Comparing BPHYT_RS11720 FitnessBrowser__BFirm:BPHYT_RS11720 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7rsfA Acetylornithine deacetylase from escherichia coli
33% identity, 93% coverage: 23:382/387 of query aligns to 28:376/380 of 7rsfA
3pfoA Crystal structure of a putative acetylornithine deacetylase (rpa2325) from rhodopseudomonas palustris cga009 at 1.90 a resolution
29% identity, 66% coverage: 8:264/387 of query aligns to 23:297/426 of 3pfoA
Sites not aligning to the query:
P44514 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 3 papers)
29% identity, 84% coverage: 54:379/387 of query aligns to 50:370/377 of P44514
5vo3A Crystal structure of dape in complex with the products (succinic acid and diaminopimelic acid) (see paper)
29% identity, 84% coverage: 54:379/387 of query aligns to 54:374/380 of 5vo3A
4pqaA Crystal structure of succinyl-diaminopimelate desuccinylase from neisseria meningitidis mc58 in complex with the inhibitor captopril (see paper)
33% identity, 50% coverage: 67:260/387 of query aligns to 62:258/375 of 4pqaA
Sites not aligning to the query:
4o23A Crystal structure of mono-zinc form of succinyl diaminopimelate desuccinylase from neisseria meningitidis mc58 (see paper)
33% identity, 50% coverage: 67:260/387 of query aligns to 62:258/376 of 4o23A
7lgpB Dape enzyme from shigella flexneri
28% identity, 86% coverage: 54:385/387 of query aligns to 52:377/377 of 7lgpB
7t1qA Crystal structure of the succinyl-diaminopimelate desuccinylase (dape) from acinetobacter baumannii in complex with succinic acid
33% identity, 53% coverage: 54:260/387 of query aligns to 50:258/377 of 7t1qA
Sites not aligning to the query:
7uoiA Crystallographic structure of dape from enterococcus faecium
23% identity, 99% coverage: 1:382/387 of query aligns to 5:374/383 of 7uoiA
P37111 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Sus scrofa (Pig) (see paper)
30% identity, 55% coverage: 67:280/387 of query aligns to 75:295/407 of P37111
Sites not aligning to the query:
2pokA Crystal structure of a m20 family metallo peptidase from streptococcus pneumoniae
25% identity, 87% coverage: 31:367/387 of query aligns to 46:441/458 of 2pokA
Sites not aligning to the query:
Q03154 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Homo sapiens (Human) (see 6 papers)
27% identity, 56% coverage: 65:280/387 of query aligns to 73:296/408 of Q03154
Sites not aligning to the query:
Q8P8J5 N-acetyl-L-citrulline deacetylase; ACDase; Acetylcitrulline deacetylase; EC 3.5.1.- from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see paper)
27% identity, 93% coverage: 10:370/387 of query aligns to 12:352/366 of Q8P8J5
2f7vA Structure of acetylcitrulline deacetylase complexed with one co (see paper)
27% identity, 93% coverage: 10:370/387 of query aligns to 13:347/360 of 2f7vA
Q96KN2 Beta-Ala-His dipeptidase; CNDP dipeptidase 1; Carnosine dipeptidase 1; Glutamate carboxypeptidase-like protein 2; Serum carnosinase; EC 3.4.13.20 from Homo sapiens (Human) (see 4 papers)
38% identity, 23% coverage: 65:153/387 of query aligns to 125:216/507 of Q96KN2
Sites not aligning to the query:
P06621 Carboxypeptidase G2; CPDG2; Folate hydrolase G2; Glutamate carboxypeptidase; Pteroylmonoglutamic acid hydrolase G2; Glucarpidase; EC 3.4.17.11 from Pseudomonas sp. (strain RS-16) (see paper)
28% identity, 71% coverage: 10:285/387 of query aligns to 47:313/415 of P06621
Sites not aligning to the query:
1cg2A Carboxypeptidase g2 (see paper)
28% identity, 71% coverage: 10:285/387 of query aligns to 22:288/389 of 1cg2A
Sites not aligning to the query:
3dljA Crystal structure of human carnosine dipeptidase 1
38% identity, 23% coverage: 65:153/387 of query aligns to 94:185/471 of 3dljA
Sites not aligning to the query:
7m6uB Crystal structure of a circular permutation and computationally designed pro-enzyme of carboxypeptidase g2 (see paper)
28% identity, 60% coverage: 54:285/387 of query aligns to 4:223/392 of 7m6uB
Sites not aligning to the query:
Q8C165 N-fatty-acyl-amino acid synthase/hydrolase PM20D1; Peptidase M20 domain-containing protein 1; PM20D1; EC 3.5.1.114; EC 3.5.1.14 from Mus musculus (Mouse) (see paper)
34% identity, 38% coverage: 68:213/387 of query aligns to 121:280/503 of Q8C165
Sites not aligning to the query:
>BPHYT_RS11720 FitnessBrowser__BFirm:BPHYT_RS11720
MNDRSSRALLERLIGFATVSRDSNLEMIDFIRGYLGELGVESELFYNAERSKANLFATIG
PREGGGIVLSGHTDVVPVEGQAWTVDAFRLTERDGRLYGRGAADMKGYIASVLAAVPGLR
ERELKLPVHLAFSYDEEVGCLGVRPMLAELAQRAHKPALCLIGEPTELKPVLGHKGKLAM
RCQVKGAPCHSAYAPYGVNAIQYAARMIGRLEEIGELLARPEHHDARFDPPFSTVQTGVI
NGGRALNIVPAECEFDFEVRALPGFDANRVADELQIYAEAELLPKMRAVKSDTDIRFQSL
SAYPGLATSPDSEAARLLALLSGSTEYGTVAFGTEGGLFDEAGIPTVVCGPGSMDQGHKP
DEFVTVAQLRECDAMLARLTEYVSAAS
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory