Comparing BPHYT_RS24290 FitnessBrowser__BFirm:BPHYT_RS24290 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 3 hits to proteins with known functional sites (download)
3nojA The structure of hmg/cha aldolase from the protocatechuate degradation pathway of pseudomonas putida (see paper)
28% identity, 73% coverage: 2:175/239 of query aligns to 17:170/235 of 3nojA
A5W059 4-hydroxy-4-methyl-2-oxoglutarate aldolase/4-carboxy-4-hydroxy-2-oxoadipate aldolase; HMG/CHA aldolase; Oxaloacetate decarboxylase; OAA decarboxylase; EC 4.1.3.17; EC 4.1.1.112 from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) (see paper)
28% identity, 73% coverage: 2:175/239 of query aligns to 18:171/238 of A5W059
1nxjA Structure of rv3853 from mycobacterium tuberculosis (see paper)
31% identity, 46% coverage: 74:184/239 of query aligns to 46:156/156 of 1nxjA
Sites not aligning to the query:
>BPHYT_RS24290 FitnessBrowser__BFirm:BPHYT_RS24290
MSDLDSATLEALRRVSTATLTTQLFKRGLRNTFMQGVAPLAAHSGANLVGPAFTLRNIPS
REDIDVLELFADPEYAQRKCVETIPAGHVLVQDCRGERGSASFGSILTQRLQVRGVAGMV
SDGPVRDSTTIAALGIPVFCAGASAPPNLIRHHAVDINVPIGCGGVAVFPGDVIVGDADG
VVVIPLKMAAEVAQAAAEQEQLEVFLTERIRDGAALPGTYPPNEATKAAYEAWKEKRKA
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory