SitesBLAST
Comparing BPHYT_RS23175 BPHYT_RS23175 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5iuwA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ and iaa (see paper)
64% identity, 98% coverage: 9:496/497 of query aligns to 7:495/495 of 5iuwA
- active site: N166 (= N168), K189 (= K191), E265 (= E266), C300 (= C301), E399 (= E399), D476 (= D477)
- binding 1h-indol-3-ylacetic acid: F167 (= F169), M170 (≠ L172), C300 (= C301), D457 (= D457), F465 (= F466)
- binding nicotinamide-adenine-dinucleotide: I162 (≠ V164), V163 (= V165), P164 (= P166), W165 (= W167), N166 (= N168), K189 (= K191), G222 (= G224), G226 (= G227), K227 (= K228), F240 (= F241), T241 (= T242), G242 (= G243), S243 (= S244), I246 (≠ V247), Y253 (= Y254), E265 (= E266), A266 (≠ L267), C300 (= C301), E399 (= E399), F401 (= F401)
5iuvA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ (see paper)
64% identity, 98% coverage: 9:496/497 of query aligns to 7:495/495 of 5iuvA
- active site: N166 (= N168), K189 (= K191), E265 (= E266), C300 (= C301), E399 (= E399), D476 (= D477)
- binding nicotinamide-adenine-dinucleotide: I162 (≠ V164), V163 (= V165), P164 (= P166), W165 (= W167), N166 (= N168), K189 (= K191), S191 (= S193), G222 (= G224), G226 (= G227), K227 (= K228), F240 (= F241), T241 (= T242), G242 (= G243), S243 (= S244), I246 (≠ V247), Y253 (= Y254), E265 (= E266), A266 (≠ L267), C300 (= C301), E399 (= E399), F401 (= F401)
7jsoA P. Syringae alda indole-3-acetaldehyde dehydrogenase c302a mutant in complex with NAD+ and iaa (see paper)
63% identity, 98% coverage: 9:496/497 of query aligns to 7:495/495 of 7jsoA
- active site: N166 (= N168), E265 (= E266), A300 (≠ C301), D476 (= D477)
- binding 1h-indol-3-ylacetic acid: F167 (= F169), W174 (= W176), V299 (≠ M300), A300 (≠ C301), T301 (= T302), D457 (= D457), F465 (= F466)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I162 (≠ V164), V163 (= V165), P164 (= P166), W165 (= W167), K189 (= K191), E192 (= E194), G222 (= G224), G226 (= G227), K227 (= K228), F240 (= F241), G242 (= G243), S243 (= S244), I246 (≠ V247), A266 (≠ L267), G267 (= G268), A300 (≠ C301), E399 (= E399), F401 (= F401)
7uyyA The crystal structure of the pseudomonas aeruginosa aldehyde dehydrogenase encoded by the pa4189 gene in complex with nadh (see paper)
51% identity, 97% coverage: 13:494/497 of query aligns to 14:493/496 of 7uyyA
- binding 1,4-dihydronicotinamide adenine dinucleotide: V165 (= V164), L166 (≠ V165), P167 (= P166), W168 (= W167), K192 (= K191), G225 (= G224), G229 (= G227), F243 (= F241), G245 (= G243), S246 (= S244), T249 (≠ V247), L252 (= L250), F253 (≠ I251), Y256 (= Y254), C269 (≠ L267), G270 (= G268), C303 (= C301), H350 (≠ Q348), K353 (≠ R351), F400 (= F401)
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
50% identity, 96% coverage: 21:497/497 of query aligns to 12:489/494 of 4pz2B
- active site: N159 (= N168), K182 (= K191), E258 (= E266), C292 (= C301), E392 (= E399), D469 (= D477)
- binding nicotinamide-adenine-dinucleotide: I155 (≠ V164), I156 (≠ V165), P157 (= P166), W158 (= W167), N159 (= N168), M164 (= M173), K182 (= K191), A184 (≠ S193), E185 (= E194), G215 (= G224), G219 (= G227), F233 (= F241), T234 (= T242), G235 (= G243), S236 (= S244), V239 (= V247), E258 (= E266), L259 (= L267), C292 (= C301), E392 (= E399), F394 (= F401)
5l13A Structure of aldh2 in complex with 2p3 (see paper)
46% identity, 96% coverage: 21:496/497 of query aligns to 15:489/494 of 5l13A
- active site: N163 (= N168), K186 (= K191), E262 (= E266), C296 (= C301), E393 (= E399), E470 (≠ D477)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (= F169), M168 (= M173), W171 (= W176), F290 (≠ Y295), C295 (≠ M300), C296 (= C301), C297 (≠ T302), D451 (= D457), F453 (≠ G459)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
46% identity, 96% coverage: 21:496/497 of query aligns to 15:489/494 of 4kwgA
- active site: N163 (= N168), K186 (= K191), E262 (= E266), C296 (= C301), E393 (= E399), E470 (≠ D477)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (= F169), M168 (= M173), C295 (≠ M300), C296 (= C301), C297 (≠ T302), D451 (= D457), F453 (≠ G459)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
46% identity, 96% coverage: 21:496/497 of query aligns to 15:489/494 of 4kwfA
- active site: N163 (= N168), K186 (= K191), E262 (= E266), C296 (= C301), E393 (= E399), E470 (≠ D477)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (= F169), M168 (= M173), W171 (= W176), E262 (= E266), C295 (≠ M300), C296 (= C301), C297 (≠ T302), D451 (= D457), F453 (≠ G459), F459 (= F466)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
46% identity, 96% coverage: 21:496/497 of query aligns to 15:489/494 of 3sz9A
- active site: N163 (= N168), K186 (= K191), E262 (= E266), C296 (= C301), E393 (= E399), E470 (≠ D477)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (= F169), C295 (≠ M300), C296 (= C301), D451 (= D457), F453 (≠ G459), F459 (= F466)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
46% identity, 96% coverage: 21:496/497 of query aligns to 15:489/494 of 3injA
- active site: N163 (= N168), K186 (= K191), E262 (= E266), C296 (= C301), E393 (= E399), E470 (≠ D477)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ G123), F164 (= F169), L167 (= L172), F286 (≠ G291), F290 (≠ Y295), D451 (= D457), F453 (≠ G459)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
46% identity, 96% coverage: 21:496/497 of query aligns to 15:489/494 of 2vleA
- active site: N163 (= N168), K186 (= K191), E262 (= E266), C296 (= C301), E393 (= E399), E470 (≠ D477)
- binding daidzin: M118 (≠ G123), F164 (= F169), M168 (= M173), W171 (= W176), F286 (≠ G291), F290 (≠ Y295), C295 (≠ M300), C296 (= C301), D451 (= D457), V452 (≠ E458), F453 (≠ G459)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+ (see paper)
46% identity, 96% coverage: 21:496/497 of query aligns to 15:489/494 of 1o01B
- active site: N163 (= N168), K186 (= K191), E262 (= E266), C296 (= C301), E393 (= E399), E470 (≠ D477)
- binding (2e)-but-2-enal: C296 (= C301), C297 (≠ T302), F453 (≠ G459)
- binding nicotinamide-adenine-dinucleotide: I159 (≠ V164), I160 (≠ V165), P161 (= P166), W162 (= W167), K186 (= K191), E189 (= E194), G219 (= G224), G223 (= G227), A224 (≠ K228), F237 (= F241), G239 (= G243), S240 (= S244), I243 (≠ V247), L263 (= L267), G264 (= G268), C296 (= C301), Q343 (= Q348), E393 (= E399), F395 (= F401)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+ (see paper)
46% identity, 96% coverage: 21:496/497 of query aligns to 15:489/494 of 1cw3A
- active site: N163 (= N168), K186 (= K191), E262 (= E266), C296 (= C301), E393 (= E399), E470 (≠ D477)
- binding magnesium ion: V34 (≠ L40), D103 (= D108), Q190 (≠ K195)
- binding nicotinamide-adenine-dinucleotide: I159 (≠ V164), I160 (≠ V165), P161 (= P166), W162 (= W167), K186 (= K191), G219 (= G224), G223 (= G227), A224 (≠ K228), F237 (= F241), G239 (= G243), S240 (= S244), I243 (≠ V247), L263 (= L267), G264 (= G268), C296 (= C301), Q343 (= Q348), K346 (≠ R351), E393 (= E399), F395 (= F401)
4fr8C Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
46% identity, 96% coverage: 21:496/497 of query aligns to 17:491/496 of 4fr8C
- active site: N165 (= N168), K188 (= K191), Q264 (≠ E266), C298 (= C301), E395 (= E399), E472 (≠ D477)
- binding nicotinamide-adenine-dinucleotide: I161 (≠ V164), I162 (≠ V165), W164 (= W167), K188 (= K191), G221 (= G224), G225 (= G227), A226 (≠ K228), F239 (= F241), G241 (= G243), S242 (= S244), I245 (≠ V247), Q345 (= Q348), E395 (= E399), F397 (= F401)
4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
46% identity, 96% coverage: 21:496/497 of query aligns to 14:488/493 of 4fr8A
- active site: N162 (= N168), K185 (= K191), Q261 (≠ E266), C295 (= C301), E392 (= E399), E469 (≠ D477)
- binding nicotinamide-adenine-dinucleotide: I158 (≠ V164), I159 (≠ V165), W161 (= W167), K185 (= K191), G218 (= G224), G222 (= G227), A223 (≠ K228), F236 (= F241), G238 (= G243), S239 (= S244), I242 (≠ V247), Q342 (= Q348), K345 (≠ R351), E392 (= E399), F394 (= F401)
- binding propane-1,2,3-triyl trinitrate: F163 (= F169), L166 (= L172), W170 (= W176), F289 (≠ Y295), S294 (≠ M300), C295 (= C301), D450 (= D457), F452 (≠ G459)
4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
47% identity, 96% coverage: 21:496/497 of query aligns to 7:480/486 of 4pxlA
- active site: N154 (= N168), K177 (= K191), E253 (= E266), C287 (= C301), E384 (= E399), D461 (= D477)
- binding nicotinamide-adenine-dinucleotide: I150 (≠ V164), V151 (= V165), P152 (= P166), W153 (= W167), K177 (= K191), E180 (= E194), G210 (= G224), G214 (= G227), A215 (≠ K228), F228 (= F241), G230 (= G243), S231 (= S244), V234 (= V247), E253 (= E266), G255 (= G268), C287 (= C301), Q334 (= Q348), K337 (≠ R351), E384 (= E399), F386 (= F401)
P20000 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Bos taurus (Bovine) (see 2 papers)
48% identity, 95% coverage: 23:496/497 of query aligns to 43:515/520 of P20000
Sites not aligning to the query:
- 1:21 modified: transit peptide, Mitochondrion
1nzwA Cys302ser mutant of human mitochondrial aldehyde dehydrogenase complexed with nadh and mg2+ (see paper)
46% identity, 96% coverage: 21:496/497 of query aligns to 15:489/494 of 1nzwA
- active site: N163 (= N168), K186 (= K191), E262 (= E266), S296 (≠ C301), E393 (= E399), E470 (≠ D477)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I159 (≠ V164), I160 (≠ V165), P161 (= P166), K186 (= K191), E189 (= E194), G219 (= G224), P220 (vs. gap), G223 (= G227), A224 (≠ K228), F237 (= F241), G239 (= G243), S240 (= S244), I243 (≠ V247), E262 (= E266), G264 (= G268), S296 (≠ C301), Q343 (= Q348), E393 (= E399), F395 (= F401)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
46% identity, 96% coverage: 18:496/497 of query aligns to 2:479/489 of 4o6rA
- active site: N150 (= N168), K173 (= K191), E248 (= E266), C282 (= C301), E383 (= E399), E460 (≠ D477)
- binding adenosine monophosphate: I146 (≠ V164), V147 (= V165), K173 (= K191), G206 (= G224), G210 (= G227), Q211 (≠ K228), F224 (= F241), G226 (= G243), S227 (= S244), T230 (≠ V247), R233 (≠ L250)
4go4A Crystal structure of pnpe in complex with nicotinamide adenine dinucleotide
47% identity, 96% coverage: 18:496/497 of query aligns to 1:477/487 of 4go4A
- active site: N149 (= N168), K172 (= K191), E247 (= E266), C281 (= C301), E381 (= E399), E458 (≠ D477)
- binding nicotinamide-adenine-dinucleotide: I145 (≠ V164), V146 (= V165), W148 (= W167), N149 (= N168), F154 (≠ M173), K172 (= K191), G205 (= G224), G209 (= G227), Q210 (≠ K228), F223 (= F241), T224 (= T242), G225 (= G243), S226 (= S244), T229 (≠ V247), E247 (= E266), G249 (= G268), C281 (= C301), E381 (= E399), F383 (= F401)
Query Sequence
>BPHYT_RS23175 BPHYT_RS23175 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase
MDKKSFAFWQDKAATLSIEGRAFIDGEYRDAEGGRTFDCLSPIDGKLLAKVADSGAADVD
AAVAAARRAFDSGVWSGLNPRQRKAVLLRWAASIREHMDELALLETLDAGKPIADTTSVD
VPGAAYCVEWFAEAIDKIGGEVAPADHHLLGLVTREPIGVVAAVVPWNFPILMASWKFGP
ALAAGNSVVLKPSEKSPLTAIRLAQLALDAGIPAGVFNVVPGAGEPGKLLALHQDVDCLA
FTGSTNVGKLIMQYAGQSNLKRVWLELGGKSPNIVMPDCPDMDRAANAAAGAIFYNMGEM
CTAGSRLLVHRDIKDVFIDKLIAAARSYTPGNPLDPDTSMGAIVDKVQLERVLGYIEAGR
AEAKLLLGGARVKEDTGGFYIEPTIFEIPGSGAKVAREEIFGPVLSVITFDTVEEAIRIA
NDSEYGLAAAVWTSNLTTAHEVSRKLRAGTVWVNCYDEGGDMNFPFGGYKQSGNGRDKSL
HALEKYTELKSTLVRLR
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory