Comparing BPHYT_RS21555 FitnessBrowser__BFirm:BPHYT_RS21555 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q9A3Q9 Omega-aminotransferase; Beta-alanine--pyruvate aminotransferase; EC 2.6.1.-; EC 2.6.1.18 from Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus) (see paper)
66% identity, 98% coverage: 8:442/442 of query aligns to 7:439/439 of Q9A3Q9
4uhmA Characterization of a novel transaminase from pseudomonas sp. Strain aac (see paper)
52% identity, 98% coverage: 9:441/442 of query aligns to 3:434/435 of 4uhmA
Q9I700 Beta-alanine--pyruvate aminotransferase; Beta-A--Py AT; Beta-alanine--pyruvate transaminase; Omega-amino acid aminotransferase; Omega-amino acid AT; Omega-amino acid--pyruvate aminotransferase; Omega-APT; EC 2.6.1.18 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
52% identity, 98% coverage: 9:441/442 of query aligns to 16:447/448 of Q9I700
4b98A The structure of the omega aminotransferase from pseudomonas aeruginosa (see paper)
52% identity, 97% coverage: 9:438/442 of query aligns to 9:437/441 of 4b98A
3a8uX Crystal structure of omega-amino acid:pyruvate aminotransferase
50% identity, 97% coverage: 10:438/442 of query aligns to 9:437/441 of 3a8uX
3i5tA Crystal structure of aminotransferase prk07036 from rhodobacter sphaeroides kd131
40% identity, 91% coverage: 24:427/442 of query aligns to 22:423/444 of 3i5tA
Sites not aligning to the query:
6gwiB The crystal structure of halomonas elongata amino-transferase (see paper)
35% identity, 94% coverage: 16:432/442 of query aligns to 17:436/450 of 6gwiB
5lhaA Amine transaminase crystal structure from an uncultivated pseudomonas species in the pmp-bound form
39% identity, 94% coverage: 11:426/442 of query aligns to 8:431/447 of 5lhaA
5lh9D Amine transaminase crystal structure from an uncultivated pseudomonas species in the plp-bound (internal aldimine) form
39% identity, 94% coverage: 11:426/442 of query aligns to 10:433/449 of 5lh9D
7qx3A Structure of the transaminase tr2e2 with eos (see paper)
34% identity, 91% coverage: 28:431/442 of query aligns to 2:407/422 of 7qx3A
5kr5A Directed evolution of transaminases by ancestral reconstruction. Using old proteins for new chemistries
37% identity, 91% coverage: 28:430/442 of query aligns to 31:441/455 of 5kr5A
Sites not aligning to the query:
6fyqA The crystal structure of a new transaminase from the marine bacterium virgibacillus (see paper)
34% identity, 98% coverage: 9:442/442 of query aligns to 7:439/443 of 6fyqA
6io1B Crystal structure of a novel thermostable (s)-enantioselective omega- transaminase from thermomicrobium roseum (see paper)
35% identity, 99% coverage: 6:441/442 of query aligns to 9:446/448 of 6io1B
7ypmA Crystal structure of transaminase cc1012 complexed with plp and l- alanine (see paper)
34% identity, 93% coverage: 24:434/442 of query aligns to 27:440/454 of 7ypmA
5kr3A Directed evolution of transaminases by ancestral reconstruction. Using old proteins for new chemistries
35% identity, 91% coverage: 28:430/442 of query aligns to 34:442/458 of 5kr3A
6s4gA Crystal structure of the omega transaminase from chromobacterium violaceum in complex with pmp (see paper)
33% identity, 94% coverage: 16:431/442 of query aligns to 16:434/453 of 6s4gA
7q9xAAA Probable aminotransferase
33% identity, 94% coverage: 16:431/442 of query aligns to 17:435/455 of 7q9xAAA
4a6tC Crystal structure of the omega transaminase from chromobacterium violaceum in complex with plp (see paper)
33% identity, 94% coverage: 16:431/442 of query aligns to 17:435/455 of 4a6tC
7qx0B Transaminase structure of plurienzyme (tr2e2) in complex with plp (see paper)
32% identity, 94% coverage: 16:431/442 of query aligns to 16:428/443 of 7qx0B
4a6rA Crystal structure of the omega transaminase from chromobacterium violaceum in the apo form, crystallised from polyacrylic acid (see paper)
33% identity, 91% coverage: 28:431/442 of query aligns to 1:403/423 of 4a6rA
>BPHYT_RS21555 FitnessBrowser__BFirm:BPHYT_RS21555
MTSRPVIDDLSSFWMPFTANRQFKAAPRLLESAKGMYYRSTDGREVLDGCAGLWCVNAGH
GREEIVAAITEQLSTLDFAPTFQMGHPLAFEAATKVAELMPEGLDRIFFTNSGSESVDTA
LKIALAYHRSRGEGQRTRLIGRERGYHGVGFGGISVGGIAPNRKTFSGALLPAVDHLPHT
HNLEHNAFTKGQPAWGAHLAEELERIVTLHDASTIAAVIVEPVAGSTGVLIPPQGYLQKL
REICTKHGILLIFDEVITAFGRVGKATASEYFGVTPDLITMAKAINNAAIPMGAVAASRT
IHDSIVNGGAQGAIELFHGYTYSAHPVATAAAVATLDLYKREGLFERAATLAPTFEAAAH
SLRGAKHVKDVRNLGMIAGVELESRDGAPGARAYEAFVKCFEAGVLVRFTGDILAFSPPL
IINEEQIAHIFKTVGDVLATVQ
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory