SitesBLAST
Comparing BPHYT_RS11215 FitnessBrowser__BFirm:BPHYT_RS11215 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see paper)
41% identity, 94% coverage: 11:508/532 of query aligns to 3:491/501 of P04983
- K43 (= K50) mutation to R: Loss of transport.
7arlD Lolcde in complex with lipoprotein and adp (see paper)
33% identity, 41% coverage: 12:231/532 of query aligns to 2:221/222 of 7arlD
P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
33% identity, 41% coverage: 12:231/532 of query aligns to 5:224/233 of P75957
- G42 (= G44) mutation to D: Loss of lipoprotein release when overexpressed.
7mdyC Lolcde nucleotide-bound
33% identity, 41% coverage: 12:231/532 of query aligns to 2:221/226 of 7mdyC
- binding adp orthovanadate: Y12 (= Y22), T19 (vs. gap), V21 (= V26), S40 (≠ E45), S41 (≠ N46), G42 (= G47), S43 (≠ A48), G44 (= G49), K45 (= K50), S46 (= S51), T47 (= T52), Q91 (= Q93), R135 (≠ D145), H138 (≠ T148), E142 (= E152), S144 (≠ G154), G145 (≠ I155), G146 (= G156), E147 (≠ H157), E168 (= E178), N172 (≠ M182), H201 (= H210)
- binding magnesium ion: S46 (= S51), Q91 (= Q93)
7v8iD Lolcd(e171q)e with bound amppnp in nanodiscs
32% identity, 41% coverage: 12:231/532 of query aligns to 4:223/229 of 7v8iD
- binding phosphoaminophosphonic acid-adenylate ester: V23 (= V26), S43 (≠ N46), G44 (= G47), S45 (≠ A48), G46 (= G49), K47 (= K50), S48 (= S51), T49 (= T52), Q93 (= Q93), R137 (≠ D145), H140 (≠ T148), E144 (= E152), L145 (= L153), S146 (≠ G154), G147 (≠ I155), G148 (= G156), E149 (≠ H157), N174 (≠ M182), H203 (= H210)
- binding magnesium ion: S48 (= S51), Q93 (= Q93)
P07821 Iron(3+)-hydroxamate import ATP-binding protein FhuC; Ferric hydroxamate uptake protein C; Ferrichrome transport ATP-binding protein FhuC; Iron(III)-hydroxamate import ATP-binding protein FhuC; EC 7.2.2.16 from Escherichia coli (strain K12) (see paper)
33% identity, 43% coverage: 26:254/532 of query aligns to 26:250/265 of P07821
- K50 (= K50) mutation to Q: Lack of activity.
- D172 (= D177) mutation to E: Lack of activity.
7w78A Heme exporter hrtba in complex with mg-amppnp (see paper)
33% identity, 41% coverage: 12:229/532 of query aligns to 4:214/218 of 7w78A
- binding phosphoaminophosphonic acid-adenylate ester: Y14 (= Y22), V21 (vs. gap), A23 (vs. gap), E42 (= E45), S43 (≠ N46), G44 (= G47), S45 (≠ A48), G46 (= G49), K47 (= K50), S48 (= S51), T49 (= T52), Q88 (= Q93), E163 (= E178), H196 (= H210)
- binding magnesium ion: S48 (= S51), Q88 (= Q93)
7w79A Heme exporter hrtba in complex with mn-amppnp (see paper)
33% identity, 41% coverage: 12:229/532 of query aligns to 4:214/216 of 7w79A
- binding adenosine-5'-triphosphate: Y14 (= Y22), V21 (vs. gap), A23 (vs. gap), E42 (= E45), S43 (≠ N46), G44 (= G47), S45 (≠ A48), G46 (= G49), K47 (= K50), S48 (= S51), T49 (= T52), Q88 (= Q93), E163 (= E178), H196 (= H210)
- binding manganese (ii) ion: S6 (= S14), E30 (≠ S33), S48 (= S51), Q88 (= Q93), E163 (= E178), H196 (= H210)
5lilA Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
32% identity, 39% coverage: 26:231/532 of query aligns to 22:221/615 of 5lilA
- binding adenosine-5'-triphosphate: V22 (= V26), S42 (≠ N46), G43 (= G47), S44 (≠ A48), G45 (= G49), K46 (= K50), S47 (= S51), T48 (= T52), Q92 (= Q93), K136 (vs. gap), N139 (≠ I144), Q143 (≠ T148), L144 (= L149), S145 (≠ V150), G146 (= G151), G147 (= G156), Q148 (≠ H157), Q169 (≠ E178), A173 (≠ M182), H201 (= H210)
- binding magnesium ion: S47 (= S51), Q92 (= Q93), D168 (= D177)
Sites not aligning to the query:
5lj7A Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
32% identity, 39% coverage: 26:231/532 of query aligns to 22:221/592 of 5lj7A
- binding adenosine-5'-triphosphate: V22 (= V26), S42 (≠ N46), G43 (= G47), S44 (≠ A48), G45 (= G49), K46 (= K50), S47 (= S51), T48 (= T52), Q92 (= Q93), K136 (vs. gap), N142 (≠ D147), Q143 (≠ T148), L144 (= L149), S145 (≠ V150), G146 (= G151), G147 (= G156), Q148 (≠ H157), Q169 (≠ E178), A173 (≠ M182), H201 (= H210)
- binding magnesium ion: S47 (= S51), Q92 (= Q93), D168 (= D177)
Sites not aligning to the query:
1g6hA Crystal structure of the adp conformation of mj1267, an atp- binding cassette of an abc transporter (see paper)
26% identity, 41% coverage: 12:231/532 of query aligns to 4:229/254 of 1g6hA
1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
26% identity, 41% coverage: 12:231/532 of query aligns to 4:229/253 of 1g9xB
P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
32% identity, 45% coverage: 11:250/532 of query aligns to 2:235/369 of P19566
- L86 (= L97) mutation to F: Loss of transport. No effect on ATP-binding activity but decrease in ATP hydrolysis. Retains repressor activity.
- P160 (= P179) mutation to L: Loss of transport. No effect on ATP-binding activity but decrease in ATP hydrolysis. Retains repressor activity.
- D165 (≠ T184) mutation to N: Loss of transport. No effect on ATP-binding activity but decrease in ATP hydrolysis. Retains repressor activity.
Sites not aligning to the query:
- 306 E→K: Loss of transport. No effect on ATP-binding and ATP hydrolysis. Retains repressor activity.
2awnB Crystal structure of the adp-mg-bound e. Coli malk (crystallized with atp-mg) (see paper)
32% identity, 45% coverage: 11:250/532 of query aligns to 1:234/374 of 2awnB
3puyA Crystal structure of an outward-facing mbp-maltose transporter complex bound to amp-pnp after crystal soaking of the pretranslocation state (see paper)
32% identity, 45% coverage: 11:250/532 of query aligns to 1:234/371 of 3puyA
- binding phosphoaminophosphonic acid-adenylate ester: W12 (≠ Y22), V17 (≠ L27), P36 (≠ E45), S37 (≠ N46), G38 (= G47), C39 (≠ A48), G40 (= G49), K41 (= K50), S42 (= S51), T43 (= T52), Q81 (= Q93), R128 (≠ A143), A132 (≠ T148), S134 (≠ V150), G135 (= G151), G136 (= G156), Q137 (≠ H157), E158 (= E178), H191 (= H210)
- binding magnesium ion: S42 (= S51), Q81 (= Q93), D157 (= D177)
3puxA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-bef3 (see paper)
32% identity, 45% coverage: 11:250/532 of query aligns to 1:234/371 of 3puxA
- binding adenosine-5'-diphosphate: W12 (≠ Y22), V17 (≠ L27), S37 (≠ N46), G38 (= G47), C39 (≠ A48), G40 (= G49), K41 (= K50), S42 (= S51), T43 (= T52), R128 (≠ A143), A132 (≠ T148), L133 (= L149), S134 (≠ V150), Q137 (≠ H157)
- binding beryllium trifluoride ion: S37 (≠ N46), G38 (= G47), K41 (= K50), Q81 (= Q93), S134 (≠ V150), G135 (= G151), G136 (= G156), E158 (= E178), H191 (= H210)
- binding magnesium ion: S42 (= S51), Q81 (= Q93), D157 (= D177)
3puwA Crystal structure of an outward-facing mbp-maltose transporter complex bound to adp-alf4 (see paper)
32% identity, 45% coverage: 11:250/532 of query aligns to 1:234/371 of 3puwA
- binding adenosine-5'-diphosphate: W12 (≠ Y22), V17 (≠ L27), S37 (≠ N46), G38 (= G47), C39 (≠ A48), G40 (= G49), K41 (= K50), S42 (= S51), T43 (= T52), R128 (≠ A143), A132 (≠ T148), S134 (≠ V150), Q137 (≠ H157)
- binding tetrafluoroaluminate ion: S37 (≠ N46), G38 (= G47), K41 (= K50), Q81 (= Q93), S134 (≠ V150), G135 (= G151), G136 (= G156), E158 (= E178), N162 (≠ M182), H191 (= H210)
- binding magnesium ion: S42 (= S51), Q81 (= Q93)
2awoA Crystal structure of the adp-mg-bound e. Coli malk (crystallized with adp-mg) (see paper)
32% identity, 45% coverage: 11:250/532 of query aligns to 1:234/372 of 2awoA