Comparing BPHYT_RS21005 FitnessBrowser__BFirm:BPHYT_RS21005 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6wywA Crystal structure of pseudomonas 7a glutaminase-asparaginase in complex with l-asp at ph 4.5
47% identity, 99% coverage: 5:330/330 of query aligns to 2:317/317 of 6wywA
6wyyA Crystal structure of pseudomonas 7a glutaminase-asparaginase in complex with l-glu at ph 6.5
46% identity, 99% coverage: 5:330/330 of query aligns to 3:315/315 of 6wyyA
P10182 Glutaminase-asparaginase; L-ASNase/L-GLNase; L-asparagine/L-glutamine amidohydrolase; PGA; EC 3.5.1.38 from Pseudomonas sp. (strain ATCC 29598 / 7A) (see paper)
49% identity, 99% coverage: 5:330/330 of query aligns to 10:337/337 of P10182
4pgaA Glutaminase-asparaginase from pseudomonas 7a (see paper)
48% identity, 99% coverage: 5:330/330 of query aligns to 3:330/330 of 4pgaA
1djpA Crystal structure of pseudomonas 7a glutaminase-asparaginase with the inhibitor don covalently bound in the active site (see paper)
48% identity, 99% coverage: 5:330/330 of query aligns to 3:330/330 of 1djpA
1djoA Crystal structure of pseudomonas 7a glutaminase-asparaginase with the inhibitor donv covalently bound in the active site (see paper)
48% identity, 99% coverage: 5:330/330 of query aligns to 3:330/330 of 1djoA
6wyzA Crystal structure of pseudomonas 7a glutaminase-asparaginase (mutant k173m) in complex with d-glu at ph 5.5
45% identity, 99% coverage: 5:330/330 of query aligns to 2:312/312 of 6wyzA
2wltA The crystal structure of helicobacter pylori l-asparaginase at 1.4 a resolution (see paper)
43% identity, 98% coverage: 7:330/330 of query aligns to 4:326/326 of 2wltA
5k45A Wolinella succinogenes l-asparaginase p121 + l-glutamic acid (see paper)
42% identity, 99% coverage: 4:330/330 of query aligns to 1:328/328 of 5k45A
5k3oA Wolinella succinogenes l-asparaginase p121 and l-aspartic acid (see paper)
42% identity, 99% coverage: 4:330/330 of query aligns to 1:328/328 of 5k3oA
1hg0A X-ray structure of the complex between erwinia chrysanthemi l- asparaginase and succinic acid (see paper)
45% identity, 98% coverage: 6:330/330 of query aligns to 6:327/327 of 1hg0A
1jsrA Crystal structure of erwinia chrysanthemi l-asparaginase complexed with 6-hydroxy-l-norleucine (see paper)
45% identity, 98% coverage: 6:330/330 of query aligns to 3:324/324 of 1jsrA
1jslA Crystal structure of erwinia chrysanthemi l-asparaginase complexed with 6-hydroxy-d-norleucine (see paper)
45% identity, 98% coverage: 6:330/330 of query aligns to 3:324/324 of 1jslA
P06608 L-asparaginase; L-ASNase; L-asparagine amidohydrolase; EC 3.5.1.1 from Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi) (see 2 papers)
45% identity, 98% coverage: 6:330/330 of query aligns to 27:348/348 of P06608
2gvnA L-asparaginase from erwinia carotovora in complex with aspartic acid (see paper)
45% identity, 98% coverage: 6:330/330 of query aligns to 4:325/325 of 2gvnA
7u6mC Albumin binding domain fused to a mutant of the erwinia asparaginase (see paper)
45% identity, 98% coverage: 6:330/330 of query aligns to 21:342/342 of 7u6mC
P00805 L-asparaginase 2; L-asparaginase II; L-ASNase II; L-asparagine amidohydrolase II; Colaspase; EC 3.5.1.1 from Escherichia coli (strain K12) (see 5 papers)
41% identity, 93% coverage: 23:330/330 of query aligns to 41:348/348 of P00805
Sites not aligning to the query:
1hg1A X-ray structure of the complex between erwinia chrysanthemi l-asparaginase and d-aspartate (see paper)
44% identity, 98% coverage: 6:330/330 of query aligns to 3:306/306 of 1hg1A
1hfwA X-ray structure of the complex between erwinia chrysanthemi l-asparaginase and l-glutamate (see paper)
44% identity, 98% coverage: 6:330/330 of query aligns to 4:307/307 of 1hfwA
2hlnA L-asparaginase from erwinia carotovora in complex with glutamic acid (see paper)
43% identity, 98% coverage: 6:330/330 of query aligns to 4:308/308 of 2hlnA
>BPHYT_RS21005 FitnessBrowser__BFirm:BPHYT_RS21005
MTAKANIVVIGTGGTIAGQGKASVNTSTYMCSVLGIDEILGSIPHAGELANLRAEQLLQT
GSENFNNTHLLAIGNRVAELLARNDVDGVVITHGTDTIEETAYFLHLTLKSAKPVVVVGS
MRPPSAMSSDAALNLYDALAVATHPSSRGLGTLVVANNEIHTARDVVKSNSFKLDAFRSP
YGALGYVIEGAPRYYRRPARAHTLDTPWSITTLRSLPKVDIVYAYGALEPGAISAITANA
RGLIYVGTGNGNVASHLIDPLRDAARRGVHVVRASRTGSGIVLHNGAQPDHEYGWLTVDD
QIPQKARILLTLALTQTDDTAALQAVFERY
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory