SitesBLAST
Comparing BPHYT_RS21705 FitnessBrowser__BFirm:BPHYT_RS21705 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
28% identity, 90% coverage: 23:570/610 of query aligns to 8:544/595 of 1t9bB
- active site: Y29 (≠ I44), G31 (= G46), G32 (≠ S47), A33 (= A48), I34 (≠ F49), E55 (= E69), T78 (≠ Q92), F117 (= F131), Q118 (= Q132), E119 (= E133), K167 (≠ R180), R226 (≠ E235), M262 (≠ Y271), V289 (vs. gap), V405 (≠ I431), L430 (≠ W456), G431 (= G457), M433 (≠ C459), D458 (= D484), N485 (= N511), E487 (≠ Q513), Q488 (≠ W514), M490 (≠ A516), V491 (≠ E517), W494 (≠ N520), L516 (≠ I542), G521 (= G547), L522 (≠ A548)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (≠ A121), P108 (≠ G122), D287 (≠ P296), R288 (vs. gap), M490 (≠ A516), W494 (≠ N520)
- binding flavin-adenine dinucleotide: R157 (≠ E170), G215 (= G225), A216 (≠ G226), G217 (= G227), N220 (vs. gap), T242 (≠ S251), L243 (≠ Y252), Q244 (≠ L253), M259 (≠ P268), L260 (= L269), M262 (≠ Y271), H263 (≠ Q272), G282 (= G291), A283 (≠ S292), R284 (= R293), D286 (≠ G295), R288 (vs. gap), V289 (vs. gap), E315 (≠ D318), V316 (≠ A319), N320 (≠ M323), G333 (= G336), D334 (= D337), A335 (= A338), Q409 (≠ N435), M410 (≠ S436), G428 (≠ M454), G429 (≠ S455)
- binding magnesium ion: D458 (= D484), N485 (= N511), E487 (≠ Q513)
Sites not aligning to the query:
6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
26% identity, 93% coverage: 23:587/610 of query aligns to 14:563/601 of 6deqA
- active site: Y35 (≠ I44), G37 (= G46), G38 (≠ S47), A39 (= A48), I40 (≠ F49), E61 (= E69), T84 (≠ Q92), F123 (= F131), Q124 (= Q132), E125 (= E133), K173 (≠ R180), K232 (≠ E235), M268 (≠ Y271), V295 (≠ G298), V411 (≠ I431), L436 (≠ W456), G437 (= G457), M439 (≠ C459), D464 (= D484), N491 (= N511), E493 (≠ Q513), Q494 (≠ W514), M496 (≠ A516), V497 (≠ E517), W500 (≠ N520), L522 (≠ I542), N527 (≠ G547), V528 (≠ A548)
- binding flavin-adenine dinucleotide: R163 (≠ E170), G221 (= G225), A222 (≠ G226), G223 (= G227), N226 (≠ M230), T248 (≠ S251), L249 (≠ Y252), Q250 (≠ L253), L266 (= L269), G288 (= G291), A289 (≠ S292), R290 (= R293), D292 (≠ G295), R294 (≠ F297), V295 (≠ G298), E321 (≠ D318), I322 (≠ A319), D340 (= D337), V341 (≠ A338), M416 (≠ S436), G434 (≠ M454)
- binding magnesium ion: D464 (= D484), N491 (= N511), E493 (≠ Q513)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (≠ Y271), R294 (≠ F297), M496 (≠ A516), V497 (≠ E517), W500 (≠ N520)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (≠ I431), G412 (= G432), Q413 (≠ N433), H414 (≠ I434), M439 (≠ C459), G463 (= G483), D464 (= D484), A465 (≠ G485), S466 (≠ A486), N491 (= N511), E493 (≠ Q513), Q494 (≠ W514), G495 (= G515), M496 (≠ A516), V497 (≠ E517)
Sites not aligning to the query:
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
27% identity, 90% coverage: 23:570/610 of query aligns to 9:546/597 of 1t9aA
- active site: Y30 (≠ I44), G32 (= G46), G33 (≠ S47), A34 (= A48), I35 (≠ F49), E56 (= E69), T79 (≠ Q92), F118 (= F131), Q119 (= Q132), E120 (= E133), K168 (≠ R180), R228 (≠ E235), M264 (≠ Y271), V291 (vs. gap), V407 (≠ I431), L432 (≠ W456), G433 (= G457), M435 (≠ C459), D460 (= D484), N487 (= N511), E489 (≠ Q513), Q490 (≠ W514), M492 (≠ A516), V493 (≠ E517), W496 (≠ N520), L518 (≠ I542), G523 (= G547), L524 (≠ A548)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (≠ S47), V108 (≠ A121), P109 (≠ G122), F118 (= F131), K168 (≠ R180), M264 (≠ Y271), D289 (≠ P296), R290 (vs. gap), M492 (≠ A516), V493 (≠ E517), W496 (≠ N520)
- binding flavin-adenine dinucleotide: R158 (≠ E170), G217 (= G225), A218 (≠ G226), G219 (= G227), N222 (vs. gap), T244 (≠ S251), L245 (≠ Y252), Q246 (≠ L253), L262 (= L269), M264 (≠ Y271), H265 (≠ Q272), G284 (= G291), A285 (≠ S292), R286 (= R293), D288 (≠ G295), R290 (vs. gap), V291 (vs. gap), E317 (≠ D318), V318 (≠ A319), N322 (≠ M323), G335 (= G336), D336 (= D337), A337 (= A338), Q411 (≠ N435), M412 (≠ S436), G430 (≠ M454), G431 (≠ S455)
- binding magnesium ion: D460 (= D484), N487 (= N511), E489 (≠ Q513)
- binding propyl trihydrogen diphosphate: V407 (≠ I431), G408 (= G432), Q409 (≠ N433), H410 (≠ I434), M435 (≠ C459), G459 (= G483), D460 (= D484), A461 (≠ G485), S462 (≠ A486), N487 (= N511), E489 (≠ Q513), Q490 (≠ W514), G491 (= G515), M492 (≠ A516)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G457), M435 (≠ C459), M465 (= M489)
Sites not aligning to the query:
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
27% identity, 90% coverage: 23:570/610 of query aligns to 8:545/596 of 1t9dA
- active site: Y29 (≠ I44), G31 (= G46), G32 (≠ S47), A33 (= A48), I34 (≠ F49), E55 (= E69), T78 (≠ Q92), F117 (= F131), Q118 (= Q132), E119 (= E133), K167 (≠ R180), R227 (≠ E235), M263 (≠ Y271), V290 (vs. gap), V406 (≠ I431), L431 (≠ W456), G432 (= G457), M434 (≠ C459), D459 (= D484), N486 (= N511), E488 (≠ Q513), Q489 (≠ W514), M491 (≠ A516), V492 (≠ E517), W495 (≠ N520), L517 (≠ I542), G522 (= G547), L523 (≠ A548)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ S47), A33 (= A48), V107 (≠ A121), P108 (≠ G122), F117 (= F131), K167 (≠ R180), M263 (≠ Y271), D288 (≠ P296), R289 (vs. gap), W495 (≠ N520)
- binding flavin-adenine dinucleotide: R157 (≠ E170), G216 (= G225), A217 (≠ G226), G218 (= G227), N221 (vs. gap), T243 (≠ S251), L244 (≠ Y252), Q245 (≠ L253), M260 (≠ P268), L261 (= L269), H264 (≠ Q272), G283 (= G291), A284 (≠ S292), R285 (= R293), D287 (≠ G295), R289 (vs. gap), V290 (vs. gap), E316 (≠ D318), V317 (≠ A319), N321 (≠ M323), G334 (= G336), D335 (= D337), A336 (= A338), Q410 (≠ N435), M411 (≠ S436), G429 (≠ M454), G430 (≠ S455)
- binding magnesium ion: D459 (= D484), N486 (= N511), E488 (≠ Q513)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E69), P81 (= P95), Q118 (= Q132), G432 (= G457), M434 (≠ C459), M464 (= M489)
Sites not aligning to the query:
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
27% identity, 90% coverage: 23:570/610 of query aligns to 8:545/596 of 1t9cA
- active site: Y29 (≠ I44), G31 (= G46), G32 (≠ S47), A33 (= A48), I34 (≠ F49), E55 (= E69), T78 (≠ Q92), F117 (= F131), Q118 (= Q132), E119 (= E133), K167 (≠ R180), R227 (≠ E235), M263 (≠ Y271), V290 (vs. gap), V406 (≠ I431), L431 (≠ W456), G432 (= G457), M434 (≠ C459), D459 (= D484), N486 (= N511), E488 (≠ Q513), Q489 (≠ W514), M491 (≠ A516), V492 (≠ E517), W495 (≠ N520), L517 (≠ I542), G522 (= G547), L523 (≠ A548)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ S47), V107 (≠ A121), P108 (≠ G122), F117 (= F131), K167 (≠ R180), D288 (≠ P296), R289 (vs. gap), W495 (≠ N520)
- binding flavin-adenine dinucleotide: R157 (≠ E170), G216 (= G225), A217 (≠ G226), G218 (= G227), N221 (vs. gap), T243 (≠ S251), L244 (≠ Y252), Q245 (≠ L253), L261 (= L269), M263 (≠ Y271), H264 (≠ Q272), G283 (= G291), A284 (≠ S292), R285 (= R293), D287 (≠ G295), R289 (vs. gap), V290 (vs. gap), E316 (≠ D318), V317 (≠ A319), N321 (≠ M323), G334 (= G336), D335 (= D337), A336 (= A338), M411 (≠ S436), G429 (≠ M454), G430 (≠ S455)
- binding magnesium ion: D459 (= D484), N486 (= N511), E488 (≠ Q513)
Sites not aligning to the query:
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
27% identity, 90% coverage: 23:570/610 of query aligns to 10:548/599 of 1n0hA
- active site: Y31 (≠ I44), G33 (= G46), G34 (≠ S47), A35 (= A48), I36 (≠ F49), E57 (= E69), T80 (≠ Q92), F119 (= F131), Q120 (= Q132), E121 (= E133), K169 (≠ R180), R230 (≠ E235), M266 (≠ Y271), V293 (vs. gap), V409 (≠ I431), L434 (≠ W456), G435 (= G457), M437 (≠ C459), D462 (= D484), N489 (= N511), E491 (≠ Q513), Q492 (≠ W514), M494 (≠ A516), V495 (≠ E517), W498 (≠ N520), L520 (≠ I542), G525 (= G547), L526 (≠ A548)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (≠ I431), G410 (= G432), Q411 (≠ N433), H412 (≠ I434), G435 (= G457), M437 (≠ C459), G461 (= G483), D462 (= D484), A463 (≠ G485), S464 (≠ A486), M467 (= M489), N489 (= N511), E491 (≠ Q513), Q492 (≠ W514), G493 (= G515), V495 (≠ E517)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (≠ S47), A35 (= A48), V109 (≠ A121), P110 (≠ G122), F119 (= F131), K169 (≠ R180), M266 (≠ Y271), D291 (≠ P296), R292 (vs. gap), V495 (≠ E517), W498 (≠ N520)
- binding flavin-adenine dinucleotide: R159 (≠ E170), G219 (= G225), A220 (≠ G226), G221 (= G227), N224 (vs. gap), T246 (≠ S251), L247 (≠ Y252), Q248 (≠ L253), L264 (= L269), G265 (= G270), M266 (≠ Y271), H267 (≠ Q272), G286 (= G291), A287 (≠ S292), R288 (= R293), D290 (≠ G295), R292 (vs. gap), V293 (vs. gap), E319 (≠ D318), V320 (≠ A319), N324 (≠ M323), G337 (= G336), D338 (= D337), A339 (= A338), M414 (≠ S436), G432 (≠ M454), G433 (≠ S455)
- binding magnesium ion: D462 (= D484), N489 (= N511), E491 (≠ Q513)
- binding thiamine diphosphate: Y31 (≠ I44), E57 (= E69), P83 (= P95)
Sites not aligning to the query:
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
27% identity, 90% coverage: 23:570/610 of query aligns to 92:636/687 of P07342
- R241 (≠ E170) binding
- 355:376 (vs. 272:293, 36% identical) binding
- 407:426 (vs. 318:337, 20% identical) binding
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
27% identity, 90% coverage: 23:570/610 of query aligns to 12:556/607 of 6u9dB
- active site: Y33 (≠ I44), G35 (= G46), G36 (≠ S47), A37 (= A48), I38 (≠ F49), E59 (= E69), T82 (≠ Q92), F121 (= F131), Q122 (= Q132), E123 (= E133), K171 (≠ R180), M274 (≠ Y271), V301 (vs. gap), V417 (≠ I431), G443 (= G457), M445 (≠ C459), D470 (= D484), N497 (= N511), E499 (≠ Q513), Q500 (≠ W514), M502 (≠ A516), V503 (≠ E517), W506 (≠ N520)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (≠ S47), V111 (≠ A121), P112 (≠ G122), F121 (= F131), K171 (≠ R180), D299 (≠ P296), R300 (vs. gap), M502 (≠ A516), W506 (≠ N520)
- binding flavin-adenine dinucleotide: R161 (≠ E170), A228 (≠ G226), G229 (= G227), N232 (vs. gap), T254 (≠ S251), L255 (≠ Y252), Q256 (≠ L253), L272 (= L269), M274 (≠ Y271), G294 (= G291), R296 (= R293), D298 (≠ G295), R300 (vs. gap), V301 (vs. gap), E327 (≠ D318), V328 (≠ A319), N332 (≠ M323), D346 (= D337), A347 (= A338), M422 (≠ S436), G440 (≠ M454), G441 (≠ S455)
- binding magnesium ion: D470 (= D484), N497 (= N511)
- binding thiamine diphosphate: E59 (= E69), P85 (= P95), V417 (≠ I431), G418 (= G432), Q419 (≠ N433), H420 (≠ I434), G443 (= G457), M445 (≠ C459), A471 (≠ G485), S472 (≠ A486), N497 (= N511), E499 (≠ Q513), Q500 (≠ W514), G501 (= G515), M502 (≠ A516), V503 (≠ E517)
6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
26% identity, 93% coverage: 23:587/610 of query aligns to 14:562/600 of 6derA
- active site: Y35 (≠ I44), G37 (= G46), G38 (≠ S47), A39 (= A48), I40 (≠ F49), E61 (= E69), T84 (≠ Q92), F123 (= F131), Q124 (= Q132), E125 (= E133), K173 (≠ R180), K231 (≠ E235), M267 (≠ Y271), V294 (≠ G298), V410 (≠ I431), L435 (≠ W456), G436 (= G457), M438 (≠ C459), D463 (= D484), N490 (= N511), E492 (≠ Q513), Q493 (≠ W514), M495 (≠ A516), V496 (≠ E517), W499 (≠ N520), L521 (≠ I542), N526 (≠ G547), V527 (≠ A548)
- binding flavin-adenine dinucleotide: R163 (≠ E170), G220 (= G225), A221 (≠ G226), G222 (= G227), N225 (≠ M230), T247 (≠ S251), L248 (≠ Y252), Q249 (≠ L253), L265 (= L269), H268 (≠ Q272), G287 (= G291), A288 (≠ S292), R289 (= R293), D291 (≠ G295), R293 (≠ F297), V294 (≠ G298), E320 (≠ D318), I321 (≠ A319), N325 (≠ M323), G338 (= G336), D339 (= D337), V340 (≠ A338), Q414 (≠ N435), M415 (≠ S436), G433 (≠ M454)
- binding Metosulam: R293 (≠ F297), M495 (≠ A516), W499 (≠ N520)
- binding magnesium ion: D463 (= D484), N490 (= N511), E492 (≠ Q513)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V410 (≠ I431), G411 (= G432), Q412 (≠ N433), H413 (≠ I434), G436 (= G457), M438 (≠ C459), G462 (= G483), D463 (= D484), A464 (≠ G485), S465 (≠ A486), N490 (= N511), E492 (≠ Q513), Q493 (≠ W514), G494 (= G515), M495 (≠ A516), V496 (≠ E517)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V410 (≠ I431), G411 (= G432), Q412 (≠ N433), H413 (≠ I434), G436 (= G457), M438 (≠ C459), G462 (= G483), D463 (= D484), A464 (≠ G485), S465 (≠ A486), M468 (= M489), N490 (= N511), E492 (≠ Q513), Q493 (≠ W514), G494 (= G515), V496 (≠ E517)
Sites not aligning to the query:
6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone (see paper)
26% identity, 93% coverage: 23:587/610 of query aligns to 12:560/598 of 6desA
- active site: Y33 (≠ I44), G35 (= G46), G36 (≠ S47), A37 (= A48), I38 (≠ F49), E59 (= E69), T82 (≠ Q92), F121 (= F131), Q122 (= Q132), E123 (= E133), K171 (≠ R180), K229 (≠ E235), M265 (≠ Y271), V292 (≠ G298), V408 (≠ I431), L433 (≠ W456), G434 (= G457), M436 (≠ C459), D461 (= D484), N488 (= N511), E490 (≠ Q513), Q491 (≠ W514), M493 (≠ A516), V494 (≠ E517), W497 (≠ N520), L519 (≠ I542), N524 (≠ G547), V525 (≠ A548)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: M265 (≠ Y271), D290 (≠ P296), R291 (≠ F297), W497 (≠ N520)
- binding flavin-adenine dinucleotide: R161 (≠ E170), G218 (= G225), A219 (≠ G226), G220 (= G227), N223 (≠ M230), T245 (≠ S251), L246 (≠ Y252), Q247 (≠ L253), L263 (= L269), G285 (= G291), A286 (≠ S292), R287 (= R293), D289 (≠ G295), R291 (≠ F297), V292 (≠ G298), E318 (≠ D318), I319 (≠ A319), N323 (≠ M323), D337 (= D337), V338 (≠ A338), Q412 (≠ N435), M413 (≠ S436), G431 (≠ M454)
- binding magnesium ion: D461 (= D484), N488 (= N511), E490 (≠ Q513)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (≠ I431), G409 (= G432), Q410 (≠ N433), H411 (≠ I434), G434 (= G457), M436 (≠ C459), G460 (= G483), D461 (= D484), A462 (≠ G485), S463 (≠ A486), N488 (= N511), E490 (≠ Q513), Q491 (≠ W514), G492 (= G515), M493 (≠ A516), V494 (≠ E517)
6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl (see paper)
26% identity, 93% coverage: 23:587/610 of query aligns to 12:560/598 of 6depA
- active site: Y33 (≠ I44), G35 (= G46), G36 (≠ S47), A37 (= A48), I38 (≠ F49), E59 (= E69), T82 (≠ Q92), F121 (= F131), Q122 (= Q132), E123 (= E133), K171 (≠ R180), K229 (≠ E235), M265 (≠ Y271), V292 (≠ G298), V408 (≠ I431), L433 (≠ W456), G434 (= G457), M436 (≠ C459), D461 (= D484), N488 (= N511), E490 (≠ Q513), Q491 (≠ W514), M493 (≠ A516), V494 (≠ E517), W497 (≠ N520), L519 (≠ I542), N524 (≠ G547), V525 (≠ A548)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D290 (≠ P296), R291 (≠ F297), M493 (≠ A516), W497 (≠ N520)
- binding flavin-adenine dinucleotide: R161 (≠ E170), G218 (= G225), A219 (≠ G226), G220 (= G227), N223 (≠ M230), T245 (≠ S251), L246 (≠ Y252), Q247 (≠ L253), L263 (= L269), G264 (= G270), G285 (= G291), A286 (≠ S292), R287 (= R293), D289 (≠ G295), R291 (≠ F297), V292 (≠ G298), E318 (≠ D318), I319 (≠ A319), N323 (≠ M323), D337 (= D337), V338 (≠ A338), M413 (≠ S436), G431 (≠ M454)
- binding magnesium ion: D461 (= D484), N488 (= N511), E490 (≠ Q513)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V408 (≠ I431), G409 (= G432), Q410 (≠ N433), H411 (≠ I434), G434 (= G457), M436 (≠ C459), G460 (= G483), D461 (= D484), A462 (≠ G485), S463 (≠ A486), M466 (= M489), N488 (= N511), E490 (≠ Q513), Q491 (≠ W514), G492 (= G515), M493 (≠ A516), V494 (≠ E517)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (≠ I431), G409 (= G432), Q410 (≠ N433), H411 (≠ I434), G434 (= G457), M436 (≠ C459), G460 (= G483), D461 (= D484), A462 (≠ G485), S463 (≠ A486), M466 (= M489), N488 (= N511), E490 (≠ Q513), Q491 (≠ W514), G492 (= G515), M493 (≠ A516), V494 (≠ E517)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
26% identity, 93% coverage: 23:587/610 of query aligns to 10:555/593 of 6deoA
- active site: Y31 (≠ I44), G33 (= G46), G34 (≠ S47), A35 (= A48), I36 (≠ F49), E57 (= E69), T80 (≠ Q92), F119 (= F131), Q120 (= Q132), E121 (= E133), K169 (≠ R180), K224 (≠ E235), M260 (≠ Y271), V287 (≠ G298), V403 (≠ I431), L428 (≠ W456), G429 (= G457), M431 (≠ C459), D456 (= D484), N483 (= N511), E485 (≠ Q513), Q486 (≠ W514), M488 (≠ A516), V489 (≠ E517), W492 (≠ N520), L514 (≠ I542), N519 (≠ G547), V520 (≠ A548)
- binding flavin-adenine dinucleotide: R159 (≠ E170), G213 (= G225), A214 (≠ G226), G215 (= G227), N218 (≠ M230), T240 (≠ S251), L241 (≠ Y252), Q242 (≠ L253), L258 (= L269), G280 (= G291), A281 (≠ S292), R282 (= R293), D284 (≠ G295), R286 (≠ F297), V287 (≠ G298), E313 (≠ D318), I314 (≠ A319), N318 (≠ M323), D332 (= D337), V333 (≠ A338), M408 (≠ S436), G426 (≠ M454)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (≠ Y271), D285 (≠ P296), R286 (≠ F297), M488 (≠ A516), W492 (≠ N520)
- binding magnesium ion: D456 (= D484), N483 (= N511), E485 (≠ Q513)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (≠ I431), G404 (= G432), Q405 (≠ N433), H406 (≠ I434), G429 (= G457), M431 (≠ C459), G455 (= G483), D456 (= D484), A457 (≠ G485), S458 (≠ A486), M461 (= M489), N483 (= N511), E485 (≠ Q513), Q486 (≠ W514), G487 (= G515), M488 (≠ A516), V489 (≠ E517)
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
28% identity, 90% coverage: 23:570/610 of query aligns to 8:540/591 of 5wkcA
- active site: Y29 (≠ I44), G31 (= G46), G32 (≠ S47), A33 (= A48), I34 (≠ F49), E55 (= E69), T78 (≠ Q92), F117 (= F131), Q118 (= Q132), E119 (= E133), K167 (≠ R180), R222 (≠ E235), M258 (≠ Y271), V285 (vs. gap), V401 (≠ I431), L426 (≠ W456), G427 (= G457), M429 (≠ C459), D454 (= D484), N481 (= N511), E483 (≠ Q513), Q484 (≠ W514), M486 (≠ A516), V487 (≠ E517), W490 (≠ N520), L512 (≠ I542), G517 (= G547), L518 (≠ A548)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (≠ I431), G402 (= G432), Q403 (≠ N433), H404 (≠ I434), G427 (= G457), M429 (≠ C459), G453 (= G483), D454 (= D484), A455 (≠ G485), S456 (≠ A486), M459 (= M489), N481 (= N511), E483 (≠ Q513), Q484 (≠ W514), G485 (= G515), M486 (≠ A516), V487 (≠ E517)
- binding ethaneperoxoic acid: G32 (≠ S47), Q118 (= Q132)
- binding flavin-adenine dinucleotide: R157 (≠ E170), G211 (= G225), A212 (≠ G226), G213 (= G227), N216 (vs. gap), T238 (≠ S251), L239 (≠ Y252), Q240 (≠ L253), L256 (= L269), M258 (≠ Y271), G278 (= G291), A279 (≠ S292), R280 (= R293), R284 (vs. gap), V285 (vs. gap), E311 (≠ D318), V312 (≠ A319), N316 (≠ M323), D330 (= D337), A331 (= A338), M406 (≠ S436), G424 (≠ M454)
- binding magnesium ion: D454 (= D484), N481 (= N511), E483 (≠ Q513)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (≠ S47), A33 (= A48), V107 (≠ A121), F117 (= F131), K167 (≠ R180), M258 (≠ Y271), R284 (vs. gap), M486 (≠ A516), W490 (≠ N520)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (≠ M45), E55 (= E69)
Sites not aligning to the query:
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
28% identity, 90% coverage: 23:570/610 of query aligns to 7:531/582 of 1t9dB
- active site: Y28 (≠ I44), G30 (= G46), G31 (≠ S47), A32 (= A48), I33 (≠ F49), E54 (= E69), T77 (≠ Q92), F116 (= F131), Q117 (= Q132), E118 (= E133), K166 (≠ R180), R213 (≠ E235), M249 (≠ Y271), V276 (vs. gap), V392 (≠ I431), L417 (≠ W456), G418 (= G457), M420 (≠ C459), D445 (= D484), N472 (= N511), E474 (≠ Q513), Q475 (≠ W514), M477 (≠ A516), V478 (≠ E517), W481 (≠ N520), L503 (≠ I542), G508 (= G547), L509 (≠ A548)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (≠ S47), A32 (= A48), V106 (≠ A121), P107 (≠ G122), F116 (= F131), K166 (≠ R180), M249 (≠ Y271), D274 (≠ P296), R275 (vs. gap), W481 (≠ N520)
- binding flavin-adenine dinucleotide: R156 (≠ E170), G202 (= G225), A203 (≠ G226), G204 (= G227), N207 (vs. gap), T229 (≠ S251), L230 (≠ Y252), Q231 (≠ L253), L247 (= L269), M249 (≠ Y271), H250 (≠ Q272), G269 (= G291), A270 (≠ S292), R271 (= R293), D273 (≠ G295), R275 (vs. gap), V276 (vs. gap), E302 (≠ D318), V303 (≠ A319), N307 (≠ M323), G320 (= G336), D321 (= D337), A322 (= A338), Q396 (≠ N435), M397 (≠ S436), G415 (≠ M454), G416 (≠ S455)
- binding magnesium ion: D445 (= D484), N472 (= N511), E474 (≠ Q513)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E69), P80 (= P95), G418 (= G457), M420 (≠ C459), M450 (= M489)
Sites not aligning to the query:
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
28% identity, 90% coverage: 23:570/610 of query aligns to 8:532/583 of 1t9bA
- active site: Y29 (≠ I44), G31 (= G46), G32 (≠ S47), A33 (= A48), I34 (≠ F49), E55 (= E69), T78 (≠ Q92), F117 (= F131), Q118 (= Q132), E119 (= E133), K167 (≠ R180), R214 (≠ E235), M250 (≠ Y271), V277 (vs. gap), V393 (≠ I431), L418 (≠ W456), G419 (= G457), M421 (≠ C459), D446 (= D484), N473 (= N511), E475 (≠ Q513), Q476 (≠ W514), M478 (≠ A516), V479 (≠ E517), W482 (≠ N520), L504 (≠ I542), G509 (= G547), L510 (≠ A548)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (≠ A121), P108 (≠ G122), F117 (= F131), D275 (≠ P296), R276 (vs. gap), M478 (≠ A516), W482 (≠ N520)
- binding flavin-adenine dinucleotide: R157 (≠ E170), G203 (= G225), A204 (≠ G226), G205 (= G227), N208 (vs. gap), T230 (≠ S251), L231 (≠ Y252), Q232 (≠ L253), M247 (≠ P268), L248 (= L269), M250 (≠ Y271), H251 (≠ Q272), G270 (= G291), A271 (≠ S292), R272 (= R293), D274 (≠ G295), R276 (vs. gap), V277 (vs. gap), E303 (≠ D318), V304 (≠ A319), N308 (≠ M323), D322 (= D337), A323 (= A338), Q397 (≠ N435), M398 (≠ S436), G416 (≠ M454), G417 (≠ S455)
- binding magnesium ion: D446 (= D484), N473 (= N511), E475 (≠ Q513)
Sites not aligning to the query:
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
26% identity, 93% coverage: 23:587/610 of query aligns to 12:559/597 of 6demA
- active site: Y33 (≠ I44), G35 (= G46), G36 (≠ S47), A37 (= A48), I38 (≠ F49), E59 (= E69), T82 (≠ Q92), F121 (= F131), Q122 (= Q132), E123 (= E133), K171 (≠ R180), K228 (≠ E235), M264 (≠ Y271), V291 (≠ G298), V407 (≠ I431), L432 (≠ W456), G433 (= G457), M435 (≠ C459), D460 (= D484), N487 (= N511), E489 (≠ Q513), Q490 (≠ W514), M492 (≠ A516), V493 (≠ E517), W496 (≠ N520), L518 (≠ I542), N523 (≠ G547), V524 (≠ A548)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (≠ Y271), D289 (≠ P296), R290 (≠ F297), M492 (≠ A516), W496 (≠ N520)
- binding flavin-adenine dinucleotide: R161 (≠ E170), G217 (= G225), A218 (≠ G226), G219 (= G227), N222 (≠ M230), T244 (≠ S251), L245 (≠ Y252), Q246 (≠ L253), L262 (= L269), G284 (= G291), A285 (≠ S292), R286 (= R293), D288 (≠ G295), R290 (≠ F297), V291 (≠ G298), E317 (≠ D318), I318 (≠ A319), N322 (≠ M323), D336 (= D337), V337 (≠ A338), M412 (≠ S436), G430 (≠ M454)
- binding magnesium ion: D460 (= D484), N487 (= N511), E489 (≠ Q513)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (≠ I431), G408 (= G432), Q409 (≠ N433), H410 (≠ I434), M435 (≠ C459), G459 (= G483), D460 (= D484), A461 (≠ G485), S462 (≠ A486), M465 (= M489), N487 (= N511), E489 (≠ Q513), Q490 (≠ W514), G491 (= G515), M492 (≠ A516), V493 (≠ E517)
Sites not aligning to the query:
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
26% identity, 93% coverage: 23:587/610 of query aligns to 12:559/597 of 6delA
- active site: Y33 (≠ I44), G35 (= G46), G36 (≠ S47), A37 (= A48), I38 (≠ F49), E59 (= E69), T82 (≠ Q92), F121 (= F131), Q122 (= Q132), E123 (= E133), K171 (≠ R180), K228 (≠ E235), M264 (≠ Y271), V291 (≠ G298), V407 (≠ I431), L432 (≠ W456), G433 (= G457), M435 (≠ C459), D460 (= D484), N487 (= N511), E489 (≠ Q513), Q490 (≠ W514), M492 (≠ A516), V493 (≠ E517), W496 (≠ N520), L518 (≠ I542), N523 (≠ G547), V524 (≠ A548)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (≠ P296), R290 (≠ F297), W496 (≠ N520)
- binding flavin-adenine dinucleotide: R161 (≠ E170), G217 (= G225), A218 (≠ G226), G219 (= G227), N222 (≠ M230), T244 (≠ S251), L245 (≠ Y252), Q246 (≠ L253), L262 (= L269), G284 (= G291), A285 (≠ S292), R286 (= R293), D288 (≠ G295), R290 (≠ F297), V291 (≠ G298), E317 (≠ D318), I318 (≠ A319), N322 (≠ M323), D336 (= D337), V337 (≠ A338), M412 (≠ S436), G430 (≠ M454)
- binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (≠ I431), G408 (= G432), Q409 (≠ N433), H410 (≠ I434), G433 (= G457), M435 (≠ C459), G459 (= G483), D460 (= D484), A461 (≠ G485), S462 (≠ A486), M465 (= M489), N487 (= N511), E489 (≠ Q513), Q490 (≠ W514), G491 (= G515), M492 (≠ A516), V493 (≠ E517)
- binding magnesium ion: D460 (= D484), N487 (= N511), E489 (≠ Q513)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (≠ I431), G408 (= G432), Q409 (≠ N433), H410 (≠ I434), G433 (= G457), M435 (≠ C459), G459 (= G483), D460 (= D484), A461 (≠ G485), S462 (≠ A486), M465 (= M489), N487 (= N511), E489 (≠ Q513), Q490 (≠ W514), G491 (= G515), M492 (≠ A516), V493 (≠ E517)
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
26% identity, 93% coverage: 23:587/610 of query aligns to 14:561/599 of 6denA
- active site: Y35 (≠ I44), G37 (= G46), G38 (≠ S47), A39 (= A48), I40 (≠ F49), E61 (= E69), T84 (≠ Q92), F123 (= F131), Q124 (= Q132), E125 (= E133), K173 (≠ R180), K230 (≠ E235), M266 (≠ Y271), V293 (≠ G298), V409 (≠ I431), L434 (≠ W456), G435 (= G457), M437 (≠ C459), D462 (= D484), N489 (= N511), E491 (≠ Q513), Q492 (≠ W514), M494 (≠ A516), V495 (≠ E517), W498 (≠ N520), L520 (≠ I542), N525 (≠ G547), V526 (≠ A548)
- binding flavin-adenine dinucleotide: R163 (≠ E170), G219 (= G225), A220 (≠ G226), G221 (= G227), N224 (≠ M230), T246 (≠ S251), L247 (≠ Y252), Q248 (≠ L253), L264 (= L269), G286 (= G291), A287 (≠ S292), R288 (= R293), D290 (≠ G295), R292 (≠ F297), V293 (≠ G298), E319 (≠ D318), I320 (≠ A319), N324 (≠ M323), D338 (= D337), V339 (≠ A338), M414 (≠ S436), G432 (≠ M454)
- binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (≠ Y271), D291 (≠ P296), R292 (≠ F297), W498 (≠ N520)
- binding magnesium ion: D462 (= D484), N489 (= N511), E491 (≠ Q513)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (≠ I431), G410 (= G432), Q411 (≠ N433), H412 (≠ I434), G435 (= G457), M437 (≠ C459), G461 (= G483), D462 (= D484), A463 (≠ G485), S464 (≠ A486), N489 (= N511), E491 (≠ Q513), Q492 (≠ W514), G493 (= G515), M494 (≠ A516), V495 (≠ E517)
6dekA Crystal structure of candida albicans acetohydroxyacid synthase catalytic subunit (see paper)
26% identity, 93% coverage: 23:587/610 of query aligns to 13:557/595 of 6dekA
- active site: Y34 (≠ I44), G36 (= G46), G37 (≠ S47), A38 (= A48), I39 (≠ F49), E60 (= E69), T83 (≠ Q92), Q118 (= Q132), E119 (= E133), K167 (≠ R180), K226 (≠ E235), M262 (≠ Y271), V289 (≠ G298), V405 (≠ I431), L430 (≠ W456), G431 (= G457), M433 (≠ C459), D458 (= D484), N485 (= N511), E487 (≠ Q513), Q488 (≠ W514), M490 (≠ A516), V491 (≠ E517), W494 (≠ N520), L516 (≠ I542), N521 (≠ G547), V522 (≠ A548)
- binding flavin-adenine dinucleotide: R157 (≠ E170), G215 (= G225), A216 (≠ G226), G217 (= G227), N220 (≠ M230), T242 (≠ S251), L243 (≠ Y252), Q244 (≠ L253), L260 (= L269), M262 (≠ Y271), G282 (= G291), A283 (≠ S292), R284 (= R293), D286 (≠ G295), R288 (≠ F297), V289 (≠ G298), E315 (≠ D318), I316 (≠ A319), N320 (≠ M323), D334 (= D337), V335 (≠ A338), M410 (≠ S436), G428 (≠ M454)
- binding magnesium ion: D458 (= D484), N485 (= N511), E487 (≠ Q513)
- binding thiamine diphosphate: V405 (≠ I431), G406 (= G432), Q407 (≠ N433), H408 (≠ I434), M433 (≠ C459), G457 (= G483), D458 (= D484), A459 (≠ G485), S460 (≠ A486), N485 (= N511), E487 (≠ Q513), Q488 (≠ W514), G489 (= G515), M490 (≠ A516), V491 (≠ E517)
6bd9A Saccharomyces cerevisiae acetohydroxyacid synthase
27% identity, 90% coverage: 23:570/610 of query aligns to 10:530/542 of 6bd9A
- active site: Y31 (≠ I44), G33 (= G46), G34 (≠ S47), A35 (= A48), I36 (≠ F49), E57 (= E69), T80 (≠ Q92), F119 (= F131), Q120 (= Q132), E121 (= E133), K169 (≠ R180), R228 (≠ E235), M264 (≠ Y271), V291 (vs. gap), V407 (≠ I431), L432 (≠ W456), G433 (= G457), M435 (≠ C459), D460 (= D484), N487 (= N511), E489 (≠ Q513), L502 (≠ I542), G507 (= G547), L508 (≠ A548)
- binding flavin-adenine dinucleotide: R159 (≠ E170), G217 (= G225), A218 (≠ G226), G219 (= G227), N222 (vs. gap), T244 (≠ S251), L245 (≠ Y252), L262 (= L269), G263 (= G270), H265 (≠ Q272), G284 (= G291), A285 (≠ S292), R286 (= R293), D288 (≠ G295), R290 (vs. gap), V291 (vs. gap), E317 (≠ D318), V318 (≠ A319), N322 (≠ M323), G335 (= G336), D336 (= D337), A337 (= A338)
- binding magnesium ion: D460 (= D484), N487 (= N511)
- binding oxygen molecule: G34 (≠ S47), T80 (≠ Q92), Q120 (= Q132), A461 (≠ G485), Q494 (= Q521)
- binding pyruvic acid: G33 (= G46), G34 (≠ S47), G34 (≠ S47), A35 (= A48), Q120 (= Q132)
- binding thiamine diphosphate: P32 (≠ M45), E57 (= E69), V407 (≠ I431), G408 (= G432), Q409 (≠ N433), H410 (≠ I434), G433 (= G457), M435 (≠ C459), G459 (= G483), D460 (= D484), A461 (≠ G485), S462 (≠ A486), M465 (= M489), N487 (= N511)
Sites not aligning to the query:
Query Sequence
>BPHYT_RS21705 FitnessBrowser__BFirm:BPHYT_RS21705
MSEQNPSPRDATADNRASGPQAMTPSEAFVETLAANGVTDMFGIMGSAFMDAMDIFAPAG
IRLIPVVHEQGAGHMADGYSRVSGRHGVVIGQNGPGISNCVTAIAAAYWAHSPVVIVTPE
AGTMGIGLGGFQEAKQLPMFQEFTKYQGHVTHPARMAEFTGRCFDRAMAEMGPTQLNIPR
DYFYGQVKVEIPQPQRLDRGAGGEQSLNEAAELLAQAKFPVIISGGGVVMADAIEECKAL
AERLNAPVVNSYLHNDSFPANHPLWCGPLGYQGSKAAMKLLSRADVVIALGSRLGPFGTL
PQHGMDYWPTNAKIIQIDADHKMLGLVKKISVGICGDAKAAAVALTERLAGRKLASDATR
EERGAQIASEKAAWEKELDDWTHERDAYSLDMIEEQKQERTPGGGTYLHPRQVLRELEKA
MPEDVMVSTDIGNINSVANSYLRFNKPRSFFAAMSWGNCGYAFPTIIGAKVAAPHRPAVS
YAGDGAWGMSLMETMTCVRHNIPVTAVVFHNRQWGAEKKNQVDFYNRRFVAGELDNQSFA
AIARAMGAEGIVVDRLEDVGPALKRAIDAQMNHGKTTIIEIMCTRELGDPFRRDALSKPV
RMLDKYKDYV
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory