SitesBLAST – Find functional sites

 

SitesBLAST

Comparing BPHYT_RS31315 FitnessBrowser__BFirm:BPHYT_RS31315 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 12 hits to proteins with known functional sites (download)

P00099 Cytochrome c-551; Cytochrome C8; Cytochrome c551 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 4 papers)
31% identity, 93% coverage: 9:111/111 of query aligns to 7:103/104 of P00099

query
sites
P00099
L
|
L
A
x
S
A
x
L
C
x
L
A
|
A
V
x
T
F
x
G
V
x
T
L
|
L
A
x
L
A
|
A
S
x
Q
T
x
G
A
|
A
H
x
W
A
|
A
E
|
E
P
 
-
E
x
D
P
|
P
T
x
E
A
x
V
L
|
L
V
x
F
D
x
K
Q
x
N
Q
x
K
H
x
G
C
|
C
M
x
V
F
x
A
C
|
C
H
|
H
T
x
A
R
x
I
D
|
D
A
x
T
P
x
K
F
x
M
L
x
V
A
x
G
P
|
P
S
x
A
F
x
Y
Q
x
K
Q
x
D
I
x
V
A
|
A
E
x
A
R
x
K
Y
x
F
R
x
A
N
x
G
V
x
Q
P
x
A
D
x
G
A
|
A
Q
x
E
F
x
A
M
x
E
L
|
L
E
x
A
H
x
Q
K
x
R
L
x
I
R
x
K
L
x
N
G
|
G
G
x
S
K
x
Q
A
x
G
H
x
V
W
|
W
G
|
G
D
x
P
M
x
I
A
x
P
M
|
M
P
|
P
L
x
P
P
x
N
A
|
A
D
 
-
R
 
-
G
 
-
G
 
-
P
 
-
L
x
V
S
|
S
A
x
D
E
x
D
D
x
E
A
|
A
H
x
Q
T
|
T
L
|
L
V
x
A
Q
x
K
W
|
W
V
|
V
L
|
L
S
|
S
Q
|
Q

Sites not aligning to the query:

1corA Investigation of the solution conformation of cytochromE C-551 from pseudomonas stutzeri (see paper)
32% identity, 74% coverage: 30:111/111 of query aligns to 5:81/82 of 1corA

query
sites
1corA
A
 
A
L
 
L
V
 
F
D
 
K
Q
 
S
Q
x
K
H
 
P
C
|
C
M
 
A
F
 
A
C
|
C
H
|
H
T
 
S
R
 
I
D
 
D
A
 
A
P
 
K
F
 
L
L
x
V
A
x
G
P
|
P
S
 
A
F
 
F
Q
 
K
Q
 
E
I
 
V
A
 
A
E
 
A
R
 
K
Y
 
Y
R
 
A
N
 
G
V
 
Q
P
 
D
D
 
G
A
 
A
Q
 
A
F
 
D
M
 
L
L
|
L
E
 
A
H
 
G
K
x
H
L
x
I
R
 
K
L
 
N
G
 
G
G
x
S
K
x
Q
A
x
G
H
x
V
W
|
W
G
|
G
D
 
P
M
x
I
A
 
P
M
|
M
P
 
P
L
 
P
P
 
-
A
 
-
D
 
-
R
 
-
G
 
-
G
x
N
P
 
P
L
 
V
S
 
T
A
 
E
E
 
E
D
 
E
A
 
A
H
 
K
T
 
I
L
 
L
V
 
A
Q
 
E
W
 
W
V
 
I
L
 
L
S
 
S
Q
 
Q

2exvA Crystal structure of the f7a mutant of the cytochrome c551 from pseudomonas aeruginosa (see paper)
29% identity, 77% coverage: 27:111/111 of query aligns to 2:81/82 of 2exvA

query
sites
2exvA
E
 
D
P
 
P
T
 
E
A
 
V
L
 
L
V
 
A
D
 
K
Q
 
N
Q
 
K
H
 
G
C
|
C
M
 
V
F
 
A
C
|
C
H
|
H
T
 
A
R
 
I
D
 
D
A
 
T
P
 
K
F
 
M
L
 
V
A
x
G
P
|
P
S
 
A
F
 
Y
Q
 
K
Q
 
D
I
 
V
A
 
A
E
 
A
R
 
K
Y
 
F
R
 
A
N
 
G
V
 
Q
P
 
A
D
 
G
A
 
A
Q
 
E
F
 
A
M
 
E
L
 
L
E
 
A
H
 
Q
K
x
R
L
x
I
R
 
K
L
 
N
G
 
G
G
x
S
K
x
Q
A
x
G
H
x
V
W
|
W
G
|
G
D
 
P
M
x
I
A
x
P
M
|
M
P
 
P
L
 
P
P
x
N
A
 
A
D
 
-
R
 
-
G
 
-
G
 
-
P
 
-
L
 
V
S
 
S
A
 
D
E
 
D
D
 
E
A
 
A
H
 
Q
T
 
T
L
 
L
V
 
A
Q
 
K
W
 
W
V
 
V
L
 
L
S
 
S
Q
 
Q

6kq1A Crystal structure of cytochrome c551 from pseudomonas sp. Strain mt-1.
32% identity, 73% coverage: 30:110/111 of query aligns to 5:80/82 of 6kq1A

query
sites
6kq1A
A
 
A
L
 
L
V
 
F
D
 
K
Q
 
S
Q
x
K
H
 
P
C
|
C
M
 
A
F
 
A
C
|
C
H
|
H
T
 
S
R
 
I
D
 
D
A
 
A
P
 
K
F
 
M
L
 
V
A
x
G
P
|
P
S
 
A
F
 
L
Q
 
K
Q
 
E
I
x
V
A
 
A
E
 
A
R
 
K
Y
|
Y
R
 
A
N
 
G
V
 
Q
P
 
E
D
 
G
A
 
A
Q
 
A
F
 
D
M
 
L
L
|
L
E
 
A
H
 
G
K
x
H
L
x
I
R
 
K
L
 
N
G
 
G
G
 
T
K
x
Q
A
x
G
H
x
N
W
|
W
G
|
G
D
 
P
M
x
I
A
 
P
M
|
M
P
 
P
L
 
P
P
 
-
A
 
-
D
 
-
R
 
-
G
 
-
G
x
N
P
 
P
L
 
V
S
 
T
A
 
E
E
 
E
D
x
E
A
 
A
H
 
K
T
 
T
L
 
L
V
 
A
Q
 
E
W
 
W
V
 
V
L
 
L
S
 
S

Sites not aligning to the query:

351cA Structure of cytochrome c551 from p. Aeruginosa refined at 1.6 angstroms resolution and comparison of the two redox forms (see paper)
29% identity, 77% coverage: 27:111/111 of query aligns to 2:81/82 of 351cA

query
sites
351cA
E
 
D
P
 
P
T
 
E
A
 
V
L
 
L
V
 
F
D
 
K
Q
 
N
Q
 
K
H
 
G
C
|
C
M
 
V
F
 
A
C
|
C
H
|
H
T
 
A
R
 
I
D
 
D
A
 
T
P
 
K
F
 
M
L
 
V
A
x
G
P
|
P
S
 
A
F
x
Y
Q
 
K
Q
 
D
I
 
V
A
 
A
E
 
A
R
 
K
Y
 
F
R
 
A
N
 
G
V
 
Q
P
 
A
D
 
G
A
 
A
Q
 
E
F
 
A
M
 
E
L
|
L
E
 
A
H
 
Q
K
x
R
L
x
I
R
 
K
L
 
N
G
 
G
G
 
S
K
x
Q
A
x
G
H
x
V
W
|
W
G
|
G
D
 
P
M
x
I
A
x
P
M
|
M
P
 
P
L
 
P
P
 
N
A
 
A
D
 
-
R
 
-
G
 
-
G
 
-
P
 
-
L
 
V
S
 
S
A
 
D
E
 
D
D
 
E
A
 
A
H
 
Q
T
 
T
L
 
L
V
 
A
Q
 
K
W
 
W
V
 
V
L
 
L
S
 
S
Q
 
Q

5xecC Heterodimer constructed from pa cyt c551-ht cyt c552 and ht cyt c552- pa cyt c551 chimeric proteins (see paper)
32% identity, 73% coverage: 31:111/111 of query aligns to 4:79/80 of 5xecC

query
sites
5xecC
L
 
L
V
 
A
D
 
K
Q
 
Q
Q
 
K
H
 
G
C
|
C
M
 
M
F
 
A
C
|
C
H
|
H
T
 
D
R
 
L
D
 
K
A
 
A
P
 
K
F
 
M
L
 
V
A
 
G
P
|
P
S
 
A
F
x
Y
Q
 
K
Q
 
D
I
 
V
A
 
A
E
 
A
R
 
K
Y
 
F
R
 
A
N
 
G
V
 
Q
P
 
A
D
 
G
A
 
A
Q
 
E
F
 
A
M
 
E
L
|
L
E
 
A
H
 
Q
K
x
R
L
 
I
R
 
K
L
 
N
G
 
G
G
 
S
K
x
Q
A
 
G
H
x
V
W
|
W
G
|
G
D
 
P
M
x
I
A
 
P
M
|
M
P
 
P
L
 
P
P
x
N
A
 
A
D
 
-
R
 
-
G
 
-
G
 
-
P
 
-
L
 
V
S
 
S
A
 
D
E
 
D
D
 
E
A
 
A
H
 
Q
T
 
T
L
 
L
V
 
A
Q
 
K
W
 
W
V
 
V
L
 
L
S
 
S
Q
 
Q

5xecA Heterodimer constructed from pa cyt c551-ht cyt c552 and ht cyt c552- pa cyt c551 chimeric proteins (see paper)
31% identity, 76% coverage: 27:110/111 of query aligns to 2:80/82 of 5xecA

query
sites
5xecA
E
 
D
P
 
P
T
 
E
A
 
V
L
 
L
V
 
F
D
 
K
Q
 
N
Q
 
K
H
 
G
C
|
C
M
 
V
F
 
A
C
|
C
H
|
H
T
 
A
R
 
I
D
 
D
A
 
T
P
 
K
F
 
K
L
 
V
A
x
G
P
|
P
S
 
A
F
x
Y
Q
 
A
Q
 
D
I
 
V
A
 
A
E
 
K
R
 
K
Y
|
Y
R
 
A
N
 
G
V
 
R
P
 
K
D
 
D
A
 
A
Q
 
V
F
 
D
M
x
Y
L
 
L
E
 
A
H
 
G
K
 
K
L
x
I
R
 
K
L
 
K
G
 
G
G
 
G
K
x
S
A
x
G
H
x
V
W
|
W
G
|
G
D
 
S
M
x
V
A
 
P
M
|
M
P
 
P
L
 
-
P
 
P
A
x
Q
D
 
N
R
 
-
G
 
-
G
 
-
P
 
-
L
 
V
S
 
T
A
 
D
E
 
A
D
 
E
A
 
A
H
 
K
T
 
Q
L
 
L
V
 
A
Q
 
Q
W
 
W
V
x
I
L
 
L
S
 
S

4xxlA Crystal structure of class 1 cytochrome mtod from sideroxydans lithotrophicus es-1 (see paper)
33% identity, 74% coverage: 29:110/111 of query aligns to 8:89/92 of 4xxlA

query
sites
4xxlA
T
 
K
A
 
S
L
 
L
V
 
A
D
 
R
Q
 
E
Q
 
N
H
 
N
C
|
C
M
 
F
F
 
K
C
|
C
H
|
H
T
 
G
R
 
V
D
 
D
A
 
K
P
 
E
F
 
K
L
 
D
A
x
G
P
|
P
S
 
S
F
x
Y
Q
 
K
Q
 
K
I
 
V
A
 
A
E
 
E
R
x
K
Y
|
Y
R
 
R
N
 
G
V
 
K
P
 
A
D
 
D
A
 
A
Q
 
E
F
 
A
M
 
K
L
 
L
E
 
I
H
 
H
K
x
H
L
 
V
R
 
T
L
 
S
G
 
G
G
 
E
K
 
K
A
|
A
H
x
K
W
 
F
G
 
P
D
 
D
M
 
G
A
 
H
M
 
E
P
 
E
L
 
E
P
x
H
A
 
K
D
 
N
R
 
I
G
 
N
G
 
G
P
 
K
L
 
A
S
 
S
A
 
P
E
 
E
D
 
A
A
 
I
H
 
K
T
 
N
L
 
L
V
 
V
Q
 
D
W
 
W
V
 
I
L
 
L
S
 
S

1a56A Primary sequence and solution conformation of ferricytochromE C-552 from nitrosomonas europaea, nmr, mean structure refined with explicit hydrogen bond constraints (see paper)
29% identity, 72% coverage: 31:110/111 of query aligns to 4:79/81 of 1a56A

query
sites
1a56A
L
 
L
V
 
A
D
 
K
Q
 
K
Q
 
N
H
x
N
C
|
C
M
 
I
F
 
A
C
|
C
H
|
H
T
 
Q
R
 
V
D
 
E
A
 
T
P
 
K
F
 
V
L
x
V
A
x
G
P
|
P
S
 
A
F
 
L
Q
 
K
Q
 
D
I
 
I
A
 
A
E
 
A
R
 
K
Y
 
Y
R
 
A
N
 
D
V
 
K
P
 
D
D
 
D
A
 
A
Q
 
A
F
 
T
M
 
Y
L
 
L
E
 
A
H
 
G
K
|
K
L
x
I
R
 
K
L
 
G
G
 
G
G
x
S
K
 
S
A
 
G
H
 
V
W
|
W
G
 
G
D
x
Q
M
x
I
A
 
P
M
|
M
P
 
P
L
 
P
P
x
N
A
x
V
D
x
N
R
 
-
G
 
-
G
 
-
P
 
-
L
 
V
S
 
S
A
 
D
E
 
A
D
 
D
A
 
A
H
 
K
T
 
A
L
 
L
V
 
A
Q
 
D
W
 
W
V
 
I
L
 
L
S
 
T

5aurA Hydrogenobacter thermophilus cytochrome c552 dimer formed by domain swapping at n-terminal region (see paper)
33% identity, 72% coverage: 31:110/111 of query aligns to 4:81/83 of 5aurA

query
sites
5aurA
L
 
L
V
 
A
D
 
K
Q
 
Q
Q
 
K
H
 
G
C
|
C
M
 
M
F
 
A
C
|
C
H
|
H
T
 
D
R
 
L
D
 
K
A
 
A
-
 
G
-
 
G
-
 
G
P
 
K
F
 
K
L
 
V
A
 
G
P
|
P
S
 
A
F
x
Y
Q
 
A
Q
 
D
I
 
V
A
 
A
E
 
K
R
 
K
Y
|
Y
R
 
A
N
 
G
V
 
R
P
 
K
D
 
D
A
 
A
Q
 
V
F
 
D
M
x
Y
L
 
L
E
 
A
H
 
G
K
 
K
L
x
I
R
 
K
L
 
K
G
 
G
G
 
G
K
x
S
A
x
G
H
x
V
W
|
W
G
|
G
D
 
S
M
x
V
A
x
P
M
|
M
P
 
P
L
 
-
P
 
P
A
x
Q
D
 
N
R
 
-
G
 
-
G
 
-
P
 
-
L
 
V
S
 
T
A
 
D
E
 
A
D
 
E
A
 
A
H
 
K
T
 
Q
L
 
L
V
 
A
Q
 
Q
W
 
W
V
 
I
L
 
L
S
 
S

1cchA The solution conformation of cytochromE C-551 from p.Stutzeri zobell determined by nmr+ (see paper)
30% identity, 73% coverage: 30:110/111 of query aligns to 5:80/82 of 1cchA

query
sites
1cchA
A
 
A
L
 
L
V
 
F
D
 
K
Q
 
S
Q
 
K
H
 
P
C
|
C
M
 
A
F
 
A
C
|
C
H
|
H
T
 
S
R
 
V
D
 
D
A
 
T
P
 
K
F
 
M
L
 
V
A
 
G
P
 
P
S
 
A
F
 
L
Q
 
K
Q
 
E
I
 
V
A
 
A
E
 
A
R
 
K
Y
 
N
R
 
A
N
 
G
V
 
V
P
 
E
D
 
G
A
 
A
Q
 
A
F
 
D
M
 
T
L
|
L
E
 
A
H
 
L
K
x
H
L
x
I
R
 
K
L
 
N
G
 
G
G
x
S
K
x
Q
A
 
G
H
x
V
W
|
W
G
|
G
D
 
P
M
x
I
A
 
P
M
|
M
P
|
P
L
 
P
P
 
-
A
 
-
D
 
-
R
 
-
G
 
-
G
x
N
P
 
P
L
 
V
S
 
T
A
 
E
E
 
E
D
 
E
A
 
A
H
 
K
T
 
I
L
 
L
V
 
A
Q
 
E
W
 
W
V
 
V
L
 
L
S
 
S

2d0sA Crystal structure of the cytochrome c552 from moderate thermophilic bacterium, hydrogenophilus thermoluteolus (see paper)
34% identity, 73% coverage: 30:110/111 of query aligns to 3:77/79 of 2d0sA

query
sites
2d0sA
A
 
A
L
 
L
V
 
A
D
 
K
Q
 
A
Q
 
K
H
 
G
C
|
C
M
 
M
F
 
A
C
|
C
H
|
H
T
 
A
R
 
I
D
 
D
A
 
K
P
 
K
F
 
L
L
 
V
A
 
G
P
|
P
S
 
S
F
 
Y
Q
 
K
Q
 
D
I
 
V
A
 
A
E
 
K
R
 
K
Y
|
Y
R
 
T
N
 
E
V
 
A
P
 
-
D
 
D
A
 
V
Q
 
P
F
 
K
M
 
L
L
 
V
E
 
E
H
 
-
K
|
K
L
x
V
R
 
K
L
 
K
G
 
G
G
 
G
K
x
A
A
x
G
H
x
V
W
|
W
G
|
G
D
 
P
M
x
V
A
 
P
M
|
M
P
|
P
L
 
-
P
 
-
A
 
-
D
 
-
R
 
-
G
 
P
G
x
H
P
 
P
L
 
Q
S
 
V
A
 
A
E
 
E
-
 
A
D
 
D
A
 
I
H
 
E
T
 
K
L
 
I
V
 
V
Q
 
R
W
 
W
V
 
V
L
 
L
S
 
T

Query Sequence

>BPHYT_RS31315 FitnessBrowser__BFirm:BPHYT_RS31315
MNILSRSCLAACAVFVLAASTAHAEPEPTALVDQQHCMFCHTRDAPFLAPSFQQIAERYR
NVPDAQFMLEHKLRLGGKAHWGDMAMPLPADRGGPLSAEDAHTLVQWVLSQ

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory