Comparing BPHYT_RS12305 FitnessBrowser__BFirm:BPHYT_RS12305 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 11 hits to proteins with known functional sites (download)
3cuxA Atomic resolution structures of escherichia coli and bacillis anthracis malate synthase a: comparison with isoform g and implications for structure based drug design (see paper)
58% identity, 95% coverage: 26:534/536 of query aligns to 9:499/501 of 3cuxA
P30952 Malate synthase 1; EC 2.3.3.9 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
52% identity, 95% coverage: 30:536/536 of query aligns to 31:541/554 of P30952
Sites not aligning to the query:
3cv2A Atomic resolution structures of escherichia coli and bacillis anthracis malate synthase a: comparison with isoform g and implications for structure based drug design (see paper)
50% identity, 94% coverage: 30:533/536 of query aligns to 15:520/524 of 3cv2A
3cv1A Atomic resolution structures of escherichia coli and bacillis anthracis malate synthase a: comparison with isoform g and implications for structure based drug design (see paper)
50% identity, 94% coverage: 30:533/536 of query aligns to 20:525/529 of 3cv1A
3cuzA Atomic resolution structures of escherichia coli and bacillis anthracis malate synthase a: comparison with isoform g and implications for structure based drug design (see paper)
50% identity, 94% coverage: 30:533/536 of query aligns to 20:525/529 of 3cuzA
1n8iA Biochemical and structural studies of malate synthase from mycobacterium tuberculosis (see paper)
23% identity, 69% coverage: 102:469/536 of query aligns to 243:627/701 of 1n8iA
5cahA Crystal structure of mycobacterium tuberculosis malate synthase in complex with 6h-thieno[2,3-b]pyrrole-5-carboxylic acid (see paper)
23% identity, 69% coverage: 102:469/536 of query aligns to 245:628/706 of 5cahA
6ba7A Crystal structure of mycobacterium tuberculosis malate synthase in complex with 2-cl-4-oh-phenyldiketoacid (see paper)
23% identity, 69% coverage: 102:469/536 of query aligns to 247:634/709 of 6ba7A
Sites not aligning to the query:
5cc7A Crystal structure of mycobacterium tuberculosis malate synthase in complex with 1h-indole-6-carboxylic acid
23% identity, 69% coverage: 102:469/536 of query aligns to 246:630/704 of 5cc7A
Sites not aligning to the query:
5cc6A Crystal structure of mycobacterium tuberculosis malate synthase in complex with 1h-indole-5-carboxylic acid
23% identity, 69% coverage: 102:469/536 of query aligns to 243:627/701 of 5cc6A
Sites not aligning to the query:
5cjmA Crystal structure of mycobacterium tuberculosis malate synthase in complex with 4h-thieno[3,2-b]pyrrole-5-carboxylic acid (see paper)
23% identity, 69% coverage: 102:469/536 of query aligns to 249:633/711 of 5cjmA
Sites not aligning to the query:
>BPHYT_RS12305 FitnessBrowser__BFirm:BPHYT_RS12305
MASPQSSHSSLQLPQGMEITAEIKPGYDAILSREALELVAALHRTFEPRRQQLLQARAER
TKRLDAGERPDFLAETKSVRDGDWTIAPLPQDLQCRRVEITGPVERKMIINALNSGADSY
MTDFEDSNAPSWDNQITGHINLKDAVRRTISLEQNGKSYTLNDKVATLIVRPRGWHLDEK
HVKVDGKRVSGGIFDFALFMVHNAKELVARGSGPYFYLPKMESHLEARLWNDIFVAAQEA
VGVPRGTIRATVLIETIVAAFEMDEILYELREHSSGLNAGRWDYIFSAIKKFKADRDFCL
ADRSQITMTSPFMRAYALLLLKTCHRRNAPAIGGMSALIPIKNDPAANDKAMSGVRSDKA
RDAGDGYDGGWVAHPGLVPIAMEEFVKVLGDKPNQIGKQRDDVLVTATDLTDFRPEAPIT
EGGLRNNINVGIHYLGAWLAGNGCVPIHNLMEDAATAEISRSQVWQWIRSPKGKLEDGRK
VTAELVRELSAQELEKVKQAVGGDTKPYERAAQIFEEMSTSEQFTDFLTLPLYEEI
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory