Comparing BPHYT_RS17395 FitnessBrowser__BFirm:BPHYT_RS17395 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P00903 Aminodeoxychorismate synthase component 2; ADC synthase; ADCS; 4-amino-4-deoxychorismate synthase component 2; Aminodeoxychorismate synthase, glutamine amidotransferase component; EC 2.6.1.85 from Escherichia coli (strain K12) (see paper)
60% identity, 94% coverage: 1:187/200 of query aligns to 1:187/187 of P00903
Q42565 Anthranilate synthase beta subunit 1, chloroplastic; Anthranilate synthase component 2-1; Anthranilate synthase, glutamine amidotransferase component 2-1; Protein TRYPTOPHAN BIOSYNTHESIS 4; Protein WEAK ETHYLENE INSENSITIVE 7; EC 4.1.3.27 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
51% identity, 93% coverage: 2:186/200 of query aligns to 75:265/276 of Q42565
8hx8A Crystal structure of 4-amino-4-deoxychorismate synthase from streptomyces venezuelae co-crystallized with chorismate (see paper)
45% identity, 91% coverage: 3:184/200 of query aligns to 7:187/673 of 8hx8A
Sites not aligning to the query:
P00900 Anthranilate synthase component 2; AS; ASII; Anthranilate synthase, GATase component; Anthranilate synthase, glutamine amidotransferase component; EC 4.1.3.27 from Serratia marcescens (see 3 papers)
45% identity, 91% coverage: 2:183/200 of query aligns to 4:185/193 of P00900
Sites not aligning to the query:
1i7qB Anthranilate synthase from s. Marcescens (see paper)
45% identity, 91% coverage: 2:183/200 of query aligns to 3:184/192 of 1i7qB
8hx9A Crystal structure of 4-amino-4-deoxychorismate synthase from streptomyces venezuelae with chorismate (see paper)
36% identity, 91% coverage: 3:184/200 of query aligns to 6:144/632 of 8hx9A
Sites not aligning to the query:
Q9LVW7 Carbamoyl phosphate synthase small chain, chloroplastic; Carbamoyl phosphate synthetase glutamine chain; Protein VENOSA 6; EC 6.3.5.5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
30% identity, 70% coverage: 38:176/200 of query aligns to 277:410/430 of Q9LVW7
7yc6A Crystal structure of d110p mutant of gatase subunit of methanocaldococcus jannaschii gmp synthetase
29% identity, 93% coverage: 1:186/200 of query aligns to 1:176/183 of 7yc6A
5tw7F Crystal structure of a gmp synthase (glutamine-hydrolyzing) from neisseria gonorrhoeae
32% identity, 81% coverage: 33:194/200 of query aligns to 36:195/490 of 5tw7F
Sites not aligning to the query:
2ywcA Crystal structure of gmp synthetase from thermus thermophilus in complex with xmp
30% identity, 97% coverage: 1:194/200 of query aligns to 1:187/475 of 2ywcA
Sites not aligning to the query:
1ce8B Carbamoyl phosphate synthetase from escherichis coli with complexed with the allosteric ligand imp (see paper)
26% identity, 77% coverage: 33:186/200 of query aligns to 221:371/379 of 1ce8B
Sites not aligning to the query:
P0A6F1 Carbamoyl phosphate synthase small chain; Carbamoyl phosphate synthetase glutamine chain; EC 6.3.5.5 from Escherichia coli (strain K12) (see paper)
26% identity, 77% coverage: 33:186/200 of query aligns to 222:372/382 of P0A6F1
Sites not aligning to the query:
1c3oB Crystal structure of the carbamoyl phosphate synthetase: small subunit mutant c269s with bound glutamine (see paper)
25% identity, 77% coverage: 33:186/200 of query aligns to 221:371/379 of 1c3oB
Sites not aligning to the query:
P49915 GMP synthase [glutamine-hydrolyzing]; GMP synthetase; Glutamine amidotransferase; EC 6.3.5.2 from Homo sapiens (Human) (see paper)
31% identity, 59% coverage: 69:185/200 of query aligns to 94:207/693 of P49915
Sites not aligning to the query:
P07259 Multifunctional protein URA2; Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase; CPSase-ATCase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
29% identity, 63% coverage: 47:171/200 of query aligns to 268:389/2214 of P07259
Sites not aligning to the query:
P05990 Multifunctional protein r; Protein rudimentary; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Drosophila melanogaster (Fruit fly) (see 2 papers)
28% identity, 61% coverage: 49:170/200 of query aligns to 237:355/2224 of P05990
Sites not aligning to the query:
2vxoB Human gmp synthetase in complex with xmp (see paper)
31% identity, 59% coverage: 69:185/200 of query aligns to 72:182/658 of 2vxoB
Sites not aligning to the query:
P27708 Multifunctional protein CAD; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Homo sapiens (Human) (see 7 papers)
30% identity, 63% coverage: 45:170/200 of query aligns to 215:338/2225 of P27708
Sites not aligning to the query:
Q18990 Multifunctional protein pyr-1; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Caenorhabditis elegans (see 3 papers)
28% identity, 61% coverage: 49:170/200 of query aligns to 223:341/2198 of Q18990
Sites not aligning to the query:
P08955 Multifunctional protein CAD; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; EC 6.3.5.5; EC 3.5.1.2; EC 6.3.4.16; EC 2.1.3.2; EC 3.5.2.3 from Mesocricetus auratus (Golden hamster) (see paper)
25% identity, 80% coverage: 11:170/200 of query aligns to 185:338/2225 of P08955
Sites not aligning to the query:
>BPHYT_RS17395 FitnessBrowser__BFirm:BPHYT_RS17395
MLLMIDNYDSFTYNLVQYFGELGEDVRTYRNDEITLDEIAKLNPERICLSPGPSNPQHAG
ITLDVLREFSGKTPILGVCLGHQAIGEAFGGRVVRAQTIMHGKVSTIETDCKGVFADLPK
HFVVTRYHSLAIERESLPDCLEVSAWTEDGEIMGVRHKELAVEGVQFHPESILSEHGHAL
LENFVKQSKLAGAQTSNRNA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory