Comparing BWI76_RS02330 FitnessBrowser__Koxy:BWI76_RS02330 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P0AC38 Aspartate ammonia-lyase; Aspartase; EC 4.3.1.1 from Escherichia coli (strain K12) (see 2 papers)
91% identity, 100% coverage: 1:478/478 of query aligns to 1:478/478 of P0AC38
6wngA Crystal structure of an aspartate ammonia-lyase from elizabethkingia anophelis nuhp1
60% identity, 97% coverage: 3:468/478 of query aligns to 1:465/466 of 6wngA
3oceA Crystal structure of fumarate lyase:delta crystallin from brucella melitensis bound to cobalt
51% identity, 93% coverage: 6:451/478 of query aligns to 3:447/461 of 3oceA
3r6vG Crystal structure of aspartase from bacillus sp. Ym55-1 with bound l- aspartate (see paper)
48% identity, 97% coverage: 4:466/478 of query aligns to 1:460/463 of 3r6vG
3r6qA A triclinic-lattice structure of aspartase from bacillus sp. Ym55-1 (see paper)
48% identity, 97% coverage: 5:466/478 of query aligns to 1:459/462 of 3r6qA
7c18B Crystal structure of fumarasec from mannheimia succiniciproducens in complex with fumarate
40% identity, 94% coverage: 5:454/478 of query aligns to 3:451/464 of 7c18B
P05042 Fumarate hydratase class II; Fumarase C; Aerobic fumarase; Iron-independent fumarase; EC 4.2.1.2 from Escherichia coli (strain K12) (see 4 papers)
38% identity, 97% coverage: 2:463/478 of query aligns to 1:460/467 of P05042
1fuqA Fumarase with bound 3-trimethylsilylsuccinic acid (see paper)
38% identity, 96% coverage: 5:462/478 of query aligns to 1:456/456 of 1fuqA
1fuoA FumarasE C with bound citrate (see paper)
38% identity, 96% coverage: 5:462/478 of query aligns to 1:456/456 of 1fuoA
1fupA Fumarase with bound pyromellitic acid (see paper)
38% identity, 96% coverage: 6:462/478 of query aligns to 1:455/455 of 1fupA
P07954 Fumarate hydratase, mitochondrial; Fumarase; HsFH; EC 4.2.1.2 from Homo sapiens (Human) (see 4 papers)
38% identity, 97% coverage: 3:465/478 of query aligns to 48:509/510 of P07954
Sites not aligning to the query:
7lubB Crystal structure of recombinant human fumarase in complex with d-2- amino-3-phosphono-propionic acid (see paper)
38% identity, 97% coverage: 4:465/478 of query aligns to 1:461/462 of 7lubB
Q9ZCQ4 Fumarate hydratase class II; Fumarase C; Aerobic fumarase; Iron-independent fumarase; EC 4.2.1.2 from Rickettsia prowazekii (strain Madrid E) (see paper)
39% identity, 97% coverage: 2:463/478 of query aligns to 1:460/461 of Q9ZCQ4
P08417 Fumarate hydratase, mitochondrial; Fumarase; EC 4.2.1.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
38% identity, 97% coverage: 1:465/478 of query aligns to 24:487/488 of P08417
Sites not aligning to the query:
4adlA Crystal structures of rv1098c in complex with malate (see paper)
40% identity, 93% coverage: 4:448/478 of query aligns to 1:437/459 of 4adlA
P9WN93 Fumarate hydratase class II; Fumarase C; Aerobic fumarase; Iron-independent fumarase; EC 4.2.1.2 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
40% identity, 93% coverage: 4:448/478 of query aligns to 9:445/474 of P9WN93
4apbD Crystal structure of mycobacterium tuberculosis fumarase (rv1098c) s318c in complex with fumarate (see paper)
40% identity, 93% coverage: 4:448/478 of query aligns to 1:437/462 of 4apbD
6s7uA Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(5-(azepan-1-ylsulfonyl)-2- methoxyphenyl)-2-(1h-indol-3-yl)acetamide (see paper)
39% identity, 93% coverage: 6:448/478 of query aligns to 2:428/450 of 6s7uA
6s7kA Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(2-methoxy-5-(n-methylsulfamoyl) phenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide (see paper)
39% identity, 93% coverage: 6:448/478 of query aligns to 2:428/450 of 6s7kA
6s43A Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(5-(azocan-1-ylsulfonyl)-2- methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide (see paper)
39% identity, 93% coverage: 6:448/478 of query aligns to 2:428/450 of 6s43A
>BWI76_RS02330 FitnessBrowser__Koxy:BWI76_RS02330
MLNNIRIEEDLLGTREVPADAYYGVHTLRAIENFYISNNKISDIPEFVRGMVMVKKAAAQ
ANKELQTIPKSVANAIIAACDEVLNNGKCMDQFPVDVFQGGAGTSVNMNTNEVLANIGLE
LMGHQKGEYQHLNPNDHVNKCQSTNDAYPTGFRIAVYASILKLIDAINQLSEGFQQKAVE
FQDILKMGRTQLQDAVPMTLGQEFHAFNVLLNEETKCILRTAELLLEVNLGATAIGTRLN
TPDGYQQLAVQKLAEVSNLPVVPAEDLIEATSDCGAYVMVHSSLKRLAVKLSKICNDLRL
LSSGPRAGLNEINLPELQAGSSIMPAKVNPVVPEVVNQVCFKVIGNDTTVTMASEAGQLQ
LNVMEPVIGQAMFESIHILTNACYNLLEKCVSGITANKAVCESYVYNSIGIVTYLNPYIG
HHNGDIVGKICAETGKSVRDVVLERGLLTAAELDDIFSAQNLMHPAYKAKRYTDESEQ
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory