SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing BPHYT_RS14915 FitnessBrowser__BFirm:BPHYT_RS14915 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1bjoA The structure of phosphoserine aminotransferase from e. Coli in complex with alpha-methyl-l-glutamate (see paper)
54% identity, 99% coverage: 2:358/360 of query aligns to 1:358/360 of 1bjoA

query
sites
1bjoA

R

Q

V

I

F

F

N

N

F

F

S

S

A
x
S

G

G

P

P

A

A

A

M

M

L

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P

E

A

E

E

V

V

L

L

R

K

Q

Q

A

A

A

Q

D

Q

E

E

M

L

L

R

D

D

W

W

Q

N

G

G

S

L

G

G

M

T

S

S

V

V

M

M

E

E

M

V

S

S

H

H

R

R

G

G

K

K

E

E

F

F

M

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Q

I

V

H

A

E

E

E

E

A

A

L

E

V

K

D

D

L

F

R

R

D

D

L

L

L

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E

N

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P

A

S

S

N

H

Y

R

K

I

V

L

L

F

F

L

C

Q

H

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G

G

G

G
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G

L
x
R

G

G

E

Q

N

F

A

A

I

A

V

V

P

P

M

L

N

N

L

I

M

L

G

G

A

D

K

K

P

T

R

T

A

A

D

D

F

Y

V

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T

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A

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K

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S

A

F

I

K

K

E

E

A

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K

K

Y

Y

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C

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H

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A

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R

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E

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W

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Q

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D

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H

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G

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D

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L

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G

-

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D

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L

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Y

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A

G

G

A

A

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Q

K
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K

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N

I

I

G

G

M

P

A

A

G

G

V

L

T

T

V

I

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I

I

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V

R

R

E

E

D

D

M

L

L

L

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G

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A

A

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N

S

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I

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C

C

P

P

S

S

A

I

F

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E

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Y

K

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T

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L

A

N

E

D

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M

Y

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N

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P

P

P

T

T

Y

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A

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Y

Y

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A

S

G

G

L

L

V

V

F

F

K

K

W

W

L

L

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K

K

A

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N

G

G

G

G

L

V

A

A

A

E

M

M

E

D

A

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R

I

N

N

V

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E

Q

K

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S

A

K

E

L

L

L

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Y

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G

A

V

V

I

D

D

T

N

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D

F

F

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Y

L

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N

K

D

V

V

E

A

R

K

G

R

S

N

R

R

S

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R

R

M

M

N

N

V

V

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P

F

F

F

Q

L

L

A

A

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D

E

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S

A

R

L

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E

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G

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R

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Y

N

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A

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E

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K

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R

active site: W100 (= W101), D172 (= D172), K196 (= K196)
binding alpha-methyl-l-glutamic acid: S7 (≠ A8), W100 (= W101), T151 (= T152), K196 (= K196)
binding pyridoxal-5'-phosphate: G74 (= G75), R75 (≠ L76), W100 (= W101), T151 (= T152), D172 (= D172), S174 (= S174), Q195 (= Q195), K196 (= K196)

3qboB Crystal structure of phosphoserine aminotransferase from yersinia pestis co92
55% identity, 99% coverage: 2:358/360 of query aligns to 1:357/359 of 3qboB

query
sites
3qboB

R

Q

V

V

F

Y

N

N

F

F

S

S

A

A

G

G

P

P

A

A

A

M

M

L

P

P

E

V

E

E

V

V

L

L

R

R

Q

R

A

A

A

Q

D

Q

E

E

M

L

L

R

D

D

W

W

Q

H

G

G

S

L

G

G

M

T

S

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V

V

M

M

E

E

M

V

S

S

H

H

R

R

G

S

K

K

E

E

F

F

M

M

S

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I

V

H

A

E

E

E

E

A

S

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E

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K

D

D

L

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R

D

D

L

L

L

L

E

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V

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A

A

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V

L

L

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F

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C

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G

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G
x
A

L
x
R

G

A

E

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N

F

A

A

I

A

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V

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P

M

L

N

N

L

L

M

L

G

G

A

D

K

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E

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W

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A

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Y

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V

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H

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Y

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G

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A

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G

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D

N

I

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D

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S

S

S

H

S

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M

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D

I

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A

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R

Y

Y

G

G

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V

L

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Y

G

A

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G

A

A

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Q

K
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K

N

N

I

I

G

G

M

P

A

A

G

G

V

L

T

T

V

L

V

V

I

I

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V

R

R

E

E

D

D

M

L

L

L

D

G

R

K

A

A

Q

H

S

T

I

A

C

L

P

P

S

S

A

I

F

L

E

D

W

Y

K

K

T

I

V

L

A

A

E

D

N

N

N

D

S

S

M

M

Y

F

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N

T
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P

P

P

P

T

T

Y

F

A

A

I

W

Y

Y

I

L

A

S

G

G

L

L

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V

F

F

K

K

W

W

L

L

K

K

K

E

Q

Q

G

G

G

G

L

L

A

G

A

E

M

M

E

E

A

K

R

R

N

N

V

Q

E

A

K

K

S

A

K

E

L

L

L

L

Y

Y

D

G

A

A

V

I

D

D

T

R

S

T

S

G

F

F

Y

Y

L

R

N

N

K

D

V

V

E

A

R

I

G

T

S

N

R

R

S

S

R

W

M

M

N

N

V

V

P

P

F

F

F

Q

L

M

A

A

D

D

E

A

S

S

R

L

N

D

E

K

D

L

F

F

L

L

A

S

G

E

A

A

K

E

A

A

R

Q

G

G

M

L

V

Q

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A

L

L

K

K

G

G

H

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S

V

V

A

G

G

G

G

M

M

R

R

A

A

S

S

I

I

Y

Y

N

N

A

A

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M

P

P

L

I

E

E

G

G

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V

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A

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E

D

Y

F

M

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K

A

E

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E

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R

R

R

binding pyridoxal-5'-phosphate: G73 (= G74), A74 (≠ G75), R75 (≠ L76), W100 (= W101), T151 (= T152), D171 (= D172), S173 (= S174), K195 (= K196), N236 (= N237), T237 (= T238)

6xdkD Crystal structure of phosphoserine aminotransferase (serc) from stenotrophomonas maltophilia k279a
52% identity, 99% coverage: 2:358/360 of query aligns to 1:357/359 of 6xdkD

query
sites
6xdkD

R

R

V

A

F

F

N

N

F

F

S

S

A

A

G

G

P

P

A

A

A

T

M

L

P

P

E

E

E

S

V

V

L

L

R

R

Q

Q

A

A

A

Q

D

A

E

E

M

M

L

L

D

D

W

W

Q

H

G

G

S

S

G

G

M

A

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S

V

I

M

V

E

E

M

M

S

S

H

H

R

R

G

G

K

A

E

E

F

F

M

M

S

S

I

V

H

A

E

A

E

E

A

A

L

E

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A

D

D

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L

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R

D

R

L

L

L

L

E

D

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I

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P

A

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S

D

H

Y

R

A

I

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L

L

F

F

L

L

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S

G

G

G

G

G

A

L

T

G

T

E

Q

N

Q

A

A

I

L

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I

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P

M

L

N

N

L

F

M

A

G

A

A

P

K

G

P

Q

R

R

A

A

D

D

F

Y

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V

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S

G

G

S

H

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W

S

G

Q

K

K

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A

F

V

K

K

E

Q

A

A

Q

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K

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Y

Y

G

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D

V

V

H

N

L

I

A

A

A

A

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S

G

S

Q

E

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-

A

A

E

N

G

G

F

Y

T

R

R

E

A

L

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P

A

A

R

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S

A

E

D

W

W

Q

Q

L

L

S

S

D

R

D

D

P

A

A

A

Y

Y

V

V

H

H

L

I

C

T

T

A

N

N

E

E

T

T

I

I

H

H

G

G

V

V

E

E

T

F

F

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E

D

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D

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T

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G

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N

I

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D

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K

R

Y

Y

G

G

V

V

L

I

F

Y

G

A

G

G

A

A

Q

Q

K

K

N

N

I

L

G

G

M

P

A

V

G

G

V

V

T

A

V

V

V

M

I

I

V

I

R

R

E

R

D

D

M

L

L

L

D

E

R

R

A

S

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S

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A

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D

W

Y

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R

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H

A

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A

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R

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D

S

S

M

M

Y

L

N
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N

T
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T

P

P

P

P

T

T

Y

W

A

N

I

W

Y

Y

I

L

A

A

G

G

L

L

V

V

F

F

K

K

W

W

L

M

K

L

K

A

Q

E

G

G

G

G

L

V

A

T

A

E

M

F

E

A

A

K

R

R

N

N

V

A

E

A

K

K

S

A

K

A

L

L

L

V

Y

Y

D

G

A

A

V

I

D

D

T

G

S

S

-

G

S

G

F

F

Y

Y

L

R

N

N

K

E

V

V

E

A

R

Y

G

A

S

A

R

R

S

S

R

R

M

M

N

N

V

I

P

P

F

F

F

F

L

L

A

P

D

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E

A

S

E

R

L

N

D

E

A

D

R

F

F

L

V

A

A

G

E

A

A

K

K

A

A

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A

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G

M

L

V

L

Q

A

L

L

K

K

G

G

H

H

K

K

S

V

V

V

G

G

G

G

M

I

R

R

A

A

S

S

I

L

Y

Y

N

N

A

A

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M

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P

L

L

E

A

G

G

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A

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E

A

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E

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M

M

K

A

E

D

F

F

E

Q

Q

Q

R

R

binding pyridoxal-5'-phosphate: N235 (= N237), T236 (= T238)

7t7jB Crystal structure of phosphoserine aminotransferase from klebsiella pneumoniae subsp. Pneumoniae in complex with pyridoxal phosphate
52% identity, 99% coverage: 2:358/360 of query aligns to 1:358/360 of 7t7jB

query
sites
7t7jB

R

Q

V

V

F

Y

N

N

F

F

S

S

A

S

G

G

P

P

A

A

A

M

M

L

P

P

E

A

E

E

V

V

L

L

R

K

Q

L

A

A

A

Q

D

Q

E

E

M

L

L

C

D

D

W

W

Q

H

G

G

S

L

G

G

M

T

S

S

V

V

M

M

E

E

M

I

S

S

H

H

R

R

G

G

K

K

E

E

F

F

M

I

S

Q

I

V

H

A

E

E

E

E

A

A

L

E

V

Q

D

D

L

F

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R

D

A

L

L

L

L

E

N

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I

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P

A

S

S

N

H

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R

K

I

V

L

L

F

F

L

C

Q

H

G

G

G
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G

G
|
G

L
x
R

G

G

E

Q

N

F

A

A

I

G

V

I

P

P

M

L

N

N

L

I

M

L

G

G

A

D

K

K

P

K

R

V

A

A

D

D

F

Y

V

V

V

D

T

A

G

G

S

Y

W
|
W

S

A

Q

A

K

S

S

A

F

V

K

K

E

E

A

A

Q

K

K

K

Y

Y

G

C

T

T

V

P

H

N

L

V

A

I

A

D

S

A

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K

Q

I

T

T

A

V

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D

G

G

F

K

T

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R

A

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K

A

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M

S

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E

E

W

W

Q

Q

L

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D

P

D

G

P

A

A

A

Y

Y

V

L

H

H

L

Y

C

C

T

P

N

N

E

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T

I

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D

G

G

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A

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D

E

E

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P

D

N

L

F

G

G

D

D

-

D

I

V

P

I

L

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V

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A

A

D
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D

A

F

S
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S

S

S

H

T

I

I

L

L

S

S

R

R

P

E

M

I

D

D

I

V

A

N

K

R

Y

F

G

G

V

V

L

I

F

Y

G

A

G

G

A

A

Q
|
Q

K
|
K

N

N

I

I

G

G

M

P

A

A

G

G

V

L

T

T

V

L

V

V

I

I

V

V

R

R

E

E

D

D

M

L

L

L

D

G

R

K

A

A

Q

S

S

V

I

A

C

C

P

P

S

S

A

I

F

L

E

D

W

Y

K

T

T

V

V

L

A

S

E

E

N

N

N

D

S

S

M

M

Y

F

N
|
N

T
|
T

P

P

P

P

T

T

Y

F

A

A

I

W

Y

Y

I

L

A

A

G

G

L

L

V

V

F

F

K

K

W

W

L

L

K

K

K

Q

Q

Q

G

G

G

G

L

V

A

A

A

A

M

M

E

D

A

K

R

I

N

N

V

Q

E

Q

K

K

S

A

K

E

L

L

L

L

Y

Y

D

G

A

V

V

I

D

D

T

N

S

S

S

G

F

F

Y

Y

L

R

N

N

K

D

V

V

E

A

R

Q

G

A

S

N

R

R

S

S

R

R

M

M

N

N

V

V

P

P

F

F

F

Q

L

L

A

A

D

D

E

S

S

A

R

L

N

D

E

K

D

L

F

F

L

L

A

E

G

E

A

S

K

F

A

A

R

A

G

G

M

L

V

H

Q

A

L

L

K

K

G

G

H

H

K

R

S

V

V

V

G

G

G

G

M

M

R

R

A

A

S

S

I

I

Y

Y

N

N

A

A

V

M

P

P

L

L

E

D

G

G

V

V

K

K

A

T

L

L

V

T

E

D

Y

F

M

M

K

L

E

D

F

F

E

E

Q

R

R

R

binding pyridoxal-5'-phosphate: G73 (= G74), G74 (= G75), R75 (≠ L76), W100 (= W101), T151 (= T152), D172 (= D172), S174 (= S174), Q195 (= Q195), K196 (= K196), N237 (= N237), T238 (= T238)

6xdkB Crystal structure of phosphoserine aminotransferase (serc) from stenotrophomonas maltophilia k279a
52% identity, 99% coverage: 2:358/360 of query aligns to 1:353/355 of 6xdkB

query
sites
6xdkB

R

R

V

A

F

F

N

N

F

F

S

S

A

A

G

G

P

P

A

A

A

T

M

L

P

P

E

E

E

S

V

V

L

L

R

R

Q

Q

A

A

A

Q

D

A

E

E

M

M

L

L

D

D

W

W

Q

H

G

G

S

S

G

G

M

A

S

S

V

I

M

V

E

E

M

M

S

S

H

H

R

R

G

G

K

A

E

E

F

F

M

M

S

S

I

V

H

A

E

A

E

E

A

A

L

E

V

A

D

D

L

L

R

R

D

R

L

L

L

L

E

D

V

I

P

P

A

D

S

D

H

Y

R

A

I

V

L

L

F

F

L

L

Q

S

G

G

G

G

G
x
A

L
x
T

G

T

E

Q

N

Q

A

A

I

L

V

I

P

P

M

L

N

N

L

F

M

A

G

A

A

P

K

G

P

Q

R

R

A

A

D

D

F

Y

V

V

V

V

T

S

G

G

S

H

W
|
W

S

G

Q

K

K

T

S

A

F

V

K

K

E

Q

A

A

Q
x
G

K

V

Y

Y

G
x
V

T
x
D

V

V

H

N

L

I

A

A

A

A

S

S

G

S

Q

E

T

-

A

A

E

N

G

G

F

Y

T

R

R

E

A

L

P

P

A

A

R

R

S

A

E

D

W

W

Q

Q

L

L

S

S

D

R

D

D

P

A

A

A

Y

Y

V

V

H

H

L

I

C

T

T

A

N

N

E

E

T
|
T

I

I

H

H

G

G

V

V

E

E

T

F

F

R

E

D

I

V

P

P

D

D

L

T

G

G

D

N

I

V

P

P

L

L

V

I

A

A

D
|
D

A

F

S
|
S

S

S

H

S

I

I

L

A

S

S

R

E

P

P

M

L

D

D

I

V

A

R

K

R

Y

Y

G

G

V

V

L

I

F

Y

G

A

G

G

A

A

Q

Q

K
|
K

N

N

I

L

G

G

M

P

A

V

G

G

V

V

T

A

V

V

V

M

I

I

V

I

R

R

E

R

D

D

M

L

L

L

D

E

R

R

A

S

Q

G

S

Q

I

P

C

R

P

A

S

D

A

I

F

F

E

D

W

Y

K

R

T

S

V

-

A

-

E

-

N

-

N

H

S

V

M

A

Y

R

N

N

T

T

P

P

P

P

T

T

Y

W

A

N

I

W

Y

Y

I

L

A

A

G

G

L

L

V

V

F

F

K

K

W

W

L

M

K

L

K

A

Q

E

G

G

G

G

L

V

A

T

A

E

M

F

E

A

A

K

R

R

N

N

V

A

E

A

K

K

S

A

K

A

L

L

L

V

Y

Y

D

G

A

A

V

I

D

D

T

G

S

S

-

G

S

G

F

F

Y

Y

L

R

N

N

K

E

V

V

E

A

R

Y

G

A

S

A

R

R

S

S

R

R

M

M

N

N

V

I

P

P

F

F

F

F

L

L

A

P

D

D

E

A

S

E

R

L

N

D

E

A

D

R

F

F

L

V

A

A

G

E

A

A

K

K

A

A

R

A

G

G

M

L

V

L

Q

A

L

L

K

K

G

G

H

H

K

K

S

V

V

V

G

G

G

G

M

I

R

R

A

A

S

S

I

L

Y

Y

N

N

A

A

V

M

P

P

L

L

E

A

G

G

V

A

K

E

A

A

L

L

V

V

E

A

Y

F

M

M

K

A

E

D

F

F

E

Q

Q

Q

R

R

binding calcium ion: G109 (≠ Q110), V112 (≠ G113), D113 (≠ T114)
binding pyridoxal-5'-phosphate: A74 (≠ G75), T75 (≠ L76), W100 (= W101), T150 (= T152), D170 (= D172), S172 (= S174), K194 (= K196)

Q96255 Phosphoserine aminotransferase 1, chloroplastic; AtPSAT1; Phosphohydroxythreonine aminotransferase; EC 2.6.1.52 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
51% identity, 100% coverage: 2:360/360 of query aligns to 72:430/430 of Q96255

query
sites
Q96255

R

R

V

V

F

F

N

N

F

F

S

A

A

A

G

G

P

P

A

A

A

T

M

L

P

P

E

E

E

N

V

V

L

L

R

L

Q

K

A

A

A

Q

D

A

E

D

M

L

L

Y

D

N

W

W

Q

R

G

G

S

S

G

G

M

M

S

S

V

V

M

M

E

E

M

M

S

S

H

H

R

R

G

G

K

K

E

E

F

F

M

L

S

S

I

I

H

I

E

Q

E

K

A

A

L

E

V

S

D

D

L

L

R

R

D

Q

L

L

L

L

E

E

V

I

P

P

A

Q

S

E

H

Y

R

S

I

V

L

L

F

F

L

L

Q

Q

G

G

G

G

G
x
A

L
x
T

G

T

E

Q

N

F

A

A

I

A

V

L

P

P

M

L

N

N

L

L

M

C

G

K

A

S

K

D

P

D

R

T

A

V

D

D

F

F

V

V

V

V

T

T

G

G

S

S

W
|
W

S

G

Q

D

K

K

S

A

F

V

K

K

E

E

A

A

Q

K

K

K

Y

Y

G

C

T

K

V

T

H

N

L

V

A

I

A

W

S

S

G

G

Q

K

T

S

A

-

E

E

G

K

F

Y

T

T

R

K

A

V

P

P

A

S

R

F

S

E

E

E

W

L

Q

E

L

Q

S

T

D

P

D

D

P

A

A

K

Y

Y

V

L

H

H

L

I

C

C

T

A

N

N

E

E

T
|
T

I

I

H

H

G

G

V

V

E

E

T

F

F

K

E

D

I

Y

P

P

D

V

L

P

G

K

D

N

I

G

P

F

L

L

V

V

A

A

D
|
D

A

M

S

S

S

S

H

N

I

F

L

C

S

S

R

K

P

P

M

V

D

D

I

V

A

S

K

K

Y

F

G

G

V

V

L

I

F

Y

G

G

G

G

A

A

Q
|
Q

K
|
K

N

N

I

V

G

G

M

P

A

S

G

G

V

V

T

T

V

I

V

V

I

I

V

I

R

R

E

K

D

D

M

L

L

I

D

G

R

N

A

A

Q

Q

S

D

I

I

C

T

P

P

S

V

A

M

F

L

E

D

W

Y

K

K

T

I

V

H

A

D

E

E

N

N

N

S

S

S

M

L

Y

Y

N
|
N

T
|
T

P

P

P

P

T

C

Y

F

A

G

I

I

Y

Y

I

M

A

C

G

G

L

L

V

V

F

F

K

E

W

D

L

L

K

L

K

E

Q

Q

G

G

G

G

L

L

A

K

A

E

M

V

E

E

A

K

R

K

N

N

V

Q

E

R

K

K

S

A

K

D

L

L

L

L

Y

Y

D

N

A

A

V

I

D

E

T

E

S

S

S

N

-

G

F

F

Y

F

L

R

N

C

K

P

V

V

E

E

R

K

G

S

S

V

R

R

S

S

R

L

M

M

N

N

V

V

P

P

F

F

F

T

L

L

A

E

D

K

E

S

S

E

R

L

N

E

E

A

D

E

F

F

L

I

A

K

G

E

A

A

K

A

A

K

R

E

G

K

M

M

V

V

Q

Q

L

L

K

K

G

G

H

H

K

R

S

S

V

V

G

G

G

G

M

M

R

R

A

A

S

S

I

I

Y

Y

N

N

A

A

V

M

P

P

L

L

E

A

G

G

V

V

K

E

A

K

L

L

V

V

E

A

Y

F

M

M

K

K

E

D

F

F

E

Q

Q

A

R

K

S

H

A

A

AT 145:146 (≠ GL 75:76) binding pyridoxal 5'-phosphate
W171 (= W101) binding pyridoxal 5'-phosphate
T221 (= T152) binding pyridoxal 5'-phosphate
D241 (= D172) binding pyridoxal 5'-phosphate
Q264 (= Q195) binding pyridoxal 5'-phosphate
K265 (= K196) modified: N6-(pyridoxal phosphate)lysine
NT 306:307 (= NT 237:238) binding pyridoxal 5'-phosphate

6czzA Crystal structure of arabidopsis thaliana phosphoserine aminotransferase isoform 1 (atpsat1) in complex with plp- phosphoserine geminal diamine intermediate (see paper)
51% identity, 100% coverage: 2:360/360 of query aligns to 2:360/360 of 6czzA

query
sites
6czzA

R

R

V

V

F

F

N

N

F

F

S

A

A

A

G

G

P

P

A

A

A

T

M

L

P

P

E

E

E

N

V

V

L

L

R

L

Q

K

A

A

A

Q

D

A

E

D

M

L

L

Y

D

N

W

W

Q

R

G

G

S

S

G

G

M

M

S

S

V

V

M

M

E

E

M

M

S

S

H

H

R

R

G

G

K

K

E

E

F

F

M

L

S

S

I

I

H

I

E

Q

E

K

A

A

L

E

V

S

D

D

L

L

R

R

D

Q

L

L

L

L

E

E

V

I

P

P

A

Q

S

E

H

Y

R

S

I

V

L

L

F

F

L

L

Q

Q

G

G

G
|
G

G
x
A

L
x
T

G

T

E

Q

N

F

A

A

I

A

V

L

P

P

M

L

N

N

L

L

M

C

G

K

A

S

K

D

P

D

R

T

A

V

D

D

F

F

V

V

V

V

T

T

G

G

S

S

W
|
W

S

G

Q

D

K

K

S

A

F

V

K

K

E

E

A

A

Q

K

K

K

Y

Y

G

C

T

K

V

T

H

N

L

V

A

I

A

W

S

S

G

G

Q

K

T

S

A

-

E

E

G

K

F

Y

T

T

R

K

A

V

P

P

A

S

R

F

S

E

E

E

W

L

Q

E

L

Q

S

T

D

P

D

D

P

A

A

K

Y

Y

V

L

H

H

L

I

C

C

T

A

N

N

E

E

T
|
T

I

I

H

H

G

G

V

V

E

E

T

F

F

K

E

D

I

Y

P

P

D

V

L

P

G

K

D

N

I

G

P

F

L

L

V

V

A

A

D
|
D

A

M

S
|
S

S

S

H

N

I

F

L

C

S

S

R

K

P

P

M

V

D

D

I

V

A

S

K

K

Y

F

G

G

V

V

L

I

F

Y

G

G

G

G

A

A

Q
|
Q

K
|
K

N

N

I

V

G

G

M

P

A

S

G

G

V

V

T

T

V

I

V

V

I

I

V

I

R

R

E

K

D

D

M

L

L

I

D

G

R

N

A

A

Q

Q

S

D

I

I

C

T

P

P

S

V

A

M

F

L

E

D

W

Y

K

K

T

I

V

H

A

D

E

E

N

N

N

S

S

S

M

L

Y

Y

N
|
N

T
|
T

P

P

P

P

T

C

Y

F

A

G

I

I

Y

Y

I

M

A

C

G

G

L

L

V

V

F

F

K

E

W

D

L

L

K

L

K

E

Q

Q

G

G

G

G

L

L

A

K

A

E

M

V

E

E

A

K

R

K

N

N

V

Q

E

R

K

K

S

A

K

D

L

L

L

L

Y

Y

D

N

A

A

V

I

D

E

T

E

S

S

S

N

-

G

F

F

Y

F

L

R

N

C

K

P

V

V

E

E

R

K

G

S

S

V

R

R

S

S

R

L

M

M

N

N

V

V

P

P

F

F

F

T

L

L

A

E

D

K

E

S

S

E

R

L

N

E

E

A

D

E

F

F

L

I

A

K

G

E

A

A

K

A

A

K

R

E

G

K

M

M

V

V

Q

Q

L

L

K

K

G

G

H
|
H

K
x
R

S

S

V

V

G

G

G

G

M

M

R
|
R

A

A

S

S

I

I

Y

Y

N

N

A

A

V

M

P

P

L

L

E

A

G

G

V

V

K

E

A

K

L

L

V

V

E

A

Y

F

M

M

K

K

E

D

F

F

E

Q

Q

A

R

K

S

H

A

A

binding pyridoxal-5'-phosphate: G74 (= G74), A75 (≠ G75), T76 (≠ L76), W101 (= W101), T151 (= T152), D171 (= D172), S173 (= S174), Q194 (= Q195), K195 (= K196), N236 (= N237), T237 (= T238)
binding phosphoserine: W101 (= W101), T151 (= T152), K195 (= K196), H326 (= H326), R327 (≠ K327), R333 (= R333)

6czyA Crystal structure of arabidopsis thaliana phosphoserine aminotransferase isoform 1 (atpsat1) in complex with pyridoxamine-5'- phosphate (pmp) (see paper)
51% identity, 100% coverage: 2:360/360 of query aligns to 4:362/362 of 6czyA

query
sites
6czyA

R

R

V

V

F

F

N

N

F

F

S

A

A

A

G

G

P

P

A

A

A

T

M

L

P

P

E

E

E

N

V

V

L

L

R

L

Q

K

A

A

A

Q

D

A

E

D

M

L

L

Y

D

N

W

W

Q

R

G

G

S

S

G

G

M

M

S

S

V

V

M

M

E

E

M

M

S

S

H

H

R

R

G

G

K

K

E

E

F

F

M

L

S

S

I

I

H

I

E

Q

E

K

A

A

L

E

V

S

D

D

L

L

R

R

D

Q

L

L

L

L

E

E

V

I

P

P

A

Q

S

E

H

Y

R

S

I

V

L

L

F

F

L

L

Q

Q

G

G

G
|
G

G
x
A

L
x
T

G

T

E

Q

N

F

A

A

I

A

V

L

P

P

M

L

N

N

L

L

M

C

G

K

A

S

K

D

P

D

R

T

A

V

D

D

F

F

V

V

V

V

T

T

G

G

S

S

W
|
W

S

G

Q

D

K

K

S

A

F

V

K

K

E

E

A

A

Q

K

K

K

Y

Y

G

C

T

K

V

T

H

N

L

V

A

I

A

W

S

S

G

G

Q

K

T

S

A

-

E

E

G

K

F

Y

T

T

R

K

A

V

P

P

A

S

R

F

S

E

E

E

W

L

Q

E

L

Q

S

T

D

P

D

D

P

A

A

K

Y

Y

V

L

H

H

L

I

C

C

T

A

N

N

E

E

T
|
T

I

I

H

H

G

G

V

V

E

E

T

F

F

K

E

D

I

Y

P

P

D

V

L

P

G

K

D

N

I

G

P

F

L

L

V

V

A

A

D
|
D

A

M

S

S

S

S

H

N

I

F

L

C

S

S

R

K

P

P

M

V

D

D

I

V

A

S

K

K

Y

F

G

G

V

V

L

I

F

Y

G

G

G

G

A

A

Q
|
Q

K
|
K

N

N

I

V

G

G

M

P

A

S

G

G

V

V

T

T

V

I

V

V

I

I

V

I

R

R

E

K

D

D

M

L

L

I

D

G

R

N

A

A

Q

Q

S

D

I

I

C

T

P

P

S

V

A

M

F

L

E

D

W

Y

K

K

T

I

V

H

A

D

E

E

N

N

N

S

S

S

M

L

Y

Y

N
|
N

T
|
T

P

P

P

P

T

C

Y

F

A

G

I

I

Y

Y

I

M

A

C

G

G

L

L

V

V

F

F

K

E

W

D

L

L

K

L

K

E

Q

Q

G

G

G

G

L

L

A

K

A

E

M

V

E

E

A

K

R

K

N

N

V

Q

E

R

K

K

S

A

K

D

L

L

L

L

Y

Y

D

N

A

A

V

I

D

E

T

E

S

S

S

N

-

G

F

F

Y

F

L

R

N

C

K

P

V

V

E

E

R

K

G

S

S

V

R

R

S

S

R

L

M

M

N

N

V

V

P

P

F

F

F

T

L

L

A

E

D

K

E

S

S

E

R

L

N

E

E

A

D

E

F

F

L

I

A

K

G

E

A

A

K

A

A

K

R

E

G

K

M

M

V

V

Q

Q

L

L

K

K

G

G

H

H

K

R

S

S

V

V

G

G

G

G

M

M

R

R

A

A

S

S

I

I

Y

Y

N

N

A

A

V

M

P

P

L

L

E

A

G

G

V

V

K

E

A

K

L

L

V

V

E

A

Y

F

M

M

K

K

E

D

F

F

E

Q

Q

A

R

K

S

H

A

A

binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G76 (= G74), A77 (≠ G75), T78 (≠ L76), W103 (= W101), T153 (= T152), D173 (= D172), Q196 (= Q195), K197 (= K196), N238 (= N237), T239 (= T238)

1bt4A Phosphoserine aminotransferase from bacillus circulans subsp. Alkalophilus
47% identity, 99% coverage: 2:357/360 of query aligns to 3:358/361 of 1bt4A

query
sites
1bt4A

R

R

V

A

F

Y

N

N

F

F

S

N

A

A

G

G

P

P

A

A

A

A

M

L

P

P

E

L

E

E

V

V

L

L

R

E

Q

R

A

A

A

Q

D

A

E

E

M

F

L

V

D

D

W

Y

Q

Q

G

H

S

T

G

G

M

M

S

S

V

I

M

M

E

E

M

M

S

S

H

H

R

R

G

G

K

A

E

V

F

Y

M

E

S

A

I

V

H

H

E

N

E

E

A

A

L

Q

V

A

D

R

L

L

R

L

D

A

L

L

L

L

E

G

V

N

P

P

A

T

S

G

H

Y

R

K

I

V

L

L

F

F

L

I

Q

Q

G

G

G

G

G
x
A

L
x
S

G

T

E

Q

N

F

A

A

I

M

V

I

P

P

M

M

N

N

L

F

M

L

G

K

A

E

K

G

P

Q

R

T

A

A

D

N

F

Y

V

V

V

M

T

T

G

G

S

S

W
|
W

S

A

Q

S

K

K

S

A

F

L

K

K

E

E

A

A

Q

K

K

L

Y

I

G

G

T

D

V

T

H

H

L

V

A

A

A

A

S

S

G

S

Q

E

T

-

A

A

E

S

G

N

F

Y

T

M

R

T

A

L

P

P

A

K

R

L

S

Q

E

E

W

I

Q

Q

L

L

S

Q

D

D

D

N

P

A

A

A

Y

Y

V

L

H

H

L

L

C

T

T

S

N

N

E

E

T

T

I

I

H

E

G

G

V

A

E

Q

T

F

F

K

E

A

I

F

P

P

D

D

L

T

G

G

D

S

I

V

P

P

L

L

V

I

A

G

D
|
D

A

M

S
|
S

S

S

H

D

I

I

L

L

S

S

R

R

P

P

M

F

D

D

I

L

A

N

K

Q

Y

F

G

G

V

L

L

V

F

Y

G

A

G

G

A

A

Q
|
Q

K
|
K

N

N

I

L

G

G

M

P

A

S

G

G

V

V

T

T

V

V

V

V

I

I

V

V

R

R

E

E

D

D

M

L

L

V

D

A

R

E

A

S

Q

P

S

K

I

H

C

L

P

P

S

T

A

M

F

L

E

R

W

Y

K

D

T

T

V

Y

A

V

E

K

N

N

N

N

S

S

M

L

Y

Y

N

N

T

T

P

P

P

P

T

S

Y

F

A

G

I

I

Y

Y

I

M

A

V

G

N

L

E

V

V

F

L

K

K

W

W

L

I

K

E

K

E

Q

R

G

G

G

G

L

L

A

E

A

G

M

V

E

Q

A

Q

R

A

N

N

V

R

E

K

K

K

S

A

K

S

L

L

L

I

Y

Y

D

D

A

A

V

I

D

D

T

Q

S

S

-

G

S

G

F

F

Y

Y

L

R

N

G

K

C

V

V

E

D

R

V

G

D

S

S

R

R

S

S

R

D

M

M

N

N

V

I

P

T

F

F

F

R

L

L

A

A

D

S

E

E

S

E

R

L

N

E

E

K

D

E

F

F

L

V

A

K

G

A

A

S

K

E

A

Q

R

E

G

G

M

F

V

V

Q

G

L

L

K

K

G

G

H

H

K

R

S

S

V

V

G

G

G

G

M

L

R

R

A

A

S

S

I

I

Y

Y

N

N

A

A

V

V

P

P

L

Y

E

E

G

S

V

C

K

E

A

A

L

L

V

V

E

Q

Y

F

M

M

K

E

E

H

F

F

E

K

Q

R

active site: W102 (= W101), D172 (= D172), K196 (= K196)
binding pyridoxal-5'-phosphate: A76 (≠ G75), S77 (≠ L76), W102 (= W101), D172 (= D172), S174 (= S174), Q195 (= Q195), K196 (= K196)

8a5wC Crystal structure of the human phosphoserine aminotransferase (psat) in complex with o-phosphoserine (see paper)
48% identity, 98% coverage: 2:355/360 of query aligns to 1:359/365 of 8a5wC

query
sites
8a5wC

R

Q

V

V

F

V

N

N

F

F

S

G

A

P

G

G

P

P

A

A

A

K

M

L

P

P

E

H

E

S

V

V

L

L

R

L

Q

E

A

I

A

Q

D

K

E

E

M

L

L

L

D

D

W

Y

Q

K

G

G

S

V

G

G

M

I

S

S

V

V

M

L

E

E

M

M

S

S

H
|
H

R
|
R

G

S

K

S

E

D

F

F

M

A

S

K

I

I

H

I

E

N

E

N

A

T

L

E

V

N

D

L

L

V

R

R

D

E

L

L

L

L

E

A

V

V

P

P

A

D

S

N

H

Y

R

K

I

V

L

I

F

F

L

L

Q

Q

G

G

G

G

G

G

L

C

G

G

E

Q

N

F

A

S

I

A

V

V

P

P

M

L

N

N

L

L

M

I

G

G

A

L

K

K

P

A

-

G

-

R

R

C

A

A

D

D

F

Y

V

V

V

V

T

T

G

G

S

A

W

W

S

S

Q

A

K

K

S

A

F

A

K

E

E

E

A

A

Q

K

K

K

Y

F

G

G

T

T

V

I

H

N

L

I

A

V

A

H

S

P

G

K

Q

L

T

G

A

S

E

-

G

-

F

Y

T

T

R

K

A

I

P

P

A

D

R

P

S

S

E

T

W

W

Q

N

L

L

S

N

D

P

D

D

P

A

A

S

Y

Y

V

V

H

Y

L

Y

C

C

T

A

N

N

E

E

T
|
T

I

V

H

H

G

G

V

V

E

E

T

F

F

D

E

F

I

I

P

P

D

D

L

V

G

K

D

G

I

A

P

V

L

L

V

V

A

C

D

D

A

M

S

S

S

S

H

N

I

F

L

L

S

S

R

K

P

P

M

V

D

D

I

V

A

S

K

K

Y

F

G

G

V

V

L

I

F

F

G

A

G

G

A

A

Q

Q

K
|
K

N

N

I

V

G

G

M

S

A

A

G

G

V

V

T

T

V

V

V

V

I

I

V

V

R

R

E

D

D

D

M

L

L

L

D

G

R

F

A

A

Q

L

S

R

I

E

C

C

P

P

S

S

A

V

F

L

E

E

W

Y

K

K

T

V

V

Q

A

A

E

G

N

N

N

S

S

S

M

L

Y

Y

N
|
N

T
|
T

P

P

P

P

T

C

Y

F

A

S

I

I

Y

Y

I

V

A

M

G

G

L

L

V

V

F

L

K

E

W

W

L

I

K

K

K

N

Q

N

G

G

G

G

L

A

A

A

A

A

M

M

E

E

A

K

R

L

N

S

V

S

E

I

K

K

S

S

K

Q

L

T

L

I

Y

Y

D

E

A

I

V

I

D

D

T

N

S

S

S

Q

-

G

F

F

Y

Y

L

V

N

C

K

P

V

V

E

E

R

P

G

Q

S

N

R

R

S

S

R

K

M

M

N

N

V

I

P

P

F

F

F

R

L

I

-

G

-

N

-

A

-

K

A

G

D

D

E

D

S

A

R

L

N

E

E

K

D

R

F

F

L

L

A

D

G

K

A

A

K

L

A

E

R

L

G

N

M

M

V

L

Q

S

L

L

K

K

G

G

H
|
H

K
x
R

S

S

V

V

G

G

G

G

M

I

R
|
R

A

A

S

S

I

L

Y

Y

N

N

A

A

V

V

P

T

L

I

E

E

G

D

V

V

K

Q

A

K

L

L

V

A

E

A

Y

F

M

M

K

K

E

K

F

F

binding (2S)-2-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3-phosphonooxy-propanoic acid: H39 (= H40), R40 (= R41), N236 (= N237), T237 (= T238)
binding phosphoserine: T151 (= T152), K195 (= K196), H330 (= H326), R331 (≠ K327), R337 (= R333)

8a5wA Crystal structure of the human phosphoserine aminotransferase (psat) in complex with o-phosphoserine (see paper)
48% identity, 98% coverage: 2:355/360 of query aligns to 1:359/365 of 8a5wA

query
sites
8a5wA

R

Q

V

V

F

V

N

N

F

F

S

G

A

P

G

G

P

P

A

A

A

K

M

L

P

P

E

H

E

S

V

V

L

L

R

L

Q

E

A

I

A

Q

D

K

E

E

M

L

L

L

D

D

W

Y

Q

K

G

G

S

V

G

G

M

I

S

S

V

V

M

L

E

E

M

M

S

S

H
|
H

R
|
R

G

S

K

S

E

D

F

F

M

A

S

K

I

I

H

I

E

N

E

N

A

T

L

E

V

N

D

L

L

V

R

R

D

E

L

L

L

L

E

A

V

V

P

P

A

D

S

N

H

Y

R

K

I

V

L

I

F

F

L

L

Q

Q

G

G

G
|
G

G
|
G

L
x
C

G

G

E

Q

N

F

A

S

I

A

V

V

P

P

M

L

N

N

L

L

M

I

G

G

A

L

K

K

P

A

-

G

-

R

R

C

A

A

D

D

F

Y

V

V

V

V

T

T

G

G

S

A

W
|
W

S

S

Q

A

K

K

S

A

F

A

K

E

E

E

A

A

Q

K

K

K

Y

F

G

G

T

T

V

I

H

N

L

I

A

V

A

H

S

P

G

K

Q

L

T

G

A

S

E

-

G

-

F

Y

T

T

R

K

A

I

P

P

A

D

R

P

S

S

E

T

W

W

Q

N

L

L

S

N

D

P

D

D

P

A

A

S

Y

Y

V

V

H

Y

L

Y

C

C

T

A

N

N

E

E

T
|
T

I

V

H

H

G

G

V

V

E

E

T

F

F

D

E

F

I

I

P

P

D

D

L

V

G

K

D

G

I

A

P

V

L

L

V

V

A

C

D
|
D

A

M

S
|
S

S

S

H

N

I

F

L

L

S

S

R

K

P

P

M

V

D

D

I

V

A

S

K

K

Y

F

G

G

V

V

L

I

F

F

G

A

G

G

A

A

Q
|
Q

K
|
K

N

N

I

V

G

G

M

S

A

A

G

G

V

V

T

T

V

V

V

V

I

I

V

V

R

R

E

D

D

D

M

L

L

L

D

G

R

F

A

A

Q

L

S

R

I

E

C

C

P

P

S

S

A

V

F

L

E

E

W

Y

K

K

T

V

V

Q

A

A

E

G

N

N

N

S

S

S

M

L

Y

Y

N

N

T

T

P

P

P

P

T

C

Y

F

A

S

I

I

Y

Y

I

V

A

M

G

G

L

L

V

V

F

L

K

E

W

W

L

I

K

K

K

N

Q

N

G

G

G

G

L

A

A

A

A

A

M

M

E

E

A

K

R

L

N

S

V

S

E

I

K

K

S

S

K

Q

L

T

L

I

Y

Y

D

E

A

I

V

I

D

D

T

N

S

S

S

Q

-

G

F

F

Y

Y

L

V

N

C

K

P

V

V

E

E

R

P

G

Q

S

N

R

R

S

S

R

K

M

M

N

N

V

I

P

P

F

F

F

R

L

I

-

G

-

N

-

A

-

K

A

G

D

D

E

D

S

A

R

L

N

E

E

K

D

R

F

F

L

L

A

D

G

K

A

A

K

L

A

E

R

L

G

N

M

M

V

L

Q

S

L

L

K

K

G

G

H
|
H

K

R

S

S

V

V

G

G

G

G

M

I

R
|
R

A

A

S

S

I

L

Y

Y

N

N

A

A

V

V

P

T

L

I

E

E

G

D

V

V

K

Q

A

K

L

L

V

A

E

A

Y

F

M

M

K

K

E

K

F

F

binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G73 (= G74), G74 (= G75), C75 (≠ L76), W102 (= W101), T151 (= T152), D171 (= D172), S173 (= S174), Q194 (= Q195), K195 (= K196)
binding phosphoserine: H39 (= H40), R40 (= R41), H330 (= H326), R337 (= R333)

8a5vA Crystal structure of the human phosposerine aminotransferase (psat) (see paper)
48% identity, 98% coverage: 2:355/360 of query aligns to 1:359/365 of 8a5vA

query
sites
8a5vA

R

Q

V

V

F

V

N

N

F

F

S

G

A

P

G

G

P

P

A

A

A

K

M

L

P

P

E

H

E

S

V

V

L

L

R

L

Q

E

A

I

A

Q

D

K

E

E

M

L

L

L

D

D

W

Y

Q

K

G

G

S

V

G

G

M

I

S

S

V

V

M

L

E

E

M

M

S

S

H

H

R

R

G

S

K

S

E

D

F

F

M

A

S

K

I

I

H

I

E

N

E

N

A

T

L

E

V

N

D

L

L

V

R

R

D

E

L

L

L

L

E

A

V

V

P

P

A

D

S

N

H

Y

R

K

I

V

L

I

F

F

L

L

Q

Q

G

G

G

G

G

G

L

C

G

G

E

Q

N

F

A

S

I

A

V

V

P

P

M

L

N

N

L

L

M

I

G

G

A

L

K

K

P

A

-

G

-

R

R

C

A

A

D

D

F

Y

V

V

V

V

T

T

G

G

S

A

W

W

S

S

Q

A

K

K

S

A

F

A

K

E

E

E

A

A

Q

K

K

K

Y

F

G

G

T

T

V

I

H

N

L

I

A

V

A

H

S

P

G

K

Q

L

T

G

A

S

E

-

G

-

F

Y

T

T

R

K

A

I

P

P

A

D

R

P

S

S

E

T

W

W

Q

N

L

L

S

N

D

P

D

D

P

A

A

S

Y

Y

V

V

H

Y

L

Y

C

C

T

A

N

N

E

E

T

T

I

V

H

H

G

G

V

V

E

E

T

F

F

D

E

F

I

I

P

P

D

D

L

V

G

K

D

G

I

A

P

V

L

L

V

V

A

C

D

D

A

M

S

S

S

S

H

N

I

F

L

L

S

S

R

K

P

P

M

V

D

D

I

V

A

S

K

K

Y

F

G

G

V

V

L

I

F

F

G

A

G

G

A

A

Q

Q

K

K

N

N

I

V

G

G

M

S

A

A

G

G

V

V

T

T

V

V

V

V

I

I

V

V

R

R

E

D

D

D

M

L

L

L

D

G

R

F

A

A

Q

L

S

R

I

E

C

C

P

P

S

S

A

V

F

L

E

E

W

Y

K

K

T

V

V

Q

A

A

E

G

N

N

N

S

S

S

M

L

Y

Y

N
|
N

T
|
T

P

P

P

P

T

C

Y

F

A

S

I

I

Y

Y

I

V

A

M

G

G

L

L

V

V

F

L

K

E

W

W

L

I

K

K

K

N

Q

N

G

G

G

G

L

A

A

A

A

A

M

M

E

E

A

K

R

L

N

S

V

S

E

I

K

K

S

S

K

Q

L

T

L

I

Y

Y

D

E

A

I

V

I

D

D

T

N

S

S

S

Q

-

G

F

F

Y

Y

L

V

N

C

K

P

V

V

E

E

R

P

G

Q

S

N

R

R

S

S

R

K

M

M

N

N

V

I

P

P

F

F

F

R

L

I

-

G

-

N

-

A

-

K

A

G

D

D

E

D

S

A

R

L

N

E

E

K

D

R

F

F

L

L

A

D

G

K

A

A

K

L

A

E

R

L

G

N

M

M

V

L

Q

S

L

L

K

K

G

G

H

H

K

R

S

S

V

V

G

G

G

G

M

I

R

R

A

A

S

S

I

L

Y

Y

N

N

A

A

V

V

P

T

L

I

E

E

G

D

V

V

K

Q

A

K

L

L

V

A

E

A

Y

F

M

M

K

K

E

K

F

F

binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: N236 (= N237), T237 (= T238)

Q9Y617 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Homo sapiens (Human) (see 6 papers)
48% identity, 98% coverage: 2:355/360 of query aligns to 6:364/370 of Q9Y617

query
sites
Q9Y617

R

Q

V

V

F

V

N

N

F

F

S

G

A

P

G

G

P

P

A

A

A

K

M

L

P

P

E

H

E

S

V

V

L

L

R

L

Q

E

A

I

A

Q

D

K

E

E

M

L

L

L

D

D

W

Y

Q

K

G

G

S

V

G

G

M

I

S

S

V

V

M

L

E

E

M

M

S
|
S

H
|
H

R
|
R

G

S

K

S

E

D

F

F

M

A

S

K

I

I

H

I

E

N

E

N

A

T

L

E

V

N

D

L

L

V

R

R

D

E

L

L

L

L

E

A

V

V

P

P

A

D

S

N

H
x
Y

R

K

I

V

L

I

F

F

L

L

Q

Q

G

G

G

G

G
|
G

L
x
C

G

G

E

Q

N

F

A

S

I

A

V

V

P
|
P

M

L

N

N

L

L

M

I

G

G

A

L

K

K

P

A

-

G

-

R

R

C

A
|
A

D
|
D

F

Y

V

V

V

V

T

T

G

G

S

A

W
|
W

S

S

Q

A

K

K

S

A

F

A

K

E

E

E

A

A

Q

K

K

K

Y

F

G

G

T

T

V

I

H

N

L

I

A

V

A

H

S

P

G

K

Q

L

T

G

A

S

E

-

G

-

F

Y

T

T

R

K

A

I

P

P

A

D

R

P

S

S

E

T

W

W

Q

N

L

L

S

N

D

P

D

D

P

A

A

S

Y

Y

V

V

H

Y

L

Y

C

C

T

A

N

N

E
|
E

T
|
T

I

V

H

H

G

G

V

V

E

E

T

F

F

D

E

F

I

I

P

P

D

D

L

V

G

K

D

G

I

A

P

V

L

L

V

V

A

C

D
|
D

A

M

S

S

S
|
S

H

N

I

F

L

L

S

S

R

K

P

P

M

V

D

D

I

V

A

S

K

K

Y

F

G

G

V

V

L

I

F

F

G

A

G

G

A

A

Q
|
Q

K
|
K

N

N

I

V

G

G

M

S

A

A

G

G

V

V

T

T

V

V

V

V

I

I

V

V

R

R

E

D

D

D

M

L

L

L

D

G

R

F

A

A

Q

L

S

R

I

E

C

C

P

P

S

S

A

V

F

L

E

E

W

Y