Comparing BPHYT_RS16075 FitnessBrowser__BFirm:BPHYT_RS16075 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 6 hits to proteins with known functional sites (download)
1m2wA Pseudomonas fluorescens mannitol 2-dehydrogenase ternary complex with NAD and d-mannitol (see paper)
37% identity, 78% coverage: 14:381/470 of query aligns to 29:397/492 of 1m2wA
1lj8A Crystal structure of mannitol dehydrogenase in complex with NAD (see paper)
37% identity, 78% coverage: 14:381/470 of query aligns to 29:397/492 of 1lj8A
7rk5B Mannitol-2-dehydrogenase bound to nadh from aspergillus fumigatus
33% identity, 93% coverage: 5:439/470 of query aligns to 27:464/501 of 7rk5B
4im7A Crystal structure of fructuronate reductase (ydfi) from e. Coli cft073 (efi target efi-506389) complexed with nadh and d-mannonate
35% identity, 75% coverage: 14:367/470 of query aligns to 21:372/483 of 4im7A
Sites not aligning to the query:
P09424 Mannitol-1-phosphate 5-dehydrogenase; EC 1.1.1.17 from Escherichia coli (strain K12) (see paper)
25% identity, 44% coverage: 167:374/470 of query aligns to 114:312/382 of P09424
Q4X1A4 Mannitol-1-phosphate 5-dehydrogenase; M1PDH; MPD; MPDH; EC 1.1.1.17 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
24% identity, 49% coverage: 153:382/470 of query aligns to 104:320/388 of Q4X1A4
>BPHYT_RS16075 FitnessBrowser__BFirm:BPHYT_RS16075
MNSGQDSGAAAHVILHIGAGSFHRAHQAWYLHRLNEAKVAGEPHWSLTVGNIRSDMNAVL
EALAAQNGVYTLETVTPQGERAYETIRSIERVVPWTESLDALIEAGADPACKIIAFTVTE
GGYYLDEQDELDTANPDLAADLEGGHTTIYGALAAILDARMKAGAGPVTLQTCDNLRSNG
ERFHAGMSEFLERRGASELAQWFDDNTASPSSMVDRITPRPTPDVRERVKAATGVDDAVP
VMGEAFIQWVIEDNFIAGRPAWEKVGAELVDSVMPYEEAKIRILNATHSCIAWAGTLVGL
NYIHEGTLDADINKFAYEYVTEDVIPCLTPSPLDLERYRDVVLERFSNPYIQDTNQRVAA
DGFSKLPGFIAPTLSECFERGVTPAATAMLPALFFRFLDRWNAGKLPYTYQDGVMDERVA
RAFFEAPDPLKAFAADRLLWGSMAQTPELESALEGAVARVDVWLAKRGAV
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory