Comparing BWI76_RS00815 FitnessBrowser__Koxy:BWI76_RS00815 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8gobA Crystal structure of glycerol dehydrogenase in the presence of NAD+ (see paper)
90% identity, 100% coverage: 1:367/367 of query aligns to 1:367/367 of 8gobA
8goaA Crystal structure of glycerol dehydrogenase in the absence of NAD+ (see paper)
90% identity, 100% coverage: 1:367/367 of query aligns to 1:367/367 of 8goaA
5zxlA Structure of glda from e.Coli (see paper)
90% identity, 100% coverage: 1:367/367 of query aligns to 1:367/367 of 5zxlA
P0A9S5 Glycerol dehydrogenase; GDH; GLDH; (R)-aminopropanol dehydrogenase; 1,2-propanediol dehydrogenase; D-1-amino-2-propanol oxidoreductase; EC 1.1.1.6; EC 1.1.1.75 from Escherichia coli (strain K12) (see paper)
90% identity, 100% coverage: 1:367/367 of query aligns to 1:367/367 of P0A9S5
4mcaA Crystal structure of glycerol dehydrogenase from serratia to 1.9a
60% identity, 100% coverage: 1:367/367 of query aligns to 1:367/367 of 4mcaA
5xn8A Structure of glycerol dehydrogenase crystallised as a contaminant
61% identity, 99% coverage: 1:363/367 of query aligns to 1:363/365 of 5xn8A
1kq3A Crystal structure of a glycerol dehydrogenase (tm0423) from thermotoga maritima at 1.5 a resolution (see paper)
54% identity, 96% coverage: 8:360/367 of query aligns to 9:359/364 of 1kq3A
Q9WYQ4 Glycerol dehydrogenase; GDH; GLDH; EC 1.1.1.6 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
54% identity, 96% coverage: 8:360/367 of query aligns to 8:358/364 of Q9WYQ4
P32816 Glycerol dehydrogenase; GDH; GLDH; GlyDH; EC 1.1.1.6 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see 2 papers)
51% identity, 99% coverage: 2:365/367 of query aligns to 4:367/370 of P32816
1jq5A Bacillus stearothermophilus glycerol dehydrogenase complex with NAD+ (see paper)
50% identity, 99% coverage: 2:365/367 of query aligns to 3:366/366 of 1jq5A
1jqaA Bacillus stearothermophilus glycerol dehydrogenase complex with glycerol (see paper)
49% identity, 99% coverage: 2:365/367 of query aligns to 2:361/361 of 1jqaA
3uhjA Crystal structure of a probable glycerol dehydrogenase from sinorhizobium meliloti 1021
46% identity, 98% coverage: 1:360/367 of query aligns to 1:355/357 of 3uhjA
1ta9B Crystal structure of glycerol dehydrogenase from schizosaccharomyces pombe
44% identity, 99% coverage: 2:365/367 of query aligns to 7:371/394 of 1ta9B
O13702 Glycerol dehydrogenase 1; GDH; GLDH; EC 1.1.1.6 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
44% identity, 99% coverage: 2:365/367 of query aligns to 63:427/450 of O13702
5fb3F Structure of glycerophosphate dehydrogenase in complex with NADPH (see paper)
28% identity, 68% coverage: 88:336/367 of query aligns to 74:317/337 of 5fb3F
Sites not aligning to the query:
4rgqB Crystal structure of the methanocaldococcus jannaschii g1pdh with NADPH and dhap (see paper)
38% identity, 24% coverage: 88:175/367 of query aligns to 70:150/333 of 4rgqB
Sites not aligning to the query:
Q9YER2 Glycerol-1-phosphate dehydrogenase [NAD(P)+]; G1P dehydrogenase; G1PDH; Gro1PDH; Enantiomeric glycerophosphate synthase; sn-glycerol-1-phosphate dehydrogenase; EC 1.1.1.261 from Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) (see paper)
27% identity, 85% coverage: 5:317/367 of query aligns to 8:312/352 of Q9YER2
4rgvA Crystal structure of the methanocaldococcus jannaschii g1pdh (see paper)
36% identity, 24% coverage: 88:175/367 of query aligns to 67:145/328 of 4rgvA
Sites not aligning to the query:
P31005 NAD-dependent methanol dehydrogenase; MDH; MEDH; Type 3 alcohol dehydrogenase; EC 1.1.1.244 from Bacillus methanolicus (see 3 papers)
26% identity, 71% coverage: 8:268/367 of query aligns to 7:275/381 of P31005
Sites not aligning to the query:
3ce9A Crystal structure of glycerol dehydrogenase (np_348253.1) from clostridium acetobutylicum at 2.37 a resolution
34% identity, 26% coverage: 83:178/367 of query aligns to 82:181/349 of 3ce9A
Sites not aligning to the query:
>BWI76_RS00815 FitnessBrowser__Koxy:BWI76_RS00815
MDRIIQSPGKYIQGADAMTRLGGYLKPLAERWLIVGDKFVLGFAEEKLRKSLADAGLVGE
IAPFGGECSHNEINRLRGIADSAQCTAVLGIGGGKTLDTAKALAHFMNLPVVIAPTIAST
DAPCSALSVIYSDDGEFDSYLMLPRNPNMVIVDTQIVAGAPARLLAAGIGDALATWFEAR
ACSRSGATTMAGGKCTQAALALAELCYNTLIEEGEKAMLAAEQHVVTPALERVIEANTYL
SGVGFESGGLAAAHAIHNGLTAIPDAHHYYHGEKVAFGTLTQLVLENAPVEEIETVAALC
HSVGLPITLAQLDIKADIPGKMRTVAEAACAEGETIHNMPGGATPDQVYAALLVADQYGQ
RFLQEWE
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory