SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing BPHYT_RS11435 FitnessBrowser__BFirm:BPHYT_RS11435 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 1 hits to proteins with known functional sites (download)

P68183 Maltose/maltodextrin transport system permease protein MalG from Escherichia coli (strain K12) (see 2 papers)
29% identity, 56% coverage: 62:214/272 of query aligns to 86:236/296 of P68183

query
sites
P68183

W

W

L

N

S

S

L

V

R

K

V

V

A

A

L

G

L

I

T

S

A

A

F

I

A

G

S

I

V

V

V

A

I

L

G

S

T

T

W

T

A

C

G

A

F

Y

V

A

L

F

A

A

R

R

M

M

G

-

R

R

F

F

R

P

G

G

-

K

F

A

T

T

L

L

Y

L

T

K

G

G

M

M

I

L

N

I

A

F

P

Q

L

M

V

-

I

F

P

P

E

A

V

V

I

L

Q

S

G

L

I

V

S

A

L

L

L

Y

L

A

L

L

F

F

I

D

E

R

M

L

A

G

K

E

W

Y

L

I

-

P

-

F

-

I

G

G

W

L

P

N

A

T

G

H

R

G

G

G

I

V

F

I

T

F

I

A

W

Y

I

L

G

G

H

G

V

I

M

A

L

L

C

H

I

V

S

-

Y

-

V

-

A

-

I

W

I

T

V

I

Q

K

S

G

R

Y

V

F

K

E

E

T

L

I

H

D

P

S

S

S

L

L

E

E

E
|
E

A

A

A
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A

L

A

D

L

L

D

G
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G

A

A

T

T

P

P

L

W

R

Q

V

A

F

F

F

R

F

L

I

V

T

L

L

L

P
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P

L

L

I

S

S

V

Q

P

A

I

L

L

V

A

S

V

G

V

W

F

L

I

L

L

S

S

F

F

T

I

L

A

S

A

I

I

D

T

D

E

L

V

V

P

L

V

S

A

A

S

F

L

L

L

E190 (= E168) mutation E->A,C,K,L: Reduction of transport rate.
A192 (= A170) mutation A->D,S,L: Loss of transport and MalK dissociation from the membrane.
G196 (= G174) mutation to A: No effect.; mutation to P: Loss of transport and MalK dissociation from the membrane.
P209 (= P187) mutation to A: No effect.

Query Sequence

>BPHYT_RS11435 FitnessBrowser__BFirm:BPHYT_RS11435
MKPNRILQLIALGIGFLFLYIPIVSLIVYSFNESQLVTVWTRFSTRWYAALLQDDELIAA
AWLSLRVALLTAFASVVIGTWAGFVLARMGRFRGFTLYTGMINAPLVIPEVIQGISLLLL
FIEMAKWLGWPAGRGIFTIWIGHVMLCISYVAIIVQSRVKELHPSLEEAALDLGATPLRV
FFFITLPLISQALVSGWLLSFTLSIDDLVLSAFLSGPGSTTLPLVVFSRVRLGLNPEMNA
LATLFIAVVTVGVVAANYFMQRAERKRAVMAV

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory