SitesBLAST
Comparing BWI76_RS00960 FitnessBrowser__Koxy:BWI76_RS00960 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
46% identity, 99% coverage: 2:544/548 of query aligns to 95:658/667 of P09342
- C161 (= C67) modified: Disulfide link with 307
- P194 (≠ A100) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (≠ V207) modified: Disulfide link with 161
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see paper)
46% identity, 99% coverage: 2:544/548 of query aligns to 92:655/664 of P09114
- P191 (≠ A100) mutation to A: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with L-568.
- W568 (= W464) mutation to L: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with A-191.
6lpiB Crystal structure of ahas holo-enzyme (see paper)
47% identity, 99% coverage: 1:544/548 of query aligns to 6:539/539 of 6lpiB
- active site: I27 (≠ Y22), G29 (= G24), G30 (= G25), S31 (≠ A26), I32 (= I27), E53 (= E47), C76 (≠ T70), F115 (= F109), Q116 (= Q110), E117 (= E111), K165 (= K159), M256 (= M250), A283 (≠ V277), V375 (= V375), G401 (= G401), M403 (= M403), D428 (= D428), N455 (= N455), A457 (≠ R457), L458 (= L458), L460 (≠ M460), V461 (= V461), Q464 (≠ W464)
- binding flavin-adenine dinucleotide: R155 (= R149), G212 (= G204), G213 (= G205), G214 (= G206), T236 (= T230), L237 (= L231), M238 (≠ K232), L254 (= L248), M256 (= M250), H257 (= H251), G276 (= G270), A277 (= A271), R278 (= R272), D280 (= D274), R282 (= R276), A283 (≠ V277), D300 (= D294), I301 (= I295), D319 (= D313), V320 (≠ L314), M380 (= M380), G398 (≠ S398)
- binding magnesium ion: D428 (= D428), N455 (= N455)
- binding thiamine diphosphate: E53 (= E47), C76 (≠ T70), P79 (= P73), G376 (= G376), Q377 (= Q377), H378 (= H378), G401 (= G401), M403 (= M403), G427 (= G427), D428 (= D428), G429 (= G429), S430 (= S430), M433 (= M433), N455 (= N455), A457 (≠ R457), L458 (= L458), G459 (= G459), L460 (≠ M460), V461 (= V461)
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium (see paper)
47% identity, 98% coverage: 2:539/548 of query aligns to 13:571/582 of 7tzzA
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: M266 (= M250), R292 (= R276), W489 (= W464), S568 (≠ P536)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V375), G401 (= G376), Q402 (= Q377), H403 (= H378), G426 (= G401), M428 (= M403), G452 (= G427), D453 (= D428), G454 (= G429), S455 (= S430), L483 (= L458), G484 (= G459), M485 (= M460), V486 (= V461)
- binding flavin-adenine dinucleotide: R161 (= R149), G222 (= G204), G223 (= G205), G224 (= G206), T246 (= T230), L247 (= L231), M248 (≠ K232), M263 (= M247), L264 (= L248), M266 (= M250), H267 (= H251), G286 (= G270), R288 (= R272), V293 (= V277), D310 (= D294), I311 (= I295), D329 (= D313), V330 (≠ L314), M405 (= M380), G423 (≠ S398)
- binding magnesium ion: A37 (= A26), T82 (= T70), S83 (= S71), Q122 (= Q110), Y381 (≠ L356), D453 (= D428), M458 (= M433), Q461 (= Q436), N480 (= N455), H482 (≠ R457), K533 (= K501)
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
47% identity, 98% coverage: 2:539/548 of query aligns to 13:571/583 of 5k3sA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (= F109), Q122 (= Q110), E123 (= E111), K171 (= K159), M266 (= M250), V293 (= V277), V400 (= V375), G426 (= G401), M428 (= M403), D453 (= D428), N480 (= N455), H482 (≠ R457), L483 (= L458), M485 (= M460), V486 (= V461), W489 (= W464), H558 (≠ E526)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R276), M485 (= M460), W489 (= W464), G569 (= G537)
- binding flavin-adenine dinucleotide: R161 (= R149), G222 (= G204), G223 (= G205), G224 (= G206), T246 (= T230), L247 (= L231), M248 (≠ K232), L264 (= L248), M266 (= M250), G286 (= G270), R288 (= R272), D290 (= D274), V293 (= V277), D310 (= D294), I311 (= I295), D329 (= D313), V330 (≠ L314), M405 (= M380), G423 (≠ S398)
- binding magnesium ion: D453 (= D428), N480 (= N455), H482 (≠ R457)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V375), G401 (= G376), Q402 (= Q377), H403 (= H378), G426 (= G401), M428 (= M403), D453 (= D428), G454 (= G429), S455 (= S430), N480 (= N455), H482 (≠ R457), L483 (= L458), G484 (= G459), M485 (= M460), V486 (= V461)
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
47% identity, 98% coverage: 2:539/548 of query aligns to 13:571/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V375), G401 (= G376), Q402 (= Q377), H403 (= H378), G426 (= G401), M428 (= M403), G452 (= G427), D453 (= D428), G454 (= G429), S455 (= S430), M458 (= M433), N480 (= N455), H482 (≠ R457), L483 (= L458), G484 (= G459), M485 (= M460), V486 (= V461)
- binding flavin-adenine dinucleotide: R161 (= R149), G222 (= G204), G223 (= G205), G224 (= G206), T246 (= T230), L247 (= L231), M248 (≠ K232), L264 (= L248), M266 (= M250), H267 (= H251), G286 (= G270), V287 (≠ A271), R288 (= R272), D290 (= D274), R292 (= R276), V293 (= V277), D310 (= D294), I311 (= I295), D329 (= D313), V330 (≠ L314), M405 (= M380), G423 (≠ S398)
- binding magnesium ion: F370 (≠ Y345), D453 (= D428), M458 (= M433), Q461 (= Q436), N480 (= N455), H482 (≠ R457), K533 (= K501)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (= M250), R292 (= R276), M485 (= M460), W489 (= W464), S568 (≠ P536)
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
47% identity, 98% coverage: 2:539/548 of query aligns to 13:571/582 of 5wj1A
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (= F109), Q122 (= Q110), E123 (= E111), K171 (= K159), M266 (= M250), V293 (= V277), V400 (= V375), G426 (= G401), M428 (= M403), D453 (= D428), N480 (= N455), H482 (≠ R457), L483 (= L458), M485 (= M460), V486 (= V461), W489 (= W464), H558 (≠ E526)
- binding flavin-adenine dinucleotide: R161 (= R149), G222 (= G204), G223 (= G205), G224 (= G206), T246 (= T230), L247 (= L231), M248 (≠ K232), M263 (= M247), L264 (= L248), G286 (= G270), R288 (= R272), V293 (= V277), D310 (= D294), I311 (= I295), D329 (= D313), V330 (≠ L314), M405 (= M380), G423 (≠ S398), G424 (= G399)
- binding magnesium ion: D453 (= D428), N480 (= N455), H482 (≠ R457)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (= M250), D291 (= D275), R292 (= R276), M485 (= M460), W489 (= W464), S568 (≠ P536)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V375), G401 (= G376), Q402 (= Q377), H403 (= H378), M428 (= M403), D453 (= D428), G454 (= G429), S455 (= S430), M458 (= M433), N480 (= N455), H482 (≠ R457), L483 (= L458), G484 (= G459), M485 (= M460), V486 (= V461)
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
47% identity, 98% coverage: 2:539/548 of query aligns to 13:571/582 of 5k6tA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (= F109), Q122 (= Q110), E123 (= E111), K171 (= K159), M266 (= M250), V293 (= V277), V400 (= V375), G426 (= G401), M428 (= M403), D453 (= D428), N480 (= N455), H482 (≠ R457), L483 (= L458), M485 (= M460), V486 (= V461), W489 (= W464), H558 (≠ E526)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (= H251), R292 (= R276), M485 (= M460), W489 (= W464), S568 (≠ P536)
- binding flavin-adenine dinucleotide: R161 (= R149), G222 (= G204), G223 (= G205), G224 (= G206), T246 (= T230), L247 (= L231), M248 (≠ K232), L264 (= L248), G286 (= G270), R288 (= R272), D290 (= D274), R292 (= R276), V293 (= V277), D310 (= D294), I311 (= I295), D329 (= D313), V330 (≠ L314), Q404 (= Q379), M405 (= M380), G423 (≠ S398)
- binding magnesium ion: D453 (= D428), N480 (= N455), H482 (≠ R457)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V375), G401 (= G376), Q402 (= Q377), H403 (= H378), G426 (= G401), M428 (= M403), G452 (= G427), G454 (= G429), S455 (= S430), N480 (= N455), H482 (≠ R457), L483 (= L458), G484 (= G459)
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
47% identity, 98% coverage: 2:539/548 of query aligns to 13:571/582 of 5k6rA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (= F109), Q122 (= Q110), E123 (= E111), K171 (= K159), M266 (= M250), V293 (= V277), V400 (= V375), G426 (= G401), M428 (= M403), D453 (= D428), N480 (= N455), H482 (≠ R457), L483 (= L458), M485 (= M460), V486 (= V461), W489 (= W464), H558 (≠ E526)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (= R276), W489 (= W464), S568 (≠ P536)
- binding flavin-adenine dinucleotide: R161 (= R149), G222 (= G204), G223 (= G205), G224 (= G206), T246 (= T230), L247 (= L231), M248 (≠ K232), L264 (= L248), M266 (= M250), G286 (= G270), R288 (= R272), R292 (= R276), V293 (= V277), D310 (= D294), I311 (= I295), G328 (= G312), D329 (= D313), V330 (≠ L314), M405 (= M380), G423 (≠ S398)
- binding magnesium ion: D453 (= D428), N480 (= N455), H482 (≠ R457)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V375), G401 (= G376), Q402 (= Q377), H403 (= H378), G426 (= G401), M428 (= M403), D453 (= D428), G454 (= G429), S455 (= S430), M458 (= M433), N480 (= N455), H482 (≠ R457), L483 (= L458), G484 (= G459), M485 (= M460), V486 (= V461)
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
47% identity, 98% coverage: 2:539/548 of query aligns to 13:571/582 of 1z8nA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (= F109), Q122 (= Q110), E123 (= E111), K171 (= K159), M266 (= M250), V293 (= V277), V400 (= V375), G426 (= G401), M428 (= M403), D453 (= D428), N480 (= N455), H482 (≠ R457), L483 (= L458), M485 (= M460), V486 (= V461), W489 (= W464), H558 (≠ E526)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K123), R161 (= R149), Y191 (≠ D177), R194 (≠ D180), D291 (= D275), R292 (= R276), D312 (= D296), W489 (= W464), G569 (= G537)
- binding flavin-adenine dinucleotide: R161 (= R149), G222 (= G204), G224 (= G206), T246 (= T230), L247 (= L231), M248 (≠ K232), L264 (= L248), G265 (= G249), M266 (= M250), H267 (= H251), G286 (= G270), V287 (≠ A271), R288 (= R272), D290 (= D274), R292 (= R276), V293 (= V277), D310 (= D294), I311 (= I295), D329 (= D313), V330 (≠ L314), M405 (= M380), G423 (≠ S398), G424 (= G399)
- binding magnesium ion: D453 (= D428), N480 (= N455)
- binding thiamine diphosphate: V400 (= V375), G401 (= G376), Q402 (= Q377), H403 (= H378), G426 (= G401), M428 (= M403), G452 (= G427), G454 (= G429), S455 (= S430), N480 (= N455), H482 (≠ R457), L483 (= L458), G484 (= G459), M485 (= M460), V486 (= V461)
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
47% identity, 98% coverage: 2:539/548 of query aligns to 13:571/582 of 1yi1A
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (= F109), Q122 (= Q110), E123 (= E111), K171 (= K159), M266 (= M250), V293 (= V277), V400 (= V375), G426 (= G401), M428 (= M403), D453 (= D428), N480 (= N455), H482 (≠ R457), L483 (= L458), M485 (= M460), V486 (= V461), W489 (= W464), H558 (≠ E526)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (= D275), R292 (= R276), W489 (= W464), S568 (≠ P536)
- binding flavin-adenine dinucleotide: R161 (= R149), G223 (= G205), G224 (= G206), T246 (= T230), L247 (= L231), M248 (≠ K232), M263 (= M247), L264 (= L248), G265 (= G249), M266 (= M250), H267 (= H251), G286 (= G270), V287 (≠ A271), R288 (= R272), D290 (= D274), V293 (= V277), D310 (= D294), I311 (= I295), D329 (= D313), V330 (≠ L314), M405 (= M380), G423 (≠ S398), G424 (= G399)
- binding magnesium ion: D453 (= D428), N480 (= N455), H482 (≠ R457)
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
47% identity, 98% coverage: 2:539/548 of query aligns to 13:571/582 of 1yi0A
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (= F109), Q122 (= Q110), E123 (= E111), K171 (= K159), M266 (= M250), V293 (= V277), V400 (= V375), G426 (= G401), M428 (= M403), D453 (= D428), N480 (= N455), H482 (≠ R457), L483 (= L458), M485 (= M460), V486 (= V461), W489 (= W464), H558 (≠ E526)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D275), R292 (= R276), W489 (= W464), S568 (≠ P536)
- binding flavin-adenine dinucleotide: R161 (= R149), G222 (= G204), G223 (= G205), G224 (= G206), T246 (= T230), L247 (= L231), M248 (≠ K232), L264 (= L248), G265 (= G249), M266 (= M250), H267 (= H251), G286 (= G270), V287 (≠ A271), R288 (= R272), D290 (= D274), R292 (= R276), V293 (= V277), D310 (= D294), I311 (= I295), G328 (= G312), D329 (= D313), V330 (≠ L314), M405 (= M380), G423 (≠ S398), G424 (= G399)
- binding magnesium ion: D453 (= D428), N480 (= N455), H482 (≠ R457)
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
47% identity, 98% coverage: 2:539/548 of query aligns to 13:571/582 of 1yhzA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (= F109), Q122 (= Q110), E123 (= E111), K171 (= K159), M266 (= M250), V293 (= V277), V400 (= V375), G426 (= G401), M428 (= M403), D453 (= D428), N480 (= N455), H482 (≠ R457), L483 (= L458), M485 (= M460), V486 (= V461), W489 (= W464), H558 (≠ E526)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (= D275), R292 (= R276), M485 (= M460), W489 (= W464), S568 (≠ P536)
- binding flavin-adenine dinucleotide: R161 (= R149), G223 (= G205), G224 (= G206), T246 (= T230), L247 (= L231), M248 (≠ K232), L264 (= L248), M266 (= M250), H267 (= H251), G286 (= G270), V287 (≠ A271), R288 (= R272), D290 (= D274), V293 (= V277), D310 (= D294), I311 (= I295), D329 (= D313), V330 (≠ L314), Q404 (= Q379), M405 (= M380), G423 (≠ S398), G424 (= G399)
- binding magnesium ion: D453 (= D428), N480 (= N455), H482 (≠ R457)
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
47% identity, 98% coverage: 2:539/548 of query aligns to 13:571/582 of 1yhyA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (= F109), Q122 (= Q110), E123 (= E111), K171 (= K159), M266 (= M250), V293 (= V277), V400 (= V375), G426 (= G401), M428 (= M403), D453 (= D428), N480 (= N455), H482 (≠ R457), L483 (= L458), M485 (= M460), V486 (= V461), W489 (= W464), H558 (≠ E526)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D275), R292 (= R276), V486 (= V461), W489 (= W464), S568 (≠ P536)
- binding flavin-adenine dinucleotide: R161 (= R149), G222 (= G204), G223 (= G205), G224 (= G206), T246 (= T230), L247 (= L231), M248 (≠ K232), L264 (= L248), G265 (= G249), M266 (= M250), H267 (= H251), G286 (= G270), V287 (≠ A271), R288 (= R272), D290 (= D274), V293 (= V277), D310 (= D294), I311 (= I295), D329 (= D313), V330 (≠ L314), Q404 (= Q379), M405 (= M380), G423 (≠ S398), G424 (= G399)
- binding magnesium ion: D453 (= D428), N480 (= N455), H482 (≠ R457)
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl (see paper)
47% identity, 98% coverage: 2:539/548 of query aligns to 13:571/582 of 1ybhA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (= F109), Q122 (= Q110), E123 (= E111), K171 (= K159), M266 (= M250), V293 (= V277), V400 (= V375), G426 (= G401), M428 (= M403), D453 (= D428), N480 (= N455), H482 (≠ R457), L483 (= L458), M485 (= M460), V486 (= V461), W489 (= W464), H558 (≠ E526)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: M266 (= M250), D291 (= D275), R292 (= R276), M485 (= M460), W489 (= W464), S568 (≠ P536)
- binding flavin-adenine dinucleotide: R161 (= R149), G223 (= G205), G224 (= G206), T246 (= T230), L247 (= L231), M248 (≠ K232), L264 (= L248), M266 (= M250), H267 (= H251), G286 (= G270), V287 (≠ A271), R288 (= R272), D290 (= D274), V293 (= V277), D310 (= D294), I311 (= I295), D329 (= D313), V330 (≠ L314), Q404 (= Q379), M405 (= M380), G423 (≠ S398), G424 (= G399)
- binding magnesium ion: D453 (= D428), N480 (= N455), H482 (≠ R457)
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
47% identity, 98% coverage: 2:539/548 of query aligns to 98:656/670 of P17597
- A122 (= A26) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (= M28) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E47) binding
- S186 (= S89) binding
- P197 (≠ A100) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ P102) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q110) binding
- K220 (= K123) binding
- R246 (= R149) binding ; binding
- K256 (= K159) binding
- G308 (= G205) binding
- TL 331:332 (= TL 230:231) binding
- C340 (≠ A239) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (= LGMH 248:251) binding
- GVRFD 371:375 (≠ GARFD 270:274) binding
- DR 376:377 (= DR 275:276) binding
- DI 395:396 (= DI 294:295) binding
- DV 414:415 (≠ DL 313:314) binding
- QH 487:488 (= QH 377:378) binding
- GG 508:509 (≠ SG 398:399) binding
- GAM 511:513 (≠ GTM 401:403) binding
- D538 (= D428) binding
- DGS 538:540 (= DGS 428:430) binding
- N565 (= N455) binding
- NQHLGM 565:570 (≠ NQRLGM 455:460) binding
- H567 (≠ R457) binding
- W574 (= W464) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (≠ P536) binding ; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
47% identity, 98% coverage: 2:539/548 of query aligns to 13:571/585 of 5k2oA
- active site: Y33 (= Y22), G35 (= G24), G36 (= G25), A37 (= A26), S38 (≠ I27), E59 (= E47), T82 (= T70), F121 (= F109), Q122 (= Q110), E123 (= E111), K171 (= K159), M266 (= M250), V293 (= V277), V400 (= V375), G426 (= G401), M428 (= M403), D453 (= D428), N480 (= N455), H482 (≠ R457), L483 (= L458), M485 (= M460), V486 (= V461), W489 (= W464), H558 (≠ E526)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (= M250), R292 (= R276), W489 (= W464), S568 (≠ P536)
- binding flavin-adenine dinucleotide: R161 (= R149), G222 (= G204), G223 (= G205), G224 (= G206), T246 (= T230), L247 (= L231), M248 (≠ K232), L264 (= L248), G286 (= G270), R288 (= R272), D290 (= D274), V293 (= V277), D310 (= D294), I311 (= I295), D329 (= D313), V330 (≠ L314), Q404 (= Q379), M405 (= M380), G423 (≠ S398)
- binding magnesium ion: D453 (= D428), N480 (= N455), H482 (≠ R457)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V375), G401 (= G376), Q402 (= Q377), H403 (= H378), M428 (= M403), D453 (= D428), G454 (= G429), S455 (= S430), N480 (= N455), H482 (≠ R457), L483 (= L458), G484 (= G459), M485 (= M460), V486 (= V461)
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
46% identity, 99% coverage: 2:544/548 of query aligns to 12:575/582 of 3ea4A
- active site: Y32 (= Y22), G34 (= G24), G35 (= G25), A36 (= A26), S37 (≠ I27), E58 (= E47), T81 (= T70), F120 (= F109), Q121 (= Q110), E122 (= E111), K170 (= K159), M265 (= M250), V292 (= V277), V399 (= V375), G425 (= G401), M427 (= M403), D452 (= D428), N479 (= N455), H481 (≠ R457), L482 (= L458), M484 (= M460), V485 (= V461), W488 (= W464), H557 (≠ E526)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (= D275), R291 (= R276), W488 (= W464), S567 (≠ P536)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R149), G221 (= G204), G222 (= G205), G223 (= G206), T245 (= T230), L246 (= L231), M247 (≠ K232), L263 (= L248), G264 (= G249), M265 (= M250), H266 (= H251), G285 (= G270), R287 (= R272), D289 (= D274), R291 (= R276), D309 (= D294), I310 (= I295), G327 (= G312), D328 (= D313), V329 (≠ L314), M404 (= M380), G422 (≠ S398)
- binding magnesium ion: D452 (= D428), N479 (= N455), H481 (≠ R457)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V375), G400 (= G376), Q401 (= Q377), H402 (= H378), M427 (= M403), G451 (= G427), D452 (= D428), G453 (= G429), S454 (= S430), N479 (= N455), H481 (≠ R457), L482 (= L458), G483 (= G459), M484 (= M460), V485 (= V461)
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
46% identity, 99% coverage: 2:544/548 of query aligns to 12:575/582 of 3e9yA
- active site: Y32 (= Y22), G34 (= G24), G35 (= G25), A36 (= A26), S37 (≠ I27), E58 (= E47), T81 (= T70), F120 (= F109), Q121 (= Q110), E122 (= E111), K170 (= K159), M265 (= M250), V292 (= V277), V399 (= V375), G425 (= G401), M427 (= M403), D452 (= D428), N479 (= N455), H481 (≠ R457), L482 (= L458), M484 (= M460), V485 (= V461), W488 (= W464), H557 (≠ E526)
- binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (= D275), R291 (= R276), W488 (= W464), S567 (≠ P536)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R149), G221 (= G204), G222 (= G205), G223 (= G206), T245 (= T230), L246 (= L231), M247 (≠ K232), L263 (= L248), G285 (= G270), R287 (= R272), D289 (= D274), R291 (= R276), D309 (= D294), I310 (= I295), G327 (= G312), D328 (= D313), V329 (≠ L314), M404 (= M380), G422 (≠ S398)
- binding magnesium ion: D452 (= D428), N479 (= N455), H481 (≠ R457)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V375), G400 (= G376), Q401 (= Q377), H402 (= H378), M427 (= M403), G451 (= G427), G453 (= G429), S454 (= S430), N479 (= N455), H481 (≠ R457), L482 (= L458), G483 (= G459), M484 (= M460), V485 (= V461)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
45% identity, 99% coverage: 1:545/548 of query aligns to 7:561/582 of 1t9dB
- active site: Y28 (= Y22), G30 (= G24), G31 (= G25), A32 (= A26), I33 (= I27), E54 (= E47), T77 (= T70), F116 (= F109), Q117 (= Q110), E118 (= E111), K166 (= K159), R213 (≠ P214), M249 (= M250), V276 (= V277), V392 (= V375), L417 (= L400), G418 (= G401), M420 (= M403), D445 (= D428), N472 (= N455), E474 (≠ R457), Q475 (≠ L458), M477 (= M460), V478 (= V461), W481 (= W464), L503 (= L487), G508 (= G492), L509 (≠ I493), K542 (≠ E526)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (= G25), A32 (= A26), V106 (= V99), P107 (≠ A100), F116 (= F109), K166 (= K159), M249 (= M250), D274 (= D275), R275 (= R276), W481 (= W464)
- binding flavin-adenine dinucleotide: R156 (= R149), G202 (= G204), A203 (≠ G205), G204 (= G206), N207 (≠ G208), T229 (= T230), L230 (= L231), Q231 (≠ K232), L247 (= L248), M249 (= M250), H250 (= H251), G269 (= G270), A270 (= A271), R271 (= R272), D273 (= D274), R275 (= R276), V276 (= V277), E302 (≠ D294), V303 (≠ I295), N307 (≠ E299), G320 (= G312), D321 (= D313), A322 (vs. gap), Q396 (= Q379), M397 (= M380), G415 (≠ S398), G416 (= G399)
- binding magnesium ion: D445 (= D428), N472 (= N455), E474 (≠ R457)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E47), P80 (= P73), G418 (= G401), M420 (= M403), M450 (= M433)
Query Sequence
>BWI76_RS00960 FitnessBrowser__Koxy:BWI76_RS00960
MNGARWVVHALRAQGVDTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARA
TGKTGVCIATSGPGATNLITGLADALLDSVPVVAITGQVAAPFIGTDAFQEVDVLGLSLA
CTKHSFLVQSLEELPRIIAEAFHVANSGRPGPVLVDIPKDIQLAQGDLDPHFSMVADDVD
FPYADIEYALQMLTQSQKPMLYVGGGVGMAQAVPALREFLTVTQMPATATLKGLGVVAAD
YPYYLGMLGMHGTKAANLAVQECDLLIAVGARFDDRVTGKLNTFAPHAKVIHMDIDPAEL
NKLRQAHIGLTGDLNVMLPALQQPLSIDAWRQRNAQLRAEHAWRYDHPGEAIYAPLLLKQ
LSERKPADCVVTTDVGQHQMWSAQHMTYTRPENFITSSGLGTMGFGLPAAVGAQVARPDD
TVICISGDGSFMMNVQELGTVKRKQLPLKIVLLDNQRLGMVRQWQQLFFQERYSETTLTD
NPDFLTLASAFGIPGQHITRKDQVEAALDTMLSSQGPYLLHVSIDELENVWPLVPPGASN
AEMLEKLS
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory