SitesBLAST
Comparing BWI76_RS03090 FitnessBrowser__Koxy:BWI76_RS03090 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
25% identity, 89% coverage: 37:609/646 of query aligns to 25:546/582 of 1t9dB
- active site: Y28 (≠ H40), G30 (vs. gap), G31 (= G41), A32 (≠ N42), I33 (≠ V43), E54 (= E65), T77 (= T88), F116 (≠ L129), Q117 (= Q130), E118 (≠ Q131), K166 (≠ Q188), R213 (≠ A248), M249 (≠ E283), V276 (≠ T310), V392 (≠ A442), L417 (≠ Y467), G418 (≠ S468), M420 (= M470), D445 (= D495), N472 (= N522), E474 (≠ A524), Q475 (≠ N525), M477 (≠ C527), V478 (≠ I528), W481 (≠ L531), L503 (≠ V566), G508 (= G571), L509 (≠ C572), K542 (≠ P605)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (= G41), A32 (≠ N42), V106 (= V119), P107 (≠ F120), F116 (≠ L129), K166 (≠ Q188), M249 (≠ E283), D274 (= D308), R275 (≠ F309), W481 (≠ L531)
- binding flavin-adenine dinucleotide: R156 (≠ E178), G202 (= G237), A203 (≠ G238), G204 (= G239), N207 (≠ Y242), T229 (= T263), L230 (≠ Q264), Q231 (≠ A265), L247 (≠ V281), M249 (≠ E283), H250 (≠ T284), G269 (= G303), A270 (≠ T304), R271 (= R305), D273 (≠ S307), R275 (≠ F309), V276 (≠ T310), E302 (≠ N326), V303 (≠ I327), N307 (= N331), G320 (≠ A344), D321 (= D345), A322 (= A346), Q396 (≠ P446), M397 (≠ G447), G415 (≠ Y465), G416 (= G466)
- binding magnesium ion: D445 (= D495), N472 (= N522), E474 (≠ A524)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E65), P80 (= P93), G418 (≠ S468), M420 (= M470), M450 (= M500)
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
25% identity, 89% coverage: 37:609/646 of query aligns to 26:547/583 of 1t9bA
- active site: Y29 (≠ H40), G31 (vs. gap), G32 (= G41), A33 (≠ N42), I34 (≠ V43), E55 (= E65), T78 (= T88), F117 (≠ L129), Q118 (= Q130), E119 (≠ Q131), K167 (≠ Q188), R214 (≠ A248), M250 (≠ E283), V277 (≠ T310), V393 (≠ A442), L418 (≠ Y467), G419 (≠ S468), M421 (= M470), D446 (= D495), N473 (= N522), E475 (≠ A524), Q476 (≠ N525), M478 (≠ C527), V479 (≠ I528), W482 (≠ L531), L504 (≠ V566), G509 (= G571), L510 (≠ C572), K543 (≠ P605)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V119), P108 (≠ F120), F117 (≠ L129), D275 (= D308), R276 (≠ F309), M478 (≠ C527), W482 (≠ L531)
- binding flavin-adenine dinucleotide: R157 (≠ E178), G203 (= G237), A204 (≠ G238), G205 (= G239), N208 (≠ Y242), T230 (= T263), L231 (≠ Q264), Q232 (≠ A265), M247 (≠ G280), L248 (≠ V281), M250 (≠ E283), H251 (≠ T284), G270 (= G303), A271 (≠ T304), R272 (= R305), D274 (≠ S307), R276 (≠ F309), V277 (≠ T310), E303 (≠ N326), V304 (≠ I327), N308 (= N331), D322 (= D345), A323 (= A346), Q397 (≠ P446), M398 (≠ G447), G416 (≠ Y465), G417 (= G466)
- binding magnesium ion: D446 (= D495), N473 (= N522), E475 (≠ A524)
6lpiB Crystal structure of ahas holo-enzyme (see paper)
25% identity, 88% coverage: 5:574/646 of query aligns to 5:495/539 of 6lpiB
- active site: I27 (= I34), G29 (≠ A36), G30 (= G41), S31 (≠ N42), I32 (≠ V43), E53 (= E65), C76 (≠ S90), F115 (≠ L129), Q116 (= Q130), E117 (≠ Q131), K165 (≠ Q188), M256 (≠ E283), A283 (≠ T310), V375 (≠ L425), G401 (≠ S468), M403 (= M470), D428 (= D495), N455 (= N522), A457 (= A524), L458 (≠ N525), L460 (≠ C527), V461 (≠ I528), Q464 (≠ L531)
- binding flavin-adenine dinucleotide: R155 (≠ E178), G212 (= G237), G213 (= G238), G214 (= G239), T236 (= T263), L237 (≠ Q264), M238 (≠ A265), L254 (≠ V281), M256 (≠ E283), H257 (≠ T284), G276 (= G303), A277 (≠ T304), R278 (= R305), D280 (≠ S307), R282 (≠ F309), A283 (≠ T310), D300 (≠ N328), I301 (≠ V329), D319 (= D345), V320 (≠ A346), M380 (≠ V439), G398 (≠ A457)
- binding magnesium ion: D428 (= D495), N455 (= N522)
- binding thiamine diphosphate: E53 (= E65), C76 (≠ S90), P79 (= P93), G376 (= G426), Q377 (≠ V427), H378 (≠ L428), G401 (≠ S468), M403 (= M470), G427 (= G494), D428 (= D495), G429 (= G496), S430 (= S497), M433 (= M500), N455 (= N522), A457 (= A524), L458 (≠ N525), G459 (= G526), L460 (≠ C527), V461 (≠ I528)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
25% identity, 89% coverage: 37:609/646 of query aligns to 26:560/596 of 1t9cA
- active site: Y29 (≠ H40), G31 (vs. gap), G32 (= G41), A33 (≠ N42), I34 (≠ V43), E55 (= E65), T78 (= T88), F117 (≠ L129), Q118 (= Q130), E119 (≠ Q131), K167 (≠ Q188), R227 (≠ A248), M263 (≠ E283), V290 (≠ T310), V406 (≠ A442), L431 (≠ Y467), G432 (≠ S468), M434 (= M470), D459 (= D495), N486 (= N522), E488 (≠ A524), Q489 (≠ N525), M491 (≠ C527), V492 (≠ I528), W495 (≠ L531), L517 (≠ V566), G522 (= G571), L523 (≠ C572), K556 (≠ P605)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G41), V107 (= V119), P108 (≠ F120), F117 (≠ L129), K167 (≠ Q188), D288 (= D308), R289 (≠ F309), W495 (≠ L531)
- binding flavin-adenine dinucleotide: R157 (≠ E178), G216 (= G237), A217 (≠ G238), G218 (= G239), N221 (≠ Y242), T243 (= T263), L244 (≠ Q264), Q245 (≠ A265), L261 (≠ V281), M263 (≠ E283), H264 (≠ T284), G283 (= G303), A284 (≠ T304), R285 (= R305), D287 (≠ S307), R289 (≠ F309), V290 (≠ T310), E316 (≠ N326), V317 (≠ I327), N321 (= N331), G334 (≠ A344), D335 (= D345), A336 (= A346), M411 (≠ G447), G429 (≠ Y465), G430 (= G466)
- binding magnesium ion: D459 (= D495), N486 (= N522), E488 (≠ A524)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
25% identity, 89% coverage: 37:609/646 of query aligns to 27:561/597 of 1t9aA
- active site: Y30 (≠ H40), G32 (vs. gap), G33 (= G41), A34 (≠ N42), I35 (≠ V43), E56 (= E65), T79 (= T88), F118 (≠ L129), Q119 (= Q130), E120 (≠ Q131), K168 (≠ Q188), R228 (≠ A248), M264 (≠ E283), V291 (≠ T310), V407 (≠ A442), L432 (≠ Y467), G433 (≠ S468), M435 (= M470), D460 (= D495), N487 (= N522), E489 (≠ A524), Q490 (≠ N525), M492 (≠ C527), V493 (≠ I528), W496 (≠ L531), L518 (≠ V566), G523 (= G571), L524 (≠ C572), K557 (≠ P605)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G41), V108 (= V119), P109 (≠ F120), F118 (≠ L129), K168 (≠ Q188), M264 (≠ E283), D289 (= D308), R290 (≠ F309), M492 (≠ C527), V493 (≠ I528), W496 (≠ L531)
- binding flavin-adenine dinucleotide: R158 (≠ E178), G217 (= G237), A218 (≠ G238), G219 (= G239), N222 (≠ Y242), T244 (= T263), L245 (≠ Q264), Q246 (≠ A265), L262 (≠ V281), M264 (≠ E283), H265 (≠ T284), G284 (= G303), A285 (≠ T304), R286 (= R305), D288 (≠ S307), R290 (≠ F309), V291 (≠ T310), E317 (≠ N326), V318 (≠ I327), N322 (= N331), G335 (≠ A344), D336 (= D345), A337 (= A346), Q411 (≠ P446), M412 (≠ G447), G430 (≠ Y465), G431 (= G466)
- binding magnesium ion: D460 (= D495), N487 (= N522), E489 (≠ A524)
- binding propyl trihydrogen diphosphate: V407 (≠ A442), G408 (= G443), Q409 (≠ S444), H410 (≠ L445), M435 (= M470), G459 (= G494), D460 (= D495), A461 (≠ G496), S462 (= S497), N487 (= N522), E489 (≠ A524), Q490 (≠ N525), G491 (= G526), M492 (≠ C527)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (≠ S468), M435 (= M470), M465 (= M500)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
25% identity, 89% coverage: 37:609/646 of query aligns to 26:560/596 of 1t9dA
- active site: Y29 (≠ H40), G31 (vs. gap), G32 (= G41), A33 (≠ N42), I34 (≠ V43), E55 (= E65), T78 (= T88), F117 (≠ L129), Q118 (= Q130), E119 (≠ Q131), K167 (≠ Q188), R227 (≠ A248), M263 (≠ E283), V290 (≠ T310), V406 (≠ A442), L431 (≠ Y467), G432 (≠ S468), M434 (= M470), D459 (= D495), N486 (= N522), E488 (≠ A524), Q489 (≠ N525), M491 (≠ C527), V492 (≠ I528), W495 (≠ L531), L517 (≠ V566), G522 (= G571), L523 (≠ C572), K556 (≠ P605)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G41), A33 (≠ N42), V107 (= V119), P108 (≠ F120), F117 (≠ L129), K167 (≠ Q188), M263 (≠ E283), D288 (= D308), R289 (≠ F309), W495 (≠ L531)
- binding flavin-adenine dinucleotide: R157 (≠ E178), G216 (= G237), A217 (≠ G238), G218 (= G239), N221 (≠ Y242), T243 (= T263), L244 (≠ Q264), Q245 (≠ A265), M260 (≠ G280), L261 (≠ V281), H264 (≠ T284), G283 (= G303), A284 (≠ T304), R285 (= R305), D287 (≠ S307), R289 (≠ F309), V290 (≠ T310), E316 (≠ N326), V317 (≠ I327), N321 (= N331), G334 (≠ A344), D335 (= D345), A336 (= A346), Q410 (≠ P446), M411 (≠ G447), G429 (≠ Y465), G430 (= G466)
- binding magnesium ion: D459 (= D495), N486 (= N522), E488 (≠ A524)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E65), P81 (= P93), Q118 (= Q130), G432 (≠ S468), M434 (= M470), M464 (= M500)
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
25% identity, 89% coverage: 37:609/646 of query aligns to 30:571/607 of 6u9dB
- active site: Y33 (≠ H40), G35 (vs. gap), G36 (= G41), A37 (≠ N42), I38 (≠ V43), E59 (= E65), T82 (= T88), F121 (≠ L129), Q122 (= Q130), E123 (≠ Q131), K171 (≠ Q188), M274 (≠ E283), V301 (≠ T310), V417 (≠ A442), G443 (≠ S468), M445 (= M470), D470 (= D495), N497 (= N522), E499 (≠ A524), Q500 (≠ N525), M502 (≠ C527), V503 (≠ I528), W506 (≠ L531)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (= G41), V111 (= V119), P112 (≠ F120), F121 (≠ L129), K171 (≠ Q188), D299 (= D308), R300 (≠ F309), M502 (≠ C527), W506 (≠ L531)
- binding flavin-adenine dinucleotide: R161 (≠ E178), A228 (≠ G238), G229 (= G239), N232 (≠ Y242), T254 (= T263), L255 (≠ Q264), Q256 (≠ A265), L272 (≠ V281), M274 (≠ E283), G294 (= G303), R296 (= R305), D298 (≠ S307), R300 (≠ F309), V301 (≠ T310), E327 (≠ N326), V328 (≠ I327), N332 (= N331), D346 (= D345), A347 (= A346), M422 (≠ G447), G440 (≠ Y465), G441 (= G466)
- binding magnesium ion: D470 (= D495), N497 (= N522)
- binding thiamine diphosphate: E59 (= E65), P85 (= P93), V417 (≠ A442), G418 (= G443), Q419 (≠ S444), H420 (≠ L445), G443 (≠ S468), M445 (= M470), A471 (≠ G496), S472 (= S497), N497 (= N522), E499 (≠ A524), Q500 (≠ N525), G501 (= G526), M502 (≠ C527), V503 (≠ I528)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
25% identity, 89% coverage: 37:609/646 of query aligns to 110:651/687 of P07342
- R241 (≠ E178) binding
- 355:376 (vs. 284:305, 50% identical) binding
- 407:426 (vs. 326:345, 15% identical) binding
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
25% identity, 89% coverage: 37:609/646 of query aligns to 26:559/595 of 1t9bB
- active site: Y29 (≠ H40), G31 (vs. gap), G32 (= G41), A33 (≠ N42), I34 (≠ V43), E55 (= E65), T78 (= T88), F117 (≠ L129), Q118 (= Q130), E119 (≠ Q131), K167 (≠ Q188), R226 (≠ A248), M262 (≠ E283), V289 (≠ T310), V405 (≠ A442), L430 (≠ Y467), G431 (≠ S468), M433 (= M470), D458 (= D495), N485 (= N522), E487 (≠ A524), Q488 (≠ N525), M490 (≠ C527), V491 (≠ I528), W494 (≠ L531), L516 (≠ V566), G521 (= G571), L522 (≠ C572), K555 (≠ P605)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V119), P108 (≠ F120), D287 (= D308), R288 (≠ F309), M490 (≠ C527), W494 (≠ L531)
- binding flavin-adenine dinucleotide: R157 (≠ E178), G215 (= G237), A216 (≠ G238), G217 (= G239), N220 (≠ Y242), T242 (= T263), L243 (≠ Q264), Q244 (≠ A265), M259 (≠ G280), L260 (≠ V281), M262 (≠ E283), H263 (≠ T284), G282 (= G303), A283 (≠ T304), R284 (= R305), D286 (≠ S307), R288 (≠ F309), V289 (≠ T310), E315 (≠ N326), V316 (≠ I327), N320 (= N331), G333 (≠ A344), D334 (= D345), A335 (= A346), Q409 (≠ P446), M410 (≠ G447), G428 (≠ Y465), G429 (= G466)
- binding magnesium ion: D458 (= D495), N485 (= N522), E487 (≠ A524)
5imsA Saccharomyces cerevisiae acetohydroxyacid synthase
24% identity, 88% coverage: 37:603/646 of query aligns to 28:539/541 of 5imsA
- active site: Y31 (≠ H40), G33 (vs. gap), G34 (= G41), A35 (≠ N42), I36 (≠ V43), E57 (= E65), T80 (= T88), F119 (≠ L129), Q120 (= Q130), E121 (≠ Q131), K169 (≠ Q188), R229 (≠ A248), M265 (≠ E283), V292 (≠ T310), V408 (≠ A442), L433 (≠ Y467), G434 (≠ S468), M436 (= M470), D461 (= D495), N488 (= N530), E490 (≠ Q532), L502 (≠ V566), G507 (= G571), L508 (≠ C572)
- binding flavin-adenine dinucleotide: R159 (≠ E178), G218 (= G237), A219 (≠ G238), G220 (= G239), N223 (≠ Y242), T245 (= T263), L246 (≠ Q264), L263 (≠ V281), G264 (= G282), H266 (≠ T284), G285 (= G303), A286 (≠ T304), R287 (= R305), D289 (≠ S307), R291 (≠ F309), V292 (≠ T310), E318 (≠ N326), V319 (≠ I327), N323 (= N331), D337 (= D345), A338 (= A346)
- binding magnesium ion: D461 (= D495), N488 (= N530)
- binding oxygen molecule: G34 (= G41), T80 (= T88), Q120 (= Q130)
- binding thiamine diphosphate: P32 (vs. gap), E57 (= E65), V408 (≠ A442), G409 (= G443), Q410 (≠ S444), H411 (≠ L445), G434 (≠ S468), M436 (= M470), G460 (= G494), D461 (= D495), A462 (≠ G496), S463 (= S497), M466 (= M500), N488 (= N530)
Sites not aligning to the query:
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium (see paper)
24% identity, 92% coverage: 23:618/646 of query aligns to 19:575/582 of 7tzzA
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: M266 (≠ E283), R292 (≠ F309), W489 (≠ M533), S568 (≠ K611)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ A442), G401 (= G443), Q402 (≠ S444), H403 (≠ L445), G426 (≠ S468), M428 (= M470), G452 (= G494), D453 (= D495), G454 (= G496), S455 (= S497), L483 (≠ N525), G484 (= G526), M485 (≠ C527), V486 (≠ I528)
- binding flavin-adenine dinucleotide: R161 (≠ E178), G222 (= G237), G223 (= G238), G224 (= G239), T246 (= T263), L247 (≠ Q264), M248 (≠ A265), M263 (≠ G280), L264 (≠ V281), M266 (≠ E283), H267 (≠ T284), G286 (= G303), R288 (= R305), V293 (≠ T310), D310 (≠ N326), I311 (= I327), D329 (= D345), V330 (≠ A346), M405 (≠ G447), G423 (≠ Y465)
- binding magnesium ion: A37 (≠ N42), T82 (≠ S90), S83 (≠ I91), Q122 (≠ R147), Y381 (≠ S422), D453 (= D495), M458 (= M500), Q461 (≠ S503), N480 (= N522), H482 (≠ A524), K533 (≠ L580)
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
24% identity, 92% coverage: 23:618/646 of query aligns to 19:575/585 of 5k2oA
- active site: Y33 (≠ I37), G35 (= G39), G36 (= G41), A37 (≠ N42), S38 (≠ V43), E59 (= E65), T82 (≠ S90), F121 (≠ I132), Q122 (≠ E133), E123 (≠ Q134), K171 (≠ Q188), M266 (≠ E283), V293 (≠ T310), V400 (≠ A442), G426 (≠ S468), M428 (= M470), D453 (= D495), N480 (= N522), H482 (≠ A524), L483 (≠ N525), M485 (≠ C527), V486 (≠ I528), W489 (≠ M533), H558 (vs. gap)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (≠ E283), R292 (≠ F309), W489 (≠ M533), S568 (≠ K611)
- binding flavin-adenine dinucleotide: R161 (≠ E178), G222 (= G237), G223 (= G238), G224 (= G239), T246 (= T263), L247 (≠ Q264), M248 (≠ A265), L264 (≠ V281), G286 (= G303), R288 (= R305), D290 (≠ S307), V293 (≠ T310), D310 (≠ N326), I311 (= I327), D329 (= D345), V330 (≠ A346), Q404 (≠ P446), M405 (≠ G447), G423 (≠ Y465)
- binding magnesium ion: D453 (= D495), N480 (= N522), H482 (≠ A524)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ A442), G401 (= G443), Q402 (≠ S444), H403 (≠ L445), M428 (= M470), D453 (= D495), G454 (= G496), S455 (= S497), N480 (= N522), H482 (≠ A524), L483 (≠ N525), G484 (= G526), M485 (≠ C527), V486 (≠ I528)
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
24% identity, 92% coverage: 23:618/646 of query aligns to 19:575/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ A442), G401 (= G443), Q402 (≠ S444), H403 (≠ L445), G426 (≠ S468), M428 (= M470), G452 (= G494), D453 (= D495), G454 (= G496), S455 (= S497), M458 (= M500), N480 (= N522), H482 (≠ A524), L483 (≠ N525), G484 (= G526), M485 (≠ C527), V486 (≠ I528)
- binding flavin-adenine dinucleotide: R161 (≠ E178), G222 (= G237), G223 (= G238), G224 (= G239), T246 (= T263), L247 (≠ Q264), M248 (≠ A265), L264 (≠ V281), M266 (≠ E283), H267 (≠ T284), G286 (= G303), V287 (≠ T304), R288 (= R305), D290 (≠ S307), R292 (≠ F309), V293 (≠ T310), D310 (≠ N326), I311 (= I327), D329 (= D345), V330 (≠ A346), M405 (≠ G447), G423 (≠ Y465)
- binding magnesium ion: F370 (= F411), D453 (= D495), M458 (= M500), Q461 (≠ S503), N480 (= N522), H482 (≠ A524), K533 (≠ L580)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (≠ E283), R292 (≠ F309), M485 (≠ C527), W489 (≠ M533), S568 (≠ K611)
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
24% identity, 92% coverage: 23:618/646 of query aligns to 19:575/582 of 5wj1A
- active site: Y33 (≠ I37), G35 (= G39), G36 (= G41), A37 (≠ N42), S38 (≠ V43), E59 (= E65), T82 (≠ S90), F121 (≠ I132), Q122 (≠ E133), E123 (≠ Q134), K171 (≠ Q188), M266 (≠ E283), V293 (≠ T310), V400 (≠ A442), G426 (≠ S468), M428 (= M470), D453 (= D495), N480 (= N522), H482 (≠ A524), L483 (≠ N525), M485 (≠ C527), V486 (≠ I528), W489 (≠ M533), H558 (vs. gap)
- binding flavin-adenine dinucleotide: R161 (≠ E178), G222 (= G237), G223 (= G238), G224 (= G239), T246 (= T263), L247 (≠ Q264), M248 (≠ A265), M263 (≠ G280), L264 (≠ V281), G286 (= G303), R288 (= R305), V293 (≠ T310), D310 (≠ N326), I311 (= I327), D329 (= D345), V330 (≠ A346), M405 (≠ G447), G423 (≠ Y465), G424 (= G466)
- binding magnesium ion: D453 (= D495), N480 (= N522), H482 (≠ A524)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (≠ E283), D291 (= D308), R292 (≠ F309), M485 (≠ C527), W489 (≠ M533), S568 (≠ K611)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ A442), G401 (= G443), Q402 (≠ S444), H403 (≠ L445), M428 (= M470), D453 (= D495), G454 (= G496), S455 (= S497), M458 (= M500), N480 (= N522), H482 (≠ A524), L483 (≠ N525), G484 (= G526), M485 (≠ C527), V486 (≠ I528)
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
24% identity, 92% coverage: 23:618/646 of query aligns to 19:575/582 of 5k6tA
- active site: Y33 (≠ I37), G35 (= G39), G36 (= G41), A37 (≠ N42), S38 (≠ V43), E59 (= E65), T82 (≠ S90), F121 (≠ I132), Q122 (≠ E133), E123 (≠ Q134), K171 (≠ Q188), M266 (≠ E283), V293 (≠ T310), V400 (≠ A442), G426 (≠ S468), M428 (= M470), D453 (= D495), N480 (= N522), H482 (≠ A524), L483 (≠ N525), M485 (≠ C527), V486 (≠ I528), W489 (≠ M533), H558 (vs. gap)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (≠ T284), R292 (≠ F309), M485 (≠ C527), W489 (≠ M533), S568 (≠ K611)
- binding flavin-adenine dinucleotide: R161 (≠ E178), G222 (= G237), G223 (= G238), G224 (= G239), T246 (= T263), L247 (≠ Q264), M248 (≠ A265), L264 (≠ V281), G286 (= G303), R288 (= R305), D290 (≠ S307), R292 (≠ F309), V293 (≠ T310), D310 (≠ N326), I311 (= I327), D329 (= D345), V330 (≠ A346), Q404 (≠ P446), M405 (≠ G447), G423 (≠ Y465)
- binding magnesium ion: D453 (= D495), N480 (= N522), H482 (≠ A524)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ A442), G401 (= G443), Q402 (≠ S444), H403 (≠ L445), G426 (≠ S468), M428 (= M470), G452 (= G494), G454 (= G496), S455 (= S497), N480 (= N522), H482 (≠ A524), L483 (≠ N525), G484 (= G526)
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
24% identity, 92% coverage: 23:618/646 of query aligns to 19:575/582 of 5k6rA
- active site: Y33 (≠ I37), G35 (= G39), G36 (= G41), A37 (≠ N42), S38 (≠ V43), E59 (= E65), T82 (≠ S90), F121 (≠ I132), Q122 (≠ E133), E123 (≠ Q134), K171 (≠ Q188), M266 (≠ E283), V293 (≠ T310), V400 (≠ A442), G426 (≠ S468), M428 (= M470), D453 (= D495), N480 (= N522), H482 (≠ A524), L483 (≠ N525), M485 (≠ C527), V486 (≠ I528), W489 (≠ M533), H558 (vs. gap)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (≠ F309), W489 (≠ M533), S568 (≠ K611)
- binding flavin-adenine dinucleotide: R161 (≠ E178), G222 (= G237), G223 (= G238), G224 (= G239), T246 (= T263), L247 (≠ Q264), M248 (≠ A265), L264 (≠ V281), M266 (≠ E283), G286 (= G303), R288 (= R305), R292 (≠ F309), V293 (≠ T310), D310 (≠ N326), I311 (= I327), G328 (≠ A344), D329 (= D345), V330 (≠ A346), M405 (≠ G447), G423 (≠ Y465)
- binding magnesium ion: D453 (= D495), N480 (= N522), H482 (≠ A524)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ A442), G401 (= G443), Q402 (≠ S444), H403 (≠ L445), G426 (≠ S468), M428 (= M470), D453 (= D495), G454 (= G496), S455 (= S497), M458 (= M500), N480 (= N522), H482 (≠ A524), L483 (≠ N525), G484 (= G526), M485 (≠ C527), V486 (≠ I528)
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
24% identity, 92% coverage: 23:618/646 of query aligns to 19:575/582 of 1z8nA
- active site: Y33 (≠ I37), G35 (= G39), G36 (= G41), A37 (≠ N42), S38 (≠ V43), E59 (= E65), T82 (≠ S90), F121 (≠ I132), Q122 (≠ E133), E123 (≠ Q134), K171 (≠ Q188), M266 (≠ E283), V293 (≠ T310), V400 (≠ A442), G426 (≠ S468), M428 (= M470), D453 (= D495), N480 (= N522), H482 (≠ A524), L483 (≠ N525), M485 (≠ C527), V486 (≠ I528), W489 (≠ M533), H558 (vs. gap)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K151), R161 (≠ E178), Y191 (≠ F201), R194 (= R204), D291 (= D308), R292 (≠ F309), D312 (≠ N328), W489 (≠ M533), G569 (≠ Y612)
- binding flavin-adenine dinucleotide: R161 (≠ E178), G222 (= G237), G224 (= G239), T246 (= T263), L247 (≠ Q264), M248 (≠ A265), L264 (≠ V281), G265 (= G282), M266 (≠ E283), H267 (≠ T284), G286 (= G303), V287 (≠ T304), R288 (= R305), D290 (≠ S307), R292 (≠ F309), V293 (≠ T310), D310 (≠ N326), I311 (= I327), D329 (= D345), V330 (≠ A346), M405 (≠ G447), G423 (≠ Y465), G424 (= G466)
- binding magnesium ion: D453 (= D495), N480 (= N522)
- binding thiamine diphosphate: V400 (≠ A442), G401 (= G443), Q402 (≠ S444), H403 (≠ L445), G426 (≠ S468), M428 (= M470), G452 (= G494), G454 (= G496), S455 (= S497), N480 (= N522), H482 (≠ A524), L483 (≠ N525), G484 (= G526), M485 (≠ C527), V486 (≠ I528)
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
24% identity, 92% coverage: 23:618/646 of query aligns to 19:575/582 of 1yi1A
- active site: Y33 (≠ I37), G35 (= G39), G36 (= G41), A37 (≠ N42), S38 (≠ V43), E59 (= E65), T82 (≠ S90), F121 (≠ I132), Q122 (≠ E133), E123 (≠ Q134), K171 (≠ Q188), M266 (≠ E283), V293 (≠ T310), V400 (≠ A442), G426 (≠ S468), M428 (= M470), D453 (= D495), N480 (= N522), H482 (≠ A524), L483 (≠ N525), M485 (≠ C527), V486 (≠ I528), W489 (≠ M533), H558 (vs. gap)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (= D308), R292 (≠ F309), W489 (≠ M533), S568 (≠ K611)
- binding flavin-adenine dinucleotide: R161 (≠ E178), G223 (= G238), G224 (= G239), T246 (= T263), L247 (≠ Q264), M248 (≠ A265), M263 (≠ G280), L264 (≠ V281), G265 (= G282), M266 (≠ E283), H267 (≠ T284), G286 (= G303), V287 (≠ T304), R288 (= R305), D290 (≠ S307), V293 (≠ T310), D310 (≠ N326), I311 (= I327), D329 (= D345), V330 (≠ A346), M405 (≠ G447), G423 (≠ Y465), G424 (= G466)
- binding magnesium ion: D453 (= D495), N480 (= N522), H482 (≠ A524)
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
24% identity, 92% coverage: 23:618/646 of query aligns to 19:575/582 of 1yi0A
- active site: Y33 (≠ I37), G35 (= G39), G36 (= G41), A37 (≠ N42), S38 (≠ V43), E59 (= E65), T82 (≠ S90), F121 (≠ I132), Q122 (≠ E133), E123 (≠ Q134), K171 (≠ Q188), M266 (≠ E283), V293 (≠ T310), V400 (≠ A442), G426 (≠ S468), M428 (= M470), D453 (= D495), N480 (= N522), H482 (≠ A524), L483 (≠ N525), M485 (≠ C527), V486 (≠ I528), W489 (≠ M533), H558 (vs. gap)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D308), R292 (≠ F309), W489 (≠ M533), S568 (≠ K611)
- binding flavin-adenine dinucleotide: R161 (≠ E178), G222 (= G237), G223 (= G238), G224 (= G239), T246 (= T263), L247 (≠ Q264), M248 (≠ A265), L264 (≠ V281), G265 (= G282), M266 (≠ E283), H267 (≠ T284), G286 (= G303), V287 (≠ T304), R288 (= R305), D290 (≠ S307), R292 (≠ F309), V293 (≠ T310), D310 (≠ N326), I311 (= I327), G328 (≠ A344), D329 (= D345), V330 (≠ A346), M405 (≠ G447), G423 (≠ Y465), G424 (= G466)
- binding magnesium ion: D453 (= D495), N480 (= N522), H482 (≠ A524)
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
24% identity, 92% coverage: 23:618/646 of query aligns to 19:575/582 of 1yhzA
- active site: Y33 (≠ I37), G35 (= G39), G36 (= G41), A37 (≠ N42), S38 (≠ V43), E59 (= E65), T82 (≠ S90), F121 (≠ I132), Q122 (≠ E133), E123 (≠ Q134), K171 (≠ Q188), M266 (≠ E283), V293 (≠ T310), V400 (≠ A442), G426 (≠ S468), M428 (= M470), D453 (= D495), N480 (= N522), H482 (≠ A524), L483 (≠ N525), M485 (≠ C527), V486 (≠ I528), W489 (≠ M533), H558 (vs. gap)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (= D308), R292 (≠ F309), M485 (≠ C527), W489 (≠ M533), S568 (≠ K611)
- binding flavin-adenine dinucleotide: R161 (≠ E178), G223 (= G238), G224 (= G239), T246 (= T263), L247 (≠ Q264), M248 (≠ A265), L264 (≠ V281), M266 (≠ E283), H267 (≠ T284), G286 (= G303), V287 (≠ T304), R288 (= R305), D290 (≠ S307), V293 (≠ T310), D310 (≠ N326), I311 (= I327), D329 (= D345), V330 (≠ A346), Q404 (≠ P446), M405 (≠ G447), G423 (≠ Y465), G424 (= G466)
- binding magnesium ion: D453 (= D495), N480 (= N522), H482 (≠ A524)
Query Sequence
>BWI76_RS03090 FitnessBrowser__Koxy:BWI76_RS03090
MGKLRLTMAQALVKFLDNQYLEVDGEEHKFVKGIFAIFGHGNVLGMGQALEQDSGEMRVY
QGRNEQGMAHVATGFARQSLRRQIIACTSSIGPGAANMITAAATATANRIPLLLLPGDVF
ATRQPDPVLQQIEQSHDLSITTNDAFRAVSKYWDRITRPEQLMSACINAMRVLTDPAETG
AVTLCLPQDVQGEAWDYPESFFTRRVHRLDRRPASAAQLADAVAAIKASRKPLIVCGGGV
KYSGAGEALTRFAERYGVPFAETQAGKGSVVSSHPYNVGGVGETGCLAANLLAKEADLVI
GLGTRFSDFTTSSKWIFQHPGVRFLNINVSNFDAWKLDGIPMLADAREALTALDGALSGE
SWQAGWGEQIESVQSRQLKETQRVYQAVWQETAFVPEIDDHLDRESVYREFRQITDSTLT
QSSVLGVLNETLPADAVIVAAAGSLPGDLQRVWRNRAANTYHVEYGYSCMGYEVSAALGV
KLAQPQSEVYSLVGDGSFMMLHSELVTSLQERAKINIVLLDNMANGCINNLQMEHGMDSF
GTEFRFRCAESGQLQGGLVPVDFATVAAGYGCKTWRVTTLEELRHALDAARRETVSTLID
IKVLPKTMVHKYGSWWNVGVAQSALSERIRKVAQMINEKRAQARDY
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory