SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing BPHYT_RS13580 FitnessBrowser__BFirm:BPHYT_RS13580 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

3c4jA Abc protein artp in complex with atp-gamma-s
60% identity, 96% coverage: 1:239/248 of query aligns to 3:241/242 of 3c4jA

query
sites
3c4jA

M

M

I

I

K

D

V

V

D

H

S

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K

K

R

S

F
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F

H

G

D

S

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H

E

V
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V

L

L

K

K

G

G

V

I

S

N

L

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N

H

V

I

E

R

R

E

G

G

Q

E

V

V

V

V

C

V

L

V

I

I

G

G

P

P

S
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S

G
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G

S
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S

G
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G

K
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K

S
|
S

T
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T

L

F

L

L

R

R

C

C

I

L

N

N

G

L

L

L

E

E

R

D

H

F

D

D

A

E

G

G

E

E

I

I

T

I

V

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E

D

G

G

R

I

T

N

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L

D

K

A

A

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K

S

D

K

T

Q

N

I

L

H

N

E

K

L

V

R

R

A

E

Q

E

V

V

G

G

M

M

V

V

F

F

Q

Q

R

R

F

F

N

N

L

L

F

F

P

P

H

H

R

M

T

T

A

V

L

L

E

N

N

N

V

I

F

T

E

L

G

A

P

P

V

M

F

K

V

V

K

R

K

K

Q

W

A

P

R

R

A

E

Q

K

A

A

R

E

E

A

R

K

A

A

R

M

H

E

L

L

L

L

D

D

K

K

V

V

G

G

L

L

A

K

H

D

R

K

M

A

N

H

A

A

H

Y

P

P

A

D

E

S

L

L

S

S

G

G

G

G

Q

Q

Q

A

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

A

A

M

M

E

E

P

P

K

K

A

I

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M

L

L

F

F

D

D

E

E

P

P

T

T

S

S

A

A

L

L

D

D

P

P

E

E

L

M

V

V

G

G

E

E

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V

L

L

G

S

V

V

M

M

R

K

Q

Q

L

L

A

A

D

N

D

E

G

G

M

M

T

T

M

M

I

V

V

V

V

V

T

T

H

H

E

E

M

M

A

G

F

F

A

A

R

R

E

E

V

V

A

G

D

D

R

R

V

V

C

L

F

F

L

M

H

D

D

G

G

G

A

Y

I

I

H

I

E

E

E

E

G

G

S

K

A

P

A

E

E

D

L

L

F

F

D

D

R

R

P

P

R

Q

H

H

A

E

R

R

T

T

R

K

E

A

F

F

L

L

G

S

K

K

M

V

binding phosphothiophosphoric acid-adenylate ester: F13 (= F11), V18 (= V16), S38 (= S36), G39 (= G37), S40 (= S38), G41 (= G39), K42 (= K40), S43 (= S41), T44 (= T42)

3c41J Abc protein artp in complex with amp-pnp/mg2+
60% identity, 96% coverage: 1:239/248 of query aligns to 3:241/242 of 3c41J

query
sites
3c41J

M

M

I

I

K

D

V

V

D

H

S

Q

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L

H

K

K

K

R

S

F
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F

H

G

D

S

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E

V
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V

L

L

K

K

G

G

V

I

S

N

L

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N

H

V

I

E

R

R

E

G

G

Q

E

V

V

V

V

C

V

L

V

I

I

G

G

P

P

S
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S

G
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G

S

S

G
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G

K
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K

S
|
S

T
|
T

L

F

L

L

R

R

C

C

I

L

N

N

G

L

L

L

E

E

R

D

H

F

D

D

A

E

G

G

E

E

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T

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D

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G

R

I

T

N

V

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A

A

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S

D

K

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N

I

L

H

N

E

K

L

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R

R

A

E

Q

E

V

V

G

G

M

M

V

V

F

F

Q

Q

R

R

F

F

N

N

L

L

F

F

P

P

H

H

R

M

T

T

A

V

L

L

E

N

N

N

V

I

F

T

E

L

G

A

P

P

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M

F

K

V

V

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R

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K

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W

A

P

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E

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K

A

A

R

E

E

A

R

K

A

A

R

M

H

E

L

L

L

L

D

D

K

K

V

V

G

G

L

L

A

K

H

D

R

K

M

A

N

H

A

A

H

Y

P

P

A

D

E

S

L

L

S

S

G

G

G

G

Q

Q

Q

A

Q

Q

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R

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V

A

A

I

I

A

A

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R

A

A

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L

A

A

M

M

E

E

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P

K

K

A

I

I

M

L

L

F

F

D
|
D

E

E

P

P

T

T

S

S

A

A

L

L

D

D

P

P

E

E

L

M

V

V

G

G

E

E

V

V

L

L

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S

V

V

M

M

R

K

Q

Q

L

L

A

A

D

N

D

E

G

G

M

M

T

T

M

M

I

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V

V

V

V

T

T

H

H

E

E

M

M

A

G

F

F

A

A

R

R

E

E

V

V

A

G

D

D

R

R

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V

C

L

F

F

L

M

H

D

D

G

G

G

A

Y

I

I

H

I

E

E

E

E

G

G

S

K

A

P

A

E

E

D

L

L

F

F

D

D

R

R

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P

R

Q

H

H

A

E

R

R

T

T

R

K

E

A

F

F

L

L

G

S

K

K

M

V

binding phosphoaminophosphonic acid-adenylate ester: F13 (= F11), V18 (= V16), S38 (= S36), G39 (= G37), G41 (= G39), K42 (= K40), S43 (= S41), T44 (= T42)
binding magnesium ion: S43 (= S41), D163 (= D161)

2olkA Abc protein artp in complex with adp-beta-s
60% identity, 96% coverage: 1:239/248 of query aligns to 3:241/242 of 2olkA

query
sites
2olkA

M

M

I

I

K

D

V

V

D

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S

Q

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L

H

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K

K

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S

F
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F

H

G

D

S

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V

L

L

K

K

G

G

V

I

S

N

L

V

N

H

V

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E

R

R

E

G

G

Q

E

V

V

V

V

C

V

L

V

I

I

G

G

P

P

S
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S

G
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G

S
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S

G
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G

K
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K

S
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S

T
|
T

L

F

L

L

R

R

C

C

I

L

N

N

G

L

L

L

E

E

R

D

H

F

D

D

A

E

G

G

E

E

I

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T

I

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E

D

G

G

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T

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D

K

A

A

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K

S

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K

T

Q

N

I

L

H

N

E

K

L

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R

R

A

E

Q

E

V

V

G

G

M

M

V

V

F

F

Q

Q

R

R

F

F

N

N

L

L

F

F

P

P

H

H

R

M

T

T

A

V

L

L

E

N

N

N

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A

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P

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M

F

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A

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K

A

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E

A

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A

A

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M

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E

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L

L

D

D

K

K

V

V

G

G

L

L

A

K

H

D

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K

M

A

N

H

A

A

H

Y

P

P

A

D

E

S

L

L

S

S

G

G

G

G

Q

Q

Q

A

Q

Q

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R

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V

A

A

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A

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R

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L

A

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M

M

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P

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K

A

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L

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F

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D

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E

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T

S

S

A

A

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L

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D

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P

E

E

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M

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V

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G

E

E

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M

M

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K

Q

Q

L

L

A

A

D

N

D

E

G

G

M

M

T

T

M

M

I

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T

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H

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M

M

A

G

F

F

A

A

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E

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A

G

D

D

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C

L

F

F

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M

H

D

D

G

G

G

A

Y

I

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H

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E

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E

E

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K

A

P

A

E

E

D

L

L

F

F

D

D

R

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P

R

Q

H

H

A

E

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T

T

R

K

E

A

F

F

L

L

G

S

K

K

M

V

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (= F11), V18 (= V16), S38 (= S36), G39 (= G37), S40 (= S38), G41 (= G39), K42 (= K40), S43 (= S41), T44 (= T42)

2oljA Abc protein artp in complex with adp/mg2+
60% identity, 96% coverage: 1:239/248 of query aligns to 3:241/242 of 2oljA

query
sites
2oljA

M

M

I

I

K

D

V

V

D

H

S

Q

I

L

H

K

K

K

R

S

F
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F

H

G

D

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Q

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H

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V
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V

L

L

K

K

G

G

V

I

S

N

L

V

N

H

V

I

E

R

R

E

G

G

Q

E

V

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C

V

L

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I

G

G

P

P

S
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S

G
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G

S
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S

G
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G

K
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K

S
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S

T
|
T

L

F

L

L

R

R

C

C

I

L

N

N

G

L

L

L

E

E

R

D

H

F

D

D

A

E

G

G

E

E

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T

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E

D

G

G

R

I

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N

V

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K

A

A

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K

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D

K

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N

I

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N

E

K

L

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R

R

A

E

Q

E

V

V

G

G

M

M

V

V

F

F

Q

Q

R

R

F

F

N

N

L

L

F

F

P

P

H

H

R

M

T

T

A

V

L

L

E

N

N

N

V

I

F

T

E

L

G

A

P

P

V

M

F

K

V

V

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R

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K

Q

W

A

P

R

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A

E

Q

K

A

A

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E

E

A

R

K

A

A

R

M

H

E

L

L

L

L

D

D

K

K

V

V

G

G

L

L

A

K

H

D

R

K

M

A

N

H

A

A

H

Y

P

P

A

D

E

S

L

L

S

S

G

G

G

G

Q

Q

Q

A

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

A

A

M

M

E

E

P

P

K

K

A

I

I

M

L

L

F

F

D

D

E

E

P

P

T

T

S

S

A

A

L

L

D

D

P

P

E

E

L

M

V

V

G

G

E

E

V

V

L

L

G

S

V

V

M

M

R

K

Q

Q

L

L

A

A

D

N

D

E

G

G

M

M

T

T

M

M

I

V

V

V

V

V

T

T

H

H

E

E

M

M

A

G

F

F

A

A

R

R

E

E

V

V

A

G

D

D

R

R

V

V

C

L

F

F

L

M

H

D

D

G

G

G

A

Y

I

I

H

I

E

E

E

E

G

G

S

K

A

P

A

E

E

D

L

L

F

F

D

D

R

R

P

P

R

Q

H

H

A

E

R

R

T

T

R

K

E

A

F

F

L

L

G

S

K

K

M

V

binding adenosine-5'-diphosphate: F13 (= F11), V18 (= V16), S38 (= S36), G39 (= G37), S40 (= S38), G41 (= G39), K42 (= K40), S43 (= S41), T44 (= T42)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
59% identity, 96% coverage: 1:239/248 of query aligns to 1:239/240 of 4ymuJ

query
sites
4ymuJ

M

M

I

I

K

F

V

V

D

N

S

D

I

V

H

Y

K

K

R

N

F
|
F

H

G

D

S

Q

L

H

E

V
|
V

L

L

K

K

G

G

V

V

S

T

L

L

N

K

V

V

E

N

R

K

G

G

Q

E

V

V

V

V

C

V

L

I

I

I

G

G

P

P

S
|
S

G
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G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

L

R

R

C

C

I

I

N

N

G

L

L

L

E

E

R

E

H

P

D

T

A

K

G

G

E

E

I

V

T

F

V

I

E

D

G

G

R

V

T

K

V

I

D

N

A

N

K

G

S

K

K

V

Q

N

I

I

H

N

E

K

L

V

R

R

A

Q

Q

K

V

V

G

G

M

M

V

V

F

F

Q

Q

R

H

F

F

N

N

L

L

F

F

P

P

H

H

R

L

T

T

A

A

L

I

E

E

N

N

V

I

F

T

E

L

G

A

P

P

V

V

F

K

V

V

K

K

K

K

Q

M

A

N

R

K

A

K

Q

E

A

A

R

E

E

E

R

L

A

A

R

V

H

D

L

L

L

L

D

A

K

K

V

V

G

G

L

L

A

L

H

D

R

K

M

K

N

D

A

Q

H

Y

P

P

A

I

E

K

L

L

S

S

G

G

G

G

Q

Q

Q

K

Q

Q

R

R

V

L

A

A

I

I

A

A

R

R

A

A

L

L

A

A

M

M

E

Q

P

P

K

E

A

V

I

M

L

L

F

F

D

D

E
|
E

P

P

T

T

S

S

A

A

L

L

D

D

P

P

E

E

L

M

V

V

G

K

E

E

V

V

L

L

G

N

V

V

M

M

R

K

Q

Q

L

L

A

A

D

N

D

E

G

G

M

M

T

T

M

M

I

V

V

V

V

V

T

T

H
|
H

E

E

M

M

A

G

F

F

A

A

R

R

E

E

V

V

A

G

D

D

R

R

V

V

C

I

F

F

L

M

H

D

D

D

G

G

A

V

I

I

H

V

E

E

E

E

G

G

S

T

A

P

A

E

E

E

L

I

F

F

D

Y

R

R

P

A

R

K

H

N

A

E

R

R

T

T

R

R

E

E

F

F

L

L

G

S

K

K

M

I

binding adenosine-5'-triphosphate: F11 (= F11), V16 (= V16), S36 (= S36), G37 (= G37), S38 (= S38), G39 (= G39), K40 (= K40), S41 (= S41), T42 (= T42), E162 (= E162), H194 (= H194)
binding magnesium ion: S41 (= S41), E162 (= E162)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
58% identity, 96% coverage: 1:239/248 of query aligns to 2:239/241 of 4u00A

query
sites
4u00A

M

I

I

I

K

R

V

I

D

R

S

N

I

L

H

H

K

K

R

W

F
|
F

H

G

D

P

Q

L

H

H

V
|
V

L

L

K

K

G

G

V

I

S

H

L

L

N

E

V

V

E

A

R

P

G

G

Q

E

V

K

V

L

C

V

L

I

I

I

G

G

P

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

I

R

R

C

T

I

I

N

N

G

R

L

L

E

E

R

D

H

F

D

Q

A

E

G

G

E

E

I

V

T

V

V

V

E

D

G

G

R

L

T

S

V

V

D

-

A

K

K

D

S

D

K

R

Q

A

I

L

H

R

E

E

L

I

R

R

A

R

Q

E

V

V

G

G

M

M

V

V

F

F

Q

Q

R

Q

F

F

N

N

L

L

F

F

P

P

H

H

R

M

T

T

A

V

L

L

E

E

N

N

V

V

F

T

E

L

G

A

P

P

V

M

F

R

V

V

K

R

K

R

Q

W

A

P

R

R

A

E

Q

K

A

A

R

E

E

K

R

K

A

A

R

L

H

E

L

L

L

L

D

E

K

R

V

V

G

G

L

I

A

L

H

D

R

Q

M

A

N

R

A

K

H

Y

P

P

A

A

E

Q

L

L

S

S

G

G

G

G

Q

Q

Q

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

A

A

M

M

E

E

P

P

K

K

A

I

I

M

L

L

F

F

D

D

E

E

P

P

T

T

S

S

A

A

L

L

D

D

P

P

E

E

L

M

V

V

G

G

E

E

V

V

L

L

G

D

V

V

M

M

R

R

Q

D

L

L

A

A

D

Q

D

G

G

G

M

M

T

T

M

M

I

V

V

V

V

V

T

T

H

H

E

E

M

M

A

G

F

F

A

A

R

R

E

E

V

V

A

A

D

D

R

R

V

V

C

V

F

F

L

M

H

D

D

G

G

G

A

Q

I

I

H

V

E

E

E

E

G

G

S

R

A

P

A

E

E

E

L

I

F

F

D

T

R

R

P

P

R

K

H

E

A

E

R

R

T

T

R

R

E

S

F

F

L

L

G

Q

K

R

M

V

binding adenosine-5'-diphosphate: F12 (= F11), V17 (= V16), S37 (= S36), G38 (= G37), S39 (= S38), G40 (= G39), K41 (= K40), S42 (= S41), T43 (= T42)

P02915 Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP; EC 7.4.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
53% identity, 95% coverage: 2:236/248 of query aligns to 7:253/258 of P02915

query
sites
P02915

I

L

K

H

V

V

D

I

S

D

I

L

H

H

K

K

R

R

F

Y

H

G

D

G

Q

H

H

E

V

V

L

L

K

K

G

G

V

V

S

S

L

L

N

Q

V

A

E

R

R

A

G

G

Q

D

V

V

V

I

C

S

L

I

I

I

G

G

P

S

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

L

L

R

R

C

C

I

I

N

N

G

F

L

L

E

E

R

K

H

P

D

S

A

E

G

G

E

A

I

I

T

I

V

V

E

N

G

G

R

Q

T

N

V

I

D

N

-

L

-

V

-

R

-

D

-

K

-

D

-

G

-

Q

-

L

-

K

-

V

A

A

K

D

S

K

K

N

Q

Q

I

L

H

R

E

L

L

L

R

R

A

T

Q

R

V

L

G

T

M

M

V

V

F

F

Q

Q

R

H

F

F

N

N

L

L

F

W

P

S

H

H

R

M

T

T

A

V

L

L

E

E

N

N

V

V

F

M

E

E

G

A

P

P

V

I

F

Q

V

V

K

L

K

G

Q

L

A

S

R

K

A

H

Q

D

A

A

R

R

E

E

R

R

A

A

R

L

H

K

L

Y

L

L

D

A

K

K

V

V

G

G

L

I

A

D

H

E

R

R

M

A

N

Q

A

G

-

K

H

Y

P

P

A

V

E

H

L

L

S

S

G

G

G

G

Q

Q

Q

Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

L

L

A

A

M

M

E

E

P

P

K

D

A

V

I

L

L

L

F

F

D

D

E

E

P

P

T

T

S

S

A

A

L

L

D

D

P

P

E

E

L

L

V

V

G

G

E

E

V

V

L

L

G

R

V

I

M

M

R

Q

Q

Q

L

L

A

A

D

E

D

E

G

G

M

K

T

T

M

M

I

V

V

V

V

V

T

T

H

H

E

E

M

M

A

G

F

F

A

A

R

R

E

H

V

V

A

S

D

S

R

H

V

V

C

I

F

F

L

L

H

H

D

Q

G

G

A

K

I

I

H

E

E

E

E

E

G

G

S

D

A

P

A

E

E

Q

L

V

F

F

D

G

R

N

P

P

R

Q

H

S

A

P

R

R

T

L

R

Q

E

Q

F

F

L

L

S41 (= S36) binding ATP
G42 (= G37) binding ATP
G44 (= G39) binding ATP
K45 (= K40) binding ATP
S46 (= S41) binding ATP
T47 (= T42) binding ATP

1b0uA Atp-binding subunit of the histidine permease from salmonella typhimurium (see paper)
53% identity, 95% coverage: 2:236/248 of query aligns to 3:249/258 of 1b0uA

query
sites
1b0uA

I

L

K

H

V

V

D

I

S

D

I

L

H

H

K

K

R

R

F
x
Y

H

G

D

G

Q
x
H

H

E

V

V

L

L

K

K

G

G

V

V

S

S

L

L

N

Q

V

A

E

R

R

A

G

G

Q

D

V

V

V

I

C

S

L

I

I

I

G

G

P

S

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

L

L

R

R

C

C

I

I

N

N

G

F

L

L

E

E

R

K

H

P

D

S

A

E

G

G

E

A

I

I

T

I

V

V

E

N

G

G

R

Q

T

N

V

I

D

N

-

L

-

V

-

R

-

D

-

K

-

D

-

G

-

Q

-

L

-

K

-

V

A

A

K

D

S

K

K

N

Q

Q

I

L

H

R

E

L

L

L

R

R

A

T

Q

R

V

L

G

T

M

M

V

V

F

F

Q

Q

R

H

F

F

N

N

L

L

F

W

P

S

H

H

R

M

T

T

A

V

L

L

E

E

N

N

V

V

F

M

E

E

G

A

P

P

V

I

F

Q

V

V

K

L

K

G

Q

L

A

S

R

K

A

H

Q

D

A

A

R

R

E

E

R

R

A

A

R

L

H

K

L

Y

L

L

D

A

K

K

V

V

G

G

L

I

A

D

H

E

R

R

M

A

N

Q

A

G

-

K

H

Y

P

P

A

V

E

H

L

L

S

S

G

G

G

G

Q

Q

Q

Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

L

L

A

A

M

M

E

E

P

P

K

D

A

V

I

L

L

L

F

F

D

D

E

E

P

P

T

T

S

S

A

A

L

L

D

D

P

P

E

E

L

L

V

V

G

G

E

E

V

V

L

L

G

R

V

I

M

M

R

Q

Q

Q

L

L

A

A

D

E

D

E

G

G

M

K

T

T

M

M

I

V

V

V

V

V

T

T

H

H

E

E

M

M

A

G

F

F

A

A

R

R

E

H

V

V

A

S

D

S

R

H

V

V

C

I

F

F

L

L

H

H

D

Q

G

G

A

K

I

I

H

E

E

E

E

E

G

G

S

D

A

P

A

E

E

Q

L

V

F

F

D

G

R

N

P

P

R

Q

H

S

A

P

R

R

T

L

R

Q

E

Q

F

F

L

L

binding adenosine-5'-triphosphate: Y12 (≠ F11), H15 (≠ Q14), S37 (= S36), G38 (= G37), G40 (= G39), K41 (= K40), S42 (= S41), T43 (= T42)

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
39% identity, 95% coverage: 1:236/248 of query aligns to 1:241/343 of P30750

query
sites
P30750

M

M

I

I

K

K

V

L

D

S

S

N

I

I

H

T

K

K

R

V

F

F

H

H

D

Q

Q

G

-

T

-

R

-

T

-

I

H

Q

V

A

L

L

K

N

G

N

V

V

S

S

L

L

N

H

V

V

E

P

R

A

G

G

Q

Q

V

I

V

Y

C

G

L

V

I

I

G

G

P

A

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

I

R

R

C

C

I

V

N

N

G

L

L

L

E

E

R

R

H

P

D

T

A

E

G

G

E

S

I

V

T

L

V

V

E

D

G

G

R

Q

T

E

V

L

D

T

A

T

K

L

S

S

K

E

-

S

Q

E

I

L

H

T

E

K

L

A

R

R

A

R

Q

Q

V

I

G

G

M

M

V

I

F

F

Q

Q

R

H

F

F

N

N

L

L

F

L

P

S

H

S

R

R

T

T

A

V

L

F

E

G

N

N

V

V

F

-

E

A

G

L

P

P

V

L

F

E

V

L

K

D

K

N

Q

T

A

P

R

K

A

D

Q

E

A

V

R

K

E

R

R

R

A

V

R

T

H

E

L

L

L

L

D

S

K

L

V

V

G

G

L

L

A

G

H

D

R

K

M

H

N

D

A

S

H

Y

P

P

A

S

E

N

L

L

S

S

G

G

G

G

Q

Q

Q

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

A

A

M

S

E

N

P

P

K

K

A

V

I

L

L

L

F

C

D

D

E
|
E

P

A

T

T

S

S

A

A

L

L

D

D

P

P

E

A

L

T

V

T

G

R

E

S

V

I

L

L

G

E

V

L

M

L

R

K

Q

D

L

I

A

N

D

R

D

R

-

L

G

G

M

L

T

T

M

I

I

L

V

L

V

I

T

T

H

H

E

E

M

M

A

D

F

V

A

V

R

K

E

R

V

I

A

C

D

D

R

C

V

V

C

A

F

V

L

I

H

S

D

N

G

G

A

E

I

L

H

I

E

E

E

Q

G

D

S

T

A

V

A

S

E

E

L

V

F

F

D

S

R

H

P

P

R

K

H

T

A

P

R

L

T

A

R

Q

E

K

F

F

L

I

40:46 (vs. 36:42, 86% identical) binding ATP
E166 (= E162) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding L-methionine
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding L-methionine

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
39% identity, 95% coverage: 1:236/248 of query aligns to 2:242/344 of 6cvlD

query
sites
6cvlD

M

M

I

I

K

K

V

L

D

S

S

N

I

I

H

T

K

K

R

V

F
|
F

H

H

D
x
Q

Q

G

-

T

-

R

-

T

-
x
I

H

Q

V

A

L

L

K

N

G

N

V

V

S

S

L

L

N

H

V

V

E

P

R

A

G

G

Q

Q

V

I

V

Y

C

G

L

V

I

I

G

G

P

A

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

I

R

R

C

C

I

V

N

N

G

L

L

L

E

E

R

R

H

P

D

T

A

E

G

G

E

S

I

V

T

L

V

V

E

D

G

G

R

Q

T

E

V

L

D

T

A

T

K

L

S

S

K

E

-

S

Q

E

I

L

H

T

E

K

L

A

R

R

A

R

Q

Q

V

I

G

G

M

M

V

I

F

F

Q

Q

R

H

F

F

N

N

L

L

F

L

P

S

H

S

R

R

T

T

A

V

L

F

E

G

N

N

V

V

F

-

E

A

G

L

P

P

V

L

F

E

V

L

K

D

K

N

Q

T

A

P

R

K

A

D

Q

E

A

V

R

K

E

R

R

R

A

V

R

T

H

E

L

L

L

L

D

S

K

L

V

V

G

G

L

L

A

G

H

D

R

K

M

H

N

D

A

S

H

Y

P

P

A

S

E
x
N

L

L

S
|
S

G

G

G

G

Q
|
Q

Q

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

A

A

M

S

E

N

P

P

K

K

A

V

I

L

L

L

F

C

D

D

E

Q

P

A

T

T

S

S

A

A

L

L

D

D

P

P

E

A

L

T

V

T

G

R

E

S

V

I

L

L

G

E

V

L

M

L

R

K

Q

D

L

I

A

N

D

R

D

R

-

L

G

G

M

L

T

T

M

I

I

L

V

L

V

I

T

T

H
|
H

E

E

M

M

A

D

F

V

A

V

R

K

E

R

V

I

A

C

D

D

R

C

V

V

C

A

F

V

L

I

H

S

D

N

G

G

A

E

I

L

H

I

E

E

E

Q

G

D

S

T

A

V

A

S

E

E

L

V

F

F

D

S

R

H

P

P

R

K

H

T

A

P

R

L

T

A

R

Q

E

K

F

F

L

I

binding phosphothiophosphoric acid-adenylate ester: F12 (= F11), Q14 (≠ D13), I19 (vs. gap), S41 (= S36), G42 (= G37), A43 (≠ S38), G44 (= G39), K45 (= K40), S46 (= S41), T47 (= T42), N141 (≠ E136), S143 (= S138), Q146 (= Q141), H200 (= H194)

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
39% identity, 95% coverage: 1:236/248 of query aligns to 2:242/344 of 3tuzC

query
sites
3tuzC

M

M

I

I

K

K

V

L

D

S

S

N

I

I

H

T

K

K

R

V

F
|
F

H

H

D
x
Q

Q

G

-

T

-

R

-

T

-

I

H

Q

V

A

L

L

K

N

G

N

V

V

S

S

L

L

N

H

V

V

E

P

R

A

G

G

Q

Q

V

I

V

Y

C

G

L

V

I

I

G

G

P

A

S

S

G
|
G

S

A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

I

R

R

C

C

I

V

N

N

G

L

L

L

E

E

R

R

H

P

D

T

A

E

G

G

E

S

I

V

T

L

V

V

E

D

G

G

R

Q

T

E

V

L

D

T

A

T

K

L

S

S

K

E

-

S

Q

E

I

L

H

T

E

K

L

A

R

R

A

R

Q

Q

V

I

G

G

M

M

V

I

F

F

Q

Q

R

H

F

F

N

N

L

L

F

L

P

S

H

S

R

R

T

T

A

V

L

F

E

G

N

N

V

V

F

-

E

A

G

L

P

P

V

L

F

E

V

L

K

D

K

N

Q

T

A

P

R

K

A

D

Q

E

A

V

R

K

E

R

R

R

A

V

R

T

H

E

L

L

L

L

D

S

K

L

V

V

G

G

L

L

A

G

H

D

R

K

M

H

N

D

A

S

H

Y

P

P

A

S

E

N

L

L

S

S

G

G

G

G

Q

Q

Q

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

A

A

M

S

E

N

P

P

K

K

A

V

I

L

L

L

F

C

D

D

E

Q

P

A

T

T

S

S

A

A

L

L

D

D

P

P

E

A

L

T

V

T

G

R

E

S

V

I

L

L

G

E

V

L

M

L

R

K

Q

D

L

I

A

N

D

R

D

R

-

L

G

G

M

L

T

T

M

I

I

L

V

L

V

I

T

T

H

H

E

E

M

M

A

D

F

V

A

V

R

K

E

R

V

I

A

C

D

D

R

C

V

V

C

A

F

V

L

I

H

S

D

N

G

G

A

E

I

L

H

I

E

E

E

Q

G

D

S

T

A

V

A

S

E

E

L

V

F

F

D

S

R

H

P

P

R

K

H

T

A

P

R

L

T

A

R

Q

E

K

F

F

L

I

binding adenosine-5'-diphosphate: F12 (= F11), Q14 (≠ D13), G42 (= G37), G44 (= G39), K45 (= K40), S46 (= S41), T47 (= T42)

Sites not aligning to the query:

binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
39% identity, 95% coverage: 1:236/248 of query aligns to 2:242/344 of 3tuiC

query
sites
3tuiC

M

M

I

I

K

K

V

L

D

S

S

N

I

I

H

T

K

K

R

V

F
|
F

H

H

D

Q

Q

G

-

T

-

R

-

T

-

I

H

Q

V

A

L

L

K

N

G

N

V

V

S

S

L

L

N

H

V

V

E

P

R

A

G

G

Q

Q

V

I

V

Y

C

G

L

V

I

I

G

G

P

A

S

S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

I

R

R

C

C

I

V

N

N

G

L

L

L

E

E

R

R

H

P

D

T

A

E

G

G

E

S

I

V

T

L

V

V

E

D

G

G

R

Q

T

E

V

L

D

T

A

T

K

L

S

S

K

E

-

S

Q

E

I

L

H

T

E

K

L

A

R

R

A

R

Q

Q

V

I

G

G

M

M

V

I

F

F

Q

Q

R

H

F

F

N

N

L

L

F

L

P

S

H

S

R

R

T

T

A

V

L

F

E

G

N

N

V

V

F

-

E

A

G

L

P

P

V

L

F

E

V

L

K

D

K

N

Q

T

A

P

R

K

A

D

Q

E

A

V

R

K

E

R

R

R

A

V

R

T

H

E

L

L

L

L

D

S

K

L

V

V

G

G

L

L

A

G

H

D

R

K

M

H

N

D

A

S

H

Y

P

P

A

S

E

N

L

L

S

S

G

G

G

G

Q

Q

Q

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

A

A

M

S

E

N

P

P

K

K

A

V

I

L

L

L

F

C

D

D

E

Q

P

A

T

T

S

S

A

A

L

L

D

D

P

P

E

A

L

T

V

T

G

R

E

S

V

I

L

L

G

E

V

L

M

L

R

K

Q

D

L

I

A

N

D

R

D

R

-

L

G

G

M

L

T

T

M

I

I

L

V

L

V

I

T

T

H

H

E

E

M

M

A

D

F

V

A

V

R

K

E

R

V

I

A

C

D

D

R

C

V

V

C

A

F

V

L

I

H

S

D

N

G

G

A

E

I

L

H

I

E

E

E

Q

G

D

S

T

A

V

A

S

E

E

L

V

F

F

D

S

R

H

P

P

R

K

H

T

A

P

R

L

T

A

R

Q

E

K

F

F

L

I

binding adenosine-5'-diphosphate: F12 (= F11), G42 (= G37), A43 (≠ S38), G44 (= G39), K45 (= K40), S46 (= S41), T47 (= T42)

1f3oA Crystal structure of mj0796 atp-binding cassette (see paper)
40% identity, 88% coverage: 1:217/248 of query aligns to 1:226/232 of 1f3oA

query
sites
1f3oA

M

M

I

I

K

K

V

L

D

K

S

N

I

V

H

T

K

K

R

T

F
x
Y

H

K

D

M

Q

G

-

E

-

E

-

I

-

I

H

Y

V

A

L

L

K

K

G

N

V

V

S

N

L

L

N

N

V

I

E

K

R

E

G

G

Q

E

V

F

V

V

C

S

L

I

I

M

G

G

P

P

S

S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

M

L

L

R

N

C

I

I

I

N

G

G

C

L

L

E

D

R

K

H

P

D

T

A

E

G

G

E

E

I

V

T

Y

V

I

E

D

G

N

-

I

R

K

T

T

V

N

D

D

A

L

K

D

S

D

K

D

Q

E

I

L

H

T

E

K

L

I

R

R

-

R

A

D

Q

K

V

I

G

G

M

F

V

V

F

F

Q

Q

R

Q

F

F

N

N

L

L

F

I

P

P

H

L

R

L

T

T

A

A

L

L

E

E

N

N

V

V

F

-

E

E

G

L

P

P

V

L

F

I

V

F

K

K

K

Y

Q

R

A

G

R

A

A

M

Q

S

A

G

R

E

E

E

R

R

A

R

R

K

H

R

L

A

L

L

D

E

K

C

V

L

G

K

L

M

A

A

H

E

R

L

-

E

-

E

-

R

-

F

M

A

N

N

A

H

H

K

P

P

A

N

E

Q

L

L

S

S

G

G

G

G

Q

Q

Q

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

A

A

M

N

E

N

P

P

K

P

A

I

I

I

L

L

F

A

D

D

E

E

P

P

T

T

S

G

A

A

L

L

D

D

P

S

E

K

L

T

V

G

G

E

E

K

V

I

L

M

G

Q

V

L

M

L

R

K

Q

K

L

L

-

N

A

E

D

E

D

D

G

G

M

K

T

T

M

V

I

V

V

V

V

V

T

T

H

H

E

D

M

I

A

N

F

V

A

A

R

R

E

-

V

F

A

G

D

E

R

R

V

I

C

I

F

Y

L

L

H

K

D

D

G

G

A

E

I

V

H

E

E

R

E

E

binding adenosine-5'-diphosphate: Y11 (≠ F11), G41 (= G37), G43 (= G39), K44 (= K40), S45 (= S41), T46 (= T42)

5lilA Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
41% identity, 86% coverage: 1:214/248 of query aligns to 3:220/615 of 5lilA

query
sites
5lilA

M

I

I

I

K

E

V

I

D

K

S

Q

I

L

H

N

K

R

R

Y

F
|
F

H

G

D

E

Q

G

-

E

-

N

-

R

-

V

H

H

V
|
V

L

L

K

K

G

D

V

I

S

S

L

L

N

S

V

I

E

E

R

R

G

G

Q

D

V

F

V

V

C

A

L

I

I

M

G

G

P

Q

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

M

R

N

C

I

I

I

N

G

G

C

L

L

E

D

R

T

H

A

D

T

A

G

G

G

E

S

I

S

T

K

V

I

E

D

G

G

R

K

-

E

T

T

V

I

D

E

A

L

K

T

S

N

K

D

Q

Q

I

L

H

S

E

D

L

L

R

R

A

S

Q

Q

-

K

V

F

G

G

M

F

V

I

F

F

Q
|
Q

R

R

F

Y

N

N

L

L

F

L

P

S

H

S

R

L

T

T

A

A

L

A

E

E

N

N

V

V

F

-

E

A

G

L

P

P

V

A

F

I

V

Y

K

A

K

G

Q

M

A

P

R

Q

A

S

Q

Q

A

R

R

L

E

E

R

R

A

A

R

K

H

Q

L

L

L

L

D

E

K

K

V

L

G

G

L

L

A

G

H

D

R
x
K

M

W

N

Q

A

N

H

K

P

P

A

N

E
x
Q

L

L

S
|
S

G

G

G
|
G

Q
|
Q

Q

Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

L

L

A

M

M

N

E

G

P

G

K

E

A

I

I

I

L

L

F

A

D

D

E

Q

P

P

T

T

S

G

A

A

L

L

D

D

P

S

E

H

L

S

V

G

G

E

E

N

V

V

L

M

G

E

V

I

M

L

R

R

Q

Q

L

L

A

H

D

E

D

E

G

G

M

H

T

T

M

I

I

I

V

M

V

V

T

T

H

H

E

D

M

K

A

H

F

I

A

A

R

A

E

S

V

-

A

A

D

N

R

R

V

I

C

I

F

E

L

I

H

K

D

D

G

G

A

E

I

I

binding adenosine-5'-triphosphate: F13 (= F11), V22 (= V16), S42 (= S36), G43 (= G37), G45 (= G39), K46 (= K40), S47 (= S41), T48 (= T42), Q92 (= Q84), K136 (≠ R129), Q143 (≠ E136), S145 (= S138), G147 (= G140), Q148 (= Q141)
binding magnesium ion: S47 (= S41), Q92 (= Q84)

5lj7A Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
41% identity, 86% coverage: 1:214/248 of query aligns to 3:220/592 of 5lj7A

query
sites
5lj7A

M

I

I

I

K

E

V

I

D

K

S

Q

I

L

H

N

K

R

R

Y

F

F

H

G

D

E

Q

G

-

E

-

N

-

R

-

V

H

H

V
|
V

L

L

K

K

G

D

V

I

S

S

L

L

N

S

V

I

E

E

R

R

G

G

Q

D

V

F

V

V

C

A

L

I

I

M

G

G

P

Q

S
|
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

L

M

R

N

C

I

I

I

N

G

G

C

L

L

E

D

R

T

H

A

D

T

A

G

G

G

E

S

I

S

T

K

V

I

E

D

G

G

R

K

-

E

T

T

V

I

D

E

A

L

K

T

S

N

K

D

Q

Q

I

L

H

S

E

D

L

L

R

R

A

S

Q

Q

-

K

V

F

G

G

M

F

V

I

F

F

Q
|
Q

R

R

F

Y

N

N

L

L

F

L

P

S

H

S

R

L

T

T

A

A

L

A

E

E

N

N

V

V

F

-

E

A

G

L

P

P

V

A

F

I

V

Y

K

A

K

G

Q

M

A

P

R

Q

A

S

Q

Q

A

R

R

L

E

E

R

R

A

A

R

K

H

Q

L

L

L

L

D

E

K

K

V

L

G

G

L

L

A

G

H

D

R
x
K

M

W

N

Q

A

N

H

K

P

P

A

N

E
x
Q

L

L

S
|
S

G

G

G
|
G

Q
|
Q

Q

Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

L

L

A

M

M

N

E

G

P

G

K

E

A

I

I

I

L

L

F

A

D

D

E

Q

P

P

T

T

S

G

A

A

L

L

D

D

P

S

E

H

L

S

V

G

G

E

E

N

V

V

L

M

G

E

V

I

M

L

R

R

Q

Q

L

L

A

H

D

E

D

E

G

G

M

H

T

T

M

I

I

I

V

M

V

V

T

T

H

H

E

D

M

K

A

H

F

I

A

A

R

A

E

S

V

-

A

A

D

N

R

R

V

I

C

I

F

E

L

I

H

K

D

D

G

G

A

E

I

I

binding adenosine-5'-triphosphate: V22 (= V16), S42 (= S36), G43 (= G37), G45 (= G39), K46 (= K40), S47 (= S41), T48 (= T42), Q92 (= Q84), K136 (≠ R129), Q143 (≠ E136), S145 (= S138), G147 (= G140), Q148 (= Q141)
binding magnesium ion: S47 (= S41), Q92 (= Q84)

1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette (see paper)
40% identity, 88% coverage: 1:217/248 of query aligns to 1:226/230 of 1l2tA

query
sites
1l2tA

M

M

I

I

K

K

V

L

D

K

S

N

I

V

H

T

K

K

R

T

F
x
Y

H

K

D

M

Q

G

-

E

-

E

-

I

-

I

H

Y

V

A

L

L

K

K

G

N

V

V

S

N

L

L

N

N

V

I

E

K

R

E

G

G

Q

E

V

F

V

V

C

S

L

I

I

M

G

G

P

P

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

L

M

L

L

R

N

C

I

I

I

N

G

G

C

L

L

E

D

R

K

H

P

D

T

A

E

G

G

E

E

I

V

T

Y

V

I

E

D

G

N

-

I

R

K

T

T

V

N

D

D

A

L

K

D

S

D

K

D

Q

E

I

L

H

T

E

K

L

I

R

R

-

R

A

D

Q

K

V

I

G

G

M

F

V

V

F

F

Q

Q

R

Q

F

F

N

N

L

L

F

I

P

P

H

L

R

L

T

T

A

A

L

L

E

E

N

N

V

V

F

-

E

E

G

L

P

P

V

L

F

I

V

F

K

K

K

Y

Q

R

A

G

R

A

A

M

Q

S

A

G

R

E

E

E

R

R

A

R

R

K

H

R

L

A

L

L

D

E

K

C

V

L

G

K

L

M

A

A

H

E

R

L

-

E

-

E

-

R

-
x
F

M

A

N

N

A

H

H

K

P

P

A

N

E
x
Q

L

L

S
|
S

G

G

G
|
G

Q
|
Q

Q

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

A

A

M

N

E

N

P

P

K

P

A

I

I

I

L

L

F

A

D

D

E

Q

P

P

T

T

S

G

A

A

L

L

D

D

P

S

E

K

L

T

V

G

G

E

E

K

V

I

L

M

G

Q

V

L

M

L

R

K

Q

K

L

L

-

N

A

E

D

E

D

D

G

G

M

K

T

T

M

V

I

V

V

V

V

V

T

T

H
|
H

E

D

M

I

A

N

F

V

A

A

R

R

E

-

V

F

A

G

D

E

R

R

V

I

C

I

F

Y

L

L

H

K

D

D

G

G

A

E

I

V

H

E

E

R

E

E

binding adenosine-5'-triphosphate: Y11 (≠ F11), S40 (= S36), G41 (= G37), S42 (= S38), G43 (= G39), K44 (= K40), S45 (= S41), T46 (= T42), F138 (vs. gap), Q145 (≠ E136), S147 (= S138), G149 (= G140), Q150 (= Q141), H204 (= H194)

P0AAH0 Phosphate import ATP-binding protein PstB; ABC phosphate transporter; Phosphate-transporting ATPase; EC 7.3.2.1 from Escherichia coli (strain K12) (see paper)
36% identity, 95% coverage: 2:236/248 of query aligns to 11:252/257 of P0AAH0

query
sites
P0AAH0

I

I

K

Q

V

V

D

R

S

N

I

L

H

N

K

F

R

Y

F

Y

H

G

D

K

Q

F

H

H

V

A

L

L

K

K

G

N

V

I

S

N

L

L

N

D

V

I

E

A

R

K

G

N

Q

Q

V

V

V

T

C

A

L

F

I

I

G

G

P

P

S

S

G

G

S

C

G
|
G

K
|
K

S

S

T

T

L

L

L

L

R

R

C

T

I

F

N

N

G

K

L

M

-

F

-

E

-

L

-

Y

-

P

E

E

R

Q

H

R

D

A

A

E

G

G

E

E

I

I

T

L

V

L

E

D

G

G

R

D

T

N

V

I

D

L

A

T

K

N

S

S

K

Q

Q

D

I

I

H

A

E

L

L

L

R

R

A

A

Q

K

V

V

G

G

M

M

V

V

F

F

Q

Q

R

K

F

P

N

T

L

P

F

F

P

P

H

M

R

-

T

S

A

I

L

Y

E

D

N

N

V

I

F

A

E

F

G

G

P

V

V

R

F

L

V

F

K

E

K

K

Q

L

A

S

R

R

A

A

Q

D

A

M

R

D

E

E

R

R

A

V

R

Q

H

W

L

A

L

L

D

T

K

K

V

A

G

A

L

L

A

W

H

N

-

E

-

T

-

K

-

D

R

K

M

L

N

H

A

Q

H

S

P

G

A

Y

E

S

L

L

S

S

G

G

G

G

Q

Q

Q

Q

Q

Q

R

R

V

L

A

C

I

I

A

A

R

R

A

G

L

I

A

A

M

I

E

R

P

P

K

E

A

V

I

L

L

L

F

L

D

D

E

E

P

P

T

C

S

S

A

A

L

L

D

D

P

P

E

I

L

S

V

T

G

G

E

R

V

I

L

E

G

E

V

L

M

I

R

T

Q

E

L

L

A

K

D

Q

D

D

G

-

M

Y

T

T

M

V

I

V

V

I

V

V

T

T

H

H

E

N

M

M

A

Q

F

Q

A

A

R

A

E

R

V

C

A

S

D

D

R

H

V

T

C

A

F

F

L

M

H

Y

D

L

G

G

A

E

I

L

H

I

E

E

E

F

G

S

S

N

A

T

A

D

E

D

L

L

F

F

D

T

R

K

P

P

R

A

H

K

A

K

R

Q

T

T

R

E

E

D

F

Y

L

I

G48 (= G39) mutation to I: Loss of phosphate transport.
K49 (= K40) mutation to Q: Loss of phosphate transport.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

2pclA Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
40% identity, 86% coverage: 1:214/248 of query aligns to 3:216/223 of 2pclA

query
sites
2pclA

M

I

I

L

K

R

V

A

D

E

S

N

I

I

H

K

K

K

R

V

F

I

H

R

D

G

Q

Y

H

E

V

I

L

L

K

K

G

G

V

I

S

S

L

L

N

S

V

V

E

K

R

K

G

G

Q

E

V

F

V

V

C

S

L

I

I

I

G

G

P

A

S

S

G

G

S

S

G

G

K

K

S

S

T

T

L

L

L

L

R

Y

C

I

I

L

N

G

G

L

L

L

E

D

R

A

H

P

D

T

A

E

G

G

E

K

I

V

T

F

V

L

E

E

G

G

R

K

T

E

V

V

D

D

-

Y

A

T

K

N

S

E

K

K

Q

E

I

L

H

S

E

L

L

L

R

R

A

N

-

R

Q

K

V

L

G

G

M

F

V

V

F

F

Q

Q

R

F

F

H

N

Y

L

L

F

I

P

P

H

E

R

L

T

T

A

A

L

L

E

E

N

N

V

V

F

I

E

V

G

-

P

P

V

M

F

L

V

K

K

M

K

G

Q

K

A

P

R

K

A

K

Q

E

A

A

R

K

E

E

R

R

A

G

R

E

H

Y

L

L

L

L

D

S

K

E

V

L

G

G

L

L

A

G

H

D

R

K

M

L

N

S

A

R

H

K

P

P

A

Y

E

E

L

L

S

S

G

G

G

G

Q

E

Q

Q

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

A

A

M

N

E

E

P

P

K

I

A

L

I

L

L

F

F

A

D

D

E
|
E

P
|
P

T
|
T

S

G

A

N

L

L

D

D

P

S

E

A

L

N

V

T

G

K

E

R

V

V

L

M

G

D

V

I

M

F

R

L

Q

K

L

I

A

N

D

E

D

G

G

G

M

T

T

S

M

I

I

V

V

M

V

V

T
|
T

H

H

E

E

M

R

A

E

F

L

A

A

R

-

E

E

V

L

A

T

D

H

R

R

V

T

C

L

F

E

L

M

H

K

D

D

G

G

A

K

I

V

binding magnesium ion: E165 (= E162), P166 (= P163), T167 (= T164), T196 (= T193)

2d62A Crystal structure of multiple sugar binding transport atp-binding protein
36% identity, 96% coverage: 2:240/248 of query aligns to 7:247/375 of 2d62A

query
sites
2d62A

I

V

K

K

V

L

D

I

S

N

I

I

H

W

K

K

R

R

F

F

H

G

D

D

Q

V

H

T

V

A

L

V

K

K

G

D

V

L

S

S

L

L

N

E

V

I

E

K

R

D

G

G

Q

E

V

F

V

L

C

V

L

L

I

L

G

G

P

P

S

S

G
|
G

S
x
C

G
|
G

K
|
K

S
x
T

T
|
T

L

T

L

L

R

R

C

M

I

I

N

A

G

G

L

L

E

E

R

E

H

P

D

T

A

R

G

G

E

Q

I

I

T

Y

V

I

E

E

G

D

R

N

T

L

V

V

D

A

A

D

K

P

S

E

K

K

Q

G

I

V

H

F

-

V

-

P

E

P

L

K

R

E

A

R

Q

D

V

V

G

A

M

M

V

V

F

F

Q

Q

R

S

F

Y

N

A

L

L

F

Y

P

P

H

H

R

M

T

T

A

V

L

Y

E

D

N

N

V

I

F

-

E

A

G

F

P

P

V

L

F

K

V

L

K

R

K

K

Q

V

A

P

R

K

A

Q

Q

E

A

I

R

D

E

K

R

R

A

V

R

R

H

E

L

V

L

A

D

E

K

M

V

L

G

G

L

L

A

T

H

E

R

L

M

L

N

N

A

R

H

K

P

P

A

R

E

E

L

L

S

S

G

G

G

G

Q

Q

Q

R

Q

Q

R

R

V

V

A

A

I

L

A

G

R

R

A

A

L

I

A

I

M

R

E

R

P

P

K

K

A

V

I

F

L

L

F

M

D

D

E

E

P

P

T

L

S

S

A

N

L

L

D

D

P

A

E

K

L

L

-

R

-

V

-

K

-

M

V

R

G

A

E

E

V

L

L

K

G

K

V

L

M

Q

R

R

Q

Q

L

L

A

-

D

-

D

-

G

G

M

V

T

T

M

T

I

I

V

Y

V

V

T

T

H

H

E

D

M

Q

A

V

F

E