SitesBLAST
Comparing BPHYT_RS33430 FitnessBrowser__BFirm:BPHYT_RS33430 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
7qh2C Cryo-em structure of ldh-etfab complex from acetobacterium woodii (see paper)
25% identity, 48% coverage: 72:554/999 of query aligns to 43:463/467 of 7qh2C
- binding flavin-adenine dinucleotide: V73 (≠ P105), G75 (= G107), S76 (≠ G108), G77 (= G109), T78 (= T110), G79 (≠ S111), L80 (≠ Q112), A83 (≠ Q115), C84 (= C116), P137 (= P168), G138 (≠ A169), E139 (≠ T170), A142 (≠ C174), T143 (= T175), G146 (= G178), N147 (≠ M179), S149 (≠ A181), T150 (≠ N182), A152 (≠ S184), G153 (≠ C185), E203 (= E285), G204 (= G286), I209 (≠ T291), E422 (= E513), H423 (= H514)
- binding fe (iii) ion: H377 (= H469), H384 (= H476), E422 (= E513)
8jdvA Crystal structure of mldhd in complex with 2-ketohexanoic acid (see paper)
25% identity, 49% coverage: 66:555/999 of query aligns to 28:454/454 of 8jdvA
- binding 2-Ketohexanoic acid: V75 (vs. gap), R317 (= R414), W321 (vs. gap), H368 (= H469), H375 (= H476), H413 (= H514)
- binding flavin-adenine dinucleotide: P68 (= P105), G70 (= G107), T71 (≠ G108), G72 (= G109), T73 (= T110), G74 (≠ S111), G78 (vs. gap), V79 (vs. gap), L90 (≠ V119), P132 (= P168), G133 (≠ A169), A134 (≠ T170), G140 (= G178), M141 (= M179), A143 (= A181), T144 (≠ N182), A146 (≠ S184), S147 (≠ C185), E200 (= E285), G201 (= G286), I206 (≠ T291), W321 (vs. gap), Y322 (≠ A418), E412 (= E513), H413 (= H514), N449 (= N550)
- binding manganese (ii) ion: H368 (= H469), H375 (= H476), E412 (= E513)
8jdxA Crystal structure of mldhd in complex with 2-ketoisovaleric acid (see paper)
25% identity, 49% coverage: 66:555/999 of query aligns to 28:455/455 of 8jdxA
- binding flavin-adenine dinucleotide: E32 (≠ A70), P68 (= P105), G70 (= G107), T71 (≠ G108), G72 (= G109), T73 (= T110), G74 (≠ S111), G78 (vs. gap), V79 (vs. gap), L90 (≠ V119), P132 (= P168), G133 (≠ A169), A134 (≠ T170), G140 (= G178), M141 (= M179), A143 (= A181), T144 (≠ N182), A146 (≠ S184), S147 (≠ C185), E200 (= E285), G201 (= G286), I206 (≠ T291), W322 (vs. gap), E413 (= E513), H414 (= H514), N450 (= N550)
- binding 3-methyl-2-oxobutanoic acid: R318 (= R414), H369 (= H469), H376 (= H476), H414 (= H514)
- binding manganese (ii) ion: H369 (= H469), H376 (= H476), E413 (= E513)
8jdeA Crystal structure of mldhd in complex with d-lactate (see paper)
25% identity, 49% coverage: 66:555/999 of query aligns to 28:455/455 of 8jdeA
- binding flavin-adenine dinucleotide: P68 (= P105), G70 (= G107), T71 (≠ G108), G72 (= G109), T73 (= T110), G74 (≠ S111), G78 (vs. gap), V79 (vs. gap), L90 (≠ V119), P132 (= P168), G133 (≠ A169), A134 (≠ T170), G140 (= G178), M141 (= M179), A143 (= A181), T144 (≠ N182), A146 (≠ S184), S147 (≠ C185), E200 (= E285), G201 (= G286), I206 (≠ T291), W322 (vs. gap), E413 (= E513), H414 (= H514), N450 (= N550)
- binding lactic acid: R318 (= R414), H369 (= H469), H376 (= H476), H414 (= H514)
- binding manganese (ii) ion: H369 (= H469), H376 (= H476), E413 (= E513)
8jdsA Crystal structure of mldhd in complex with pyruvate (see paper)
25% identity, 49% coverage: 66:555/999 of query aligns to 28:456/456 of 8jdsA
- binding flavin-adenine dinucleotide: E32 (≠ A70), P68 (= P105), G70 (= G107), T71 (≠ G108), G72 (= G109), T73 (= T110), G74 (≠ S111), G78 (vs. gap), V79 (vs. gap), L90 (≠ V119), P132 (= P168), G133 (≠ A169), A134 (≠ T170), G140 (= G178), M141 (= M179), A143 (= A181), T144 (≠ N182), A146 (≠ S184), S147 (≠ C185), E200 (= E285), G201 (= G286), I206 (≠ T291), W323 (vs. gap), E414 (= E513), H415 (= H514), N451 (= N550)
- binding manganese (ii) ion: H370 (= H469), H377 (= H476), E414 (= E513)
- binding pyruvic acid: R319 (= R414), H370 (= H469), H377 (= H476), H415 (= H514)
8jdtA Crystal structure of mldhd in complex with 2-ketobutanoic acid (see paper)
25% identity, 49% coverage: 66:555/999 of query aligns to 28:455/455 of 8jdtA
- binding 2-ketobutyric acid: R318 (= R414), H369 (= H469), H376 (= H476), H414 (= H514)
- binding flavin-adenine dinucleotide: P68 (= P105), G70 (= G107), T71 (≠ G108), G72 (= G109), T73 (= T110), G74 (≠ S111), G78 (vs. gap), V79 (vs. gap), L90 (≠ V119), P132 (= P168), G133 (≠ A169), A134 (≠ T170), G140 (= G178), M141 (= M179), A143 (= A181), T144 (≠ N182), A146 (≠ S184), S147 (≠ C185), E200 (= E285), G201 (= G286), I206 (≠ T291), W322 (vs. gap), E413 (= E513), H414 (= H514), N450 (= N550)
- binding manganese (ii) ion: H369 (= H469), H376 (= H476), E413 (= E513)
8jduA Crystal structure of mldhd in complex with 2-ketovaleric acid (see paper)
25% identity, 49% coverage: 66:555/999 of query aligns to 28:455/455 of 8jduA
- binding 2-oxopentanoic acid: R318 (= R414), W322 (vs. gap), H369 (= H469), H376 (= H476), H414 (= H514)
- binding flavin-adenine dinucleotide: P68 (= P105), G70 (= G107), T71 (≠ G108), G72 (= G109), T73 (= T110), G74 (≠ S111), G78 (vs. gap), V79 (vs. gap), L90 (≠ V119), P132 (= P168), G133 (≠ A169), A134 (≠ T170), G140 (= G178), M141 (= M179), A143 (= A181), T144 (≠ N182), A146 (≠ S184), S147 (≠ C185), E200 (= E285), G201 (= G286), I206 (≠ T291), W322 (vs. gap), E413 (= E513), N450 (= N550)
- binding manganese (ii) ion: H369 (= H469), H376 (= H476), E413 (= E513)
8jdzA Crystal structure of mldhd in complex with 2-keto-3-methylvaleric acid (see paper)
25% identity, 49% coverage: 66:555/999 of query aligns to 28:454/454 of 8jdzA
- binding (3S)-3-methyl-2-oxopentanoic acid: R318 (= R414), W322 (vs. gap), H369 (= H469), H376 (= H476), H413 (= H514)
- binding flavin-adenine dinucleotide: E32 (≠ A70), P68 (= P105), G70 (= G107), T71 (≠ G108), G72 (= G109), T73 (= T110), G74 (≠ S111), G78 (vs. gap), V79 (vs. gap), L90 (≠ V119), P132 (= P168), G133 (≠ A169), A134 (≠ T170), G140 (= G178), M141 (= M179), A143 (= A181), T144 (≠ N182), A146 (≠ S184), S147 (≠ C185), E200 (= E285), G201 (= G286), I206 (≠ T291), W322 (vs. gap), E412 (= E513), H413 (= H514), N449 (= N550)
- binding manganese (ii) ion: H369 (= H469), H376 (= H476), E412 (= E513)
8jdyA Crystal structure of mldhd in complex with 2-ketoisocaproic acid (see paper)
25% identity, 49% coverage: 66:555/999 of query aligns to 28:454/454 of 8jdyA
- binding 2-oxo-4-methylpentanoic acid: R318 (= R414), W322 (vs. gap), S336 (≠ W436), H369 (= H469), H376 (= H476), H413 (= H514)
- binding flavin-adenine dinucleotide: P68 (= P105), G70 (= G107), T71 (≠ G108), G72 (= G109), T73 (= T110), G74 (≠ S111), G78 (vs. gap), V79 (vs. gap), L90 (≠ V119), P132 (= P168), G133 (≠ A169), A134 (≠ T170), G140 (= G178), M141 (= M179), A143 (= A181), T144 (≠ N182), A146 (≠ S184), S147 (≠ C185), E200 (= E285), G201 (= G286), I206 (≠ T291), E412 (= E513), N449 (= N550)
- binding manganese (ii) ion: H369 (= H469), H376 (= H476), E412 (= E513)
8jdrA Crystal structure of h405a mldhd in complex with d-2-hydroxy-3-methyl- valeric acid (see paper)
25% identity, 49% coverage: 66:555/999 of query aligns to 28:456/456 of 8jdrA
- binding flavin-adenine dinucleotide: P68 (= P105), G70 (= G107), T71 (≠ G108), G72 (= G109), T73 (= T110), G74 (≠ S111), G78 (vs. gap), V79 (vs. gap), L90 (≠ V119), P132 (= P168), G133 (≠ A169), A134 (≠ T170), G140 (= G178), M141 (= M179), A143 (= A181), T144 (≠ N182), A146 (≠ S184), S147 (≠ C185), E200 (= E285), G201 (= G286), I206 (≠ T291), Y324 (≠ A418), H370 (= H469), E414 (= E513), N451 (= N550)
- binding (2R,3S)-3-methyl-2-oxidanyl-pentanoic acid: R319 (= R414), W323 (vs. gap), H415 (= H514)
8jdqA Crystal structure of h405a mldhd in complex with d-2-hydroxyisocaproic acid (see paper)
25% identity, 49% coverage: 66:555/999 of query aligns to 28:456/456 of 8jdqA
- binding (2R)-2-hydroxy-4-methylpentanoic acid: R319 (= R414), W323 (vs. gap), H370 (= H469), H415 (= H514)
- binding flavin-adenine dinucleotide: P68 (= P105), G70 (= G107), T71 (≠ G108), G72 (= G109), T73 (= T110), G74 (≠ S111), G78 (vs. gap), V79 (vs. gap), L90 (≠ V119), P132 (= P168), G133 (≠ A169), A134 (≠ T170), G140 (= G178), M141 (= M179), A143 (= A181), T144 (≠ N182), A146 (≠ S184), S147 (≠ C185), E200 (= E285), G201 (= G286), I206 (≠ T291), H370 (= H469), E414 (= E513), N451 (= N550)
8jdoA Crystal structure of h405a mldhd in complex with d-2-hydroxyhexanoic acid (see paper)
25% identity, 49% coverage: 66:555/999 of query aligns to 28:456/456 of 8jdoA
- binding (2R)-2-hydroxyhexanoic acid: R319 (= R414), W323 (vs. gap), H415 (= H514)
- binding flavin-adenine dinucleotide: P68 (= P105), G70 (= G107), T71 (≠ G108), G72 (= G109), T73 (= T110), G74 (≠ S111), G78 (vs. gap), V79 (vs. gap), L90 (≠ V119), P132 (= P168), G133 (≠ A169), A134 (≠ T170), G140 (= G178), M141 (= M179), A143 (= A181), T144 (≠ N182), A146 (≠ S184), S147 (≠ C185), E200 (= E285), G201 (= G286), I206 (≠ T291), Y324 (≠ A418), H370 (= H469), E414 (= E513), N451 (= N550)
8jdnA Crystal structure of h405a mldhd in complex with d-2-hydroxyvaleric acid (see paper)
25% identity, 49% coverage: 66:555/999 of query aligns to 28:456/456 of 8jdnA
- binding flavin-adenine dinucleotide: P68 (= P105), G70 (= G107), T71 (≠ G108), G72 (= G109), T73 (= T110), G74 (≠ S111), G78 (vs. gap), V79 (vs. gap), L90 (≠ V119), P132 (= P168), G133 (≠ A169), A134 (≠ T170), G140 (= G178), M141 (= M179), A143 (= A181), T144 (≠ N182), A146 (≠ S184), S147 (≠ C185), E200 (= E285), G201 (= G286), I206 (≠ T291), H370 (= H469), E414 (= E513), N451 (= N550)
- binding (2R)-2-oxidanylpentanoic acid: R319 (= R414), W323 (vs. gap), H415 (= H514)
8jdgA Crystal structure of h405a mldhd in complex with d-2-hydroxybutanoic acid (see paper)
25% identity, 49% coverage: 66:555/999 of query aligns to 28:456/456 of 8jdgA
- binding flavin-adenine dinucleotide: P68 (= P105), G70 (= G107), T71 (≠ G108), G72 (= G109), T73 (= T110), G74 (≠ S111), G78 (vs. gap), V79 (vs. gap), L90 (≠ V119), P132 (= P168), G133 (≠ A169), A134 (≠ T170), G140 (= G178), M141 (= M179), A143 (= A181), T144 (≠ N182), A146 (≠ S184), S147 (≠ C185), E200 (= E285), G201 (= G286), I206 (≠ T291), H370 (= H469), E414 (= E513), N451 (= N550)
- binding (2R)-2-oxidanylbutanoic acid: R319 (= R414), H415 (= H514)
8jdbA Crystal structure of h405a mldhd in complex with d-2-hydroxyoctanoic acid (see paper)
25% identity, 49% coverage: 66:555/999 of query aligns to 28:456/456 of 8jdbA
- binding flavin-adenine dinucleotide: P68 (= P105), G70 (= G107), T71 (≠ G108), G72 (= G109), T73 (= T110), G74 (≠ S111), G78 (vs. gap), V79 (vs. gap), L90 (≠ V119), P132 (= P168), G133 (≠ A169), A134 (≠ T170), G140 (= G178), M141 (= M179), A143 (= A181), T144 (≠ N182), A146 (≠ S184), S147 (≠ C185), E200 (= E285), G201 (= G286), I206 (≠ T291), Y324 (≠ A418), H370 (= H469), E414 (= E513), N451 (= N550)
- binding (2R)-2-oxidanyloctanoic acid: V75 (vs. gap), R319 (= R414), W323 (vs. gap), H415 (= H514)
8jdpA Crystal structure of h405a mldhd in complex with d-2-hydroxyisovaleric acid (see paper)
25% identity, 49% coverage: 66:555/999 of query aligns to 28:455/455 of 8jdpA
- binding flavin-adenine dinucleotide: P68 (= P105), G70 (= G107), T71 (≠ G108), G72 (= G109), T73 (= T110), G74 (≠ S111), G78 (vs. gap), V79 (vs. gap), L90 (≠ V119), P132 (= P168), G133 (≠ A169), A134 (≠ T170), G140 (= G178), M141 (= M179), A143 (= A181), T144 (≠ N182), A146 (≠ S184), S147 (≠ C185), E200 (= E285), G201 (= G286), I206 (≠ T291), H369 (= H469), E413 (= E513), N450 (= N550)
- binding deaminohydroxyvaline: R319 (= R414), H414 (= H514)
P9WIT1 Uncharacterized FAD-linked oxidoreductase Rv2280; EC 1.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
25% identity, 48% coverage: 75:554/999 of query aligns to 38:455/459 of P9WIT1
- K354 (≠ D448) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
3pm9A Crystal structure of a putative dehydrogenase (rpa1076) from rhodopseudomonas palustris cga009 at 2.57 a resolution
23% identity, 49% coverage: 66:555/999 of query aligns to 29:465/465 of 3pm9A
- active site: A149 (≠ S184), L159 (≠ K194)
- binding flavin-adenine dinucleotide: P69 (= P105), Q70 (≠ R106), G71 (= G107), G72 (= G108), N73 (≠ G109), T74 (= T110), G75 (≠ S111), L76 (≠ Q112), G79 (= G114), Q80 (= Q115), L91 (≠ S126), L133 (≠ P168), G134 (≠ A169), A135 (≠ T170), C139 (= C174), T140 (= T175), G142 (= G177), G143 (= G178), S146 (≠ A181), T147 (≠ N182), A149 (≠ S184), G150 (≠ C185), E200 (= E285), G201 (= G286), I205 (≠ L290), I206 (≠ T291), E423 (= E513)
Q8N465 D-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.39 from Homo sapiens (Human) (see 7 papers)
23% identity, 47% coverage: 83:555/999 of query aligns to 106:517/521 of Q8N465
- S109 (≠ V86) to W: in D2HGA1; uncertain significance; significant loss of catalytic activity; dbSNP:rs142050154
- N127 (≠ L104) to K: in D2HGA1; uncertain significance; complete loss of catalytic activity; dbSNP:rs762857195
- G131 (= G108) to V: in D2HGA1; uncertain significance; complete loss of catalytic activity
- I147 (≠ A123) to S: in D2HGA1; uncertain significance; severe phenotype; almost complete loss of catalytic activity; dbSNP:rs121434361
- M153 (≠ V129) to T: in D2HGA1; uncertain significance; significant loss of catalytic activity; to V: in D2HGA1; uncertain significance; significant loss of catalytic activity; dbSNP:rs1432270139
- C172 (≠ V148) to Y: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs773735172
- P189 (≠ A165) to L: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs587783517
- A205 (= A181) to V: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs750889931
- A231 (≠ F207) to V: in D2HGA1; uncertain significance; significant loss of catalytic activity
- G233 (= G209) to S: in D2HGA1; uncertain significance; no effect on catalytic activity; dbSNP:rs374535734
- D375 (= D403) to Y: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs267606759
- R386 (= R414) binding ; binding ; binding ; mutation to A: Loss of catalytic activity.
- T390 (≠ A418) binding ; binding ; mutation to A: Significantly reduced catalytic activity.
- V399 (= V434) to M: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs746519212
- K401 (≠ W436) binding ; binding ; mutation to A: Loss of catalytic activity.
- R419 (≠ Q454) to H: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs199908032
- A426 (≠ G461) to T: in D2HGA1; uncertain significance; no effect on catalytic activity; dbSNP:rs146578303
- H434 (= H469) binding ; mutation to A: Loss of catalytic activity.
- G436 (= G471) to V: slight reduction in catalytic activity
- N439 (≠ C474) to D: in D2HGA1; uncertain significance; mild phenotype; moderate reduction in catalytic activity; dbSNP:rs121434362
- H441 (= H476) binding ; mutation to A: Loss of catalytic activity.
- N443 (≠ R478) binding ; mutation to A: Significantly reduced catalytic activity.
- V444 (≠ I479) to A: in D2HGA1; uncertain significance; severe phenotype; significant reduction in catalytic activity; dbSNP:rs121434360
- A446 (≠ F481) to V: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs746956176
- E475 (= E513) binding ; mutation to A: Loss of catalytic activity.
- H476 (= H514) binding ; binding ; binding ; mutation to A: Loss of catalytic activity.
- G477 (= G515) to R: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs1453924640
Sites not aligning to the query:
- 15 R → G: in dbSNP:rs4675887
- 169:521 natural variant: Missing (in D2HGA1; uncertain significance)
- 400:521 natural variant: Missing (in D2HGA1; uncertain significance; complete loss of catalytic activity)
6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og) (see paper)
23% identity, 47% coverage: 83:555/999 of query aligns to 53:464/466 of 6lpxA
- binding 2-oxoglutaric acid: R333 (= R414), T337 (≠ A418), K348 (≠ W436), Y379 (= Y467), H381 (= H469), H388 (= H476), H423 (= H514)
- binding flavin-adenine dinucleotide: P75 (= P105), Q76 (≠ R106), G77 (= G107), G78 (= G108), N79 (≠ G109), T80 (= T110), G81 (≠ S111), M82 (≠ Q112), G85 (≠ Q115), S86 (≠ C116), L139 (≠ P168), G140 (≠ A169), A141 (≠ T170), C145 (= C174), G149 (= G178), N150 (≠ M179), A152 (= A181), T153 (≠ N182), G157 (= G186), G207 (= G286), I212 (≠ Q293), E422 (= E513), N459 (= N550)
- binding zinc ion: H381 (= H469), H388 (= H476), E422 (= E513)
Sites not aligning to the query:
Query Sequence
>BPHYT_RS33430 FitnessBrowser__BFirm:BPHYT_RS33430
MGTSFDEQQGAGVDELHDNGTSALKRAPHVATPFTGTAAVMQALEADLRSHVRGEVRFDQ
GSKALYAADASNYRQVPLAVVVPADVDDLLATLAACRRNDVPFLPRGGGTSQNGQCVNVA
VVADASKYVNRVVSVDPVARVAIVEPGVVCDTLRDAAEQHGLTFAPDPATHSRCTLGGMI
ANNSCGAHSVMAGKTVENVEALEIATFDGARFWVGPTSDQELEHIIAAGGRQGEIYAALK
QLRDTYAEQIRARFPQIKRRVSGFNLDQLLPENGFNVARALVGTEGTCALTLQAKVRLVK
SPAMRVIVVVGFTDIYTAADAVPHFMRCEPIAVEGLDRAIIRGLQARGLKKDEIALLPEG
DAWVVLEFGADTQDDVMLKARAAAACFASGEAGPNVSAMLVEDRALQAKVWSIRETGASA
VALSVDSGTPDPVVGWEDAAVDPLRLGDYLRAFQALVDRYGYETSLYGHFGDGCVHARIT
FDLRSAEGVATWRKFLREAAELVVEFGGSLSGEHGDGQAKAEFLPIMYGPELMQAMEQFK
AIWDPANRLNPGKVVHAYRADENLRMGPAYKPVTLQTRLTFASQEGEGFQREIERCIGMG
KCRSLEGGTMCPSYRATREEKYSTRGRAHLFWEMLQGDVIADGWQSREVKEALDTCLACK
GCKSDCPTHTDMASYKAEFLSHYYETNRRPRQALFMGRIGEWAPWAARFPRLTNFMTSAP
CLSSFGKWLAGVAQTRELPRFADATYRQIARRSPQSARDARGDVKKVILWVDTFNDHFTP
EIAQAAADVLKQLGWHVVLPKNRLCCGRPLYDFGLLERARELLTHILDDLADDIAAGVPL
VGLEPGCLSVFKDELLKQLPNHALAKKLSAQTFLFSDFVARQSFDWPTLAADVIVHGHCH
QKALFGMQGDTALLNKLGVKWKLLDTGCCGMAGSFGFNAEHHALSTKIGEDKLFPAVRAA
SVETIVLTNGFSCREQIEQGTGRHAMHIAQLAQRALAAR
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory