SitesBLAST
Comparing BPHYT_RS34425 FitnessBrowser__BFirm:BPHYT_RS34425 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
7qh2C Cryo-em structure of ldh-etfab complex from acetobacterium woodii (see paper)
25% identity, 46% coverage: 75:537/1007 of query aligns to 61:465/467 of 7qh2C
- binding flavin-adenine dinucleotide: V73 (≠ A87), G75 (= G89), S76 (≠ A90), G77 (= G91), T78 (= T92), G79 (≠ S93), L80 (≠ Q94), A83 (≠ Q97), C84 (≠ T98), P137 (≠ V150), G138 (≠ S151), E139 (≠ T152), A142 (≠ C156), T143 (= T157), G146 (= G160), N147 (≠ M161), S149 (≠ G163), T150 (≠ N164), A152 (≠ S166), G153 (≠ C167), E203 (= E269), G204 (= G270), I209 (≠ S275), E422 (= E494), H423 (= H495)
- binding fe (iii) ion: H377 (= H451), H384 (= H458), E422 (= E494)
8jdzA Crystal structure of mldhd in complex with 2-keto-3-methylvaleric acid (see paper)
25% identity, 49% coverage: 42:536/1007 of query aligns to 22:454/454 of 8jdzA
- binding (3S)-3-methyl-2-oxopentanoic acid: R318 (= R398), W322 (≠ L402), H369 (= H451), H376 (= H458), H413 (= H495)
- binding flavin-adenine dinucleotide: E32 (≠ A52), P68 (vs. gap), G70 (vs. gap), T71 (vs. gap), G72 (≠ A87), T73 (≠ R88), G74 (= G89), G78 (≠ S93), V79 (≠ Q94), L90 (≠ T107), P132 (≠ T152), G133 (≠ A153), A134 (= A154), G140 (= G160), M141 (= M161), A143 (≠ G163), T144 (≠ N164), A146 (≠ S166), S147 (≠ C167), E200 (= E269), G201 (= G270), I206 (≠ S275), W322 (≠ L402), E412 (= E494), H413 (= H495), N449 (= N531)
- binding manganese (ii) ion: H369 (= H451), H376 (= H458), E412 (= E494)
8jdyA Crystal structure of mldhd in complex with 2-ketoisocaproic acid (see paper)
25% identity, 49% coverage: 42:536/1007 of query aligns to 22:454/454 of 8jdyA
- binding 2-oxo-4-methylpentanoic acid: R318 (= R398), W322 (≠ L402), S336 (≠ I418), H369 (= H451), H376 (= H458), H413 (= H495)
- binding flavin-adenine dinucleotide: P68 (vs. gap), G70 (vs. gap), T71 (vs. gap), G72 (≠ A87), T73 (≠ R88), G74 (= G89), G78 (≠ S93), V79 (≠ Q94), L90 (≠ T107), P132 (≠ T152), G133 (≠ A153), A134 (= A154), G140 (= G160), M141 (= M161), A143 (≠ G163), T144 (≠ N164), A146 (≠ S166), S147 (≠ C167), E200 (= E269), G201 (= G270), I206 (≠ S275), E412 (= E494), N449 (= N531)
- binding manganese (ii) ion: H369 (= H451), H376 (= H458), E412 (= E494)
8jdvA Crystal structure of mldhd in complex with 2-ketohexanoic acid (see paper)
25% identity, 49% coverage: 42:536/1007 of query aligns to 22:454/454 of 8jdvA
- binding 2-Ketohexanoic acid: V75 (≠ A90), R317 (= R398), W321 (≠ L402), H368 (= H451), H375 (= H458), H413 (= H495)
- binding flavin-adenine dinucleotide: P68 (vs. gap), G70 (vs. gap), T71 (vs. gap), G72 (≠ A87), T73 (≠ R88), G74 (= G89), G78 (≠ S93), V79 (≠ Q94), L90 (≠ I105), P132 (≠ T152), G133 (≠ A153), A134 (= A154), G140 (= G160), M141 (= M161), A143 (≠ G163), T144 (≠ N164), A146 (≠ S166), S147 (≠ C167), E200 (= E269), G201 (= G270), I206 (≠ S275), W321 (≠ L402), Y322 (≠ N403), E412 (= E494), H413 (= H495), N449 (= N531)
- binding manganese (ii) ion: H368 (= H451), H375 (= H458), E412 (= E494)
8jdeA Crystal structure of mldhd in complex with d-lactate (see paper)
25% identity, 49% coverage: 42:536/1007 of query aligns to 22:455/455 of 8jdeA
- binding flavin-adenine dinucleotide: P68 (vs. gap), G70 (vs. gap), T71 (vs. gap), G72 (≠ A87), T73 (≠ R88), G74 (= G89), G78 (≠ S93), V79 (≠ Q94), L90 (≠ T107), P132 (≠ T152), G133 (≠ A153), A134 (= A154), G140 (= G160), M141 (= M161), A143 (≠ G163), T144 (≠ N164), A146 (≠ S166), S147 (≠ C167), E200 (= E269), G201 (= G270), I206 (≠ S275), W322 (≠ L402), E413 (= E494), H414 (= H495), N450 (= N531)
- binding lactic acid: R318 (= R398), H369 (= H451), H376 (= H458), H414 (= H495)
- binding manganese (ii) ion: H369 (= H451), H376 (= H458), E413 (= E494)
8jduA Crystal structure of mldhd in complex with 2-ketovaleric acid (see paper)
25% identity, 49% coverage: 42:536/1007 of query aligns to 22:455/455 of 8jduA
- binding 2-oxopentanoic acid: R318 (= R398), W322 (≠ L402), H369 (= H451), H376 (= H458), H414 (= H495)
- binding flavin-adenine dinucleotide: P68 (vs. gap), G70 (vs. gap), T71 (vs. gap), G72 (≠ A87), T73 (≠ R88), G74 (= G89), G78 (≠ S93), V79 (≠ Q94), L90 (≠ T107), P132 (≠ T152), G133 (≠ A153), A134 (= A154), G140 (= G160), M141 (= M161), A143 (≠ G163), T144 (≠ N164), A146 (≠ S166), S147 (≠ C167), E200 (= E269), G201 (= G270), I206 (≠ S275), W322 (≠ L402), E413 (= E494), N450 (= N531)
- binding manganese (ii) ion: H369 (= H451), H376 (= H458), E413 (= E494)
8jdxA Crystal structure of mldhd in complex with 2-ketoisovaleric acid (see paper)
26% identity, 49% coverage: 42:536/1007 of query aligns to 22:455/455 of 8jdxA
- binding flavin-adenine dinucleotide: E32 (≠ A52), P68 (vs. gap), G70 (vs. gap), T71 (vs. gap), G72 (≠ A87), T73 (≠ R88), G74 (= G89), G78 (≠ S93), V79 (≠ Q94), L90 (≠ T107), P132 (≠ T152), G133 (≠ A153), A134 (= A154), G140 (= G160), M141 (= M161), A143 (≠ G163), T144 (≠ N164), A146 (≠ S166), S147 (≠ C167), E200 (= E269), G201 (= G270), I206 (≠ S275), W322 (≠ L402), E413 (= E494), H414 (= H495), N450 (= N531)
- binding 3-methyl-2-oxobutanoic acid: R318 (= R398), H369 (= H451), H376 (= H458), H414 (= H495)
- binding manganese (ii) ion: H369 (= H451), H376 (= H458), E413 (= E494)
8jdtA Crystal structure of mldhd in complex with 2-ketobutanoic acid (see paper)
25% identity, 49% coverage: 42:536/1007 of query aligns to 22:455/455 of 8jdtA
- binding 2-ketobutyric acid: R318 (= R398), H369 (= H451), H376 (= H458), H414 (= H495)
- binding flavin-adenine dinucleotide: P68 (vs. gap), G70 (vs. gap), T71 (vs. gap), G72 (≠ A87), T73 (≠ R88), G74 (= G89), G78 (≠ S93), V79 (≠ Q94), L90 (≠ T107), P132 (≠ T152), G133 (≠ A153), A134 (= A154), G140 (= G160), M141 (= M161), A143 (≠ G163), T144 (≠ N164), A146 (≠ S166), S147 (≠ C167), E200 (= E269), G201 (= G270), I206 (≠ S275), W322 (≠ L402), E413 (= E494), H414 (= H495), N450 (= N531)
- binding manganese (ii) ion: H369 (= H451), H376 (= H458), E413 (= E494)
8jdsA Crystal structure of mldhd in complex with pyruvate (see paper)
25% identity, 49% coverage: 42:536/1007 of query aligns to 22:456/456 of 8jdsA
- binding flavin-adenine dinucleotide: E32 (≠ A52), P68 (vs. gap), G70 (vs. gap), T71 (vs. gap), G72 (≠ A87), T73 (≠ R88), G74 (= G89), G78 (≠ S93), V79 (≠ Q94), L90 (≠ T107), P132 (≠ T152), G133 (≠ A153), A134 (= A154), G140 (= G160), M141 (= M161), A143 (≠ G163), T144 (≠ N164), A146 (≠ S166), S147 (≠ C167), E200 (= E269), G201 (= G270), I206 (≠ S275), W323 (≠ L402), E414 (= E494), H415 (= H495), N451 (= N531)
- binding manganese (ii) ion: H370 (= H451), H377 (= H458), E414 (= E494)
- binding pyruvic acid: R319 (= R398), H370 (= H451), H377 (= H458), H415 (= H495)
8jdrA Crystal structure of h405a mldhd in complex with d-2-hydroxy-3-methyl- valeric acid (see paper)
25% identity, 49% coverage: 42:536/1007 of query aligns to 22:456/456 of 8jdrA
- binding flavin-adenine dinucleotide: P68 (vs. gap), G70 (vs. gap), T71 (vs. gap), G72 (≠ A87), T73 (≠ R88), G74 (= G89), G78 (≠ S93), V79 (≠ Q94), L90 (≠ T107), P132 (≠ T152), G133 (≠ A153), A134 (= A154), G140 (= G160), M141 (= M161), A143 (≠ G163), T144 (≠ N164), A146 (≠ S166), S147 (≠ C167), E200 (= E269), G201 (= G270), I206 (≠ S275), Y324 (≠ N403), H370 (= H451), E414 (= E494), N451 (= N531)
- binding (2R,3S)-3-methyl-2-oxidanyl-pentanoic acid: R319 (= R398), W323 (≠ L402), H415 (= H495)
8jdqA Crystal structure of h405a mldhd in complex with d-2-hydroxyisocaproic acid (see paper)
25% identity, 49% coverage: 42:536/1007 of query aligns to 22:456/456 of 8jdqA
- binding (2R)-2-hydroxy-4-methylpentanoic acid: R319 (= R398), W323 (≠ L402), H370 (= H451), H415 (= H495)
- binding flavin-adenine dinucleotide: P68 (vs. gap), G70 (vs. gap), T71 (vs. gap), G72 (≠ A87), T73 (≠ R88), G74 (= G89), G78 (≠ S93), V79 (≠ Q94), L90 (≠ T107), P132 (≠ T152), G133 (≠ A153), A134 (= A154), G140 (= G160), M141 (= M161), A143 (≠ G163), T144 (≠ N164), A146 (≠ S166), S147 (≠ C167), E200 (= E269), G201 (= G270), I206 (≠ S275), H370 (= H451), E414 (= E494), N451 (= N531)
8jdoA Crystal structure of h405a mldhd in complex with d-2-hydroxyhexanoic acid (see paper)
25% identity, 49% coverage: 42:536/1007 of query aligns to 22:456/456 of 8jdoA
- binding (2R)-2-hydroxyhexanoic acid: R319 (= R398), W323 (≠ L402), H415 (= H495)
- binding flavin-adenine dinucleotide: P68 (vs. gap), G70 (vs. gap), T71 (vs. gap), G72 (≠ A87), T73 (≠ R88), G74 (= G89), G78 (≠ S93), V79 (≠ Q94), L90 (≠ T107), P132 (≠ T152), G133 (≠ A153), A134 (= A154), G140 (= G160), M141 (= M161), A143 (≠ G163), T144 (≠ N164), A146 (≠ S166), S147 (≠ C167), E200 (= E269), G201 (= G270), I206 (≠ S275), Y324 (≠ N403), H370 (= H451), E414 (= E494), N451 (= N531)
8jdnA Crystal structure of h405a mldhd in complex with d-2-hydroxyvaleric acid (see paper)
25% identity, 49% coverage: 42:536/1007 of query aligns to 22:456/456 of 8jdnA
- binding flavin-adenine dinucleotide: P68 (vs. gap), G70 (vs. gap), T71 (vs. gap), G72 (≠ A87), T73 (≠ R88), G74 (= G89), G78 (≠ S93), V79 (≠ Q94), L90 (≠ T107), P132 (≠ T152), G133 (≠ A153), A134 (= A154), G140 (= G160), M141 (= M161), A143 (≠ G163), T144 (≠ N164), A146 (≠ S166), S147 (≠ C167), E200 (= E269), G201 (= G270), I206 (≠ S275), H370 (= H451), E414 (= E494), N451 (= N531)
- binding (2R)-2-oxidanylpentanoic acid: R319 (= R398), W323 (≠ L402), H415 (= H495)
8jdgA Crystal structure of h405a mldhd in complex with d-2-hydroxybutanoic acid (see paper)
25% identity, 49% coverage: 42:536/1007 of query aligns to 22:456/456 of 8jdgA
- binding flavin-adenine dinucleotide: P68 (vs. gap), G70 (vs. gap), T71 (vs. gap), G72 (≠ A87), T73 (≠ R88), G74 (= G89), G78 (≠ S93), V79 (≠ Q94), L90 (≠ T107), P132 (≠ T152), G133 (≠ A153), A134 (= A154), G140 (= G160), M141 (= M161), A143 (≠ G163), T144 (≠ N164), A146 (≠ S166), S147 (≠ C167), E200 (= E269), G201 (= G270), I206 (≠ S275), H370 (= H451), E414 (= E494), N451 (= N531)
- binding (2R)-2-oxidanylbutanoic acid: R319 (= R398), H415 (= H495)
8jdbA Crystal structure of h405a mldhd in complex with d-2-hydroxyoctanoic acid (see paper)
25% identity, 49% coverage: 42:536/1007 of query aligns to 22:456/456 of 8jdbA
- binding flavin-adenine dinucleotide: P68 (vs. gap), G70 (vs. gap), T71 (vs. gap), G72 (≠ A87), T73 (≠ R88), G74 (= G89), G78 (≠ S93), V79 (≠ Q94), L90 (≠ T107), P132 (≠ T152), G133 (≠ A153), A134 (= A154), G140 (= G160), M141 (= M161), A143 (≠ G163), T144 (≠ N164), A146 (≠ S166), S147 (≠ C167), E200 (= E269), G201 (= G270), I206 (≠ S275), Y324 (≠ N403), H370 (= H451), E414 (= E494), N451 (= N531)
- binding (2R)-2-oxidanyloctanoic acid: V75 (≠ A90), R319 (= R398), W323 (≠ L402), H415 (= H495)
8jdpA Crystal structure of h405a mldhd in complex with d-2-hydroxyisovaleric acid (see paper)
25% identity, 49% coverage: 42:536/1007 of query aligns to 22:455/455 of 8jdpA
- binding flavin-adenine dinucleotide: P68 (vs. gap), G70 (vs. gap), T71 (vs. gap), G72 (≠ A87), T73 (≠ R88), G74 (= G89), G78 (≠ S93), V79 (≠ Q94), L90 (≠ T107), P132 (≠ T152), G133 (≠ A153), A134 (= A154), G140 (= G160), M141 (= M161), A143 (≠ G163), T144 (≠ N164), A146 (≠ S166), S147 (≠ C167), E200 (= E269), G201 (= G270), I206 (≠ S275), H369 (= H451), E413 (= E494), N450 (= N531)
- binding deaminohydroxyvaline: R319 (= R398), H414 (= H495)
P9WIT1 Uncharacterized FAD-linked oxidoreductase Rv2280; EC 1.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
23% identity, 46% coverage: 65:532/1007 of query aligns to 46:452/459 of P9WIT1
- K354 (≠ E430) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
6lpnB Crystal structure of human d-2-hydroxyglutarate dehydrogenase in apo form (see paper)
20% identity, 47% coverage: 65:536/1007 of query aligns to 54:465/467 of 6lpnB
- binding flavin-adenine dinucleotide: P76 (≠ A87), G78 (= G89), G79 (≠ A90), N80 (≠ G91), T81 (= T92), G82 (≠ S93), M83 (≠ Q94), G86 (≠ Q97), S87 (≠ T98), L140 (≠ V150), A142 (≠ T152), C146 (= C156), H147 (≠ T157), G150 (= G160), N151 (≠ M161), A153 (≠ G163), T154 (≠ N164), G208 (= G270), I212 (≠ F274), I213 (≠ S275), E423 (= E494), N460 (= N531)
Sites not aligning to the query:
6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og) (see paper)
20% identity, 47% coverage: 65:536/1007 of query aligns to 53:464/466 of 6lpxA
- binding 2-oxoglutaric acid: R333 (= R398), T337 (≠ M405), K348 (≠ S416), Y379 (= Y449), H381 (= H451), H388 (= H458), H423 (= H495)
- binding flavin-adenine dinucleotide: P75 (≠ A87), Q76 (≠ R88), G77 (= G89), G78 (≠ A90), N79 (≠ G91), T80 (= T92), G81 (≠ S93), M82 (≠ Q94), G85 (≠ Q97), S86 (≠ T98), L139 (≠ V150), G140 (≠ S151), A141 (≠ T152), C145 (= C156), G149 (= G160), N150 (≠ M161), A152 (≠ G163), T153 (≠ N164), G157 (= G168), G207 (= G270), I212 (≠ S275), E422 (= E494), N459 (= N531)
- binding zinc ion: H381 (= H451), H388 (= H458), E422 (= E494)
Sites not aligning to the query:
6lpuA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with l-2-hydroxyglutarate (l-2-hg) (see paper)
20% identity, 47% coverage: 65:536/1007 of query aligns to 53:464/466 of 6lpuA
- binding flavin-adenine dinucleotide: P75 (≠ A87), G77 (= G89), G78 (≠ A90), N79 (≠ G91), T80 (= T92), G81 (≠ S93), G85 (≠ Q97), S86 (≠ T98), L139 (≠ V150), G140 (≠ S151), A141 (≠ T152), C145 (= C156), H146 (≠ T157), G148 (= G159), G149 (= G160), N150 (≠ M161), A152 (≠ G163), T153 (≠ N164), A155 (≠ S166), E206 (= E269), G207 (= G270), I211 (≠ F274), I212 (≠ S275), E422 (= E494), N459 (= N531)
- binding (2s)-2-hydroxypentanedioic acid: R333 (= R398), T337 (≠ M405), K348 (≠ S416), Y379 (= Y449), H381 (= H451), H388 (= H458), H423 (= H495)
- binding zinc ion: H381 (= H451), H388 (= H458), E422 (= E494)
Sites not aligning to the query:
Query Sequence
>BPHYT_RS34425 FitnessBrowser__BFirm:BPHYT_RS34425
MTNPTSALLVKPIHLVPSAARLTSPLAQHLRKSLRGDVLFDAASRGRYATDASIYQITPI
GVVVPRDQDDLRIALEIARSEKVPLLARGAGTSQCGQTVGEALVIDTSKWLNNIVAFDAE
ARTVTVEPGVVLDHLNAWLKPHGLWFPVDVSTAAQCTIGGMAGNNSCGSRSIEYGNMVHN
VDAIDAILADGSEAHFASLREAPQGARLQQILAGVKQIAERERDEIVARVPKVLRRVAGY
NIDVFDCQNPRAYTDDGVANLAHLLVGSEGTLAFSRQLTLRLAPLPVHKTLGVVNFPTFW
QSMNLTQHIVKLKPVAVELVDRTMIDLAMSNPAFRPVIGKALVGEPQAILLVEFAGEDRD
AQLASLKQLTELMADLGLPDSVVEMPDANEQKALWEVRKAGLNIMMSMKGDGKPVSFIED
CAVPLEHLAEYTSRLTEVFHRHGTEGTWYAHASVGTLHVRPILDMRRDGAQKMRAIADEA
AALVREYKGAYSGEHGDGLCRGEWVAWQYGPRLNQAFSEIKALFDPDNRFNPDKIVRPPK
MDDARNFRFAPGYKEHRIDTALDWSAWNVERDPLTGQESLPGSGNDLAGGLAKAVEMCNN
NGHCRKFDAGTMCPSYRVTKDEQHVTRGRANTLRLAISGQLGEAGLASDEVKETLDLCVS
CKGCKRDCPTGVDMAKFKIEARAARVKRHGLRLRDKLVAFMPRYASTASRMPGLMALADN
VPVLSAWLKRSVGFAPERSLPRFKKSFLADAVSSRNAAQGAELKEVVLFVDTFNNNMEPE
NARAAQQVLEAAGYTVHFNTRQGERPVCCGRTFLAAGLVDEAKQEARRMLDLFKPFVERG
VPVVGLEPSCLLSLRDEFLHYGFGDEAQRLSKQAFLFEEFLVREEKAGRLELALKPLAKQ
QALVHGHCHQKAFDAFTPVQTVLKWIPELKVSTVESSCCGMAGSFGYEAEHYATSQAMAE
LSLLPAVRKMDGDTLMVADGTSCRHQIHDGAGVDAIHVARVLAMALR
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory