paper)
25% identity, 78% coverage: 29:814/1012 of query aligns to 504:1229/1254 of 8emtA
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 215, 216, 217, 218, 219, 221, 222, 223, 296, 297, 306, 309, 310, 312, 319
- binding fe2/s2 (inorganic) cluster: 40, 41, 42, 44, 45, 46, 49, 69, 71, 111, 112, 114, 146, 148
3nvzC Crystal structure of bovine xanthine oxidase in complex with indole-3- aldehyde (see paper)
25% identity, 75% coverage: 29:782/1012 of query aligns to 3:691/755 of 3nvzC
- active site: Q197 (≠ S234), E232 (≠ Q273), R310 (= R351), H314 (≠ C355), R342 (= R383), G690 (= G781), E691 (= E782)
- binding 1h-indole-3-carbaldehyde: E232 (≠ Q273), L303 (≠ P344), S306 (≠ A347), R310 (= R351), F344 (= F385), F439 (≠ Y485), T440 (≠ I486), V441 (≠ T487), L444 (≠ M490)
3nvvC Crystal structure of bovine xanthine oxidase in complex with arsenite (see paper)
25% identity, 75% coverage: 29:782/1012 of query aligns to 3:691/755 of 3nvvC
3ns1C Crystal structure of bovine xanthine oxidase in complex with 6- mercaptopurine (see paper)
25% identity, 75% coverage: 29:782/1012 of query aligns to 3:691/755 of 3ns1C
- active site: Q197 (≠ S234), E232 (≠ Q273), R310 (= R351), H314 (≠ C355), R342 (= R383), G690 (= G781), E691 (= E782)
- binding 9H-purine-6-thiol: E232 (≠ Q273), R310 (= R351), F344 (= F385), F439 (≠ Y485), T440 (≠ I486)
Query Sequence
>BPHYT_RS10835 FitnessBrowser__BFirm:BPHYT_RS10835
MNQRDLIHAGDTATHERDPELDKRPQRHLGRPMERLEDPAILTGHGRYGDDIGIRPGTLH
AAILRSPHAHAELVSIDTDAASKLPGVHAILTRDDLRAWSRPFVVGVKSPMEQWALAMDR
VRYVGEPVAVVLAQSRAIAEDGLDLLKVEYATLDPVTSIEQAASDESPVLHEKVGSNVIS
DRHFRYGEPEAAFEKAPHRVKLVAHYPRNTCAPIECGVVIAEYLAGDEGYDVTSNFMGPF
SLHAVMAMALNVPANRLRHKAPRDSGGSFGVKQAVFPYVVLMCLASRKAGAPVKWVEDRF
EHLSAATSATARLSTLEAAVESDGRITALSYDQLEDCGGYLRAPEPATFYRMHGCLTGAY
AIDNLLVRNRVVLTNKTPTGLVRGFGGPQVYFALERLMQRIALELKLDVLDVYRRNFVAA
DAFPYRAAAGALLDSGNYQEALRRALAEGGYDELRARRDAARKEGRLYGIGFAAIVEPSV
SNMGYITTVMPAEARKKAGPKSGAIASATVSVDLLGGVVVTIASTPAGQGHMTVCAQVVA
DVLGVSPHDVVVNVEFDTHKDAWSVAAGNYSSRFAGAVAGTVHLAAVRVRDKIARIVSKQ
MGCAPEDICFEEGRIFAKGAEDRAQPFGRVAANAPHWAPALLPEGEEPGLRETVFWNPPN
MAAPDENDRVNTSAAYGFAFDMCGVELDRATGRVRIDRYVTAHDAGTLLNPALADGQIRG
AFAQGLGAALMEEFRYGSDGSFQSGTLADYLMPTTCEVPDPVIVHLETPSPFTPLGAKGL
GEGNNMSTPPCIANAVADALGVDDIRLPLTPSKVMALIGIDDPEPSRPEFREAPAAKPAT
PGSGKALTAQGSVDLPASPEAIFAVLLDPNALAKVIPGCHALEAEATNQYRADVTVGVGM
IKARFEAKIGLSEIDAPHRLRLAGAGMSSLGSARGSGLVELTPIETGTRLSYDYEAQVSG
KVAAVGGRMLEGAAKVVLRQLFESLGRQAAGKPVHTGGSWLSRLLARFRRQA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory