SitesBLAST

P53322 High-affinity nicotinic acid transporter; Nicotinic acid permease from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
20% identity, 74% coverage: 3:329/443 of query aligns to 71:397/534 of P53322

query
sites
P53322

S

D

A

G

L

I

T

P

T

S

A

P

A

S

D

H

P

P

L

M

E

E

S

K

A

R

V

V

-

L

S

R

K

K

V

M

K

D

R

I

H

Y

V

L

L

I

P

P

L

L

F

M

L

G

I

M

M

L

F

Y

I

F

A

L

N

S

Y

N

I

L

D

D

R

K

V

S

N

N

I

I

G

G

F

N

V

A

N

E

-

V

S

A

H

G

M

L

Q

S

T

K

D

D

L

I

G

H

I

L

G

V

A

G

A

T

A

Q

Y

Y

G

N

L

T

G

C

S

V

G

T

L

V

F

F

I

A

G

T

Y

Y

A

V

L

L

F

F

E

D

V

P

P

I

S

G

N

T

V

N

L

L

M

L

Q

K

K

I

Y

M

G

G

A

P

R

P

A

L

W

M

L

M

T

S

R

I

I

C

M

L

G

T

T

C

W

F

G

G

L

A

V

I

A

S

A

L

A

G

M

T

A

A

F

W

V

V

W

K

N

N

D

Y

T

A

S

Q

F

L

Y

I

V

V

L

V

R

R

F

L

L

L

G

G

I

A

A

F

E

E

A

G

G

M

F

I

F

Y

P

P

G

A

V

I

V

N

F

M

Y

Y

F

L

T

S

Q

V

W

C

L

Y

P

R

Q

R

K

E

E

Q

R

Y

G

A

K

L

A

R

V

F

A

A

V

F

F

V

L

F

G

S

G

A

S

A

A

C

L

L

A

S

S

S

V

S

L

F

S

G

G

G

P

L

I

I

T

A

G

Y

S

G

L

C

L

S

S

K

I

I

R

S

G

G

F

-

G

S

L

L

H

K

G

D

W

W

Q

Q

W

Y

M

I

F

Y

L

I

V

V

E

E

G

G

G

C

F

I

S

S

I

L

V

G

L

F

C

V

A

P

V

F

S

Y

W

A

M

F

L

G

L

L

K

S

S

K

R

N

I

L

R

E

D

D

A

S

S

W

W

F

L

F

T

N

A
x
K

E

E

Q

K

H

E

V

Y

L

I

E

S

T

E

S

R

I

Y

A

K

A

T

E

M

Q

N

A

T

A

F

R

D

E

P

A

D

H

E

G

K

G

F

A

E

H

W

L

F

P

Q

A

V

M

W

K

Q

L

A

L

V

K

K

D

D

P

V

Q

K

I

T

L

W

L

A

F

S

C

A

F

V

L

A

Y

L

F

F

A

G

I

I

Q

D

L

L

T

T

I

T

Y

F

A

G

A

L

T

T

F

V

W

F

L

L

P

P

T

I

I

I

R

T

K

S

M

M

G

-

G

G

L

F

S

T

D

N

F

V

Q

R

V

A

G

Q

M

L

L

M

N

T

A

V

I

P

P

I

W

Y

L

F

I

L

A

T

M

A

F

I

A

V

M

F

Y

F

C

I

F

C

A

A

L

V

L

W

S

S

A

D

K

R

W

I

R

K

F

L

Q

R

Q

S

A

P

W

F

L

I

A

L

V

G

A

A

L

C

V

L

I

T

A

T

A

S

C

I

G

G

L

I

K283 (≠ A214) modified: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

6e9oA E. Coli d-galactonate:proton symporter mutant e133q in the outward substrate-bound form (see paper)
25% identity, 89% coverage: 20:413/443 of query aligns to 4:377/393 of 6e9oA

query
sites
6e9oA

K

R

R

R

H

R

V

Y

L

L

P

T

L

L

F

V

L

M

I

I

M

F

F

I

-

T

-

V

I

V

A

I

N

C

Y
|
Y

I

V

D

D

R

R

V

A

N

N

I

L

G

A

F

V

V

A

N

S

S

A

H

H

M

I

Q

Q

T

E

D

E

L

F

G

G

I

I

G

T

A

K

A

A

A

E

Y

M

G

G

L

Y

G

V

S

F

G

S

L

A

F

F

F

A

I

W

G

L

Y

Y

A

T

L

L

F

C

E

Q

V

I

P

P

S

G

N

G

V

W

L

F

M

L

Q

D

K

R

Y

V

G

G

A

S

R

R

-

V

A

T

W

Y

L

F

T

I

R

A

I

I

M

F

G

G

T

-

W

W

G

S

L

V

V

A

A

T

A

L

A

F

M

Q

A

G

F

F

V

A

W

T

N

G

D

L

T

M

S

S

F

L

Y

I

V

G

L

L

R

R

F

A

L

I

L

T

G

G

I

I

A

F

E

Q

A

A

G

P

F

A

F
|
F

P

P

G

T

V

N

F

R

Y

M

F

V

T

T

Q

S

W

W

L

F

P

P

Q

E

K

H

E

E

R

R

G

A

K

S

A

A

V

V

A

G

V

F

F

Y

L

T

G

S

G

G

S
x
Q

A

F

L

V

A

G

S

L

V

A

L

F

S

L

G

T

P

P

I

L

T

-

G

-

S

-

L

L

L

I

S

W

I

I

R

Q

G

-

F

-

G

E

L

M

H

L

G

S

W

W

Q

H

W

W

M

V

F

F

L

I

V

V

E

T

G

G

F

I

S

G

I

I

V

I

L

-

C

-

A

-

V

-

S

-

W

W

M

S

L

L

L

I

K

-

S

-

R

-

I

-

R

-

D

-

A

-

S

-

W

W

L

F

T

K

A

V

E

Y

E

Q

Q

P

H

P

V

R

L

L

E

T

T

K

S

G

I

I

A

S

-

K

A

A

E

E

Q

L

A

D

A

Y

R

I

E

R

A

D

H

G

G

G

A

L

H

V

L

L

P

T

A

A

M

K

-

D

-

W

K

K

L

L

L

V

K

F

D

H

P

R

Q

K

I

L

L

I

L

G

F

V

C

Y

F

L

L

G

Y
x
Q

F

F

A

A

I

V

Q

-

L

-

T

-

I

-

Y

-

A

A

A

S

T

T

F

L

W

W

L

F

P

-

T

-

I

-

R

-

K

-

M

-

G

-

L

F

S

L

D

T

F

L

Q

K

V

A

G

G

M

F

L

M

N

T

A

T

I

V

P

P

W

F

L

L

I

A

A

A

M

F

F

V

A

G

M

V

Y

L

C

L

-

S

-

G

-

W

F

V

A

A

L

D

L

L

S

L

A

V

K

R

W

K

R

G

F

F

-

S

-

L

-

G

-

F

-

A

Q

R

Q

K

A

T

W

P

L

I

A

I

V

C

A

G

L

L

V

L

I

I

A

S

A

T

C

C

G

I

L

M

F

G

A

A

S

N

T

Y

S

T

G

N

N

D

P

P

-

M

V

I

L

M

S

C

F

L

V

M

A

A

I

L

C

A

F

F

S

F

A

G

I

N

G

G

F

F

K

-

A

-

A

A

S
|
S

L

I

F

T

W

W

P

S

I

L

P

V

Q

S

G

S

Y

L

L

A

D

P

A

M

R

R

V

L

A

I

A

G

A

L

V

T

I

G

A

G

L

V

I

F

N
|
N

S

F

V

A

G

G

N

G

L

L

G

G

F

I

F

T

A

V

P

P

A

L

A

V

F

V

G

G

Y

Y

L

L

Q

A

Q

Q

H

G

T

Y

G

G

S

F

I

A

T

P

G

A

G

L

L

V

Y

Y

G

I

L

S

A

A

V

V

A

A

binding D-galactonic acid: Y21 (= Y35), F114 (= F128), Q141 (≠ S155), Q228 (≠ Y257), S320 (= S356), N343 (= N379)

Q9JI12 Vesicular glutamate transporter 2; VGluT2; Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6 from Rattus norvegicus (Rat) (see 2 papers)
24% identity, 77% coverage: 60:399/443 of query aligns to 125:470/582 of Q9JI12

query
sites
Q9JI12

G

G

L

M

G

I

S
x
H

G

G

L

S

F

F

I

W

G

G

Y

Y

A

I

L

I

F

T

E

Q

V

I

P

P

S

G

N

G

V

Y

L

I

M

A

Q

S

K

R

-

L

-

A

-

N

-

R

-

V

Y

F

G

G

A

A

R

A

A

I

W

L

L

L

T

T

R

S

I

T

M

L

G

N

T

M

W

-

G

-

L

L

V

I

A

P

A

S

A

A

M

A

A

R

F

V

V

H

W

Y

N

G

D

C

T

V

S

I

F

F

Y

-

V

-

L

V

R
|
R

F

I

L

L

L

Q

G

G

I

L

A

V

E
|
E

A

G

G

V

F

T

F

Y

P

P

G

A

V

C

V

H

F

G

Y

I

F

W

T

S

Q

K

W

W

L

A

P

P

Q

P

K

L

E

E

R

R

G

S

K

R

A

L

V

A

A

T

V

T

F

S

L

F

G

C

G

G

S

S

A

Y

L

A

A

G

S

A

V

V

L

I

S

A

G

M

P

P

I

L

T

A

G

G

S

I

L

L

L

V

S

Q

I

-

R

-

G

-

F

-

G

-

L

Y

H

T

G

G

W

W

Q

S

W

S

M

V

F

F

L

Y

V

V

E

Y

G

G

G

S

F

F

S

G

I

M

V

V

L

W

C

-

A

Y

V

M

S

F

W

W

M

L

L

L

L

V

-

S

-

Y

K

E

S

S

R

P

I

A

R

K

D

H

A

P

S

T

W

-

L

I

T

T

A

D

E

E

Q

R

H

R

V

Y

L

I

E

E

T

E

S

S

I

I

A

G

A

E

E

S

Q

A

A

N

A

L

R

L

E

G

A

A

H

M

G

E

G

K

A

F

H

K

L

T

P

P

A

W

M

R

K

K

L

F

K

T

D

S

P

M

Q

P

I

V

L

Y

L

A

F

I

C

I

F

V

L

A

Y

N

F

F

A

C

I
x
R

Q

S

L

W

T

T

I

F

Y

Y

A

L

T

L

F

I

W

S

L

Q

P

P

T

A

I

Y

I

F

R

E

K

E

M

V

G

F

G

G

L

F

S

E

D

I

F

S

Q

K

V

V

G

G

M

M

L

L

N

S

A

A

I

V

P

P

W

H

L

L

I

V

A

M

M

T

F

I

A

I

M

V

Y

P

C

I

F

G

A

G

L

Q

L

I

S

A

A

D

K

F

W

L

R

R

F

S

Q

K

Q

Q

A

I

W

-

L

L

A

S

V

T

A

T

L

T

V

V

-

R

-

K

I

I

A

M

A

N

C

C

G

G

L

G

F

F

A

G

S

M

T

E

S

A

-

T

-

L

-

V

G

G

N

Y

P

S

V

H

L

T

S

R

F

G

V

V

A

A

I

I

C

S

F

F

-

L

-

V

S

L

A

A

I

V

G

G

F

F

K

S

A

G

A

F

A

A

S

I

L

S

F

G

W

F

P

N

I

V

P

N

Q

H

G

L

Y

D

L

I

D

A

A

P

R

R

V

Y

A

A

A

S

A

I

V

L

I

M

A

G

L

I

I

S

N

N

S

G

V

V

G

G

N

T

L

L

G

S

G

G

F

M

F

V

A

C

P

P

A

I

F

V

G

G

Y

A

L

M

Q

T

Q

K

H

N

H128 (≠ S63) mutation to A: Greatly lowers L-glutamate transport.
R184 (= R117) mutation R->A,E,K: Greatly lowers L-glutamate transport.
E191 (= E124) mutation to A: Greatly lowers L-glutamate transport.; mutation E->D,Q: Lowers L-glutamate transport.
R322 (≠ I260) mutation to A: Loss of L-glutamate release. Abolishes the chloride ion conductance.

Sites not aligning to the query:

88 R→A: Impairs synaptic transmission. Abolishes the chloride ion conductance.

Q9NRA2 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Homo sapiens (Human) (see 8 papers)
22% identity, 57% coverage: 64:314/443 of query aligns to 113:359/495 of Q9NRA2

query
sites
Q9NRA2

G

G

L

S

F

F

I

Y

G

G

Y

Y

A

I

L

I

F

T

E

Q

V

I

P

P

S

G

N

G

V

Y

L

V

M

A

Q

S

K

K

Y

I

G

G

A

G

R
x
K

A

M

W

L

L

L

-

G

-

F

-

G

-

I

-

L

-

G

T

T

R

A

I

V

M

L

G

T

T

L

W

F

G

T

L

P

V

I

A

A

A

D

M

L

A

G

F

V

V

-

W

-

N

-

D

-

T

G

S

P

F

L

Y

I

V

V

L

L

R

R

F

A

L

L

L

E

G

G

I

L

A

G

E

E

A

G

G

V

F

T

F

F

P

P

G

A

V

M

V
x
H

F

A

Y

M

F

W

T

S

Q

S

W

W

L

A

P

P

Q

P

K

L

E

E

R

R

G

S

K

K

A
x
L

V
x
L

A

S

V

I

F

S

L

Y

G

A

G

G

S

A

A

Q

L

L

A

G

S

T

V

V

L

I

S

S

G

L

P

P

I

L

T

S

G

G

S

I

L

I

L

C

S

Y

I

Y

R

M

G

-

F

-

G

-

L

-

H

-

G

N

W

W

Q

T

W

Y

M

V

F

F

L

Y

V

F

E

F

G

G

G

T

F

I

S

G

I

I

V

F

L

W

C

F

A

L

V

L

S

W

W

I

M

W

L

L

L

V

K

S

S

D

R

T

I

P

R

Q

D

K

A

H

S

K

W

R

L

I

T

S

A

H

E

Y

E

E

Q

K

H

E

V

Y

L
x
I

E
x
L

T
x
S

S
|
S

I
x
L

A
x
R

A
x
N

E

Q

Q

L

A

S

R

Q

E

K

A

S

H

-

G

-

A

-

H

-

L

V

P

P

A

W

M

V

K

P

L

I

L

L

K

K

D

S

P

L

Q

P

I

L

L

W

L

A

F

I

C

V

F

V

L

A

Y

H

F

F

A

S

I

Y

Q

N

L

W

T

T

I

F

Y

Y

A

T

A

L

T

L

F

T

W

L

L

L

P

P

T

T

I

Y

I

M

R

K

K

E

M

I

G

L

G

R

L

F

S

N

D

V

F

Q

Q

E

V

N

G
|
G

M

F

L

L

N

S

A

S

I

L

P
|
P

-

Y

-

L

-

G

-

S

W

W

L

L

I

C

A

M

M

I

F

L

A

S

M

G

Y

Q

C

A

F

A

A

D

L

N

L

L

S

R

A

A

K

K

W

W

R

N

F

F

Q

S

K136 (≠ R87) to E: in SD; alters intracellular localization, only partially targeted to lysosomes and mainly detected in LAMP1-negative vesicles and in the Golgi apparatus; completely devoid of L-aspartate and L-glutamate transporter activity, but retains appreciable H(+)-coupled sialic acid transporter activity; dbSNP:rs80338795
H183 (≠ V132) to R: in ISSD; alters intracellular localization, only partially targeted to lysosomes and mainly detected in LAMP1-negative vesicles and in the Golgi apparatus; abolishes H(+)-coupled sialic acid transporter activity; has normal L-aspartate and L-glutamate transporter activity; dbSNP:rs119491109
LL 198:199 (≠ AV 147:148) mutation to AA: Localizes in vesicular structures mainly concentrated in the perinuclear region.
IL 266:267 (≠ LE 220:221) mutation to LA: Localizes in vesicular structures mainly concentrated in the perinuclear region.
SSLRN 268:272 (≠ TSIAA 222:226) natural variant: Missing (in ISSD; alters intracellular localization, only partially targeted to lysosomes and mainly detected in LAMP1-negative vesicles and in the Golgi apparatus; abolishes H(+)-coupled sialic acid transporter activity; has normal L-aspartate and L-glutamate transporter activity)
G328 (= G287) to E: in ISSD; some patients may manifest a milder phenotype consistent with Salla disease; markedly decreases H(+)-coupled sialic acid transporter activity; abolishes L-aspartate and L-glutamate transporter activity; dbSNP:rs386833996
P334 (= P293) to R: in ISSD; does not affect intracellular localization, targeted to lysosomes; abolishes H(+)-coupled sialic acid transporter activity; abolishes L-aspartate and L-glutamate transporter activity; dbSNP:rs119491110

Sites not aligning to the query:

22:23 Dileucine internalization motif; LL→AA: Targeted to plasma membrane.; LL→GG: Targeted to plasma membrane; sialic acid uptake strongly activated at acidic pH.
39 R → C: in SD; frequent variant in Finland; alters intracellular localization, only partially targeted to lysosomes and mainly detected in LAMP1-negative vesicles and in the Golgi apparatus; completely devoid of L-aspartate and L-glutamate transport activity, but retains appreciable H(+)-coupled sialic acid and nitrate transporter activity; dbSNP:rs80338794
371 G → V: in ISSD; abolishes H(+)-coupled sialic acid transporter activity; abolishes L-aspartate and L-glutamate transporter activity; dbSNP:rs777862172

Q03567 Uncharacterized transporter slc-17.2 from Caenorhabditis elegans (see paper)
22% identity, 75% coverage: 66:399/443 of query aligns to 90:433/493 of Q03567

query
sites
Q03567

F

F

I

Y

G

G

Y

Y

A

I

L

G

F

S

E

Q

V

I

P

I

S

G

N

G

V

H

L

L

M

A

Q

S

K

R

Y

Y

G

G

A

G

-

K

R

R

A

V

W

V

L

F

T

V

R

T

I

I

M

L

G

G

T

S

W

A

G

L

L

L

-

T

V

L

A

L

A

N

A

P

M

V

A

A

F

A

V

R

W

T

N

S

D

E

T

Y

S

A

F

L

Y

A

V

I

L

L

R

R

F

A

L

A

L

I

G

G

I

F

A

L

E

Q

A

G

G

A

F

T

F

F

P

P

G

A

V

M

V

H

F

T

Y

M

F

W

T

S

Q

V

W

W

L

G

P

P

Q

P

K

L

E

E

R

L

G

S

K

V

A

L

V

T

A

G

V

V

F

T

L

Y

G

A

G

G

S

A

A

Q

L

I

A

G

S

N

V

V

L

I

S

V

G

L

P

P

I

L

T

S

G

G

S

-

L

F

L

L

S

C

I

E

R

Y

G

G

F

F

G

D

L

-

H

G

G

G

W

W

Q

P

W

S

M

I

F

F

L

Y

V

I

E

I

G

G

G

V

F

F

S

G

I

V

V

L

L

W

C

T

A

A

V

V

S

W

W

W

M

Y

L

V

L

S

K

S

S

D

R

K

I

P

R

A

D

T

A

H

S

P

W

R

L

I

T

T

A

P

E

E

Q

K

H

Q

V

Y

L

I

E

V

T

T

S

A

I

V

A

E

A

A

E

S

Q

M

A

-

A

G

R

K

E

D

A

T

H

G

G

K

G

V

A

P

H

S

L

T

P

P

A

W

M

I

K

K

L

I

L

L

K

T

D

S

P

P

Q

A

I

V

L

W

L

A

F

C

C

W

F

A

L

G

Y

H

F

F

A

A

I

G

Q

D

L

W

T

G

I

A

Y

Y

A

T

A

M

T

L

F

V

W

S

L

L

P

P

T

S

I

F

I

L

R

K

K

D

M

V

G

L

G

G

L

L

S

N

D

L

F

S

Q

S

V

L

G

G

M

A

L

V

N

A

A

S

I

I

P

P

W

Y

L

I

I

A

A

Y

M

F

F

L

A

A

M

I

Y

N

C

A

F

G

A

G

L

V

L

L

S

A

A

D

K

T

W

L

R

R

-

S

-

K

-

G

-

I

-

L

-

S

-

T

-

L

-

N

F

T

Q

R

A

A

W

A

L

M

A

L

V

V

A

A

L

L

V

I

I

G

A

Q

A

G

C

I

G

F

L

L

F

V

A

A

S

S

T

G

S

Y

G

C

N

G

P

C

V

G

L

Q

S

D

F

V

V

L

A

V

I

I

C

I

F

F

S

I

A

T

I

C

G

G

F

M

K

A

A

I

A

S

A

G

S

L

L

Q

F

Y

W

A

P

G

I

F

P

V

Q

V

G

N

Y

Y

L

L

D

E

-

I

-

A

A

P

R

P

V

F

A

S

A

G

A

T

V

V

I

M

A

G

L

T

I

G

N

N

S

T

V

I

G

S

N

A

L

L

G

A

G

G

F

I

A

S

P

P

A

A

A

V

F

S

G

S

Y

Y

L

L

Q

T

Q

P

H

N

Sites not aligning to the query:

69 modified: carbohydrate, N-linked (GlcNAc...) asparagine

7t3nA R184q/e191q mutant of rat vesicular glutamate transporter 2 (vglut2)
23% identity, 77% coverage: 60:399/443 of query aligns to 67:412/452 of 7t3nA

query
sites
7t3nA

G

G

L

M

G

I

S

H

G

G

L

S

F

F

I

W

G

G

Y
|
Y

A

I

L

I

F

T

E

Q

V

I

P

P

S

G

N

G

V

Y

L

I

M

A

Q

S

K

R

-

L

-

A

-

N

-

R

-

V

Y

F

G

G

A

A

R

A

A

I

W

L

L

L

T

T

R

S

I

T

M

L

G

N

T

M

W

-

G

-

L

L

V

I

A

P

A

S

A

A

M

A

A

R

F

V

V

H

W

Y

N

G

D

C

T

V

S

I

F

F

Y

-

V

-

L

V

R

Q

F

I

L

L

L

Q

G

G

I

L

A

V

E

Q

A

G

G

V

F

T

F
x
Y

P

P

G

A

V

C

V

H

F

G

Y

I

F

W

T

S

Q

K

W

W

L

A

P

P

Q

P

K

L

E
|
E

R

R

G

S

K

R

A

L

V

A

A

T

V

T

F

S

L

F

G

C

G
|
G

S

S

A
x
Y

L

A

A

G

S

A

V

V

L

I

S

A

G

M

P

P

I

L

T

A

G

G

S

I

L

L

L

V

S

Q

I

Y

R

T

G

G

F

-

G

-

L

-

H

-

G

-

W

W

Q

S

W

S

M

V

F

F

L

Y

V

V

E

Y

G

G

G

S

F

F

S

G

I

M

V

V

L

W

C

-

A

Y

V

M

S

F

W

W

M

L

L

L

L

V

-

S

-

Y

K

E

S

S

R

P

I

A

R

K

D

H

A

P

S

T

W

-

L

I

T

T

A

D

E

E

Q

R

H

R

V

Y

L

I

E

E

T

E

S

S

I

I

A

G

A

E

E

S

Q

A

A

N

A

L

R

L

E

G

A

A

H

M

G

E

G

K

A

F

H

K

L

T

P

P

A

W

M

R

K

K

L

F

K

T

D

S

P

M

Q

P

I

V

L

Y

L

A

F

I

C

I

F

V

L

A

Y

N

F

F

A

C

I
x
R

Q

S

L

W

T

T

I
x
F

Y
|
Y

A

L

T

L

F

I

W

S

L

Q

P

P

T

A

I

Y

I

F

R

E

K

E

M

V

G

F

G

G

L

F

S

E

D

I

F

S

Q

K

V

V

G

G

M

M

L

L

N

S

A

A

I

V

P

P

W

H

L

L

I

V

A

M

M

T

F

I

A

I

M

V

Y

P

C

I

F

G

A

G

L

Q

L

I

S

A

A

D

K

F

W

L

R

R

F

S

Q

K

Q

Q

A

I

W

-

L

L

A

S

V

T

A

T

L

T

V

V

-

R

-

K

I

I

A

M

A

N

C

C

G

G

L

G

F

F

A

G

S

M

T

E

S

A

-

T

-

L

-

V

G

G

N

Y

P

S

V

H

L

T

S

R

F

G

V

V

A

A

I

I

C

S

F

F

-

L

-

V

S

L

A

A

I

V

G

G

F

F

K

S

A

G

A

F

A

A

S

I

L

S

F

G

W

F

P

N

I

V

P

N

Q

H

G

L

Y

D

L

I

D

A

A

P

R

R

V

Y

A

A

A

S

A

I

V

L

I

M

A

G

L

I

I

S

N

N

S

G

V

V

G

G

N

T

L

L

G

S

G

G

F

M

F

V

A

C

P

P

A

I

F

V

G

G

Y

A

L

M

Q

T

Q

K

H

N

binding (1s,3r)-1-aminocyclopentane-1,3-dicarboxylic acid: Y77 (= Y70), Y137 (≠ F128), Y165 (≠ A156), R264 (≠ I260), F268 (≠ I264), Y269 (= Y265)
binding (2R)-2-(methoxymethyl)-4-{[(25R)-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside: E152 (= E143), G163 (= G154)

Sites not aligning to the query:

binding (2R)-2-(methoxymethyl)-4-{[(25R)-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside: 12, 13

Q5Q0U0 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Solute carrier family 17 (Anion/sugar transporter), member 5; Vesicular excitatory amino acid transporter; VEAT from Rattus norvegicus (Rat) (see 2 papers)
23% identity, 57% coverage: 64:314/443 of query aligns to 113:359/495 of Q5Q0U0

query
sites
Q5Q0U0

G

G

L

S

F

F

I

Y

G

G

Y

Y

A

I

L

V

F

T

E

Q

V

I

P

P

S

G

N

G

V

Y

L

M

M

A

Q

S

K

R

Y

I

G

G

A

G

R
x
K

A

L

W

L

L

L

-

G

-

L

-

G

-

I

-

L

-

G

T

T

R

A

I

V

M

F

G

T

T

L

W

F

G

T

L

P

V

L

A

A

A

D

M

L

A

G

F

V

V

V

W

-

N

-

D

-

T

-

S

A

F

L

Y

I

V

V

L

L

R
|
R

F

A

L

L

L
x
E

G
|
G

I

L

A

G

E
|
E

A
x
G

G

V

F

T

F
|
F

P
|
P

G

A

V

M

V
x
H

F

A

Y

M

F
x
W

T

S

Q

S

W

W

L

A

P

P

Q

P

K

L

E

E

R

R

G

S

K

K

A

L

V

L

A

T

V

I

F

S

L

Y

G

A

G

G

S

A

A

Q

L

L

A

G

S

T

V

V

L

I

S

S

G

L

P

P

I

L

T

S

G

G

S

I

L

I

L

C

S

Y

I

Y

R

M

G

-

F

-

G

-

L

-

H

-

G

N

W

W

Q

T

W

Y

M

V

F

F

L

Y

V

L

E

F

G

G

G

L

F

V

S

G

I

I

V

V

L

W

C

-

A

F

V

I

S

L

W

W

M

M

L

W

L

I

K

V

S

S

R

D

I

T

R

P

D

E

A

T

-

H

S

K

W

T

L

I

T

S

A

H

E

Y

E

E

Q

K

H

E

V

Y

L

I

E

V

T
x
S

S
|
S

I
x
L

A
x
K

A
x
N

E

Q

Q

L

A

S

R

Q

E

K

A

V

H

-

G

-

A

-

H

-

L

V

P

P

A

W

M

V

K

S

L

I

L

L

K

K

D

S

P

L

Q

P

I

L

L

W

L

A

F

I

C

V

F

V

L

A

Y

H

F

F

A

S

I

Y

Q

N

L

W

T

T

I

F

Y

Y

A

T

A

L

T

L

F

T

W

L

L

L

P

P

T

T

I

Y

I

M

R

K

K

E

M

I

G

L

G

R

L

F

S

N

D

V

F

Q

Q

E

V

N

G

G

M

F

L

L

N

S

A

A

I

L

P
|
P

-

Y

-

F

-

G

-

C

W

W

L

L

I

C

A

M

M

I

F

V

A

C

M

G

Y

Q

C

A

F

A

A

D

L

Y

L

L

S

R

A

V

K

K

W

W

R

N

F

F

Q

S

K136 (≠ R87) mutation to E: Markedly decreases H(+)-coupled sialic acid transporter activity.
R168 (= R117) mutation to C: Abolishes H(+)-coupled sialic acid transporter activity.
E171 (≠ L120) mutation to C: Decreases H(+)-coupled sialic acid transporter activity; when associated with C-175.
G172 (= G121) mutation to C: Decreases protein levels and alters subcellular localization.
E175 (= E124) mutation to C: Decreases H(+)-coupled sialic acid transporter activity; when associated with C-171.
G176 (≠ A125) mutation to C: Decreases protein levels and alters subcellular localization.
F179 (= F128) mutation to C: Decreases the affinity and transport rate for D-glucuronate. Does not affect H(+)-coupled sialic acid transporter activity.
P180 (= P129) mutation to C: Decreases protein levels and alters subcellular localization.
H183 (≠ V132) mutation to R: Abolishes H(+)-coupled sialic acid transporter activity.
W186 (≠ F135) mutation to C: Abolishes H(+)-coupled sialic acid transporter activity.
SSLKN 268:272 (≠ TSIAA 222:226) mutation Missing: Abolishes H(+)-coupled sialic acid transporter activity.
P334 (= P293) mutation to R: Abolishes H(+)-coupled sialic acid transporter activity.

Sites not aligning to the query:

22:23 Dileucine internalization motif; LL→AA: Targeted to plasma membrane; sialic acid uptake strongly activated at acidic pH.
39 R→C: Markedly decreases H(+)-coupled sialic acid transporter activity.
371 G→V: Remains in the endoplasmic reticulum.

Q8BN82 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Mus musculus (Mouse) (see paper)
22% identity, 57% coverage: 64:314/443 of query aligns to 113:359/495 of Q8BN82

query
sites
Q8BN82

G

G

L

S

F

F

I

Y

G

G

Y

Y

A

I

L

V

F

T

E

Q

V

I

P

P

S

G

N

G

V

Y

L

I

M

A

Q

S

K

R

-

V

-

G

-

K

-

L

Y

L

G

G

A

L

R

G

A

I

W

L

L

G

T

T

R

S

I

V

M

F

G

T

T

L

W

F

G

T

L

P

V

L

A

A

A

D

M

L

A

G

F

V

V

V

W

-

N

-

D

-

T

-

S

T

F

L

Y

V

V

V

L

L

R

R

F

A

L

L

L

E

G

G

I

L

A

G

E

E

A

G

G

V

F

T

F

F

P

P

G

A

V

M

V
x
H

F

A

Y

M

F

W

T

S

Q

S

W

W

L

A

P

P

Q

P

K

L

E

E

R

R

G

S

K

K

A

L

V

L

A

T

V

I

F

S

L

Y

G

A

G

G

S

A

A

Q

L

L

A

G

S

T

V

V

L

I

S

S

G

L

P

P

I

L

T

S

G

G

S

I

L

I

L

C

S

Y

I

Y

R

M

G

-

F

-

G

-

L

-

H

-

G

N

W

W

Q

T

W

Y

M

V

F

F

L

Y

V

L

E

F

G

G

G

I

F

V

S

G

I

I

V

V

L

W

C

-

A

F

V

I

S

L

W

W

M

M

L

W

L

I

K

V

S

S

R

D

I

T

R

P

D

E

A

T

-

H

S

K

W

T

L

I

T

S

A

H

E

Y

E

E

Q

K

H

E

V

Y

L

I

E

V

T

S

S

S

I

L

A

K

A

N

E

Q

Q

L

A

S

R

Q

E

K

A

V

H

-

G

-

A

-

H

-

L

V

P

P

A

W

M

G

K

S

L

I

L

L

K

K

D

S

P

L

Q

P

I

L

L

W

L

A

F

I

C

V

F

V

L

A

Y

H

F

F

A

S

I

Y

Q

N

L

W

T

S

I

F

Y

Y

A

T

A

L

T

L

F

T

W

L

L

L

P

P

T

T

I

Y

I

M

R

K

K

E

M

I

G

L

G

R

L

F

S

N

D

V

F

Q

Q

E

V

N

G

G

M

F

L

L

N

S

A

A

I

L

P

P

-

Y

-

F

-

G

-

C

W

W

L

L

I

C

A

M

M

I

F

L

A

C

M

G

Y

Q

C

A

F

A

A

D

L

Y

L

L

S

R

A

V

K

K

W

W

R

N

F

F

Q

S

H183 (≠ V132) mutation to R: Abolishes sialic acid transporter activity. Does not affect L-aspartate and L-glutamate transporter activity.

Sites not aligning to the query:

39 R→C: Completely abolishes L-aspartate and L-glutamate transporter activity. Retains appreciable H(+)-coupled sialic acid transporter activity.

Q9C0U9 Uncharacterized transporter PB1C11.03 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
21% identity, 58% coverage: 51:309/443 of query aligns to 131:394/570 of Q9C0U9

query
sites
Q9C0U9

D

D

L

V

G

H

I

I

G

T

A

S

A

N

A

Q

Y

Y

G

N

L

N

G

L

S

N

G

T

L

L

F

F

F

Y

I

V

G

G

Y

Y

A

I

L

V

F

G

E

Q

V

F

P

P

S

G

N

H

V

Y

L

I

M

M

Q

Q

K

T

Y

F

G

P

A

L

R

G

A

K

W

F

L

V

T

G

R

L

I

V

M

T

G

F

T

S

W

W

G

S

L

V

V

I

A

V

A

F

A

L

M

H

A

C

F

C

V

A

W

Y

N

N

D

Y

T

G

S

G

F

L

Y

I

V

A

L

L

R

R

F

F

L

F

L

L

G

G

I

F

A

T

E

E

A

S

G

C

F

L

P

P

G

A

V

M

V

E

F

A

Y

T

F

M

T

G

Q

M

W

F

L

F

P

T

Q

H

K

Q

E

E

R

Q

G

A

K

F

A

L

V

Q

A

P

V

V

F

F

L

W

G

I

G

S

S

C

A

L

L

S

A

C

S

G

V

I

L

P

S

A

G

G

P

F

I

I

T

A

G

Y

S

G

L

L

L

E

S

F

I

V

R

T

G

K

F

-

G

S

L

I

H

A

G

P

W

W

Q

K

W

L

M

F

F

M

L

I

V

I

E

T

G

G

F

I

S

T

I

F

V

F

L

L

C

S

A

I

V

F

S

L

W

F

M

F

L

Y

K

P

S

D

R

N

I

P

R

S

D

K

A

A

S

R

W

F

L

L

T

T

A

D

E

E

Q

K

-

L

H

Y

V

T

L

I

E

D

T

R

S

V

I

R

A

K

A

S

E

T

Q

R

A

G

R

I

E

E

A

N

H

K

G

I

G

F

A

K

H

K

L

H

P

Q

A

F

M

I

K

E

L

A

L

L

K

K

D

D

P

P

Q

I

I

T

L

W

L

L

F

F

C

T

F

F

L

A

Y

A

F

F

A

T

I

L

Q

M

L

L

T

S

I

N

Y

N

A

L

A

A

T

-

F

-

W

Y

L

Q

P

Q

T

N

I

L

I

I

R

F

K

T

M

S

G

L

G

N

L

V

S

S

D

D

F

L

Q

N

V

S

G

T

M

L

L

V

-

G

-

V

-

A

-

L

-

A

-

G

-

Y

N

N

A

T

I

V

P

S

W

A

L

I

I

I

A

A

M

T

F

F

A

A

M

M

Y

Y

C

L

F

I

A

P

L

N

L

Q

S

S

A

A

Sites not aligning to the query:

14 modified: Phosphoserine

Q51955 4-hydroxybenzoate transporter PcaK from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 2 papers)
24% identity, 58% coverage: 21:279/443 of query aligns to 29:294/448 of Q51955

query
sites
Q51955

R

R

H

V

V

V

L

L

P

L

L

C

F

F

L

L

I

I

M

V

F

F

I

L

A

-

N
x
D

Y

G

I

L

D
|
D

R

T

V

A

N

A

I

M

G

G

F

F

V

I

N

A

S

P

H

A

M

L

Q

S

T

Q

D

E

L

W

G

G

I

I

G

D

A

R

A

A

A

S

Y

L

G

G

L

P

G

V

S

M

G

S

L

A

F

A

F

L

I

I

G

G

Y

M

A

V

L

F

F

G

E

A

V

L

P

G

S

S

N
x
G

V

P

L

L

M

A

Q
x
D

K

R

Y

F

G
|
G

A

R

R

K

A

G

W

V

L

L

T

V

R

G

I

A

M

V

G

L

T

V

W

F

G

G

L

G

V

F

A

S

A

L

A

A

M

S

A

A

F

Y

V

A

W

T

N

N

D

V

T

D

S

Q

F

L

Y

L

V

V

L

L

R
|
R

F

F

L

L

L

T

G

G

I

L

A

G

E

L

A

G

G

A

F

G

F

M

P

P

G

N

V

A

V

T

F

T

Y

L

F

L

T

S

Q
x
E

W

Y

L

T

P

P

Q

E

K

R

E

L

R

K

G

S

K

L

A

L

V

V

A

T

V

S

F

M

L

F

G

C

G

G

S

F

A

N

L

L

A

-

S

-

V

-

L

-

S

-

G

G

P

M

I

A

T

G

G

G

S

G

L

F

L

I

S

S

I

A

R

K

G

M

F

I

G

P

L

A

H

Y

G

G

W

W

Q
x
H

W

S

M

L

F

L

L

V

V

I

E

G

G

G

G

V

F

L

S

P

I

L

V

L

L

L

C

A

A

L

V

V

S

L

W

M

M

V

L

W

L

L

K

P

S

E

R

S

I

A

R

R

D

F

A

L

S

V

W

V

L

R

T

N

A

R

E

G

E

T

Q

D

H

K

V

I

L

R

E

K

T

T

-

L

S

S

I

P

A

I

A

A

E

P

Q

Q

A

V

R

A

E

E

A

A

H

-

G

G

G

S

A

F

H

S

L

V

P

P

A

E

M

Q

K

K

L

A

L

V

K

A

D

A

P

R

Q

S

I

V

-

F

-

A

-

V

-

I

-

F

-

S

-

G

-

T

-

Y

-

G

-

L

-

G

-

T

L

M

L

L

F

L

C

W

F

L

L

T

Y

Y

F

F

A

M

I

G

Q

L

L

V

T

I

I

V

Y

Y

A

L

T

T

F

S

W

W

L

L

P

P

T

T

I

L

I

M

R

R

K

D

M

S

G

G

D41 (≠ N34) mutation D->A,N: Abolishes 4-HBA transport.; mutation to E: Decrease in 4-HBA transport.
D44 (= D37) mutation D->A,N: Abolishes 4-HBA transport.; mutation to E: Decrease in 4-HBA transport.
G85 (≠ N78) mutation to V: Abolishes 4-HBA transport and chemotaxis.
D89 (≠ Q82) mutation to N: Abolishes 4-HBA transport and chemotaxis.
G92 (= G85) mutation to A: Decrease in 4-HBA transport and chemotaxis.; mutation to C: No change in 4-HBA transport and chemotaxis.; mutation G->L,V: Abolishes 4-HBA transport and chemotaxis.; mutation to Q: Decrease in 4-HBA transport and strong decrease in chemotaxis.
R124 (= R117) mutation to A: Abolishes 4-HBA transport.
E144 (≠ Q137) mutation to A: Strong decrease in 4-HBA transport.
H183 (≠ Q181) mutation to A: Decrease in 4-HBA transport and chemotaxis.

Sites not aligning to the query:

323 D→N: Abolishes 4-HBA transport and chemotaxis.
328 H→A: Decrease in 4-HBA transport and chemotaxis.; H→R: Decrease in 4-HBA transport and loss of chemotaxis.
386 R→A: Strong decrease in 4-HBA transport.
398 R→A: Abolishes 4-HBA transport.
444 H→A: No change in 4-HBA transport and chemotaxis.

Q5EXK5 3-hydroxybenzoate transporter MhbT from Klebsiella oxytoca (see paper)
23% identity, 45% coverage: 80:279/443 of query aligns to 80:285/452 of Q5EXK5

query
sites
Q5EXK5

L

L

M

S

Q
x
D

K

R

Y

F

G

G

A

R

R

K

A

R

W

V

L

I

T

E

R

F

I

C

M

V

G

A

T

L

W

F

G

G

L

L

V

F

A

S

A

L

M

S

A

A

F

F

V

A

W

P

N

D

D

L

T

Q

S

M

F

L

Y

V

V

F

L

L

R

R

F

F

L

L

L

T

G

G

I

L

A

G

E

L

A

G

G

G

F

A

F

M

P

P

G

N

V

T

V

I

F

T

Y

M

F

T

T

S

Q

E

W

Y

L

L

P

P

Q

A

K

R

E

R

R

R

G

G

K

A

A

L

V

V

A

T

V

L

F

M

L

F

G

C

G

G

S

F

A

T

L

L

A

G

S

S

V

A

L

F

S

G

G

G

P

V

I

V

T

S

G

A

S

Q

L

L

L

V

S

P

I

-

R

-

G

-

F

-

G

-

L

L

H

I

G

G

W

W

Q

H

W

G

M

I

F

L

L

V

V

L

E

G

G

G

G

V

F

L

S

P

I

L

V

I

L

L

C

A

A

V

V

A

S

L

W

V

M

P

L

L

K

P

S

E

R

S

I

P

R

R

D

-

A

-

S

-

W

W

L

Q

T

I

A

R

E

R

E

Q

-

L

-

P

Q

Q

H

A

V

T

L

I

E

A

T

R

S

T

I

V

A

G

A

A

E

I

Q

T

A

G

A

E

R

R

-

Y

-

N

-

D

-

T

-

H

-

F

-

W

-

L

-

D

E

E

A

P

H

A

G

A

G

G

A

A

H

K

L

G

P

S

A

I

M

S

K

Q

L

L

L

F

K

A

D

G

P

R

Q

Q

I

L

-

A

-

I

-

T

L

L

L

M

F

L

C

W

F

V

L

V

Y

F

F

F

A

M

I

S

Q

L

L

L

T

I

I

I

Y

Y

A

L

T

S

F

S

W

W

L

M

P

P

T

T

I

L

R

N

K

H

M

R

G

G

D82 (≠ Q82) mutation to A: Loss of activity.

Sites not aligning to the query:

311 V→W: Loss of activity.
314 D→A: Loss of activity.

Q9Y2C5 Probable small intestine urate exporter; Solute carrier family 17 member 4 from Homo sapiens (Human) (see 2 papers)
23% identity, 44% coverage: 115:308/443 of query aligns to 168:352/497 of Q9Y2C5

query
sites
Q9Y2C5

V

V

L

L

R

R

F

I

L

V

L

Q

G

G

I

I

A

A

E

Q

A

V

G

M

F

V

F

L

P

T

G

G

V

Q

V

Y

F

S

Y

I

F

W

T

V

Q

K

W

W

L

A

P

P

Q

P

K

L

E

E

R

R

G

S

K

Q

A

L

V

T

A

T

V

I

F

A

L

G

G

S

G

G

S

S

A

M

L

L

A

G

S

S

V

F

L

I

S

V

G

L

P

-

I

L

T

A

G

G

S

G

L

L

S

C

I

-

R

-

G

-

F

-

G

Q

L

T

H

I

G

G

W

W

Q

P

W

Y

M

V

F

F

L

Y

V

I

E

F

G

G

F

I

S

G

I

C

V

A

L

C

C

C

A

P

V

L

S

W

W

F

M

P

L

L

L

I

K

Y

S

D

R

D

I

P

R

V

D

N

A

H

S

P

W

F

L

I

T

S

A

A

E

G

E

E

Q

K

H

R

V

Y

L

I

E

V

T

C

S

S

I

L

A

A

A

Q

E

Q

Q

-

A

-

R

-

E

D

A

C

H

S

G

P

G

G

A

W

H

S

L

L

P

P

A

I

M

R

K

A

L

M

L

I

K

K

D

S

P

L

Q

P

I

L

L

W

L

A

F

I

C

L

F

V

L

S

Y

Y

F

F

A

C

I

E

Q

Y

L

W

T

L

I

F

Y

Y

A

T

A

I

T

M

F

A

W

Y

L

T

P

P

T

T

I

Y

I

I

R

S

K

S

M

V

G

L

G

Q

L

A

S

N

D

L

F

R

Q

D

V

S

G

G

M

I

L

L

N

S

A

A

I

L

P

P

W

F

L

V

I

V

A

G

M

C

F

I

A

C

M

I

Y

I

C

L

F

G

A

G

L

L

S

A

Sites not aligning to the query:

66 modified: carbohydrate, N-linked (GlcNAc...) asparagine; N→A: Loss of glycosylation and significant reduction in the tranport of thyroid hormones T3 and T4; when associated with A-75 and A-90.
75 modified: carbohydrate, N-linked (GlcNAc...) asparagine; N→A: Loss of glycosylation and significant reduction in the tranport of thyroid hormones T3 and T4; when associated with A-66 and A-90.
90 modified: carbohydrate, N-linked (GlcNAc...) asparagine; N→A: Loss of glycosylation and significant reduction in the tranport of thyroid hormones T3 and T4; when associated with A-75 and A-90.
372 A → T: in dbSNP:rs11754288

Q9GQQ0 Protein spinster; Protein benchwarmer; Protein diphthong from Drosophila melanogaster (Fruit fly) (see paper)
26% identity, 47% coverage: 14:223/443 of query aligns to 107:307/605 of Q9GQQ0

query
sites
Q9GQQ0

S

S

A

S

V

V

S

G

K

R

V

S

K

Q

R

W

H

F

V

T

L

V

P

T

L

V

F

L

L

C

I

F

M

V

F

N

I

L

A

I

N

N

Y

Y

I

M

D

D

R

R

V

F

N

T

I

I

G

A

F

G

V

V

N

L

S

T

H

D

M

V

Q

R

T

N

D

D

L

F

G

D

I

I

G

G

A

N

A

D

A

S

Y

A

G

G

L

L

G

L

S

Q

G

T

L

V

F

F

F

V

I

I

G

S

Y

Y

A

M

L

V

F

C

E

A

V

P

P

I

S

F

N

G

V

Y

L

L

M

G

Q

D

K

R

Y

Y

G

-

A

S

R

R

A

P

W

W

L

I

T

M

R

A

I

V

-

G

M

V

G

G

T

L

W

W

G

S

L

T

V

T

A

T

A

L

M

G

A

S

F

F

V

M

W

K

N

Q

D

F

T

G

S

W

F

F

Y

I

V

A

L

F

R

R

F

A

L

L

L

V

G

G

I

I

A

G

E
|
E

A

A

G

S

F

Y

F

S

P

T

G

I

V

A

V

P

F

T

Y

I

F

I

T

S

Q

D

W

L

L

F

P

V

Q

H

K

D

E

M

R

R

G

S

K

K

A

M

V

L

A

A

V

L

F

F

L

Y

G

F

G

A

S

I

A

P

L

V

A

G

S

S

V

G

L

L

S

-

G

G

P

Y

I

I

T

V

G

G

S

S

L

K

L

T

S

A

I

H

R

L

G

A

F

-

G

-

L

-

H

N

G

D

W

W

Q

R

W

W

M

A

F

L

L

R

V

V

E

T

G

P

G

I

F

L

S

G

I

I

V

V

L

-

C

-

A

A

V

V

S

F

W

L

M

I

L

L

K

-

S

-

R

-

I

I

R

K

D

D

A

P

S

V

W

R

L

G

T

H

A

S

E

E

E

G

Q

S

H

H

V

N

L

L

E

E

T

A

S

T

E217 (= E124) mutation to K: In bnch(N); leads to storage in yolk spheres during oogenesis and results in widespread accumulation of enlarged lysosomal and late endosomal inclusions.

Query Sequence

>BPHYT_RS20405 FitnessBrowser__BFirm:BPHYT_RS20405
MTSALTTAADPLESAVSKVKRHVLPLFLIMFIANYIDRVNIGFVNSHMQTDLGIGAAAYG
LGSGLFFIGYALFEVPSNVLMQKYGARAWLTRIMGTWGLVAAAMAFVWNDTSFYVLRFLL
GIAEAGFFPGVVFYFTQWLPQKERGKAVAVFLGGSALASVLSGPITGSLLSIRGFGLHGW
QWMFLVEGGFSIVLCAVSWMLLKSRIRDASWLTAEEQHVLETSIAAEQAAREAHGGAHLP
AMKLLKDPQILLFCFLYFAIQLTIYAATFWLPTIIRKMGGLSDFQVGMLNAIPWLIAMFA
MYCFALLSAKWRFQQAWLAVALVIAACGLFASTSGNPVLSFVAICFSAIGFKAAASLFWP
IPQGYLDARVAAAVIALINSVGNLGGFFAPAAFGYLQQHTGSITGGLYGLAVASLIAAAA
GFLTRNRRVNHDALPESLQHKVH

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory