Comparing BPHYT_RS12370 FitnessBrowser__BFirm:BPHYT_RS12370 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P0AAH4 Putrescine export system ATP-binding protein SapD from Escherichia coli (strain K12) (see paper)
36% identity, 52% coverage: 16:299/544 of query aligns to 2:299/330 of P0AAH4
7z18I E. Coli c-p lyase bound to a phnk abc dimer and atp (see paper)
37% identity, 43% coverage: 311:542/544 of query aligns to 17:248/250 of 7z18I
Sites not aligning to the query:
7z15I E. Coli c-p lyase bound to a phnk/phnl dual abc dimer and adp + pi (see paper)
37% identity, 43% coverage: 311:542/544 of query aligns to 17:248/253 of 7z15I
Sites not aligning to the query:
7z16I E. Coli c-p lyase bound to phnk/phnl dual abc dimer with amppnp and phnk e171q mutation (see paper)
37% identity, 43% coverage: 311:542/544 of query aligns to 17:248/250 of 7z16I
Sites not aligning to the query:
4fwiB Crystal structure of the nucleotide-binding domain of a dipeptide abc transporter (see paper)
36% identity, 45% coverage: 25:268/544 of query aligns to 15:256/310 of 4fwiB
Sites not aligning to the query:
Q8RDH4 Dipeptide transport ATP-binding protein DppD; EC 7.4.2.9 from Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis) (see paper)
36% identity, 45% coverage: 25:268/544 of query aligns to 16:257/326 of Q8RDH4
Sites not aligning to the query:
P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
33% identity, 45% coverage: 297:542/544 of query aligns to 3:245/343 of P30750
Sites not aligning to the query:
4u00A Crystal structure of ttha1159 in complex with adp (see paper)
35% identity, 46% coverage: 16:266/544 of query aligns to 1:236/241 of 4u00A
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
33% identity, 45% coverage: 297:542/544 of query aligns to 4:246/344 of 3tuzC
Sites not aligning to the query:
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
33% identity, 45% coverage: 297:542/544 of query aligns to 4:246/344 of 3tuiC
6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
33% identity, 45% coverage: 297:542/544 of query aligns to 4:246/344 of 6cvlD
3c4jA Abc protein artp in complex with atp-gamma-s
32% identity, 46% coverage: 17:268/544 of query aligns to 3:240/242 of 3c4jA
3c41J Abc protein artp in complex with amp-pnp/mg2+
32% identity, 46% coverage: 17:268/544 of query aligns to 3:240/242 of 3c41J
2olkA Abc protein artp in complex with adp-beta-s
32% identity, 46% coverage: 17:268/544 of query aligns to 3:240/242 of 2olkA
2oljA Abc protein artp in complex with adp/mg2+
32% identity, 46% coverage: 17:268/544 of query aligns to 3:240/242 of 2oljA
P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 3 papers)
36% identity, 40% coverage: 317:533/544 of query aligns to 37:243/378 of P69874
Sites not aligning to the query:
4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
31% identity, 46% coverage: 17:268/544 of query aligns to 1:238/240 of 4ymuJ
7ahhC Opua inhibited inward-facing, sbd docked (see paper)
33% identity, 47% coverage: 26:278/544 of query aligns to 35:275/382 of 7ahhC
Sites not aligning to the query:
7aheC Opua inhibited inward facing (see paper)
33% identity, 47% coverage: 26:278/544 of query aligns to 35:275/382 of 7aheC
Sites not aligning to the query:
1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
33% identity, 42% coverage: 305:530/544 of query aligns to 13:233/353 of 1oxvD
>BPHYT_RS12370 FitnessBrowser__BFirm:BPHYT_RS12370
MSANLQNTASRTTPPPLLELDHLHVRFGDTVAVSDVTLAIQRGERVALVGESGSGKSVTA
LSILRLLSDAQVSGSIRFDGEDLLGKTEREMRGMRGSDIAMIFQEPMTALNPLYTVGDQI
AETIVVHDGVSANEARKRAVALLGRTGIAEPGKRVNSYPHQLSGGQRQRAMIAMALACRP
RLLLADEPTTALDVTIRAQIVDLLLELQRDEAEKRGMAVLLITHDLNLVRHFAQRIAVME
KGVLVESGPVEQVFESPQHPYTQRLLASRPQRTVVPVLPISPVLLEAREISVDFKTKLPG
FSGWFRSGRFRAVADANVSVRQGETLGIVGESGSGKSTLAMALLGLQRTVHGEIEFQGRA
LGSYRGAEQTALRSNMQVVFQDPFSSLSPRQTIERIVGEGLALHRPAMTPQARRDKVISV
LREVGLDRTVLQRYPHEFSGGQRQRIAIARALVLEPRILILDEPTSALDVSIQQQVLKLL
AGLQQKYNLGFVFISHDLAVIGAMAHRVAVMQNGSIVESGEVEEIFSTPAHPYTRKLLKA
ALDH
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory