Comparing BWI76_RS04675 FitnessBrowser__Koxy:BWI76_RS04675 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1cnzA 3-isopropylmalate dehydrogenase (ipmdh) from salmonella typhimurium (see paper)
93% identity, 100% coverage: 1:363/363 of query aligns to 1:363/363 of 1cnzA
P37412 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
93% identity, 100% coverage: 1:363/363 of query aligns to 1:363/363 of P37412
6xxyA Crystal structure of haemophilus influenzae 3-isopropylmalate dehydrogenase in complex with o-isobutenyl oxalylhydroxamate. (see paper)
71% identity, 98% coverage: 3:359/363 of query aligns to 2:358/358 of 6xxyA
3vmkA 3-isopropylmalate dehydrogenase from shewanella benthica db21 mt-2 (see paper)
68% identity, 99% coverage: 4:362/363 of query aligns to 8:369/369 of 3vmkA
3vkzA 3-isopropylmalate dehydrogenase from shewanella oneidensis mr-1 at atmospheric pressure (see paper)
68% identity, 99% coverage: 4:363/363 of query aligns to 2:364/364 of 3vkzA
P93832 3-isopropylmalate dehydrogenase 2, chloroplastic; 3-IPM-DH 2; AtIMDH2; AtIMDH3; IMDH 2; Beta-IPM dehydrogenase 2; Isopropylmalate dehydrogenase 2; AtIMD2; EC 1.1.1.85 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
51% identity, 98% coverage: 3:359/363 of query aligns to 41:397/405 of P93832
5j32A Isopropylmalate dehydrogenase in complex with isopropylmalate (see paper)
51% identity, 98% coverage: 3:359/363 of query aligns to 11:367/369 of 5j32A
5j33A Isopropylmalate dehydrogenase in complex with NAD+ (see paper)
51% identity, 98% coverage: 3:359/363 of query aligns to 1:357/360 of 5j33A
4xxvA Crystal structure of 3-isopropylmalate dehydrogenase from burkholderia thailandensis in complex with NAD
54% identity, 96% coverage: 7:355/363 of query aligns to 4:352/356 of 4xxvA
4iwhA Crystal structure of a 3-isopropylmalate dehydrogenase from burkholderia pseudomallei
54% identity, 96% coverage: 7:355/363 of query aligns to 6:354/358 of 4iwhA
1a05A Crystal structure of the complex of 3-isopropylmalate dehydrogenase from thiobacillus ferrooxidans with 3-isopropylmalate (see paper)
52% identity, 96% coverage: 6:352/363 of query aligns to 3:347/357 of 1a05A
Q56268 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Acidithiobacillus ferrooxidans (Thiobacillus ferrooxidans) (see paper)
52% identity, 96% coverage: 6:352/363 of query aligns to 3:347/358 of Q56268
Q9SA14 3-isopropylmalate dehydrogenase 3, chloroplastic; 3-IPM-DH 3; AtIMDH2; AtIMDH3; IMDH 3; Beta-IPM dehydrogenase 3; Isopropylmalate dehydrogenase 3; AtIMD3; EC 1.1.1.85 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
51% identity, 100% coverage: 1:363/363 of query aligns to 40:402/404 of Q9SA14
Q9FMT1 3-isopropylmalate dehydrogenase 1, chloroplastic; 3-IPM-DH 1; AtIMDH1; IMDH 1; Beta-IPM dehydrogenase 1; Isopropylmalate dehydrogenase 1; AtIMD1; Methylthioalkylmalate dehydrogenase 1; EC 1.1.1.85 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
52% identity, 99% coverage: 3:363/363 of query aligns to 45:405/409 of Q9FMT1
2y42D Structure of isopropylmalate dehydrogenase from thermus thermophilus - complex with nadh and mn (see paper)
51% identity, 91% coverage: 4:332/363 of query aligns to 1:322/355 of 2y42D
2y41A Structure of isopropylmalate dehydrogenase from thermus thermophilus - complex with ipm and mn (see paper)
51% identity, 91% coverage: 4:332/363 of query aligns to 1:322/346 of 2y41A
2ztwA Structure of 3-isopropylmalate dehydrogenase in complex with the inhibitor and NAD+ (see paper)
52% identity, 90% coverage: 7:332/363 of query aligns to 3:321/345 of 2ztwA
Q5SIY4 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 2 papers)
52% identity, 90% coverage: 7:332/363 of query aligns to 3:321/345 of Q5SIY4
P18869 3-isopropylmalate dehydrogenase; 3-IPM-DH; IMDH; Beta-IPM dehydrogenase; EC 1.1.1.85 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
45% identity, 95% coverage: 6:349/363 of query aligns to 5:358/371 of P18869
2g4oA Anomalous substructure of 3-isopropylmalate dehydrogenase (see paper)
37% identity, 98% coverage: 1:356/363 of query aligns to 1:334/337 of 2g4oA
>BWI76_RS04675 FitnessBrowser__Koxy:BWI76_RS04675
MSKNYHIAVLPGDGIGPEVMNQALKVLEAVRHRFDMRITTSQHDVGGIAIDRQGTPLPQS
TVEGCEQADAILFGSVGGPKWEHLPPAEQPERGALLPLRKHFKLFSNLRPAKLYQGLEEF
CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQHEKAFDTEVYHRFEIERIAHIAF
ESARKRRHKVTSIDKANVLQSSILWREIVSEISKQYPDVELSHMYIDNATMQLIKDPSQF
DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA
QILSLALLLRYSLDADSAATAIENAINRALEEGVRTGDLARGAAAVSTDEMGDIIARYVA
EGV
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory