Comparing BPHYT_RS30325 FitnessBrowser__BFirm:BPHYT_RS30325 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
G2IQQ5 2-keto-4-carboxy-3-hexenedioate hydratase; KCH hydratase; EC 4.2.1.- from Sphingobium sp. (strain NBRC 103272 / SYK-6) (see paper)
65% identity, 96% coverage: 1:335/349 of query aligns to 3:336/341 of G2IQQ5
6dxsA Crystal structure of the ligj hydratase e284q mutant substrate complex with (3z)-2-keto-4-carboxy-3-hexenedioate (see paper)
65% identity, 96% coverage: 1:335/349 of query aligns to 2:335/342 of 6dxsA
6dxqA Crystal structure of the ligj hydratase product complex with 4- carboxy-4-hydroxy-2-oxoadipate (see paper)
65% identity, 96% coverage: 2:335/349 of query aligns to 1:333/338 of 6dxqA
2gwgA Crystal structure of 4-oxalomesaconate hydratase, ligj, from rhodopseudomonas palustris, northeast structural genomics target rpr66.
60% identity, 96% coverage: 1:335/349 of query aligns to 1:321/329 of 2gwgA
5vn5C Crystal structure of ligy from sphingobium sp. Strain syk-6 (see paper)
39% identity, 94% coverage: 1:328/349 of query aligns to 1:328/334 of 5vn5C
6e6iA Crystal structure of 4-methyl hopda bound to ligy from sphingobium sp. Strain syk-6
39% identity, 94% coverage: 1:328/349 of query aligns to 1:328/332 of 6e6iA
4qroA Crystal structure of dihydroxybenzoic acid decarbboxylase bpro_2061 (target efi-500288) from polaromonas sp. Js666 with bound manganese and an inhibitor, 2-nitroresorcinol
25% identity, 83% coverage: 48:337/349 of query aligns to 39:330/332 of 4qroA
Sites not aligning to the query:
4qrnA High-resolution crystal structure of 5-carboxyvanillate decarboxylase (target efi-505250) from novosphingobium aromaticivorans dsm 12444 complexed with manganese and 4-hydroxy-3-methoxy-5-nitrobenzoic acid
24% identity, 77% coverage: 60:328/349 of query aligns to 82:350/352 of 4qrnA
Sites not aligning to the query:
4infA Crystal structure of amidohydrolase saro_0799 (target efi-505250) from novosphingobium aromaticivorans dsm 12444 with bound calcium
24% identity, 77% coverage: 60:328/349 of query aligns to 81:349/351 of 4infA
Sites not aligning to the query:
Q12BV1 Gamma-resorcylate decarboxylase; Gamma-RSD; 2,6-dihydroxybenzoate decarboxylase; 2,6-DHBD; EC 4.1.1.103 from Polaromonas sp. (strain JS666 / ATCC BAA-500) (see paper)
25% identity, 82% coverage: 48:333/349 of query aligns to 39:326/326 of Q12BV1
Sites not aligning to the query:
Q8TDX5 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Picolinate carboxylase; EC 4.1.1.45 from Homo sapiens (Human) (see paper)
23% identity, 84% coverage: 44:336/349 of query aligns to 49:336/336 of Q8TDX5
Sites not aligning to the query:
7pwyC Structure of human dimeric acmsd in complex with the inhibitor tes- 1025 (see paper)
24% identity, 81% coverage: 44:324/349 of query aligns to 39:294/301 of 7pwyC
Sites not aligning to the query:
4ofcA 2.0 angstroms x-ray crystal structure of human 2-amino-3- carboxymuconate-6-semialdehye decarboxylase (see paper)
23% identity, 81% coverage: 44:324/349 of query aligns to 49:324/335 of 4ofcA
Sites not aligning to the query:
7pwyA Structure of human dimeric acmsd in complex with the inhibitor tes- 1025 (see paper)
23% identity, 81% coverage: 44:324/349 of query aligns to 48:323/334 of 7pwyA
Sites not aligning to the query:
4ih3A 2.5 angstroms x-ray crystal structure of of human 2-amino-3- carboxymuconate-6-semialdehyde decarboxylase in complex with dipicolinic acid (see paper)
23% identity, 81% coverage: 44:324/349 of query aligns to 49:324/332 of 4ih3A
Sites not aligning to the query:
2wm1A The crystal structure of human alpha-amino-beta-carboxymuconate- epsilon-semialdehyde decarboxylase in complex with 1,3- dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis (see paper)
23% identity, 81% coverage: 44:324/349 of query aligns to 49:324/332 of 2wm1A
Sites not aligning to the query:
7a19A 2,3-dihydroxybenzoate decarboxylase of aspergillus oryzae (see paper)
24% identity, 82% coverage: 44:328/349 of query aligns to 36:329/339 of 7a19A
Sites not aligning to the query:
7wjrA Crystal structure of dihydroxybenzoate decarboxylase mutant a63s from aspergillus oryzae in complex with catechol
23% identity, 82% coverage: 44:328/349 of query aligns to 36:329/339 of 7wjrA
Sites not aligning to the query:
3ij6A Crystal structure of an uncharacterized metal-dependent hydrolase from lactobacillus acidophilus
26% identity, 51% coverage: 151:327/349 of query aligns to 134:300/303 of 3ij6A
Sites not aligning to the query:
7bp1A Crystal structure of 2, 3-dihydroxybenzoic acid decarboxylase from fusarium oxysporum in complex with catechol (see paper)
23% identity, 79% coverage: 52:328/349 of query aligns to 45:326/336 of 7bp1A
Sites not aligning to the query:
>BPHYT_RS30325 FitnessBrowser__BFirm:BPHYT_RS30325
MIIDCHGHYTTSPPQHEAWRAQQIAALKDGGTTPPRPVITDDEIRESIEGGQLRIQHERG
TDLTIFSPRAAGMGHHLATAEANALWSSECNDLVHRVCELFPRNFVGVCQLPQAPGVAPA
NCIGELRRCVEELGFIGCNLNPDPSGGHWSGLPLTDRCWYPLYEAMVELDVPAMIHVSSS
CNPNFHATGAHYINGDTSAFMQLLQGDLFADFPTLRFIIPHGGGAVPYHWGRYRGLAQDM
KRPLLSEYLLKNVFFDTCVYHQPGAELLAKVIPVENILFASETIGAVQGIDPETGHYYDD
TRRYIDAIEWLSDADRQRIYEDNARSVYPRLSRQLDLQLAAQVTQGATV
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory