SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing BPHYT_RS13575 FitnessBrowser__BFirm:BPHYT_RS13575 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 1 hits to proteins with known functional sites (download)

3pvcA Crystal structure of apo mnmc from yersinia pestis (see paper)
26% identity, 48% coverage: 35:242/430 of query aligns to 236:434/635 of 3pvcA

query
sites
3pvcA

D

D

V

I

A

A

I

I

V
x
I

G
|
G

A
x
G

G
|
G

Y
x
I

T
x
V

G

S

L

A

S

L

T

T

A

A

L

L

H

A

L

L

A

Q

E

R

Q

R

G

G

L

A

R

V

V

V

C

T

V

L

I

Y

D

C

A
|
A

N
x
D

-

A

E

Q

P

P

G

A

W

Q

G

G

A
|
A

S
|
S

G

G

R
x
N

N

R

G

Q

G

G

Q
x
A

V

L

I

Y

P

P

G

L

L

L

K

N

Y

G

D

K

P

N

D

D

E

A

L

L

I

-

R

-

R

-

Y

-

G

-

P

-

R

-

D

-

G

-

N

E

A

T

L

F

V

F

Q

T

M

S

A

A

G

F

G

T

A

F

A

A

D

R

T

R

V

Q

F

Y

D

D

L

Q

V

L

A

L

R

E

H

Q

G

G

I

I

R

A

C

F

D

D

A

H

T

Q

R

W

A

C

G

G

W

V

I

S

Q

Q

P

L

T

A

H

F

S

D

H

D

-

K

-

S

-

R

-

G

K

K

L

I

L

E

K

K

T

M

L

L

Y

H

A

T

R

-

A

-

G

-

Q

Q

W

W

E

P

A

V

R

E

G

F

A

A

P

-

V

-

E

E

L

A

L

M

D

S

R

R

A

E

Q

Q

V

L

S

S

K

E

R

L

L

A

G

G

T

L

D

D

A

C

F

A

V

H

G

D

G

G

W

I

V

H

D

Y

R

P

R

A

A

G

G

G

S

W

V

L

Q

C

P

P

L

S

S

D

Y

L

A

T

R

H

G

A

L

L

A

M

R

M

A

L

A

A

Q

Q

A

Q

A

N

G

G

A

M

Q

T

I

C

H

H

G

Y

G

Q

T

H

R
x
E

A
x
L

A

Q

G

R

I

L

E

K

R

R

G

I

A

D

N

S

G

Q

W

W

R

Q

I

L

R

T

T

F

A

G

H

S

G

Q

P

A

V

A

I

K

E

H

S

H

K

A

Q

T

V

V

L

I

L

L

A

A

T
|
T

binding flavin-adenine dinucleotide: I240 (≠ V39), G241 (= G40), G242 (≠ A41), G243 (= G42), I244 (≠ Y43), V245 (≠ T44), A265 (= A64), D266 (≠ N65), A273 (= A71), S274 (= S72), N276 (≠ R74), A280 (≠ Q78), E404 (≠ R212), L405 (≠ A213), T434 (= T242)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 437, 454, 456, 477, 538, 588, 589, 590, 591, 592, 593

Query Sequence

>BPHYT_RS13575 FitnessBrowser__BFirm:BPHYT_RS13575
MVEVEVAKPLPPSLWAATAEPAVVTPPLDNSTVVDVAIVGAGYTGLSTALHLAEQGLRVC
VIDANEPGWGASGRNGGQVIPGLKYDPDELIRRYGPRDGNALVQMAGGAADTVFDLVARH
GIRCDATRAGWIQPTHSHKLLKTLYARAGQWEARGAPVELLDRAQVSKRLGTDAFVGGWV
DRRAGSVQPLSYARGLARAAQAAGAQIHGGTRAAGIERGANGWRIRTAHGPVIESKQVLL
ATNGYTDGLWPRLAQSVIAANSFIVATKPLADDVGATILAGGEVASDSRRLLLYFRKDAD
GRLLMGGRGPFREPRNAADWAHLERAAQLMFPQLRGTEYEFRWAGRIAITRNFLPHVHMP
AKGMTIALGYNGRGIAMATTLGKHLAAYLGGAAKGLPLPPTPIEPVPLHALQRFYISAGV
AWYALLDALS

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory