Comparing BPHYT_RS23245 FitnessBrowser__BFirm:BPHYT_RS23245 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4hsoA Crystal structure of s213g variant dah7ps from neisseria meningitidis (see paper)
60% identity, 93% coverage: 26:371/372 of query aligns to 3:343/345 of 4hsoA
5dceA Neisseria meningitidis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase regulated (tryptophan) (see paper)
59% identity, 93% coverage: 26:371/372 of query aligns to 3:343/344 of 5dceA
5dcdA Neisseria meningitidis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase regulated (tyrosine)
59% identity, 93% coverage: 26:371/372 of query aligns to 5:345/346 of 5dcdA
5dcbC Neisseria meningitidis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase regulated and complexed with pep
59% identity, 93% coverage: 26:371/372 of query aligns to 7:347/348 of 5dcbC
4umbA Structural analysis of substrate-mimicking inhibitors in complex with neisseria meningitidis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase - the importance of accommodating the active site water (see paper)
59% identity, 91% coverage: 34:371/372 of query aligns to 1:333/335 of 4umbA
4umcA Structural analysis of substrate-mimicking inhibitors in complex with neisseria meningitidis 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase - the importance of accommodating the active site water (see paper)
59% identity, 91% coverage: 34:371/372 of query aligns to 1:333/334 of 4umcA
4umaA Structural analysis of substrate-mimicking inhibitors in complex with neisseria meningitidis 3 deoxy d arabino heptulosonate 7 phosphate synthase the importance of accommodating the active site water (see paper)
60% identity, 90% coverage: 36:371/372 of query aligns to 2:332/333 of 4umaA
1kflA Crystal structure of phenylalanine-regulated 3-deoxy-d-arabino- heptulosonate-7-phosphate synthase (dahp synthase) from e.Coli complexed with mn2+, pep, and phe (see paper)
57% identity, 93% coverage: 26:370/372 of query aligns to 6:349/350 of 1kflA
P0AB91 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive; 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; DAHP synthase; Phospho-2-keto-3-deoxyheptonate aldolase; EC 2.5.1.54 from Escherichia coli (strain K12) (see paper)
57% identity, 93% coverage: 26:370/372 of query aligns to 6:349/350 of P0AB91
5cksB Dahp (3-deoxy-d-arabinoheptulosonate-7-phosphate) synthase in complex with dahp oxime. (see paper)
57% identity, 93% coverage: 26:370/372 of query aligns to 1:344/345 of 5cksB
8e0sD Dahp (3-deoxy-d-arabinoheptulosonate-7-phosphate) synthase complexed with dahp oxime in unbound:(bound)2:unbound conformations (see paper)
56% identity, 92% coverage: 27:370/372 of query aligns to 1:343/343 of 8e0sD
7rudB Dahp synthase complex with trifluoropyruvate oxime (see paper)
56% identity, 92% coverage: 27:370/372 of query aligns to 1:343/343 of 7rudB
1gg1A Crystal structure analysis of dahp synthase in complex with mn2+ and 2-phosphoglycolate (see paper)
56% identity, 92% coverage: 27:370/372 of query aligns to 1:339/339 of 1gg1A
1qr7A Crystal structure of phenylalanine-regulated 3-deoxy-d-arabino- heptulosonate-7-phosphate synthase from escherichia coli complexed with pb2+ and pep (see paper)
56% identity, 92% coverage: 28:370/372 of query aligns to 1:337/338 of 1qr7A
7rueA Dahp synthase complexed with trifluoropyruvate semicarbazone (see paper)
56% identity, 93% coverage: 26:370/372 of query aligns to 2:339/339 of 7rueA
5cksA Dahp (3-deoxy-d-arabinoheptulosonate-7-phosphate) synthase in complex with dahp oxime. (see paper)
55% identity, 93% coverage: 26:370/372 of query aligns to 2:338/339 of 5cksA
8e0sA Dahp (3-deoxy-d-arabinoheptulosonate-7-phosphate) synthase complexed with dahp oxime in unbound:(bound)2:unbound conformations (see paper)
55% identity, 92% coverage: 27:370/372 of query aligns to 1:335/336 of 8e0sA
3tqkA Structure of phospho-2-dehydro-3-deoxyheptonate aldolase from francisella tularensis schu s4 (see paper)
53% identity, 91% coverage: 34:370/372 of query aligns to 6:340/341 of 3tqkA
7reuB Crystal structure of aro4p, 3-deoxy-d-arabino-heptulosonate-7- phosphate (dahp) synthase from candida auris, l-tyr complex
52% identity, 93% coverage: 26:370/372 of query aligns to 4:354/358 of 7reuB
1ofoA Crystal structure of the tyrosine regulated 3-deoxy-d-arabino- heptulosonate-7-phosphate synthase from saccharomyces cerevisiae in complex with 2-phosphoglycolate (see paper)
54% identity, 92% coverage: 27:370/372 of query aligns to 1:340/344 of 1ofoA
>BPHYT_RS23245 FitnessBrowser__BFirm:BPHYT_RS23245
MSAIDNPLHDQEVGSADATQDTTRIDDVRIGAVRPLISPALLQDELPVPPSVQTLVEKTR
AEIADILHGRDDRLVMIVGPCSIHDHDQAIEYAHKLKVAADTYKDDLLIVMRVYFEKPRT
TVGWKGYINDPRLDGSFRINEGLRLARQLLLDINGLGLATATEFLDLLSPQYIADLIAWG
AIGARTTESQSHRQLASGLSCPIGFKNGTDGGVQIAADAIVAARASHAFMGMTKMGMAAI
FETRGNDDAHVILRGGKKGPNYDSASVEATCEALKSAGLREQVMVDCSHANSGKSHLRQL
EVVQDLTQQLSQRERRIIGVMLESHLEEGRQDLKPGVPLRHGVSITDACVSWTQTEPALE
TLAEATRKRRAG
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory