SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing BWI76_RS00610 FitnessBrowser__Koxy:BWI76_RS00610 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 6 hits to proteins with known functional sites (download)

P96517 Melibiose permease; Melibiose transporter MelY from Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCTC 10005 / WDCM 00083 / NCDC 279-56) (see 2 papers)
81% identity, 97% coverage: 1:408/421 of query aligns to 1:408/425 of P96517

query
sites
P96517

M

M

N

N

P

T

T

T

V

T

C

C

T

T

H

H

K

K

N

D

N

N

P

P

N

N

F

F

W

W

I

I

F

F

G

G

L

L

F

F

L

L

Y

Y

F

F

I

I

M

M

A

A

T

T

C

C

F

F

P

P

F

F

L

L

P

P

I

I

W

W

L

L

S

S

D

D

V

I

I

I

G

G

L

L

N

N

K

K

T

T

E

H

T

T

G

G

I

I

V

V

F

F

S

S

S

C

L

I

S

S

L

L

F

S

A

A

I

I

C

A

F

F

Q

Q

P

P

I

V

L

L

G

G

V

V

I

I

S

S

D

D

K

K

L

L

G

G

L

L

K

K

H

H

L

L

M

L

W

W

I

I

V

I

T

S

V

V

L
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L

L

L

V

F

L
|
L

I

F

A

A

P

P

F

F

L

L

Y

Y

V

V

F

F

A

A

P

P

L

L

K

K

T

T

N

N

I

I

W

W

L

L

G

G

A

A

L

L

S

S

G

G

A

L

Y

Y

I

I

G

G

F

F

V

V

F

F

S

S

A

A

G

G

A

S

G

G

A

A

M

I

E

E

A

A

Y

Y

I

I

E

E

R

R

V

V

S

S

R

R

N

N

S

S

G

A

F

F

E

E

Y

Y

G

G

K

K

A

A

R

R

T

M

F

F

G

G

C

C

L

L

G

G

W

W

A

G

L

L

C

C

A

A

T

S

T

T

A

G

G

G

M

I

L

L

F

F

S

G

V

I

N

D

P

P

E

S

W

Y

V

V

F

F

W

W

M

M

G

G

S

S

A

A

A
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A

L

L

V

L

L

L

V

M

V

L

L

L

V

L

A

V

I

V

A

A

K

K

P

P

Q

K

A

P

S

N

Q

Q

T

T

A

A

Q

Q

V

V

M

M

D

N

S

A

L

L

G

G

A

A

N

N

R

Q

S

P

S

Q

V

I

D

T

L

A

K

K

T

K

A

V

V

F

R

N

M

L

F

F

R

R

Q

Q

R

R

K

R

M

M

W

W

M

M

F

F

I

I

L

L

Y

Y

V

V

I

I

G

G

V

V

A

A

C

C

V

V

Y

Y

D

D

V

V

F

F

D

D

Q

Q

F

F

A

A

T

T

F

F

K

K

S

T

F

F

A

A

T

T

P

P

E

Q

S

E

G

G

T

T

R

R

A

A

F

F

G

G

F

F

A

A

T

T

A

A

G

G

E

E

I

I

C

C

N

N

A

A

I

I

M

M

F

F

S

C

S

S

P

P

W

W

I

I

N

N

R

R

I

I

G

G

A

A

K

K

N

N

T

T

L

L

I

I

A

A

G

G

M

L

V

I

M

M

A

A

A

T

R

R

M

I

I

I

G

G

S

S

F

F

A

A

T

T

A

A

A

V

E

E

V

V

V

I

A

A

L

L

K

K

M

M

L

L

H

H

A

A

L

L

E

E

V

V

P

P

F

F

L

L

V

V

G

G

A

A

F

F

K

K

Y

Y

I

I

T

T

G

G

V

V

F

F

D

D

V

T

R

R

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L

S

S

A

A

T

T

I

I

Y

Y

L

L

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I

G

G

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F

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Q

F

F

S

A

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K

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Q

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A

A

A
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A

I

I

F

F

L

L

S

S

A

A

F

F

A

A

G

G

N

N

M

M

Y

Y

D

D

R

R

I

I

G

G

F

F

Q

Q

D

E

T

T

Y

Y

M

L

I

M

L

L

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G

G

C

I

F

A

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L

T

A

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S

A

A

F

F

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T

L

L

S

S

G

S

K

R

L88 (= L88) mutation to P: Does not affect melibiose transport. Increases affinity for maltose and maltose transport.
L91 (= L91) mutation to P: Does not affect melibiose transport. Increases affinity for maltose and maltose transport.
A182 (= A182) mutation to P: Does not affect melibiose transport. Increases affinity for maltose and maltose transport.
A367 (= A367) mutation to V: No change in transport activity.

P16552 Raffinose permease; Raf permease from Escherichia coli (see paper)
76% identity, 95% coverage: 7:406/421 of query aligns to 6:404/425 of P16552

query
sites
P16552

T

T

H

H

K

K

N

N

N

T

P

-

N

D

F

F

W

W

I

I

F

F

G

G

L

L

F

F

L

L

Y

Y

F

F

I

I

M

M

A

A

T

T

C

C

F

F

P

P

F

F

L

L

P

P

I
x
V

W

W

L

L

S

S

D

D

V

V

I

V

G

G

L

L

N

S

K

K

T

T

E

D

T

T

G

G

I

I

V

V

F

F

S

S

S

C

L

L

S

S

L

L

F

F

A

A

I

I

C

S

F

F

Q

Q

P

P

I

L

L

L

G

G

V

V

I

I

S

S

D

D

K

R

L

L

G

G

L

L

K

K

H

N

L

L

M

I

W

W

I

S

V

I

T

S

V

L

L

L

V

V

L

F

I

F

A

A

P

P

F

F

L

L

Y

Y

V

V

F

F

A

A

P

P

L

L

K

H

T

L

N

N

I

I

W

W

L

A

G

G

A

A

L

L

S

T

G

G

A

V

Y

F

I

I

G

G

F

F

V

V

F

F

S

S

A

A

G

G

A

A

G

G

A

A

M

I

E

E

A

A

Y

Y

I

I

E

E

R

R

V

V

S

S

R

R

N
x
S

S
|
S

G

G

F

F

E

E

Y

Y

G

G

K

K

A

A

R

R

T

M

F

F

G

G

C

C

L

L

G

G

W

W

A

A

L

L

C

C

A

A

T

T

T

M

A

A

G

G

M

I

L

L

F

F

S

N

V

V

N

D

P

P

E

S

W

L

V

V

F

F

W

W

M

M

G

G

S

S

A

G

A

A

L

L

V

L

L

L

V

L

L

L

V

L

A

Y

I

L

A

A

K

R

P

P

Q

S

A

T

S

S

Q

Q

T

T

A

A

Q

M

V

V

M

M

D

N

S

A

L

L

G

G

A

A

N

N

R

S

S

S

S

L

V

I

D

S

L

T

K

R

T

M

A

V

V

F

R

S

M

L

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F

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M

R

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Q

M

M

W

W

M

M

F

F

I

V

L

L

Y

Y

V

T

I

I

G

G

V

V

A

A

C

C

V

V

Y

Y

D

D

V

V

F

F

D

D

Q

Q

F

F

A

A

T

I

F

F

K

R

S

S

F

F

A

D

T

T

P

P

E

Q

S

A

G

G

T

I

R

K

A

A

F

F

G

G

F

F

A

A

T

T

A

A

G

G

E

E

I

I

C

C

N

N

A

A

I

I

M

M

F

F

S

C

S

T

P

P

W

W

I

I

N

N

R

R

I

I

G

G

A

A

K

K

N

N

T

T

L

L

I

V

A

A

G

G

M

G

V

I

M

M

A

T

A

I

R

R

M

I

I

T

G

G

S

S

S

A

F

F

A

A

T

T

A

M

A

T

E

E

V

V

A

I

L

L

K

K

M

M

L

L

H

H

A

A

L

L

E

E

V

V

P

P

F

F

L

L

V

V

G

G

A

A

F

F

K

K

Y

Y

I

I

T

T

G

G

V

V

F

F

D

D

V

T

R

R

L

L

S

S

A

A

T

T

I

V

Y

Y

L

L

V

I

G

G

F

F

Q

Q

F

F

S

S

K

K

Q

Q

V

L

A

A

I

I

F

L

L

L

S

S

A

T

F

F

A

A

G

G

N

H

M

L

Y

Y

D

D

R

R

I

M

G

G

F

F

Q

Q

D

N

T

T

Y

Y

M

F

I

V

L

L

G
|
G

G

M

I
|
I

A

V

L

L

T

T

V

V

T

T

L

V

I

I

S

S

A

A

F

F

T

T

L

L

S

S

V35 (≠ I37) mutation to A: Significantly reduces raffinose transport, enhances maltose transport.
S138 (≠ N140) mutation to D: Significantly reduces raffinose transport, enhances maltose transport; when associated with L-139 and A-389.
S139 (= S141) mutation to L: Significantly reduces raffinose transport, enhances maltose transport; when associated with D-138 and A-389.
G389 (= G391) mutation to A: Significantly reduces raffinose transport, enhances maltose transport; when associated with D-138 and L-139.
I391 (= I393) mutation to S: Significantly reduces raffinose transport, enhances maltose transport.

P02920 Lactose permease; Lactose-proton symport from Escherichia coli (strain K12) (see 3 papers)
59% identity, 94% coverage: 27:421/421 of query aligns to 22:416/417 of P02920

query
sites
P02920

I

I

M

M

A

G

T

A

C

Y

F

F

P

P

F

F

L

F

P

P

I

I

W

W

L

L

S

H

D

D

V

I

I

N

G

H

L

I

N

S

K

K

T

S

E

D

T

T

G

G

I

I

V

I

F

F

S

A

L

I

S

S

L

L

F

F

A

S

I

L

C

L

F

F

Q

Q

P

P

I

L

L

F

G

G

V
x
L

I

L

S

S

D

D

K

K

L

L

G

G

L

L

K

R

K

K

H

Y

L

L

M

L

W

W

I

I

V

I

T

T

V

G

L

M

L

L

V

V

L

M

I

F

A

A

P

P

F

F

L

I

Y

F

V

I

F

F

A
x
G

P

P

L

L

K

Q

T

Y

N

N

I

I

W

L

L

V

G

G

A

S

L

I

S

V

G

G

A

I

Y

Y

I

L

G

G

F

F

V

C

F

F

S

N

A

A

G

G

A
|
A

G

P

A

A

M

V

E

E

A

A

Y

F

I

I

E

E

R

K

V

V

S

S

R

R

N

R

S

S

G

N

F

F

E

E

Y

F

G

G

K

R

A

A

R

R

T

M

F

F

G

G

C

C

L

V

G

G

W

W

A

A

L

L

C

C

A

A

T

S

T

I

A

V

G

G

M

I

L

M

F

F

S

T

V

I

N

N

P

N

E

Q

W

F

V

V

F

F

W

W

M

L

G

G

S

S

A

G

A

C

A

A

L

L

V

I

L

L

V

A

V

V

L

L

V

L

A

F

I

F

A

A

K

K

P

T

Q

D

A

A

S

P

Q

S

T

S

A

A

Q

T

V

V

M

A

D

N

S

A

L

V

G

G

A

A

N

N

R

H

S

S

S

A

V

F

D

S

L

L

K

K

T

L

A

A

V

L

R

E

M

L

F

F

R

R

Q

Q

R

P

K

K

M

L

W

W

M

F

F

L

I

S

L

L

Y

Y

V

V

I

I

G

G

V

V

A

S

C

C

V

T

Y

Y

D
|
D

V

V

F

F

D

D

Q

Q

F

F

A

A

T

N

F

F

K

T

S

S

F

F

A

A

T

T

P

G

E

E

S

Q

G

G

T

T

R

R

A

V

F

F

G

G

F

Y

A
x
V

T

T

A

M

G

G

E

E

I

L

C

L

N

N

A

A

I

S

I

I

M

M

F

F

S

F

S
x
A

P

P

W

L

I

I

N

N

R

R

I

I

G

G

A

G

K

K

N

N

T

A

L

L

I

L

A

A

G

G

M

T

V

I

M

M

A

S

A

V

R

R

M

I

I

I

G

G

S

S

F

F

A

A

T

T

T

S

A

A

A

L

E

E

V

V

A

I

L

L

K

K

M

T

L

L

H

H

A

M

L

F

E

E

V

V

P

P

F

F

L

L

V

V

G

G

A

C

F

F

K

K

Y

Y

I

I

T

T

G

S

V

Q

F

F

D

E

V

V

R

R

L

F

S

S

A

A

T

T

I

I

Y

Y

L

L

V

V

G

C

F

F

Q
x
C

F

F

S

F

K
|
K

Q

Q

V

L

A

A

A

M

I

I

F

F

L

M

S

S

A
x
V

F

L

A

A

G

G

N

N

M

M

Y

Y

D

E

R

S

I

I

G

G

F

F

Q

Q

D

G

T

A

Y

Y

M

L

I

V

L

L

G

G

G

L

I

V

A

A

L

L

T

G

V

F

T

T

L

L

I

I

S

S

A

V

F

F

T

T

L

L

S

S

G

G

K

P

A

G

T

P

S

L

E

S

K

L

M

L

R

R

D

R

N

Q

A

V

M

N

T

E

V

V

L65 (≠ V70) mutation to V: No change in transport activity.
G96 (≠ A101) mutation to A: No change in transport activity.
A122 (= A127) mutation to S: No change in transport activity.
D237 (= D242) mutation D->N,G: Loss of activity.
V264 (≠ A269) mutation to A: No change in transport activity.
A279 (≠ S284) mutation to S: No change in transport activity.
C355 (≠ Q360) mutation to Q: No change in transport activity.
K358 (= K363) mutation to T: Loss of activity.
V367 (≠ A372) mutation to A: Increases transport of melibiose and impairs transport of TMG.

Sites not aligning to the query:

1 modified: N-formylmethionine; partial

6vbgB Lactose permease complex with thiodigalactoside and nanobody 9043 (see paper)
59% identity, 90% coverage: 27:407/421 of query aligns to 22:390/397 of 6vbgB

query
sites
6vbgB

I

I

M

M

A

G

T

A

C

Y

F
|
F

P

P

F

F

L

F

P

P

I

I

W

W

L

L

S

H

D

D

V

I

I

N

G

H

L

I

N

S

K

K

T

S

E

D

T

T

G

W

I

I

V

I

F

F

S

A

L

I

S

S

L

L

F

F

A

S

I

L

C

L

F

F

Q

Q

P

P

I

L

L

F

G

G

V

L

I

L

S

S

D

D

K

K

L

L

G

G

L

L

K

R

K

K

H

Y

L

L

M

L

W

W

I

I

V

I

T

T

V

G

L

M

L

L

V

V

L

M

I

F

A

A

P

P

F

F

L

I

Y

F

V

I

F

F

A

G

P

P

L

L

K

Q

T

Y

N

N

I

I

W

L

L

V

G

G

A

S

L

I

S

V

G

G

A

I

Y

Y

I

L

G

G

F

F

V

C

F

F

S

N

A

A

G

G

A

A

G

P

A

A

M

V

E
|
E

A

A

Y

F

I

I

E

E

R

K

V

V

S

S

R

R

N

R

S

S

G

N

F

F

E

E

Y

F

G

G

K

R

A

A

R
|
R

T

M

F

F

G

G

C
|
C

L

V

G

G

W
|
W

A

A

L

L

C

C

A

A

T

S

T

I

A

V

G

G

M

I

L

M

F

F

S

T

V

I

N

N

P

N

E

Q

W

F

V

V

F

F

W

W

M

L

G

G

S

S

A

G

A

C

A

A

L

L

V

I

L

L

V

A

V

V

L

L

V

L

A

F

I

F

A

A

K

K

P

T

Q

D

A

A

S

-

Q

-

T

-

A

-

Q

-

V

-

M

-

D

-

S

-

L

-

G

-

A

-

N

N

R

H

S

S

S

A

V

F

D

S

L

L

K

K

T

L

A

A

V

L

R

E

M

L

F

F

R

R

Q

Q

R

P

K

K

M

L

W

W

M

F

F

L

I

S

L

L

Y

Y

V

V

I

I

G

G

V

V

A

S

C

C

V

T

Y

Y

D

D

V

V

F

F

D

D

Q

Q

F

F

A

A

T

N

F

F

K

T

S

S

F

F

A

A

T

T

P

G

E

E

S

Q

G

G

T

T

R

R

A

V

F

F

G

W

F

Y

A

V

T

T

A

M

G

G

E
|
E

I

L

C

L

N
|
N

A

A

I

S

I

I

M

M

F

F

S

F

S

A

P

P

W

L

I

I

N

N

R

R

I

I

G

G

A

G

K

K

N

N

T

A

L

L

I

L

A

A

G

G

M

T

V

I

M

M

A

S

A

V

R

R

M

I

I

I

G

G

S

S

F

F

A

A

T

T

T

S

A

A

A

L

E

E

V

V

A

I

L

L

K

K

M

T

L

L

H
|
H

A

M

L

F

E

E

V

V

P

P

F

F

L

L

L
|
L

V

V

G

G

A

C

F

F

K

K

Y

Y

I

I

T

T

G

S

V

Q

F

F

D

E

V

V

R

R

L

F

S

S

A

A

T

T

I

I

Y

Y

L

L

V

V

G

C

F

F

Q

C

F

F

S

F

K

K

Q

Q

V

L

A

A

A

M

I

I

F

F

L

M

S

S

A

V

F

L

A

A

G

G

N

N

M

M

Y

Y

D

E

R

S

I

I

G

G

F

F

Q

Q

D

G

T

A

Y

Y

M

L

I

V

L

L

G

G

G

L

I

V

A

A

L

L

T

G

V

F

T

T

L

L

I

I

S

S

A

V

F

F

T

T

L

L

S

S

G

G

binding beta-D-galactopyranose: R144 (= R149), C148 (= C153), W151 (= W156), E257 (= E274), N260 (= N277), H310 (= H327)
binding 1-thio-beta-D-galactopyranose: F27 (= F32), E126 (= E131), R144 (= R149), L318 (= L335)

2y5yA Crystal structure of lacy in complex with an affinity inactivator (see paper)
58% identity, 90% coverage: 27:407/421 of query aligns to 19:385/386 of 2y5yA

query
sites
2y5yA

I

I

M

M

A

G

T

A

C

Y

F

F

P

P

F

F

L

F

P

P

I

I

W

W

L

L

S

H

D

D

V

I

I

N

G

H

L

I

N

S

K

K

T

S

E

D

T

T

G

G

I

I

V

I

F

F

S

A

L

I

S

S

L

L

F

F

A

S

I

L

C

L

F

F

Q

Q

P

P

I

L

L

F

G

G

V

L

I

L

S

S

D

D

K

K

L

L

G

G

L

L

K

R

K

K

H

Y

L

L

M

L

W

W

I

I

V

I

T

T

V

G

L

M

L

L

V

V

L

M

I

F

A

A

P

P

F

F

L

I

Y

F

V

I

F

F

A

G

P

P

L

L

K

Q

T

Y

N

N

I

I

W

L

L

V

G

G

A

S

L

I

S

V

G

G

A

I

Y

Y

I

L

G

G

F

F

V

S

F

F

S

N

A

A

G

G

A
x
C

G

P

A

A

M

V

E

E

A

A

Y

F

I

I

E

E

R

K

V

V

S

S

R

R

N

R

S

S

G

N

F

F

E

E

Y

F

G

G

K

R

A

A

R

R

T

M

F

F

G

G

C

A

L

V

G

G

W
|
W

A

A

L

L

C

V

A

A

T

S

T

I

A

V

G

G

M

I

L

M

F

F

S

T

V

I

N

N

P

N

E

Q

W

F

V

V

F

F

W

W

M

L

G

G

S

S

A

G

A

M

A

A

L

L

V

I

L

L

V

A

V

V

L

L

V

L

A

F

I

F

A

A

K

K

P

-

Q

-

A

-

S

-

Q

-

T

-

A

-

Q

-

V

-

M

-

D

-

S

-

L

-

G

-

A

A

N

N

R

H

S

S

S

A

V

F

D

S

L

L

K

K

T

L

A

A

V

L

R

E

M

L

F

F

R

R

Q

Q

R

P

K

K

M

L

W

W

M

F

F

L

I

S

L

L

Y

Y

V

V

I

I

G

G

V

V

A

S

C

S

V

T

Y

Y

D

D

V

V

F

F

D

D

Q

Q

F

F

A

A

T

N

F

F

K

T

S

S

F

F

A

A

T

T

P

G

E

E

S

Q

G

G

T

T

R

R

A

V

F

F

G

G

F

Y

A

V

T

T

A

M

G

G

E
|
E

I

L

C

L

N

N

A

A

I

S

I

I

M

M

F

F

S

F

S

A

P

P

W

L

I

I

N

N

R

R

I

I

G

G

A

G

K

K

N

N

T

A

L

L

I

L

A

A

G

G

M

T

V

I

M

M

A

S

A

V

R

R

M

I

I

I

G

G

S

S

F

F

A

A

T

T

T

S

A

A

A

L

E

E

V

V

A

I

L

L

K

K

M

T

L

L

H

H

A

M

L

F

E

E

V

V

P

P

F

F

L

L

V

V

G

G

A

S

F

F

K

K

Y

Y

I

I

T

T

G

S

V

Q

F

F

D

E

V

V

R

R

L

F

S

S

A

A

T

T

I

I

Y

Y

L

L

V

V

G

A

F

F

Q

A

F

F

S

F

K

K

Q

Q

V

L

A

A

A

M

I

I

F

F

L

M

S

S

A

V

F

L

A

A

G

G

N

N

M

M

Y

Y

D

E

R

S

I

I

G

G

F

F

Q

Q

D

G

T

A

Y

Y

M

L

I

V

L

L

G

G

G

L

I

V

A

A

L

L

T

G

V

F

T

T

L

L

I

I

S

S

A

V

F

F

T

T

L

L

S

S

G

G

binding 2-sulfanylethyl beta-D-galactopyranoside: C119 (≠ A127), W148 (= W156), E252 (= E274)

Sites not aligning to the query:

binding 2-sulfanylethyl beta-D-galactopyranoside: 17

4zyrA Crystal structure of e. Coli lactose permease g46w/g262w bound to p- nitrophenyl alpha-d-galactopyranoside (alpha-npg) (see paper)
58% identity, 91% coverage: 27:409/421 of query aligns to 17:383/387 of 4zyrA

query
sites
4zyrA

I

I

M
|
M

A

G

T

A

C

Y

F

F

P

P

F

F

L

F

P

P

I

I

W

W

L

L

S

H

D

D

V

I

I

N

G

H

L

I

N

S

K

K

T

S

E

D

T

T

G

W

I

I

V

I

F

F

S

A

L

I

S

S

L

L

F

F

A

S

I

L

C

L

F

F

Q

Q

P

P

I

L

L

F

G

G

V

L

I

L

S

S

D

D

K

K

L

L

G

G

L

L

K

R

K

K

H

Y

L

L

M

L

W

W

I

I

V

I

T

T

V

G

L

M

L

L

V

V

L

M

I

F

A

A

P

P

F

F

L

I

Y

F

V

I

F

F

A

G

P

P

L

L

K

Q

T

Y

N

N

I

I

W

L

L

V

G

G

A

S

L

I

S

V

G

G

A

I

Y

Y

I

L

G

G

F

F

V

C

F

F

S

N

A

A

G

G

A

A

G

P

A

A

M

V

E

E

A

A

Y

F

I

I

E

E

R

K

V

V

S

S

R

R

N

R

S

S

G

N

F

F

E

E

Y

F

G

G

K

R

A

A

R
|
R

T

M

F

F

G

G

C
|
C

L

V

G

G

W
|
W

A

A

L

L

C

C

A

A

T

S

T

I

A

V

G

G

M

I

L

M

F

F

S

T

V

I

N

N

P

N

E

Q

W

F

V

V

F

F

W

W

M

L

G

G

S

S

A

G

A

C

A

A

L

L

V

I

L

L

V

A

V

V

L

L

V

L

A

F

I

F

A

A

K

K

P

T

Q

D

A

A

S

-

Q

-

T

-

A

-

Q

-

V

-

M

-

D

-

S

-

L

-

G

-

A

-

N

-

R

-

S

-

V

F

D

S

L

L

K

K

T

L

A

A

V

L

R

E

M

L

F

F

R

R

Q

Q

R

P

K

K

M

L

W

W

M

F

F

L

I

S

L

L

Y

Y

V

V

I

I

G

G

V

V

A

S

C

C

V

T

Y

Y

D

D

V

V

F

F

D

D

Q

Q

F

F

A

A

T

N

F

F

K

T

S

S

F

F

A

A

T

T

P

G

E

E

S

Q

G

G

T

T

R

R

A

V

F

F

G

W

F

Y

A

V

T

T

A

M

G

G

E
|
E

I

L

C

L

N

N

A

A

I

S

I

I

M

M

F

F

S

F

S

A

P

P

W

L

I

I

N

N

R

R

I

I

G

G

A

G

K

K

N

N

T

A

L

L

I

L

A

A

G

G

M

T

V

I

M

M

A

S

A

V

R

R

M

I

I

I

G

G

S

S

F

F

A

A

T

T

T

S

A

A

A

L

E

E

V

V

A

I

L

L

K

K

M

T

L

L

H
|
H

A

M

L

F

E

E

V

V

P

P

F

F

L

L

V

V

G

G

A

C

F

F

K

K

Y

Y

I

I

T

T

G

S

V

Q

F

F

D

E

V

V

R

R

L

F

S

S

A

A

T

T

I

I

Y

Y

L

L

V

V

G

C

F

F

Q

C

F

F

S

F

K

K

Q

Q

V

L

A

A

A

M

I

I

F

F

L

M

S

S

A

V

F

L

A

A

G

G

N

N

M

M

Y

Y

D

E

R

S

I

I

G

G

F

F

Q

Q

D

G

T

A

Y

Y

M

L

I

V

L

L

G

G

G

L

I

V

A

A

L

L

T

G

V

F

T

T

L

L

I

I

S

S

A

V

F

F

T

T

L

L

S

S

G

G

K

P

A

G

binding 4-nitrophenyl alpha-D-galactopyranoside: M18 (= M28), R139 (= R149), C143 (= C153), W146 (= W156), E248 (= E274), H301 (= H327)

Query Sequence

>BWI76_RS00610 FitnessBrowser__Koxy:BWI76_RS00610
MNPTVCTHKNNPNFWIFGLFFFLYFFIMATCFPFLPIWLSDVIGLNKTETGIVFSSLSLF
AICFQPILGVISDKLGLKKHLMWIVTVLLVLIAPFFLYVFAPLLKTNIWLGALSGGAYIG
FVFSAGAGAMEAYIERVSRNSGFEYGKARTFGCLGWALCATTAGMLFSVNPEWVFWMGSA
AALVLVVLVAIAKPQASQTAQVMDSLGANRSSVDLKTAVRMFRQRKMWMFILYVIGVACV
YDVFDQQFATFFKSFFATPESGTRAFGFATTAGEICNAIIMFSSPWIINRIGAKNTLLIA
GMVMAARMIGSSFATTAAEVVALKMLHALEVPFLLVGAFKYITGVFDVRLSATIYLVGFQ
FSKQVAAIFLSAFAGNMYDRIGFQDTYMILGGIALTVTLISAFTLSGKATSEKMRDNAMT
V

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory