SitesBLAST
Comparing BPHYT_RS20915 FitnessBrowser__BFirm:BPHYT_RS20915 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 15 hits to proteins with known functional sites (download)
P77324 Aldehyde oxidoreductase FAD-binding subunit PaoB; EC 1.2.99.6 from Escherichia coli (strain K12) (see paper)
50% identity, 99% coverage: 1:332/335 of query aligns to 1:316/318 of P77324
- 26:34 (vs. 32:40, 67% identical) binding
- T108 (= T114) binding
- C119 (= C125) binding
- C129 (= C135) binding
- C138 (= C144) binding
- C157 (= C163) binding
- D164 (= D170) binding
- I213 (= I218) binding
- K230 (= K236) binding
5g5gB Escherichia coli periplasmic aldehyde oxidase (see paper)
50% identity, 99% coverage: 1:332/335 of query aligns to 1:316/316 of 5g5gB
- binding flavin-adenine dinucleotide: K26 (≠ R32), F27 (= F33), A29 (= A35), G30 (= G36), G31 (= G37), T32 (= T38), N33 (≠ T39), L34 (= L40), G98 (= G104), A99 (= A105), L103 (= L109), A107 (= A113), T108 (= T114), A110 (≠ G116), G111 (= G117), N112 (= N118), L114 (= L120), Q115 (= Q121), S163 (= S169), D164 (= D170), L212 (= L217), I213 (= I218), F239 (= F245)
- binding iron/sulfur cluster: C119 (= C125), C129 (= C135), N130 (= N136), K131 (= K137), C138 (= C144), H148 (≠ L154), C157 (= C163), I158 (= I164), A159 (= A165)
5y6qB Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
47% identity, 91% coverage: 26:330/335 of query aligns to 21:326/330 of 5y6qB
- binding flavin-adenine dinucleotide: I26 (≠ V31), A28 (= A35), G29 (= G36), G30 (= G37), T31 (= T38), T32 (= T39), Q33 (≠ L40), A97 (≠ G104), A98 (= A105), I102 (≠ L109), A106 (= A113), T107 (= T114), G110 (= G117), N111 (= N118), R113 (≠ L120), Q114 (= Q121), G164 (≠ S169), D165 (= D170), I213 (≠ L217), I214 (= I218), K232 (= K236), F241 (= F245)
- binding iron/sulfur cluster: C118 (= C125), Y121 (≠ F128), C130 (= C135), N131 (= N136), C139 (= C144), A141 (= A146), C158 (= C163), I159 (= I164), A160 (= A165)
O33820 4-hydroxybenzoyl-CoA reductase subunit beta; 4-HBCR subunit beta; EC 1.1.7.1 from Thauera aromatica (see paper)
32% identity, 87% coverage: 4:293/335 of query aligns to 7:280/324 of O33820
- 29:36 (vs. 26:40, 33% identical) binding
- T111 (= T114) binding
- N115 (= N118) binding
- Q118 (= Q121) binding
- D162 (= D170) binding
- K224 (= K236) binding
1rm6B Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
32% identity, 87% coverage: 4:293/335 of query aligns to 7:280/323 of 1rm6B
- binding flavin-adenine dinucleotide: P29 (≠ Q26), G31 (= G28), A32 (= A29), G33 (= G37), T34 (= T38), D35 (≠ T39), L36 (= L40), L53 (≠ I57), V101 (≠ G104), A102 (= A105), A110 (= A113), T111 (= T114), G114 (= G117), N115 (= N118), C117 (≠ L120), Q118 (= Q121), D162 (= D170), L207 (≠ I218), V231 (≠ Y243), D232 (≠ E244), F233 (= F245)
- binding iron/sulfur cluster: C122 (= C125), F124 (≠ Y127), C138 (= C144), C146 (≠ L154), H147 (≠ A155), V148 (≠ I156), C155 (= C163), Y156 (≠ I164), A157 (= A165)
1ffuC Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
29% identity, 75% coverage: 20:271/335 of query aligns to 17:219/287 of 1ffuC
- binding flavin-adenine dinucleotide: K29 (≠ R32), L30 (≠ F33), A32 (= A35), G33 (= G36), G34 (= G37), H35 (≠ T38), S36 (≠ T39), L37 (= L40), I54 (= I57), I101 (≠ G104), A102 (= A105), G110 (≠ A113), T111 (= T114), G114 (= G117), D115 (≠ N118), A117 (≠ L120), N123 (≠ S142), D124 (≠ G143), L161 (= L212), V166 (≠ L217), M167 (≠ I218), W193 (≠ F245)
Q0QLF4 Nicotinate dehydrogenase FAD-subunit; NDH; Nicotinic acid hydroxylase FAD-subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see paper)
27% identity, 76% coverage: 34:288/335 of query aligns to 30:240/296 of Q0QLF4
Sites not aligning to the query:
3hrdG Crystal structure of nicotinate dehydrogenase (see paper)
27% identity, 76% coverage: 34:288/335 of query aligns to 30:240/292 of 3hrdG
- binding flavin-adenine dinucleotide: A31 (= A35), G32 (= G36), G33 (= G37), T34 (= T38), D35 (≠ T39), F77 (≠ N81), V100 (≠ G104), G101 (≠ A105), I105 (≠ L109), T110 (= T114), G113 (= G117), N114 (= N118), S116 (= S160), T117 (≠ D161), G122 (≠ S169), D123 (= D170), I168 (≠ L217), M169 (≠ I218)
Sites not aligning to the query:
4zohB Crystal structure of glyceraldehyde oxidoreductase (see paper)
26% identity, 90% coverage: 26:327/335 of query aligns to 22:273/274 of 4zohB
- active site: Y256 (vs. gap)
- binding flavin-adenine dinucleotide: R28 (= R32), P29 (≠ F33), A31 (= A35), G32 (= G36), G33 (= G37), H34 (≠ T38), S35 (≠ T39), L36 (= L40), H77 (≠ N81), I95 (≠ G104), G96 (≠ A105), V100 (≠ L109), T105 (= T114), G108 (= G117), S109 (≠ N118), S111 (≠ N136), A117 (≠ S142), D118 (≠ G143), L160 (= L217), V161 (≠ I218), D185 (≠ E244), F186 (= F245)
7dqxE Crystal structure of xanthine dehydrogenase family protein
26% identity, 78% coverage: 25:285/335 of query aligns to 22:234/293 of 7dqxE
- binding flavin-adenine dinucleotide: K29 (≠ R32), I30 (≠ F33), I31 (≠ L34), G33 (= G36), G34 (= G37), Q35 (≠ T38), S36 (≠ T39), L37 (= L40), H78 (≠ N81), I101 (≠ G104), A102 (= A105), I106 (≠ L109), G110 (≠ A113), T111 (= T114), G113 (= G116), G114 (= G117), S115 (≠ N118), A117 (≠ L120), A123 (≠ S169), E124 (≠ D170), I167 (= I218), Y193 (≠ F245)
P19920 Carbon monoxide dehydrogenase medium chain; CO dehydrogenase subunit M; CO-DH M; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
26% identity, 92% coverage: 4:311/335 of query aligns to 6:259/288 of P19920
1n5wC Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
26% identity, 92% coverage: 4:312/335 of query aligns to 6:260/287 of 1n5wC
1t3qC Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
23% identity, 89% coverage: 32:329/335 of query aligns to 28:273/285 of 1t3qC
- binding flavin-adenine dinucleotide: I29 (≠ F33), A31 (= A35), G32 (= G36), G33 (= G37), Q34 (≠ T38), S35 (≠ T39), L36 (= L40), V100 (≠ G104), A101 (= A105), V105 (≠ L109), T110 (= T114), G113 (= G117), S114 (≠ N118), A116 (≠ L120), A122 (≠ S169), E123 (≠ D170), L166 (≠ I218), Y190 (= Y243)
2w54A Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus in complex with bound inhibitor pterin-6-aldehyde (see paper)
25% identity, 76% coverage: 33:287/335 of query aligns to 189:391/450 of 2w54A
- binding flavin-adenine dinucleotide: L189 (≠ F33), A191 (= A35), G192 (= G36), G193 (= G37), T194 (= T38), D195 (≠ T39), V196 (≠ L40), W199 (≠ L43), L213 (≠ I57), F258 (≠ G104), A259 (= A105), A267 (= A113), T268 (= T114), G271 (= G117), N272 (= N118), A274 (≠ C135), N275 (= N136), G280 (= G141), D281 (≠ S142), R318 (≠ L212), V324 (≠ I218), Q347 (≠ Y243)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 42
- binding fe2/s2 (inorganic) cluster: 38, 39, 40, 42, 44, 45, 47, 63, 103, 104, 106, 134, 135, 136
- binding {[(5aR,8R,9aR)-2-amino-4-oxo-6,7-di(sulfanyl-kappaS)-3,5,5a,8,9a,10-hexahydro-4H-pyrano[3,2-g]pteridin-8-yl]methyl dihydrogenato(2-) phosphate}(hydroxy)oxo(thioxo)molybdenum: 102, 136
1jroA Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus (see paper)
25% identity, 76% coverage: 33:287/335 of query aligns to 189:391/450 of 1jroA
- binding flavin-adenine dinucleotide: L189 (≠ F33), A191 (= A35), G192 (= G36), G193 (= G37), T194 (= T38), D195 (≠ T39), V196 (≠ L40), F258 (≠ G104), A259 (= A105), T268 (= T114), G271 (= G117), N272 (= N118), A274 (≠ C135), G280 (= G141), D281 (≠ S142), R318 (≠ L212), V324 (≠ I218)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 42, 43
- binding fe2/s2 (inorganic) cluster: 37, 38, 39, 40, 42, 44, 45, 47, 63, 103, 106, 134, 136
Query Sequence
>BPHYT_RS20915 FitnessBrowser__BFirm:BPHYT_RS20915
MEIFQLSRANGVRDAITAGATSATAQQGAQVRFLAGGTTLLDLMKLNVEQPTQVIDISRL
PLDRIEALPDGGVKIGATARNADLALHPLIRAPYAVLSQALLAGASAQLRNMATTGGNLL
QRTRCVYFRDTAMPCNKREPGSGCPAIQGFNRTLAILGASDACIATNPSDMNVALTALDA
TIHVEGTGGARSIAIDDFFVLPGTTPQRENVLDAGDLITHVTLPPLPAGARSVYLKLRDR
ASYEFALASAAVVVTLDGGRIGHVRVALGGVGTRPWHALEAEAVLRGAAPDAATFRKAAD
AALANAKPQSQNGFKVELARRCIVHALTQATAATP
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory