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Comparing BPHYT_RS27390 FitnessBrowser__BFirm:BPHYT_RS27390 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P0CH37 NADP-dependent alcohol dehydrogenase C 2; Ms-ADHC 2; EC 1.1.1.2 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
53% identity, 97% coverage: 8:351/353 of query aligns to 7:349/349 of P0CH37
- K210 (≠ G211) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
P0CH36 NADP-dependent alcohol dehydrogenase C 1; Ms-ADHC 1; EC 1.1.1.2 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
53% identity, 97% coverage: 8:351/353 of query aligns to 7:349/349 of P0CH36
- K210 (≠ G211) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
P9WQC5 NADP-dependent alcohol dehydrogenase C; EC 1.1.1.2 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
52% identity, 97% coverage: 8:349/353 of query aligns to 7:346/346 of P9WQC5
- K209 (≠ G211) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
1uufA Crystal structure of a zinc-type alcohol dehydrogenase-like protein yahk
52% identity, 97% coverage: 6:349/353 of query aligns to 2:338/339 of 1uufA
- active site: C38 (= C42), H39 (= H43), S40 (= S44), H43 (= H47), H60 (= H64), E61 (= E65), C91 (= C95), C94 (= C98), C97 (= C101), C105 (= C109), T109 (= T114), C156 (= C160), T160 (= T164), R330 (= R341)
- binding zinc ion: C38 (= C42), H60 (= H64), C91 (= C95), C94 (= C98), C97 (= C101), C105 (= C109), C156 (= C160)
Sites not aligning to the query:
1yqdA Sinapyl alcohol dehydrogenase complexed with NADP+ (see paper)
48% identity, 97% coverage: 5:348/353 of query aligns to 10:352/359 of 1yqdA
- active site: C47 (= C42), H48 (= H43), S49 (= S44), H52 (= H47), H69 (= H64), E70 (= E65), C100 (= C95), C103 (= C98), C106 (= C101), C114 (= C109), I118 (≠ T114), C163 (= C160), T167 (= T164), R345 (= R341)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: C47 (= C42), H48 (= H43), S49 (= S44), H52 (= H47), C163 (= C160), T167 (= T164), G188 (= G184), L189 (= L185), G190 (= G186), G191 (= G187), L192 (= L188), S211 (≠ T207), T212 (≠ R208), S213 (= S209), K216 (= K212), T251 (= T246), V252 (≠ I247), S253 (≠ P248), V274 (= V269), G275 (= G270), A276 (≠ G273), G299 (≠ F295), I300 (= I296), N340 (≠ S336), R345 (= R341)
- binding zinc ion: C47 (= C42), H69 (= H64), C100 (= C95), C103 (= C98), C106 (= C101), C114 (= C109), C163 (= C160)
5z0cA Nerol dehydrogenase from persicaria minor (see paper)
50% identity, 97% coverage: 5:348/353 of query aligns to 7:349/367 of 5z0cA
- active site: C44 (= C42), S46 (= S44), H49 (= H47), H66 (= H64), C160 (= C160)
- binding zinc ion: C44 (= C42), H66 (= H64), C97 (= C95), C100 (= C98), C103 (= C101), C111 (= C109), C160 (= C160)
6k3gB Crystal structure of 10-hydroxygeraniol dehydrogenase from cantharanthus roseus in complex with NADP+ (see paper)
50% identity, 98% coverage: 5:351/353 of query aligns to 10:356/356 of 6k3gB
- active site: C47 (= C42), S49 (= S44), H52 (= H47), H69 (= H64), C163 (= C160)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: H48 (= H43), S49 (= S44), H52 (= H47), W58 (= W53), C163 (= C160), T167 (= T164), G188 (= G184), L189 (= L185), G190 (= G186), G191 (= G187), L192 (= L188), S211 (≠ T207), T212 (≠ R208), S213 (= S209), K216 (= K212), T251 (= T246), V252 (≠ I247), S253 (≠ P248), A254 (≠ Y249), V274 (= V269), G275 (= G270), A276 (≠ G273), A299 (≠ F295), I300 (= I296), R345 (= R341)
- binding zinc ion: C47 (= C42), H69 (= H64), C100 (= C95), C103 (= C98), C106 (= C101), C114 (= C109), C163 (= C160)
5vktA Cinnamyl alcohol dehydrogenases (sbcad4) from sorghum bicolor (l.) Moench (see paper)
46% identity, 99% coverage: 3:352/353 of query aligns to 1:351/353 of 5vktA
- active site: C40 (= C42), H41 (= H43), T42 (≠ S44), H45 (= H47), H62 (= H64), E63 (= E65), C93 (= C95), C96 (= C98), C99 (= C101), C107 (= C109), V111 (≠ A113), C158 (= C160), T162 (= T164), R340 (= R341)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: C40 (= C42), H41 (= H43), T42 (≠ S44), H45 (= H47), C158 (= C160), T162 (= T164), G183 (= G184), L184 (= L185), G185 (= G186), G186 (= G187), L187 (= L188), S206 (≠ T207), S207 (≠ R208), S208 (= S209), K211 (= K212), T246 (= T246), V247 (≠ I247), S248 (≠ P248), A249 (≠ Y249), V269 (= V269), G270 (= G270), N293 (≠ S294), G294 (≠ F295), N335 (≠ S336), R340 (= R341)
- binding zinc ion: C40 (= C42), H62 (= H64), C93 (= C95), C96 (= C98), C99 (= C101), C107 (= C109), C158 (= C160)
3twoB The crystal structure of cad from helicobacter pylori complexed with NADP(h) (see paper)
42% identity, 97% coverage: 5:346/353 of query aligns to 5:343/348 of 3twoB
- active site: C42 (= C42), H43 (= H43), S44 (= S44), H47 (= H47), H64 (= H64), E65 (= E65), C95 (= C95), C98 (= C98), C101 (= C101), C109 (= C109), V113 (≠ T114), C160 (= C160), T164 (= T164), R338 (= R341)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: C42 (= C42), H43 (= H43), S44 (= S44), H47 (= H47), C160 (= C160), T164 (= T164), G184 (= G184), F185 (≠ L185), G186 (= G186), G187 (= G187), L188 (= L188), R208 (= R208), T241 (= T246), I242 (= I247), P243 (= P248), T244 (≠ Y249), V264 (= V269), G265 (= G270), L266 (≠ F272), L292 (≠ F295), I293 (= I296), L330 (≠ M333), G333 (≠ S336), R338 (= R341)
- binding zinc ion: C42 (= C42), H64 (= H64), C95 (= C95), C98 (= C98), C101 (= C101), C109 (= C109), C160 (= C160)
7cguA Crystal structure of abhar
45% identity, 96% coverage: 7:346/353 of query aligns to 6:345/352 of 7cguA
5h83A Heteroyohimbine synthase hys from catharanthus roseus - apo form (see paper)
44% identity, 98% coverage: 7:351/353 of query aligns to 13:353/354 of 5h83A
8a3nB Geissoschizine synthase from catharanthus roseus - binary complex with NADP+ (see paper)
41% identity, 99% coverage: 5:352/353 of query aligns to 7:352/352 of 8a3nB
- binding nadp nicotinamide-adenine-dinucleotide phosphate: N45 (≠ H43), V161 (≠ T164), G182 (= G184), L183 (= L185), L186 (= L188), S205 (≠ T207), T206 (≠ R208), K210 (= K212), T245 (= T246), P247 (= P248), V269 (= V269), A271 (≠ Y271), S294 (≠ F295), L335 (≠ S336), R340 (= R341)
- binding zinc ion: C44 (= C42), H66 (= H64), E67 (= E65), C97 (= C95), C100 (= C98), C103 (= C101), C111 (= C109), C157 (= C160)
5h81B Heteroyohimbine synthase thas2 from catharanthus roseus - complex with NADP+ (see paper)
41% identity, 98% coverage: 5:351/353 of query aligns to 4:354/354 of 5h81B
- active site: A343 (≠ R341)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: V174 (≠ T164), F196 (≠ L185), G197 (= G186), R198 (≠ G187), I199 (≠ L188), S218 (≠ T207), T219 (≠ R208), S220 (= S209), K223 (= K212), V259 (≠ I247), P260 (= P248), L281 (≠ V269), I297 (≠ F295)
- binding zinc ion: C41 (= C42), H63 (= H64), E64 (= E65), C94 (= C95), C97 (= C98), C100 (= C101), C108 (= C109), C170 (= C160)
5fi3A Heteroyohimbine synthase thas1 from catharanthus roseus - complex with NADP+ (see paper)
41% identity, 98% coverage: 5:351/353 of query aligns to 6:344/344 of 5fi3A
- active site: C43 (= C42), Q44 (≠ H43), Y45 (≠ S44), E48 (≠ H47), H65 (= H64), E66 (= E65), C96 (= C95), C99 (= C98), C102 (= C101), C110 (= C109), G114 (≠ A113), C151 (= C160), R333 (= R341)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: Q44 (≠ H43), E48 (≠ H47), T155 (= T164), G176 (= G184), L177 (= L185), G178 (= G186), G179 (= G187), L180 (= L188), S199 (≠ T207), S200 (≠ R208), K204 (= K212), T239 (= T246), I240 (= I247), P241 (= P248), L262 (≠ V269), G263 (= G270), T287 (≠ F295), S328 (= S336)
- binding zinc ion: C43 (= C42), H65 (= H64), E66 (= E65), C96 (= C95), C99 (= C98), C102 (= C101), C110 (= C109), C151 (= C160)
Q6ZHS4 Cinnamyl alcohol dehydrogenase 2; OsCAD2; Protein GOLD HULL AND INTERNODE 2; EC 1.1.1.195 from Oryza sativa subsp. japonica (Rice) (see paper)
45% identity, 98% coverage: 3:347/353 of query aligns to 8:351/363 of Q6ZHS4
- G185 (≠ A181) mutation to D: Loss of activity.
8b25B Dihydroprecondylocarpine acetate synthase 2 from tabernanthe iboga - stemmadenine acetate bound structure (see paper)
42% identity, 97% coverage: 5:346/353 of query aligns to 10:351/359 of 8b25B
8b1vA Dihydroprecondylocarpine acetate synthase 2 from tabernanthe iboga (see paper)
42% identity, 97% coverage: 5:346/353 of query aligns to 10:351/358 of 8b1vA
2cf6A Crystal structures of the arabidopsis cinnamyl alcohol dehydrogenases atcad5 (see paper)
43% identity, 97% coverage: 3:346/353 of query aligns to 3:345/352 of 2cf6A
- active site: C42 (= C42), H43 (= H43), T44 (≠ S44), H47 (= H47), H64 (= H64), E65 (= E65), C95 (= C95), C98 (= C98), C101 (= C101), C109 (= C109), I113 (≠ A113), C158 (= C160), T162 (= T164), R340 (= R341)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: H43 (= H43), T44 (≠ S44), T162 (= T164), L184 (= L185), G185 (= G186), G186 (= G187), V187 (≠ L188), S206 (≠ T207), S207 (≠ R208), K211 (= K212), T246 (= T246), M269 (≠ V269), S293 (= S294), F294 (= F295), I295 (= I296)
- binding zinc ion: C42 (= C42), H64 (= H64), E65 (= E65), C98 (= C98), C109 (= C109)
2cf5A Crystal structures of the arabidopsis cinnamyl alcohol dehydrogenases, atcad5 (see paper)
43% identity, 97% coverage: 3:346/353 of query aligns to 3:345/352 of 2cf5A
- active site: C42 (= C42), H43 (= H43), T44 (≠ S44), H47 (= H47), H64 (= H64), E65 (= E65), C95 (= C95), C98 (= C98), C101 (= C101), C109 (= C109), I113 (≠ A113), C158 (= C160), T162 (= T164), R340 (= R341)
- binding zinc ion: C42 (= C42), H64 (= H64), E65 (= E65), C95 (= C95), C98 (= C98), C101 (= C101), C109 (= C109), C158 (= C160)
O49482 Cinnamyl alcohol dehydrogenase 5; AtCAD5; Cinnamyl alcohol dehydrogenase D; EC 1.1.1.195 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
43% identity, 97% coverage: 3:346/353 of query aligns to 8:350/357 of O49482
- C47 (= C42) binding
- T49 (≠ S44) binding
- H69 (= H64) binding
- E70 (= E65) binding ; mutation to A: Loss of activity.
- C100 (= C95) binding
- C103 (= C98) binding
- C106 (= C101) binding
- C114 (= C109) binding
- C163 (= C160) binding
- T167 (= T164) binding
- GLGGVG 188:193 (≠ GLGGLG 184:189) binding
- SSSNKK 211:216 (≠ TRSAGK 207:212) binding
- T251 (= T246) binding
- G275 (= G270) binding
- SFI 298:300 (= SFI 294:296) binding
Query Sequence
>BPHYT_RS27390 FitnessBrowser__BFirm:BPHYT_RS27390
MVRAARGYAATSATTPLSLFDFQRRSLRNDDVVIEVLYCGVCHSDLHTTRNNWGNARYPI
VPGHEIVGRVKELGAEATRFTVGDYVGVGCMVDSCQHCKTCRNGFEQYCESGATSTYNNT
DRHDQSRTQGGYSDQIIVSEKFVLRMPDNLDLKGAAPLLCAGITTYSPLRHWNVGEGSRV
AVIGLGGLGHMAIKLASAMGADVTLITRSAGKETDARALGARDVVLSSDVEQMAAAKSRF
DLIIDTIPYQHDLNPYVATLDSGGTLVLVGYFGPVEPALNSSPMVSKRKTVAGSFIGGIA
ETQEMLDFCGKHGITCEIEMIDIQQVNEAFDRMLRSDVKYRFVIDLGSLKSEI
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory