SitesBLAST
Comparing BPHYT_RS29710 FitnessBrowser__BFirm:BPHYT_RS29710 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 15 hits to proteins with known functional sites (download)
P77324 Aldehyde oxidoreductase FAD-binding subunit PaoB; EC 1.2.99.6 from Escherichia coli (strain K12) (see paper)
54% identity, 99% coverage: 1:329/333 of query aligns to 1:318/318 of P77324
- 26:34 (vs. 25:33, 78% identical) binding
- T108 (= T108) binding
- C119 (= C119) binding
- C129 (= C130) binding
- C138 (= C139) binding
- C157 (= C158) binding
- D164 (= D165) binding
- I213 (= I213) binding
- K230 (= K231) binding
5g5gB Escherichia coli periplasmic aldehyde oxidase (see paper)
54% identity, 98% coverage: 1:325/333 of query aligns to 1:314/316 of 5g5gB
- binding flavin-adenine dinucleotide: K26 (≠ V25), F27 (= F26), A29 (≠ G28), G30 (= G29), G31 (= G30), T32 (= T31), N33 (= N32), L34 (= L33), G98 (= G98), A99 (= A99), L103 (= L103), A107 (= A107), T108 (= T108), A110 (≠ G110), G111 (= G111), N112 (= N112), L114 (= L114), Q115 (= Q115), S163 (= S164), D164 (= D165), L212 (= L212), I213 (= I213), F239 (= F240)
- binding iron/sulfur cluster: C119 (= C119), C129 (= C130), N130 (= N131), K131 (= K132), C138 (= C139), H148 (= H149), C157 (= C158), I158 (= I159), A159 (= A160)
5y6qB Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
47% identity, 97% coverage: 1:322/333 of query aligns to 1:323/330 of 5y6qB
- binding flavin-adenine dinucleotide: I26 (≠ F26), A28 (≠ G28), G29 (= G29), G30 (= G30), T31 (= T31), T32 (≠ N32), Q33 (≠ L33), A97 (≠ G98), A98 (= A99), I102 (≠ L103), A106 (= A107), T107 (= T108), G110 (= G111), N111 (= N112), R113 (≠ L114), Q114 (= Q115), G164 (≠ S164), D165 (= D165), I213 (≠ L212), I214 (= I213), K232 (= K231), F241 (= F240)
- binding iron/sulfur cluster: C118 (= C119), Y121 (≠ F122), C130 (= C130), N131 (= N131), C139 (= C139), A141 (= A141), C158 (= C158), I159 (= I159), A160 (= A160)
1rm6B Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
37% identity, 79% coverage: 7:270/333 of query aligns to 10:263/323 of 1rm6B
- binding flavin-adenine dinucleotide: P29 (≠ F26), G31 (= G28), A32 (≠ G29), G33 (= G30), T34 (= T31), D35 (≠ N32), L36 (= L33), L53 (≠ I50), V101 (≠ G98), A102 (= A99), A110 (= A107), T111 (= T108), G114 (= G111), N115 (= N112), C117 (≠ L114), Q118 (= Q115), D162 (= D165), L207 (≠ I213), V231 (≠ Y238), D232 (≠ A239), F233 (= F240)
- binding iron/sulfur cluster: C122 (= C119), F124 (≠ Y121), C138 (= C139), C146 (≠ T148), H147 (= H149), V148 (≠ A150), C155 (= C158), Y156 (≠ I159), A157 (= A160)
O33820 4-hydroxybenzoyl-CoA reductase subunit beta; 4-HBCR subunit beta; EC 1.1.7.1 from Thauera aromatica (see paper)
37% identity, 79% coverage: 7:270/333 of query aligns to 10:263/324 of O33820
- 29:36 (vs. 26:33, 50% identical) binding
- T111 (= T108) binding
- N115 (= N112) binding
- Q118 (= Q115) binding
- D162 (= D165) binding
- K224 (= K231) binding
4zohB Crystal structure of glyceraldehyde oxidoreductase (see paper)
26% identity, 89% coverage: 27:323/333 of query aligns to 30:274/274 of 4zohB
- active site: Y256 (≠ H305)
- binding flavin-adenine dinucleotide: A31 (≠ G28), G32 (= G29), G33 (= G30), H34 (≠ T31), S35 (≠ N32), L36 (= L33), H77 (≠ N80), I95 (≠ G98), G96 (≠ A99), V100 (≠ L103), T105 (= T108), G108 (= G111), S109 (≠ N112), S111 (≠ T148), A117 (vs. gap), D118 (= D165), L160 (= L212), V161 (≠ I213), D185 (≠ A239), F186 (= F240)
Sites not aligning to the query:
1n5wC Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
26% identity, 98% coverage: 3:329/333 of query aligns to 5:286/287 of 1n5wC
P19920 Carbon monoxide dehydrogenase medium chain; CO dehydrogenase subunit M; CO-DH M; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
26% identity, 98% coverage: 3:329/333 of query aligns to 5:286/288 of P19920
Q0QLF4 Nicotinate dehydrogenase FAD-subunit; NDH; Nicotinic acid hydroxylase FAD-subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see paper)
25% identity, 80% coverage: 26:291/333 of query aligns to 29:248/296 of Q0QLF4
- 29:36 (vs. 26:33, 63% identical) binding
- G101 (≠ A99) binding
- TIGGN 110:114 (≠ TVGGN 108:112) binding
- D123 (≠ S137) binding
- R160 (≠ D204) binding
- M169 (≠ I213) binding
- K187 (= K231) binding
1t3qC Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
27% identity, 92% coverage: 19:326/333 of query aligns to 22:280/285 of 1t3qC
- binding flavin-adenine dinucleotide: I29 (≠ F26), A31 (≠ G28), G32 (= G29), G33 (= G30), Q34 (≠ T31), S35 (≠ N32), L36 (= L33), V100 (≠ G98), A101 (= A99), V105 (≠ L103), T110 (= T108), G113 (= G111), S114 (≠ N112), A116 (≠ T148), A122 (= A154), E123 (≠ D165), L166 (≠ I213), Y190 (= Y238)
3hrdG Crystal structure of nicotinate dehydrogenase (see paper)
25% identity, 80% coverage: 26:291/333 of query aligns to 29:248/292 of 3hrdG
- binding flavin-adenine dinucleotide: I29 (≠ F26), A31 (≠ G28), G32 (= G29), G33 (= G30), T34 (= T31), D35 (≠ N32), F77 (≠ N75), V100 (≠ G98), G101 (≠ A99), I105 (≠ L103), T110 (= T108), G113 (= G111), N114 (= N112), S116 (≠ C130), T117 (≠ N131), G122 (= G136), D123 (≠ S137), I168 (≠ L212), M169 (≠ I213)
7dqxE Crystal structure of xanthine dehydrogenase family protein
25% identity, 98% coverage: 3:329/333 of query aligns to 5:287/293 of 7dqxE
- binding flavin-adenine dinucleotide: K29 (≠ V25), I30 (≠ F26), I31 (= I27), G33 (= G29), G34 (= G30), Q35 (≠ T31), S36 (≠ N32), L37 (= L33), H78 (≠ N75), I101 (≠ G98), A102 (= A99), I106 (≠ L103), G110 (≠ A107), T111 (= T108), G113 (= G110), G114 (= G111), S115 (≠ N112), A117 (≠ T148), A123 (= A154), E124 (≠ D165), I167 (= I213), Y193 (≠ F240)
1jroA Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus (see paper)
24% identity, 94% coverage: 21:332/333 of query aligns to 184:445/450 of 1jroA
- binding flavin-adenine dinucleotide: L189 (≠ F26), A191 (≠ G28), G192 (= G29), G193 (= G30), T194 (= T31), D195 (≠ N32), V196 (≠ L33), F258 (≠ G98), A259 (= A99), T268 (= T108), G271 (= G111), N272 (= N112), A274 (≠ L114), G280 (= G120), D281 (= D165), R318 (≠ L207), V324 (≠ I213)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 42, 43
- binding fe2/s2 (inorganic) cluster: 37, 38, 39, 40, 42, 44, 45, 47, 63, 103, 106, 134, 136
2w54A Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus in complex with bound inhibitor pterin-6-aldehyde (see paper)
24% identity, 94% coverage: 21:332/333 of query aligns to 184:445/450 of 2w54A
- binding flavin-adenine dinucleotide: L189 (≠ F26), A191 (≠ G28), G192 (= G29), G193 (= G30), T194 (= T31), D195 (≠ N32), V196 (≠ L33), W199 (≠ L36), L213 (≠ I50), F258 (≠ G98), A259 (= A99), A267 (= A107), T268 (= T108), G271 (= G111), N272 (= N112), A274 (≠ L114), N275 (≠ Q115), G280 (= G120), D281 (= D165), R318 (≠ L207), V324 (≠ I213), Q347 (≠ Y238)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 42
- binding fe2/s2 (inorganic) cluster: 38, 39, 40, 42, 44, 45, 47, 63, 103, 104, 106, 134, 135, 136
- binding {[(5aR,8R,9aR)-2-amino-4-oxo-6,7-di(sulfanyl-kappaS)-3,5,5a,8,9a,10-hexahydro-4H-pyrano[3,2-g]pteridin-8-yl]methyl dihydrogenato(2-) phosphate}(hydroxy)oxo(thioxo)molybdenum: 102, 136
1ffuC Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
26% identity, 92% coverage: 24:328/333 of query aligns to 28:285/287 of 1ffuC
- binding flavin-adenine dinucleotide: K29 (≠ V25), L30 (≠ F26), A32 (≠ G28), G33 (= G29), G34 (= G30), H35 (≠ T31), S36 (≠ N32), L37 (= L33), I54 (= I50), I101 (≠ G98), A102 (= A99), G110 (≠ A107), T111 (= T108), G114 (= G111), D115 (≠ N112), A117 (≠ L114), N123 (≠ S137), D124 (≠ G138), L161 (= L207), V166 (≠ L212), M167 (≠ I213), W193 (≠ F240)
Query Sequence
>BPHYT_RS29710 FitnessBrowser__BFirm:BPHYT_RS29710
MDAISYERAGDVAGAVRAAQQPGAVFIGGGTNLLDLMKGGVARPMRLIDITHISGLDMVT
TLPDGGIRLGALVRNSDAANHALVREQYPLLSQAFLAGASSQLRNMATVGGNLLQRTRCG
YFYDTAFTQCNKRMPGSGCAALDGHNRTHAILGASPQCIAVNPSDMSVALAALDAVVRVS
GPAGERTIAFADFHRLPGDRPDVDTTLQPGELITAVDLPPPLFSANSHYLKVRDRASYAF
ALVSVAAALQMDGGRVKTARIALGGVAHKPWRASVAEQMLNGQPLTQATLNNAAAAALRE
ARPQHDNRFKVQLAQRAIVRAVNQAAGRAGGVA
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory