SitesBLAST

P40939 Trifunctional enzyme subunit alpha, mitochondrial; 78 kDa gastrin-binding protein; Monolysocardiolipin acyltransferase; TP-alpha; EC 2.3.1.-; EC 4.2.1.17; EC 1.1.1.211 from Homo sapiens (Human) (see 5 papers)
34% identity, 29% coverage: 62:222/556 of query aligns to 67:224/763 of P40939

query
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P40939

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Sites not aligning to the query:

282 V → D: in MTPD1; mild phenotype with slowly progressive myopathy and sensorimotor polyneuropathy; dbSNP:rs137852773
305 I → N: in MTPD1; mild phenotype with slowly progressive myopathy and sensorimotor polyneuropathy; dbSNP:rs137852774
342 L → P: in LCHAD deficiency; dbSNP:rs137852772
510 active site, For hydroxyacyl-coenzyme A dehydrogenase activity; E → Q: in AFLP and LCHAD deficiency; loss of long-chain-3-hydroxyacyl-CoA dehydrogenase activity; dbSNP:rs137852769

5jbxB Crystal structure of liuc in complex with coenzyme a and malonic acid (see paper)
36% identity, 22% coverage: 62:184/556 of query aligns to 36:150/261 of 5jbxB

query
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5jbxB

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active site: A67 (= A94), R72 (≠ L99), L84 (≠ C111), R88 (≠ N115), G112 (= G143), E115 (= E146), T134 (≠ P167), E135 (= E168), I140 (≠ V174), P142 (= P176), G143 (= G177)
binding coenzyme a: A65 (≠ S92), D68 (≠ N95), L69 (≠ I96), K70 (≠ F97), L110 (≠ A141), G111 (= G142), T134 (≠ P167), E135 (= E168), L138 (= L172)

Sites not aligning to the query:

active site: 228, 238
binding coenzyme a: 24, 25, 26, 28, 168

2hw5C The crystal structure of human enoyl-coenzyme a (coa) hydratase short chain 1, echs1
30% identity, 42% coverage: 52:284/556 of query aligns to 28:252/260 of 2hw5C

query
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2hw5C

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active site: A68 (= A94), M73 (= M98), S83 (≠ K107), L87 (≠ C111), G111 (= G143), E114 (= E146), P133 (= P167), E134 (= E168), T139 (≠ V174), P141 (= P176), G142 (= G177), K227 (≠ D258), F237 (≠ L268)
binding crotonyl coenzyme a: L28 (= L52), A30 (≠ S54), K62 (≠ R88), I70 (= I96), F109 (≠ A141)

Sites not aligning to the query:

binding crotonyl coenzyme a: 26, 27

1mj3A Crystal structure analysis of rat enoyl-coa hydratase in complex with hexadienoyl-coa (see paper)
29% identity, 42% coverage: 52:284/556 of query aligns to 28:250/258 of 1mj3A

query
sites
1mj3A

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active site: A68 (= A94), M73 (≠ L99), S83 (≠ N119), L85 (= L121), G109 (= G143), E112 (= E146), P131 (= P167), E132 (= E168), T137 (≠ V174), P139 (= P176), G140 (= G177), K225 (≠ D258), F235 (≠ L268)
binding hexanoyl-coenzyme a: L28 (= L52), A30 (≠ S54), A66 (≠ S92), G67 (= G93), A68 (= A94), D69 (≠ N95), I70 (= I96), G109 (= G143), P131 (= P167), E132 (= E168), L135 (= L172), G140 (= G177)

Sites not aligning to the query:

binding hexanoyl-coenzyme a: 26, 27

2dubA Enoyl-coa hydratase complexed with octanoyl-coa (see paper)
29% identity, 42% coverage: 52:284/556 of query aligns to 27:246/254 of 2dubA

query
sites
2dubA

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active site: A67 (= A94), M72 (≠ L101), S82 (≠ C111), G105 (= G143), E108 (= E146), P127 (= P167), E128 (= E168), T133 (≠ V174), P135 (= P176), G136 (= G177), K221 (≠ D258), F231 (≠ L268)
binding octanoyl-coenzyme a: L27 (= L52), A29 (≠ S54), A65 (≠ S92), A67 (= A94), D68 (≠ N95), I69 (= I96), K70 (≠ L99), G105 (= G143), E108 (= E146), P127 (= P167), E128 (= E168), G136 (= G177), A137 (≠ T178)

Sites not aligning to the query:

binding octanoyl-coenzyme a: 25, 26

3q0gD Crystal structure of the mycobacterium tuberculosis crotonase bound to a reaction intermediate derived from crotonyl coa
32% identity, 28% coverage: 133:287/556 of query aligns to 93:248/250 of 3q0gD

query
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3q0gD

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R

T

A

A

L

T

E

T

L

I

A

S

E

Q

Q

M

S

S

D

A

R

S

P

A

A

A

D

R

A

M

Q

A

G

K

V

E

V

A

L

V

T

N

R

R

I

A

E

F

R

E

T

S

D

S

R

L

E

S

E

E

G

G

L

L

T
x
L

Y

Y

K

E

-

R

-

L

-
x
F

-

H

T

S

L

A

D
x
F

V

A

T

T

I

E

D

D

R

Q

A

S

K

E

R

G

I

M

A

A

T

A

F
|
F

T

I

A

E

K

K

-

R

A

A

P

P

Q

Q

active site: G103 (= G143), E106 (= E146), P125 (= P167), E126 (= E168), V131 (= V174), P133 (= P176), G134 (= G177), L219 (≠ T264), F229 (≠ D269)
binding Butyryl Coenzyme A: F225 (vs. gap), F241 (= F281)

Sites not aligning to the query:

active site: 64, 69, 75, 79

3h81A Crystal structure of enoyl-coa hydratase from mycobacterium tuberculosis (see paper)
32% identity, 28% coverage: 133:287/556 of query aligns to 97:252/256 of 3h81A

query
sites
3h81A

L

I

A

A

V

V

N

A

G

G

A

Y

C

A

A

L

G

G

G
|
G

G

G

Y

C

E
|
E

L

L

A

A

L

M

A

M

C

C

D

D

E

V

I

L

Y

I

L

A

V

A

D

D

D

-

R

-

S

T

S

A

S

K

V

F

S

G

L

Q

P
|
P

E
|
E

V

I

P

K

L

-

L

L

G

G

V
|
V

L

L

P
|
P

G
|
G

T

M

G

G

L

S

T

Q

R

R

V

L

T

T

D

-

K

-

R

R

K

A

V

I

R

G

H

K

D

A

R

K

A

A

-

M

D

D

I

L

F

I

C

L

T

T

-

G

-

R

V

T

V

M

E

D

G

A

V

A

R

E

G

A

E

E

R

R

A

S

K

G

A

-

W

-

R

-

L

L

V

V

D

S

E

R

V

V

K

P

P

A

N

D

Q

D

F

L

D

L

Q

T

A

E

I

A

Q

R

A

A

R

T

A

A

L

T

E

T

L

I

A

S

E

Q

Q

M

S

S

D

A

R

S

P

A

A

A

D

R

A

M

Q

A

G

K

V

E

V

A

L

V

T

N

R

R

I

A

E

F

R

E

T

S

D

S

R

L

E

S

E

E

G

G

L

L

T
x
L

Y

Y

K

E

-

R

-

L

-

F

-

H

T

S

L

A

D
x
F

V

A

T

T

I

E

D

D

R
x
Q

A

S

K

E

R

G

I

M

A

A

T

A

F

F

T

I

A

E

K

K

-

R

A

A

P

P

Q

Q

active site: G107 (= G143), E110 (= E146), P129 (= P167), E130 (= E168), V135 (= V174), P137 (= P176), G138 (= G177), L223 (≠ T264), F233 (≠ D269)
binding calcium ion: F233 (≠ D269), Q238 (≠ R274)

Sites not aligning to the query:

active site: 64, 69, 79, 83

3q0jC Crystal structure of the mycobacterium tuberculosis crotonase in complex with the inhibitor acetoacetylcoa
32% identity, 28% coverage: 133:287/556 of query aligns to 98:253/255 of 3q0jC

query
sites
3q0jC

L

I

A

A

V

V

N

A

G

G

A

Y

C

A

A

L

G
|
G

G

G

Y

C

E
|
E

L

L

A

A

L

M

A

M

C

C

D

D

E

V

I

L

Y

I

L

A

V

A

D

D

D

-

R

-

S

T

S

A

S

K

V

F

S

G

L

Q

P
|
P

E
|
E

V

I

P

K

L

-

L

L

G

G

V
|
V

L

L

P
|
P

G
|
G

T
x
M

G

G

L

S

T

Q

R

R

V

L

T

T

D

-

K

-

R

R

K

A

V

I

R

G

H

K

D

A

R

K

A

A

-

M

D

D

I

L

F

I

C

L

T

T

-

G

-

R

V

T

V

M

E

D

G

A

V

A

R

E

G

A

E

E

R

R

A

S

K

G

A

-

W

-

R

-

L

L

V

V

D

S

E

R

V

V

K

P

P

A

N

D

Q

D

F

L

D

L

Q

T

A

E

I

A

Q

R

A

A

R

T

A

A

L

T

E

T

L

I

A

S

E

Q

Q

M

S

S

D

A

R

S

P

A

A

A

D

R

A

M

Q

A

G

K

V

E

V

A

L

V

T

N

R

R

I

A

E

F

R

E

T

S

D

S

R

L

E

S

E

E

G

G

L

L

T
x
L

Y

Y

K

E

-

R

-

L

-

F

-

H

T

S

L

A

D
x
F

V

A

T

T

I

E

D

D

R

Q

A

S

K

E

R

G

I

M

A

A

T

A

F

F

T

I

A

E

K

K

-

R

A

A

P

P

Q

Q

active site: G108 (= G143), E111 (= E146), P130 (= P167), E131 (= E168), V136 (= V174), P138 (= P176), G139 (= G177), L224 (≠ T264), F234 (≠ D269)
binding acetoacetyl-coenzyme a: G107 (= G142), G108 (= G143), E111 (= E146), P130 (= P167), E131 (= E168), P138 (= P176), G139 (= G177), M140 (≠ T178)

Sites not aligning to the query:

active site: 65, 70, 80, 84
binding acetoacetyl-coenzyme a: 23, 24, 25, 27, 63, 64, 65, 66, 67, 68, 70, 84

3q0gC Crystal structure of the mycobacterium tuberculosis crotonase bound to a reaction intermediate derived from crotonyl coa
32% identity, 28% coverage: 133:287/556 of query aligns to 98:253/255 of 3q0gC

query
sites
3q0gC

L

I

A

A

V

V

N

A

G

G

A
x
Y

C

A

A

L

G

G

G
|
G

G

G

Y

C

E
|
E

L

L

A

A

L

M

A

M

C

C

D

D

E

V

I

L

Y

I

L

A

V

A

D

D

D

-

R

-

S

T

S

A

S

K

V

F

S

G

L

Q

P
|
P

E
|
E

V

I

P

K

L

-

L
|
L

G

G

V
|
V

L

L

P
|
P

G
|
G

T

M

G

G

L

S

T

Q

R

R

V

L

T

T

D

-

K

-

R

R

K

A

V

I

R

G

H

K

D

A

R

K

A

A

-

M

D

D

I

L

F

I

C

L

T

T

-

G

-

R

V

T

V

M

E

D

G

A

V

A

R

E

G

A

E

E

R

R

A

S

K

G

A

-

W

-

R

-

L

L

V

V

D

S

E

R

V

V

K

P

P

A

N

D

Q

D

F

L

D

L

Q

T

A

E

I

A

Q

R

A

A

R

T

A

A

L

T

E

T

L

I

A

S

E

Q

Q

M

S

S

D

A

R

S

P

A

A

A

D

R

A

M

Q

A

G

K

V

E

V

A

L

V

T

N

R

R

I

A

E

F

R

E

T

S

D

S

R

L

E

S

E

E

G

G

L

L

T
x
L

Y

Y

K

E

-

R

-

L

-

F

-

H

T

S

L

A

D
x
F

V

A

T

T

I

E

D

D

R

Q

A

S

K

E

R

G

I

M

A

A

T

A

F

F

T

I

A

E

K

K

-

R

A

A

P

P

Q

Q

active site: G108 (= G143), E111 (= E146), P130 (= P167), E131 (= E168), V136 (= V174), P138 (= P176), G139 (= G177), L224 (≠ T264), F234 (≠ D269)
binding coenzyme a: Y104 (≠ A139), P130 (= P167), E131 (= E168), L134 (= L172)

Sites not aligning to the query:

active site: 65, 70, 80, 84
binding coenzyme a: 25, 63, 67, 68

1ey3A Structure of enoyl-coa hydratase complexed with the substrate dac-coa (see paper)
29% identity, 42% coverage: 52:284/556 of query aligns to 26:250/258 of 1ey3A

query
sites
1ey3A

L
|
L

N

N

S
x
A

Y

L

D

C

L

N

G

G

V

L

D

I

I

E

E

E

L

L

H

N

D

Q

A

A

V

L

Q

E

R

T

I

F

R

E

F

-

E

E

H

D

P

P

E

A

V

V

K

G

T

A

V

I

V

V

L

L

T

T

S

G

L

-

K

G

D

E

R

K

V

A

F

F

C

A

S
x
A

G
|
G

A
|
A

N
x
D

I
|
I

F

K

M

E

L
x
M

G

Q

L

N

S

R

T

T

H

F

A

-

W

Q

K

D

V

C

N

Y

F
x
S

C

G

K

K

F

F

T
x
L

N

S

E

H

T
x
W

R

-

N

-

G

-

L

-

E

-

D

D

S

H

S

I

R

T

H

R

S

I

G

K

L

K

K

P

F

V

L

I

A

A

V

V

N

N

G

G

A

Y

C

A

A

L

G

G

G
|
G

G

G

Y

C

E
|
E

L

L

A

A

L

M

A

M

C

C

D

D

E

I

I

I

Y

Y

L

A

V

-

D

-

D

G

R

E

S

K

S

A

S

Q

V

F

S

G

L

Q

P
|
P

E
|
E

V

I

P

-

L

L

L
|
L

G

G

V
x
T

L

I

P
|
P

G
|
G

T

A

G

G

L

T

T

Q

R

R

V

L

T

T

D

-

K

-

R

R

K

A

V

V

R

G

H

K

D

S

R

L

A

A

D

M

I

E

F

M

C

V

T

L

V

T

V

G

E

D

G

R

V

I

R

S

G

A

E

Q

R

D

A

A

K

K

A

Q

W

A

R

G

L

L

V

V

D

S

E

K

V

I

V

F

K

P

P

V

N

E

Q

T

F

L

-

V

D

E

Q

E

A

A

I

I

Q

Q

A

C

R

-

A

A

L

E

E

K

L

I

A

A

E

N

Q

N

S

S

D

K

-

I

-

V

-

A

-

M

-

A

R

K

P

E

A

S

D

V

A

N

Q

A

G

A

V

F

V

E

L

M

T

T

R

L

I

T

E

E

R

G

T

N

D
x
K

R

L

E

E

E

K

G

K

L

L

T

F

Y

Y

K

S

T

T

L
x
F

D

-

V

A

T

T

I

D

D

D

R

R

A

R

K

E

R

G

I

M

A

S

T

A

F

F

T

V

A

E

K

K

active site: A66 (= A94), M71 (≠ L99), S81 (≠ F110), L85 (≠ T114), G109 (= G143), E112 (= E146), P131 (= P167), E132 (= E168), T137 (≠ V174), P139 (= P176), G140 (= G177), K225 (≠ D258), F235 (≠ L268)
binding 4-(n,n-dimethylamino)cinnamoyl-coa: L26 (= L52), A28 (≠ S54), A64 (≠ S92), G65 (= G93), A66 (= A94), D67 (≠ N95), I68 (= I96), L85 (≠ T114), W88 (≠ T117), G109 (= G143), P131 (= P167), L135 (= L172), G140 (= G177)

Sites not aligning to the query:

binding 4-(n,n-dimethylamino)cinnamoyl-coa: 24

Q4WF54 Mevalonyl-coenzyme A hydratase sidH; Siderophore biosynthesis protein H; EC 4.2.1.- from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
30% identity, 30% coverage: 74:242/556 of query aligns to 53:207/270 of Q4WF54

query
sites
Q4WF54

H

Q

P

P

E

A

V

L

K

Y

T

V

V

A

V

I

L

I

T

T

S

G

L

T

K

G

D

E

R

S

V

-

F

F

C

C

S

A

G

G

A

A

N

D

I

L

F

-

M

-

L

-

G

-

L

-

S

-

T

-

H

K

A

E

W

W

K

N

-

D

V

L

N

N

F

A

C

R

K

G

F

I

T

T

N

N

E

E

-

M

T

T

R

A

N

P

G

G

L

L

E

A

D

G

S

L

S

P

R

R

H

R

S

R

G

G

L

S

K

K

-

P

F

I

L

I

A

A

V

V

N

N

G

G

A

Y

C

C

A

L

G

G

Y

F

E

E

L

M

A

V

L

A

A

N

C

C

D

D

E

-

I

-

Y

I

L

V

V

V

D

A

D

S

R

E

S

N

S

A

S

T

V

F

S

G

L

L

P

P

E

E

V

V

P

Q

L

-

L

R

G

G

V

I

L

A

P

A

G

V

T

A

G

G

G

S

L

L

T

P

R

R

V

L

T

V

D

-

K

-

R

R

K

V

V

L

R

G

H

K

D

Q

R

R

A

A

D

A

I

E

F

I

C

A

T

L

V

S

V

G

E

L

G

S

V

F

R

S

G

A

E

S

R

Q

A

L

K

E

A

R

W

W

R

G

L

L

V

V

D

N

E

R

V

V

K

E

P

H

N

D

Q

Q

F

-

D

-

Q

-

A

-

I

L

Q

L

A

A

R

T

A

A

L

V

E

E

L

I

A

A

E

T

Q

A

S

I

D

S

R

R

Sites not aligning to the query:

268:270 PTS1-type peroxisomal targeting signal

6tnmA E. Coli aerobic trifunctional enzyme subunit-alpha (see paper)
28% identity, 50% coverage: 33:312/556 of query aligns to 7:267/719 of 6tnmA

query
sites
6tnmA

T

T

L

L

G

Y

I

L

D

D

I

W

A

L

E

E

D

D

G

G

G

I

I

A

R

E

D

L

G

V

Y

F

K

D

L

A

-

P

-

G

K

S

L

V

N

N

S

K

Y

L

D

D

L

T

G

A

V

T

D

V

I

A

E

S

L

L

H

G

D

E

A

A

V

I

Q

G

R

V

I

L

R

E

F

-

E

Q

H

Q

P

S

E

D

V

L

K

K

T

G

V

L

L

L

T

R

S

S

L

N

K

K

D

-

R

A

V

A

F

F

C

I

S

V

G

G

A
|
A

N

D

I

I

-

T

-

E

-
x
F

F

L

M

S

L

L

G

F

L

L

S

V

T

P

H

E

A

E

W

Q

K

L

V

S

N

Q

F

W

C

L

K

H

F

F

T

A

N

N

E

S

T

V

R

F

N

N

G

R

L

L

E

E

D

D

S

L

S

P

R

-

H

-

S

-

G

-

L

V

K

P

F

T

L

I

A

A

V

V

N

N

G

G

A

Y

C

A

A

L

G

G

G
|
G

G

G

Y

C

E
|
E

L

C

A

V

L

L

A

A

C

T

D

D

E

-

I

-

Y

Y

L

R

V

L

D

A

D

T

R

P

S

D

S

L

S

R

V

I

S

G

L

L

P
|
P

E
|
E

V

T

P

K

L

-

L

L

G

G

V

I

L

M

P

P

G
|
G

T

F

G

G

L

S

T

V

R

R

V

M

T

P

D

-

K

-

R

R

K

M

V

L

R

G

H

A

D

D

R

S

A

A

D

L

I

E

F

I

C

I

T

A

V

A

V

G

E

K

G

D

V

V

R

G

G

A

E

D

R

Q

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A

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I

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A

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-

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-

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E

active site: A68 (= A94), F73 (vs. gap), G116 (= G143), E119 (= E146), P138 (= P167), E139 (= E168), G147 (= G177)

Sites not aligning to the query:

active site: 271, 429, 450, 462, 500
binding adenosine-5'-triphosphate: 343, 344, 400, 401, 406, 584

P21177 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Escherichia coli (strain K12) (see 2 papers)
29% identity, 37% coverage: 52:257/556 of query aligns to 28:230/729 of P21177

query
sites
P21177

L

V

N

N

S

K

Y

L

D

D

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G

A

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G

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G116 (= G143) mutation to F: Absence of both enoyl-CoA hydratase and 3-hydroxyacyl-CoA epimerase activities. Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase is only slightly affected.

Sites not aligning to the query:

322 G→A: 10-fold increase in KM for NADH.
450 active site, For 3-hydroxyacyl-CoA dehydrogenase activity; mutation H->A,Q: Almost complete loss of 3-hydroxyacyl-CoA dehydrogenase activity.

8oqrA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-80
33% identity, 19% coverage: 63:169/556 of query aligns to 47:151/728 of 8oqrA

query
sites
8oqrA

L

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A

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A

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F

F

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x
G

G
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G

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N

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x
T

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M

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x
A

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A
x
D

W

A

K

G

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D

N

V

F

F

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F

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T

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G

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binding 4-cyanobenzenesulfonic acid: G76 (≠ S92), G77 (= G93), T81 (≠ F97), M82 (= M98), M82 (= M98), A85 (≠ L101), D89 (≠ A105), T96 (= T114), L123 (≠ A141), G124 (= G142), P149 (= P167), E150 (= E168)

Sites not aligning to the query:

binding 4-cyanobenzenesulfonic acid: 366, 367, 368, 420, 421, 422

8pf8A Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-72
33% identity, 19% coverage: 63:169/556 of query aligns to 47:151/729 of 8pf8A

query
sites
8pf8A

L

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D

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N

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A

A

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A

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binding [2-methyl-5-(trifluoromethyl)pyrazol-3-yl]boronic acid: G76 (≠ S92)
binding bis[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]-bis(oxidanyl)boranuide: T81 (≠ F97), D92 (≠ V108), V93 (≠ N109)
binding [(2~{R})-2,3-bis(oxidanyl)propoxy]-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]borinic acid: G77 (= G93), D78 (≠ A94), M82 (= M98), V93 (≠ N109)

Sites not aligning to the query:

8oquA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-92
33% identity, 19% coverage: 63:169/556 of query aligns to 48:152/730 of 8oquA

query
sites
8oquA

L

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x
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x
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-

F

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G

L

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F

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x
L

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G

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L

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binding 4-chloranylbenzenesulfonic acid: G77 (≠ S92), G78 (= G93), D79 (≠ A94), V80 (≠ N95), D90 (≠ A105), V94 (≠ N109), L124 (≠ A141), G125 (= G142), P150 (= P167), E151 (= E168)

Sites not aligning to the query:

binding 4-chloranylbenzenesulfonic acid: 40, 41, 42

8oqtA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-91
33% identity, 19% coverage: 63:169/556 of query aligns to 47:151/729 of 8oqtA

query
sites
8oqtA

L

M

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A

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x
G

G
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G

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x
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x
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x
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T

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F

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N

G

G

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A

A

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G

Y

L

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E

L

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A

A

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binding 4-bromanylbenzenesulfonic acid: G76 (≠ S92), G77 (= G93), D78 (≠ A94), V79 (≠ N95), M82 (= M98), D89 (≠ A105), V93 (≠ N109), T96 (= T114), T96 (= T114), P149 (= P167), E150 (= E168)

Sites not aligning to the query:

binding 4-bromanylbenzenesulfonic acid: 5, 41

8oqnA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-53
33% identity, 19% coverage: 63:169/556 of query aligns to 47:151/729 of 8oqnA

query
sites
8oqnA

L

M

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A

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S

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G

G

G

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N

V

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M

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V

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F

C

N

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F

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T

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G

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F

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L

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A

A

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I

N

N

G

G

A

A

C

A

A

L

G

G

Y

L

E

E

L

I

A

A

L

L

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C

D

H

E

H

I

R

Y

I

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A

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A

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binding 1-benzyl-1H-pyrazole-4-carboxylic acid: M82 (= M98), E150 (= E168)

Sites not aligning to the query:

binding 1-benzyl-1H-pyrazole-4-carboxylic acid: 39, 172, 175, 176, 181, 241, 254, 257, 261, 262, 266, 268, 282, 283, 302, 303, 304, 521, 525

Query Sequence

>BPHYT_RS13345 FitnessBrowser__BFirm:BPHYT_RS13345
MSTAETAVAPVDYRTEPSQYKHWKLSFNGPVATLGIDIAEDGGIRDGYKLKLNSYDLGVD
IELHDAVQRIRFEHPEVKTVVLTSLKDRVFCSGANIFMLGLSTHAWKVNFCKFTNETRNG
LEDSSRHSGLKFLAAVNGACAGGGYELALACDEIYLVDDRSSSVSLPEVPLLGVLPGTGG
LTRVTDKRKVRHDRADIFCTVVEGVRGERAKAWRLVDEVVKPNQFDQAIQARALELAEQS
DRPADAQGVVLTRIERTDREEGLTYKTLDVTIDRAKRIATFTAKAPQSEPPTNIDEIVAA
GVNWWPLQFARELDDAILCMRTNELAVGTWVFKTEGDARNLLAADASLMQHKDHWFVRET
IGLLRRTLARIDVSSRSLFALIEPGSCFAGTFAELAFAADRTYMAALPSNEEEEPAITLS
EVNFGLYPMVTHQSRLGRRFYEEAEPLDAVRSLIGQPIKPVEAERLGLVTASPDDIDWAD
EIRIALEERAAMSPDALTGLEANLRFNGPETMETRIFGRLTAWQNWIFNRPNAVGEKGAL
KVYGKGSKAQFDVSRV

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory