Comparing BPHYT_RS22485 FitnessBrowser__BFirm:BPHYT_RS22485 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q9P7U2 Putative aryl-alcohol dehydrogenase C977.14c; EC 1.1.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
46% identity, 99% coverage: 3:324/326 of query aligns to 9:349/351 of Q9P7U2
6ow0A Crystal structure of mithramycin 3-side chain keto-reductase mtmw in complex with NAD+ and peg (see paper)
35% identity, 97% coverage: 1:316/326 of query aligns to 1:315/323 of 6ow0A
6ow0B Crystal structure of mithramycin 3-side chain keto-reductase mtmw in complex with NAD+ and peg (see paper)
35% identity, 97% coverage: 1:316/326 of query aligns to 1:291/301 of 6ow0B
Q3L181 Perakine reductase; EC 1.1.1.317 from Rauvolfia serpentina (Serpentine wood) (Ophioxylon serpentinum) (see paper)
33% identity, 97% coverage: 1:315/326 of query aligns to 1:307/337 of Q3L181
4aubB The complex structure of the bacterial aldo-keto reductase akr14a1 with NADP and citrate (see paper)
34% identity, 97% coverage: 1:315/326 of query aligns to 11:319/335 of 4aubB
Sites not aligning to the query:
3n6qD Crystal structure of yghz from e. Coli (see paper)
34% identity, 97% coverage: 1:315/326 of query aligns to 12:306/315 of 3n6qD
8hw0A The structure of akr6d1
34% identity, 93% coverage: 1:302/326 of query aligns to 1:302/329 of 8hw0A
5t79A X-ray crystal structure of a novel aldo-keto reductases for the biocatalytic conversion of 3-hydroxybutanal to 1,3-butanediol (see paper)
35% identity, 93% coverage: 1:302/326 of query aligns to 13:297/315 of 5t79A
1pz0A Structure of NADPH-dependent family 11 aldo-keto reductase akr11a(holo) (see paper)
32% identity, 97% coverage: 5:319/326 of query aligns to 4:310/311 of 1pz0A
3erpA Structure of idp01002, a putative oxidoreductase from and essential gene of salmonella typhimurium (see paper)
35% identity, 93% coverage: 1:302/326 of query aligns to 12:292/312 of 3erpA
P46336 Aldo-keto reductase IolS; AKR11A; Vegetative protein 147; VEG147; EC 1.1.1.- from Bacillus subtilis (strain 168) (see paper)
31% identity, 97% coverage: 1:317/326 of query aligns to 1:309/310 of P46336
4aubF The complex structure of the bacterial aldo-keto reductase akr14a1 with NADP and citrate (see paper)
33% identity, 97% coverage: 1:315/326 of query aligns to 11:296/298 of 4aubF
4aubE The complex structure of the bacterial aldo-keto reductase akr14a1 with NADP and citrate (see paper)
34% identity, 93% coverage: 1:302/326 of query aligns to 12:280/297 of 4aubE
Sites not aligning to the query:
3v0sA Crystal structure of perakine reductase, founder member of a novel akr subfamily with unique conformational changes during NADPH binding (see paper)
33% identity, 97% coverage: 1:315/326 of query aligns to 1:275/287 of 3v0sA
6hg6A Clostridium beijerinckii aldo-keto reductase cbei_3974 with NADPH (see paper)
32% identity, 97% coverage: 1:316/326 of query aligns to 12:310/313 of 6hg6A
P80874 Aldo-keto reductase YhdN; AKR11B; General stress protein 69; GSP69; EC 1.1.1.- from Bacillus subtilis (strain 168) (see paper)
32% identity, 97% coverage: 1:316/326 of query aligns to 1:309/331 of P80874
1pz1A Structure of NADPH-dependent family 11 aldo-keto reductase akr11b(holo) (see paper)
32% identity, 97% coverage: 1:316/326 of query aligns to 1:309/333 of 1pz1A
1lqaA Tas protein from escherichia coli in complex with NADPH (see paper)
30% identity, 97% coverage: 1:317/326 of query aligns to 1:338/346 of 1lqaA
P0A9T4 Protein tas from Escherichia coli (strain K12) (see paper)
30% identity, 97% coverage: 1:317/326 of query aligns to 1:338/346 of P0A9T4
8hnqA The structure of a alcohol dehydrogenase akr13b2 with NADP
32% identity, 93% coverage: 11:314/326 of query aligns to 23:286/286 of 8hnqA
>BPHYT_RS22485 FitnessBrowser__BFirm:BPHYT_RS22485
MDYVKLGRTGLDVSRLCLGCMSYGVPSRGTHPWSLDDEAARPFIKQALDHGINFFDTANV
YSDGTSEEIVGRALKDFAKRDEIVLATKVNSRMHPGPNGAGLSRKAIMSEIDHSLRRLGT
DYVDLYQIHRWDYGTPIEETMEALHDVVKAGKARYIGASSMYAWQFAKALHVAEKNGWTR
FVTMQNYVNLLYREEEREMLPLCESEGIGVIPWSPLARGRLTRDWNTESARSETDEFGQT
LYAQTEDADRRVVERVSQIAKERGVPRAQVALAWVLQKKPITAPIVGATKLHHLDDAVAA
LSLSLSADEIRQLEELYVPHAVTGFK
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory