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Comparing BPHYT_RS28885 FitnessBrowser__BFirm:BPHYT_RS28885 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2d4eC Crystal structure of the hpcc from thermus thermophilus hb8
47% identity, 99% coverage: 5:484/485 of query aligns to 29:514/515 of 2d4eC
- active site: N173 (= N146), K196 (= K169), E271 (= E242), C305 (= C276), E409 (= E379), E486 (= E456)
- binding nicotinamide-adenine-dinucleotide: I169 (= I142), T170 (≠ S143), P171 (= P144), W172 (= W145), K196 (= K169), A198 (≠ S171), G229 (= G202), G233 (= G206), A234 (≠ E207), T248 (= T221), G249 (= G222), E250 (≠ S223), T253 (= T226), E271 (= E242), L272 (= L243), C305 (= C276), E409 (= E379), F411 (= F381), F475 (= F445)
Q9H2A2 2-aminomuconic semialdehyde dehydrogenase; Aldehyde dehydrogenase 12; Aldehyde dehydrogenase family 8 member A1; EC 1.2.1.32 from Homo sapiens (Human) (see paper)
42% identity, 98% coverage: 1:473/485 of query aligns to 8:485/487 of Q9H2A2
- R109 (= R102) mutation to A: About 65-fold loss of catalytic efficiency.
- N155 (= N146) mutation to A: Complete loss of activity.
- R451 (= R439) mutation to A: Complete loss of activity.
4npiA 1.94 angstroms x-ray crystal structure of NAD- and intermediate- bound alpha-aminomuconate-epsilon-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
40% identity, 98% coverage: 2:475/485 of query aligns to 2:483/483 of 4npiA
- active site: N152 (= N146), K175 (= K169), E251 (= E242), C285 (= C276), E387 (= E379), E464 (= E456)
- binding (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid: R103 (= R102), L157 (≠ T151), W160 (= W154), E251 (= E242), C285 (= C276), Y445 (≠ N437), R447 (= R439), F453 (= F445)
- binding nicotinamide-adenine-dinucleotide: I148 (= I142), S149 (= S143), P150 (= P144), W151 (= W145), K175 (= K169), E178 (= E172), G208 (= G202), G213 (= G206), E214 (= E207), F227 (= F220), G229 (= G222), E230 (≠ S223), T233 (= T226), G253 (= G244), C285 (= C276), K335 (= K326), E387 (= E379), F389 (= F381)
4i2rA 2.15 angstroms x-ray crystal structure of NAD- and alternative substrate-bound 2-aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
40% identity, 98% coverage: 2:475/485 of query aligns to 2:483/483 of 4i2rA
- active site: N152 (= N146), K175 (= K169), E251 (= E242), C285 (= C276), E387 (= E379), E464 (= E456)
- binding (2E,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid: R103 (= R102), L157 (≠ T151), C285 (= C276), Y445 (≠ N437), R447 (= R439), F453 (= F445)
- binding nicotinamide-adenine-dinucleotide: I148 (= I142), S149 (= S143), W151 (= W145), N152 (= N146), K175 (= K169), E178 (= E172), G208 (= G202), F227 (= F220), T228 (= T221), G229 (= G222), E230 (≠ S223), T233 (= T226), E251 (= E242), L252 (= L243), G253 (= G244), C285 (= C276), E387 (= E379), F389 (= F381)
4i25A 2.00 angstroms x-ray crystal structure of NAD- and substrate-bound 2- aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
40% identity, 98% coverage: 2:475/485 of query aligns to 2:483/483 of 4i25A
- active site: N152 (= N146), K175 (= K169), E251 (= E242), C285 (= C276), E387 (= E379), E464 (= E456)
- binding (2E,4E)-2-amino-6-oxohexa-2,4-dienoic acid: R103 (= R102), L157 (≠ T151), C285 (= C276), Y445 (≠ N437), R447 (= R439), F453 (= F445)
- binding nicotinamide-adenine-dinucleotide: I148 (= I142), S149 (= S143), P150 (= P144), W151 (= W145), N152 (= N146), K175 (= K169), E178 (= E172), G208 (= G202), G213 (= G206), F227 (= F220), T228 (= T221), G229 (= G222), E230 (≠ S223), T233 (= T226), E251 (= E242), L252 (= L243), C285 (= C276), E387 (= E379), F389 (= F381)
5kllA Crystal structure of 2-hydroxymuconate-6-semialdehyde derived tautomeric intermediate in 2-aminomuconate 6-semialdehyde dehydrogenase n169d (see paper)
40% identity, 98% coverage: 2:475/485 of query aligns to 2:483/483 of 5kllA
- active site: D152 (≠ N146), K175 (= K169), E251 (= E242), C285 (= C276), E387 (= E379), E464 (= E456)
- binding (3~{E},5~{E})-6-oxidanyl-2-oxidanylidene-hexa-3,5-dienoic acid: R103 (= R102), D152 (≠ N146), L157 (≠ T151), W160 (= W154), C285 (= C276), Y445 (≠ N437), R447 (= R439), F453 (= F445)
5kj5B Crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase n169d in complex with NAD+ (see paper)
40% identity, 98% coverage: 2:475/485 of query aligns to 3:484/484 of 5kj5B
- active site: D153 (≠ N146), K176 (= K169), E252 (= E242), C286 (= C276), E388 (= E379), E465 (= E456)
- binding nicotinamide-adenine-dinucleotide: I149 (= I142), S150 (= S143), P151 (= P144), W152 (= W145), D153 (≠ N146), L158 (≠ T151), K176 (= K169), G209 (= G202), K210 (= K203), G214 (= G206), F228 (= F220), T229 (= T221), G230 (= G222), E231 (≠ S223), T234 (= T226), E252 (= E242), L253 (= L243), C286 (= C276), E388 (= E379), F390 (= F381), F454 (= F445)
4ou2A A 2.15 angstroms x-ray crystal structure of e268a 2-aminomuconate 6- semialdehyde dehydrogenase catalytic intermediate from pseudomonas fluorescens (see paper)
40% identity, 98% coverage: 2:475/485 of query aligns to 2:483/483 of 4ou2A
- active site: N152 (= N146), K175 (= K169), A251 (≠ E242), C285 (= C276), E387 (= E379), E464 (= E456)
- binding (2Z,4E)-2,6-dihydroxyhexa-2,4-dienoic acid: R103 (= R102), L157 (≠ T151), C285 (= C276), Y445 (≠ N437), R447 (= R439), F453 (= F445)
- binding nicotinamide-adenine-dinucleotide: I148 (= I142), S149 (= S143), P150 (= P144), W151 (= W145), N152 (= N146), K175 (= K169), G208 (= G202), G213 (= G206), E214 (= E207), F227 (= F220), T228 (= T221), G229 (= G222), E230 (≠ S223), T233 (= T226), A251 (≠ E242), L252 (= L243), G253 (= G244), C285 (= C276), E387 (= E379), F389 (= F381)
Q9HTJ1 NAD/NADP-dependent betaine aldehyde dehydrogenase; BADH; EC 1.2.1.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
41% identity, 95% coverage: 18:478/485 of query aligns to 24:486/490 of Q9HTJ1
- GAWN 150:153 (≠ SPWN 143:146) binding
- K162 (= K155) active site, Charge relay system
- KPSE 176:179 (≠ KMSE 169:172) binding
- G209 (= G202) binding
- GTST 230:233 (≠ STAT 223:226) binding
- E252 (= E242) active site, Proton acceptor
- C286 (= C276) binding covalent; modified: Cysteine sulfenic acid (-SOH)
- E387 (= E379) binding
- E464 (= E456) active site, Charge relay system
4cazA Crystal structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa in complex with nadh
41% identity, 95% coverage: 18:478/485 of query aligns to 23:485/489 of 4cazA
- active site: N152 (= N146), K175 (= K169), E251 (= E242), C285 (= C276), E386 (= E379), E463 (= E456)
- binding [[(2R,3S,4R,5R)-5-[(3R)-3-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate: I148 (= I142), G149 (≠ S143), W151 (= W145), N152 (= N146), K175 (= K169), E178 (= E172), G208 (= G202), G212 (= G206), F226 (= F220), T227 (= T221), G228 (= G222), G229 (≠ S223), T232 (= T226), V236 (≠ I230), E251 (= E242), L252 (= L243), C285 (= C276), E386 (= E379), F388 (= F381)
2woxA Betaine aldehyde dehydrogenase from pseudomonas aeruginosa with NAD(p) h-catalytic thiol adduct. (see paper)
41% identity, 95% coverage: 18:478/485 of query aligns to 23:485/489 of 2woxA
- active site: N152 (= N146), K175 (= K169), E251 (= E242), C285 (= C276), E386 (= E379), E463 (= E456)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I148 (= I142), G149 (≠ S143), W151 (= W145), N152 (= N146), K175 (= K169), S177 (= S171), E178 (= E172), G208 (= G202), G212 (= G206), F226 (= F220), T227 (= T221), G228 (= G222), G229 (≠ S223), T232 (= T226), V236 (≠ I230), E251 (= E242), L252 (= L243), C285 (= C276), E386 (= E379), F388 (= F381)
2wmeA Crystallographic structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa (see paper)
41% identity, 95% coverage: 18:478/485 of query aligns to 23:485/489 of 2wmeA
- active site: N152 (= N146), K175 (= K169), E251 (= E242), C285 (= C276), E386 (= E379), E463 (= E456)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G149 (≠ S143), W151 (= W145), K175 (= K169), S177 (= S171), E178 (= E172), G208 (= G202), G212 (= G206), F226 (= F220), G228 (= G222), G229 (≠ S223), T232 (= T226), V236 (≠ I230)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
41% identity, 98% coverage: 2:475/485 of query aligns to 16:490/491 of 5gtlA
- active site: N165 (= N146), K188 (= K169), E263 (= E242), C297 (= C276), E394 (= E379), E471 (= E456)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I142), P163 (= P144), K188 (= K169), A190 (≠ S171), E191 (= E172), Q192 (≠ L173), G221 (= G202), G225 (= G206), G241 (= G222), S242 (= S223), T245 (= T226), L264 (= L243), C297 (= C276), E394 (= E379), F396 (= F381)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
41% identity, 98% coverage: 2:475/485 of query aligns to 16:490/491 of 5gtkA
- active site: N165 (= N146), K188 (= K169), E263 (= E242), C297 (= C276), E394 (= E379), E471 (= E456)
- binding nicotinamide-adenine-dinucleotide: I161 (= I142), I162 (≠ S143), P163 (= P144), W164 (= W145), K188 (= K169), E191 (= E172), G221 (= G202), G225 (= G206), A226 (≠ E207), F239 (= F220), G241 (= G222), S242 (= S223), T245 (= T226), Y248 (≠ R229), L264 (= L243), C297 (= C276), Q344 (≠ H323), R347 (≠ K326), E394 (= E379), F396 (= F381)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
40% identity, 100% coverage: 1:483/485 of query aligns to 2:487/489 of 4o6rA
- active site: N150 (= N146), K173 (= K169), E248 (= E242), C282 (= C276), E383 (= E379), E460 (= E456)
- binding adenosine monophosphate: I146 (= I142), V147 (≠ S143), K173 (= K169), G206 (= G202), G210 (= G206), Q211 (≠ E207), F224 (= F220), G226 (= G222), S227 (= S223), T230 (= T226), R233 (= R229)
8vr1A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (ctp bound)
40% identity, 97% coverage: 7:476/485 of query aligns to 9:482/488 of 8vr1A
8vr0A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (gmp bound)
40% identity, 97% coverage: 7:476/485 of query aligns to 9:482/488 of 8vr0A
8vqzA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (cmp bound)
40% identity, 97% coverage: 7:476/485 of query aligns to 9:482/488 of 8vqzA
8vqwC Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (coa bound)
40% identity, 97% coverage: 7:476/485 of query aligns to 9:482/488 of 8vqwC
- binding coenzyme a: I147 (= I142), W150 (= W145), K174 (= K169), S176 (= S171), E177 (= E172), G207 (= G202), G211 (= G206), F225 (= F220), G227 (= G222), G228 (≠ S223), S231 (≠ T226), H331 (= H323), F387 (= F381)
8vj3A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (fad bound)
40% identity, 97% coverage: 7:476/485 of query aligns to 9:482/488 of 8vj3A
Query Sequence
>BPHYT_RS28885 FitnessBrowser__BFirm:BPHYT_RS28885
MRIEHLINGKASAAKDYFETVNPATQEVLAEVARGGAEEVDAAVRAAKDAFPAWAAKPAA
ERAKLVRKLGELIAKNVPDISETETKDTGQTISQTRKQLVPRAADNFSYFAEMCTRVDGH
TYPTDTHLNYTLFHPVGVCALISPWNVPFMTATWKVAPCLAFGNTAVLKMSELSPLTASM
LGNLALEAGIPAGVLNVVHGFGKDTGEPLVAHPDVHAVSFTGSTATGNRIVQTAGLKKFS
MELGGKSPFVIFDDADFERALDAAVFMIFSNNGERCTAGSRILVQRSIYARFAERFIERA
KRLTVGDPLADSTIVGPMISQGHLAKVRSYIELGPKEGATLACGGLDMPELPDAMRKGNF
VQPTVFVDVDNRMRIAQEEIFGPVACLIPFDDEADAIKLANDISYGLSSYIWTENTGRAL
RVAAAVEAGMCFVNSQNVRDLRQPFGGTKASGVGREGGTWSYEVFLEPKNVCVSLGSHHI
PRWGA
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory