SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing BWI76_RS05975 FitnessBrowser__Koxy:BWI76_RS05975 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
55% identity, 100% coverage: 1:230/231 of query aligns to 6:238/240 of 1ji0A

query
sites
1ji0A

M

V

L

L

S

E

A

V

R

Q

E

S

L

L

K

H

V

V

F

Y

Y
|
Y

G

G

V

A

I

I

Q

H

G

A

L

I

K

K

G

G

V

I

D

D

I

L

D

K

I

V

H

P

D

R

R

G

E

Q

I

I

V

V

T

T

L

L

I

I

G

G

S

A

N

N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

S
x
T

T

T

L

L

N

S

G

A

I

I

V

A

N

G

L

L

V

V

R

R

S

A

-

Q

T

K

G

G

R

K

V

I

N

I

F

F

L

N

N

G

E

Q

D

D

I

I

S

T

R

N

S

K

Q

P

T

A

H

H

Q

V

I

I

V

N

R

R

K

M

G

G

L

I

A

A

L

L

V

V

P

P

E
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E

G

G

R

R

R

R

I

I

F

F

T

P

N

E

L

L

T

T

I

V

E

Y

E

E

N

N

L

L

R

M

M

M

G

G

A

A

Y

Y

N

N

-

R

-

K

N

D

L

K

A

E

G

G

F

I

P

K

R

R

L

D

R

L

D

E

R

W

M

I

Y

F

S

S

L

L

F

F

P

P

R

R

L

L

K

K

E

E

R

R

R

L

T

K

Q

Q

M

L

A

G

G

G

T

T

M

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

M

M

L

L

A

A

I

I

A

G

R

R

A

A

L

L

M

M

S

S

E

R

P

P

V

K

L

L

L

L

M

M

L

M

D

D

E
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E

P

P

S

S

L

L

G

G

L

L

A

A

P

P

K

I

I

L

V

V

G

S

E

E

L

V

F

F

A

E

T

V

I

I

K

Q

Q

K

L

I

R

N

E

Q

E

E

N

G

I

T

T

T

V

I

L

L

L

L

V

V

E

E

Q

Q

N

N

A

A

T

L

A

G

A

A

L

L

T

K

I

V

A

A

D

H

R

Y

A

G

Y

Y

V

V

L

L

E

E

N

T

G

G

K

Q

I

I

M

V

L

L

S

E

G

G

P

K

A

A

A

S

E

E

V

L

L

L

A

D

N

N

P

E

E

M

I

V

K

R

R

K

M

A

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y16 (= Y11), G42 (= G37), G44 (= G39), K45 (= K40), T46 (= T41), T47 (≠ S42), E88 (= E82), E165 (= E157)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
32% identity, 99% coverage: 2:230/231 of query aligns to 3:235/238 of 6s8nB

query
sites
6s8nB

L

L

S

T

A

A

R

K

E

N

L

L

K

A

V

K

F

A

Y

Y

G

K

V

G

I

R

Q

R

G

V

L

V

K

E

G

D

V

V

D

S

I

L

D

T

I

V

H

N

D

S

R

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

S

P

N

N

G

G

A

A

G

G

K

K

T

T

S

T

T

T

L

F

N

Y

G

M

I

V

V

V

N

G

L

I

V

V

-

P

R

R

S

D

T

A

G

G

R

N

V

I

N

I

F

I

L

D

N

D

E

D

D

D

I

I

S

S

R

L

S

L

Q

P

T

L

H

H

Q

A

I

R

V

A

R

R

K

R

G

G

L

I

A

G

L

Y

V

L

P

P

E

Q

G

E

R

A

R

S

I

I

F

F

T
x
R

N

R

L

L

T

S

I

V

E

Y

E

D

N

N

L

L

R

M

-

A

-

V

M

L

G

Q

A

I

Y

R

N

D

N

D

L

L

A

S

G

A

F

E

P

Q

R

R

L

-

R

E

D

D

R

R

M

A

Y

N

S

E

L

L

F

M

P

E

-

E

-

F

R

H

L

I

K

E

E

H

R

L

R

R

T

D

Q

S

M
|
M

A
x
G

G
x
Q

T

S

M

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

I

I

A

A

R

R

A

A

L

L

M

A

S

A

E

N

P

P

V

K

L

F

L

I

M

L

L

L

D

D

E

E

P

P

S

F

L

A

G

G

L

V

A

D

P

P

K

I

I

S

V

V

G

I

E

D

L

I

F

K

A

R

T

I

I

I

K

E

Q

H

L

L

R

R

E

D

E

S

N

G

I

L

T

G

V

V

L

L

L

I

V

T

E

D

Q

H

N

N

A

V

T

R

A

E

A

T

L

L

T

A

I

V

A

C

D

E

R

R

A

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

K

H

I

L

M

I

L

A

S

H

G

G

P

T

A

P

A

T

E

E

V

I

L

L

A

Q

N

D

P

E

E

H

I

V

K

K

R

R

M

V

Y

Y

L

L

G

G

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (≠ T88), M133 (= M128), G134 (≠ A129), Q135 (≠ G130)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
32% identity, 99% coverage: 2:230/231 of query aligns to 3:235/238 of 6s8gA

query
sites
6s8gA

L

L

S

T

A

A

R

K

E

N

L

L

K

A

V

K

F

A

Y
|
Y

G

K

V

G

I
x
R

Q

R

G

V

L

V

K

E

G

D

V

V

D

S

I

L

D

T

I

V

H

N

D

S

R

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

S

P

N
|
N

G

G

A

A

G
|
G

K
|
K

T
|
T

S
x
T

T

T

L

F

N

Y

G

M

I

V

V

V

N

G

L

I

V

V

-

P

R

R

S

D

T

A

G

G

R

N

V

I

N

I

F

I

L

D

N

D

E

D

D

D

I

I

S

S

R

L

S

L

Q

P

T

L

H

H

Q

A

I

R

V

A

R

R

K

R

G

G

L

I

A

G

L

Y

V

L

P

P

E
x
Q

G

E

R

A

R

S

I

I

F

F

T

R

N

R

L

L

T

S

I

V

E

Y

E

D

N

N

L

L

R

M

-

A

-

V

M

L

G

Q

A

I

Y

R

N

D

N

D

L

L

A

S

G

A

F

E

P

Q

R

R

L

-

R

E

D

D

R

R

M

A

Y

N

S

E

L

L

F

M

P

E

-

E

-

F

R

H

L

I

K

E

E

H

R

L

R

R

T

D

Q

S

M

M

A

G

G

Q

T
x
S

M

L

S
|
S

G

G

G

G

E
|
E

Q

R

Q

R

M

R

L

V

A

E

I

I

A

A

R

R

A

A

L

L

M

A

S

A

E

N

P

P

V

K

L

F

L

I

M

L

L

L

D

D

E

E

P

P

S

F

L

A

G

G

L

V

A

D

P

P

K

I

I

S

V

V

G

I

E

D

L

I

F

K

A

R

T

I

I

I

K

E

Q

H

L

L

R

R

E

D

E

S

N

G

I

L

T

G

V

V

L

L

L

I

V

T

E

D

Q

H

N

N

A

V

T

R

A

E

A

T

L

L

T

A

I

V

A

C

D

E

R

R

A

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

K

H

I

L

M

I

L

A

S

H

G

G

P

T

A

P

A

T

E

E

V

I

L

L

A

Q

N

D

P

E

E

H

I

V

K

K

R

R

M

V

Y

Y

L

L

G

G

binding phosphoaminophosphonic acid-adenylate ester: Y12 (= Y11), R15 (≠ I14), N37 (= N36), G40 (= G39), K41 (= K40), T42 (= T41), T43 (≠ S42), Q84 (≠ E82), S136 (≠ T131), S138 (= S133), E141 (= E136)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
32% identity, 99% coverage: 2:230/231 of query aligns to 3:235/235 of 6mhzA

query
sites
6mhzA

L

L

S

T

A

A

R

K

E

N

L

L

K

A

V

K

F

A

Y
|
Y

G

K

V

G

I

R

Q

R

G

V

L

V

K

E

G

D

V

V

D

S

I

L

D

T

I

V

H

N

D

S

R

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

S

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

S
x
T

T

T

L

F

N

Y

G

M

I

V

V

V

N

G

L

I

V

V

-

P

R

R

S

D

T

A

G

G

R

N

V

I

N

I

F

I

L

D

N

D

E

D

D

D

I

I

S

S

R

L

S

L

Q

P

T

L

H

H

Q

A

I

R

V

A

R

R

K

R

G

G

L

I

A

G

L

Y

V

L

P

P

E
x
Q

G

E

R

A

R

S

I

I

F

F

T

R

N

R

L

L

T

S

I

V

E

Y

E

D

N

N

L

L

R

M

-

A

-

V

M

L

G

Q

A

I

Y

R

N

D

N

D

L

L

A

S

G

A

F

E

P

Q

R

R

L

-

R

E

D

D

R

R

M

A

Y

N

S

E

L

L

F

M

P

E

-

E

-

F

R

H

L

I

K

E

E

H

R

L

R

R

T

D

Q

S

M

M

A

G

G

Q

T
x
S

M

L

S
|
S

G
|
G

G
|
G

E

E

Q

R

Q

R

M

R

L

V

A

E

I

I

A

A

R

R

A

A

L

L

M

A

S

A

E

N

P

P

V

K

L

F

L

I

M

L

L

L

D

D

E
|
E

P

P

S

F

L

A

G
|
G

L

V

A

D

P

P

K

I

I

S

V

V

G

I

E

D

L

I

F

K

A

R

T

I

I

I

K

E

Q

H

L

L

R

R

E

D

E

S

N

G

I

L

T

G

V

V

L

L

L

I

V

T

E

D

Q
x
H

N

N

A

V

T

R

A

E

A

T

L

L

T

A

I

V

A

C

D

E

R

R

A

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

K

H

I

L

M

I

L

A

S

H

G

G

P

T

A

P

A

T

E

E

V

I

L

L

A

Q

N

D

P

E

E

H

I

V

K

K

R

R

M

V

Y

Y

L

L

G

G

binding adp orthovanadate: Y12 (= Y11), N37 (= N36), G38 (= G37), G40 (= G39), K41 (= K40), T42 (= T41), T43 (≠ S42), Q84 (≠ E82), S136 (≠ T131), S138 (= S133), G139 (= G134), G140 (= G135), E162 (= E157), G166 (= G161), H194 (≠ Q189)

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
31% identity, 100% coverage: 1:230/231 of query aligns to 2:235/240 of 6mjpA

query
sites
6mjpA

M

I

L

L

S

K

A

A

R

Q

E

H

L

L

K

A

V

K

F

S

Y

Y

G

K

V

K

I

R

Q

K

G

V

L

V

K

S

G

D

V

V

D

S

I

L

D

Q

I

V

H

E

D

S

R

G

E

Q

I

I

V

V

T

G

L

L

I

L

G

G

S

P

N

N

G

G

A

A

G

G

K

K

T

T

S

T

T

S

L

F

N

Y

G

M

I

I

V

V

N

G

L

L

V

V

-

A

R

R

S

D

T

E

G

G

R

T

V

I

N

T

F

I

L

D

N

D

E

N

D

D

I

I

S

S

R

I

S

L

Q

P

T

M

H

H

Q

S

I

R

V

S

R

R

K

M

G

G

L

I

A

G

L

Y

V

L

P

P

E

Q

G

E

R

A

R

S

I

I

F

F

T

R

N

K

L

L

T

S

I

V

E

E

E

D

N

N

L

I

R

M

-

A

-

V

M

L

G

Q

A

T

Y

R

N

E

N

E

L

L

A

T

G

H

F
x
E

P

E

R

R

L

-

R

Q

D
|
D

R

K

M

L

Y

E

S

D

L

L

F

L

P

E

-

E

-

F

R

H

L

I

K

Q

E

H

R

I

R

R

T

K

Q

S

M

A

A

G

G

M

T

A

M

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

I

I

A

A

R

R

A

A

L

L

M

A

S

A

E

N

P

P

V

Q

L

F

L

I

M

L

L

L

D

D

E

Q

P

P

S

F

L

A

G

G

L

V

A

D

P

P

K

I

I

S

V

V

G

I

E

D

L

I

F

K

A

K

T

I

I

I

K

E

Q

H

L

L

R

R

E

D

E

R

N

G

I

L

T

G

V

V

L

L

L

I

V

T

E

D

Q

H

N

N

A

V

T

R

A

E

A

T

L

L

T

D

I

V

A

C

D

E

R

K

A

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

K

R

I

L

M

I

L

A

S

E

G

G

P

T

A

P

A

Q

E

D

V

V

L

L

A

N

N

N

P

E

E

Q

I

V

K

K

R

Q

M

V

Y

Y

L

L

G

G

binding calcium ion: E111 (≠ F107), D115 (= D112)

1g6hA Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
28% identity, 96% coverage: 10:230/231 of query aligns to 13:253/254 of 1g6hA

query
sites
1g6hA

F

Y

Y
x
F

G

G

V

E

I
x
F

Q

K

G

A

L

L

K

D

G

G

V

V

D

S

I

I

D

S

I

V

H

N

D

K

R

G

E

D

I

V

V

T

T

L

L

I

I

I

G

G

S

P

N
|
N

G
|
G

A

S

G
|
G

K
|
K

T
x
S

S
x
T

T

L

L

I

N

N

G

V

I

I

V

T

N

G

L

F

V

L

R

K

S

A

T

D

-

E

G

G

R

R

V

V

N

Y

F

F

L

E

N

N

E

K

D

D

I

I

S

T

R

N

S

K

Q

E

T

P

H

A

Q

E

I

L

V

Y

R

H

K

Y

G

G

L

I

A

V

L

R

V

T

P

F

E

Q

G

T

R

P

R

Q

I

P

F

L

T

K

N

E

L

M

T

T

I

V

E

L

E

E

N

N

L

L

R

L

M

I

G

G

-

E

-

I

-

C

-

P

-

G

-

E

-

S

A

P

Y

L

N

N

N

S

L

L

-

F

-

Y

-

K

A

K

G

W

F

I

P

P

R

K

-

E

-

E

-

E

L

M

R

V

D

E

R

K

M

A

Y

F

S

K

L

I

-

L

-

E

F

F

P

L

R

K

L

L

K

S

E

H

R

L

R

Y

T

D

Q

R

M

K

A

A

G

G

T

E

M

L

S

S

G

G

G

G

E

Q

Q

M

Q

K

M

L

L

V

A

E

I

I

A

G

R

R

A

A

L

L

M

M

S

T

E

N

P

P

V

K

L

M

L

I

M

V

L

M

D

D

E

E

P

P

S

I

L

A

G

G

L

V

A

A

P

P

K

G

I

L

V

A

G

H

E

D

L

I

F

F

A

N

T

H

I

V

K

L

Q

E

L

L

R

K

E

A

E

K

N

G

I

I

T

T

V

F

L

L

L

I

V

I

E

E

Q

H

N

R

A

L

T

D

A

I

A

V

L

L

T

N

I

Y

A

I

D

D

R

H

A

L

Y

Y

V

V

L

M

E

F

N

N

G

G

K

Q

I

I

M

I

L

A

S

E

G

G

P

R

A

G

A

E

E

E

-

E

-

I

-

K

-

N

V

V

L

L

A

S

N

D

P

P

E

K

I

V

K

V

R

E

M

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (≠ Y11), F17 (≠ I14), N39 (= N36), G40 (= G37), G42 (= G39), K43 (= K40), S44 (≠ T41), T45 (≠ S42)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
28% identity, 96% coverage: 10:230/231 of query aligns to 13:253/253 of 1g9xB

query
sites
1g9xB

F

Y

Y
x
F

G

G

V

E

I
x
F

Q

K

G

A

L

L

K

D

G

G

V

V

D

S

I

I

D

S

I

V

H

C

D

K

R

G

E

D

I

V

V

T

T

L

L

I

I

I

G

G

S

P

N

N

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

S
x
T

T

L

L

I

N

N

G

V

I

I

V

T

N

G

L

F

V

L

R

K

S

A

T

D

-

E

G

G

R

R

V

V

N

Y

F

F

L

E

N

N

E

K

D

D

I

I

S

T

R

N

S

K

Q

E

T

P

H

A

Q

E

I

L

V

Y

R

H

K

Y

G

G

L

I

A

V

L

R

V

T

P

F

E

Q

G

T

R

P

R

Q

I

P

F

L

T

K

N

E

L

M

T

T

I

V

E

L

E

E

N

N

L

L

R

L

M

I

G

G

A

E

Y

I

N

N

-

P

-

G

-

E

-

S

-

P

-

L

-

N

-

S

-

L

-

F

N

Y

L

K

A

K

G

W

F

I

P

P

R

K

-

E

-

E

-

E

L

M

R

V

D

E

R

K

M

A

Y

F

S

K

L

I

-

L

-

E

F

F

P

L

R

K

L

L

K

S

E

H

R

L

R

Y

T

D

Q

R

M

K

A

A

G

G

T

E

M

L

S

S

G

G

G

G

E

Q

Q

M

Q

K

M

L

L

V

A

E

I

I

A

G

R

R

A

A

L

L

M

M

S

T

E

N

P

P

V

K

L

M

L

I

M

V

L

M

D

D

E
|
E

P

P

S

I

L

A

G

G

L

V

A

A

P

P

K

G

I

L

V

A

G

H

E

D

L

I

F

F

A

N

T

H

I

V

K

L

Q

E

L

L

R

K

E

A

E

K

N

G

I

I

T

T

V

F

L

L

L

I

V

I

E

E

Q

H

N

R

A

L

T

D

A

I

A

V

L

L

T

N

I

Y

A

I

D

D

R

H

A

L

Y

Y

V

V

L

M

E

F

N

N

G

G

K

Q

I

I

M

I

L

A

S

E

G

G

P

R

A

G

A

E

E

E

-

E

-

I

-

K

-

N

V

V

L

L

A

S

N

D

P

P

E

K

I

V

K

V

R

E

M

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (≠ Y11), F17 (≠ I14), G40 (= G37), S41 (≠ A38), G42 (= G39), K43 (= K40), S44 (≠ T41), T45 (≠ S42)
binding magnesium ion: S44 (≠ T41), E176 (= E157)

6mbnA Lptb e163q in complex with atp (see paper)
32% identity, 99% coverage: 2:230/231 of query aligns to 4:236/241 of 6mbnA

query
sites
6mbnA

L

L

S

T

A

A

R

K

E

N

L

L

K

A

V

K

F

A

Y
|
Y

G

K

V

G

I
x
R

Q

R

G
x
V

L

V

K

E

G

D

V

V

D

S

I

L

D

T

I

V

H

N

D

S

R

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

S

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

S
x
T

T

T

L

F

N

Y

G

M

I

V

V

V

N

G

L

I

V

V

-

P

R

R

S

D

T

A

G

G

R

N

V

I

N

I

F

I

L

D

N

D

E

D

D

D

I

I

S

S

R

L

S

L

Q

P

T

L

H

H

Q

A

I

R

V

A

R

R

K

R

G

G

L

I

A

G

L

Y

V

L

P

P

E

Q

G

E

R

A

R

S

I

I

F

F

T

R

N

R

L

L

T

S

I

V

E

Y

E

D

N

N

L

L

R

M

-

A

-

V

M

L

G

Q

A

I

Y

R

N

D

N

D

L

L

A

S

G

A

F

E

P

Q

R

R

L

-

R

E

D

D

R

R

M

A

Y

N

S

E

L

L

F

M

P

E

-

E

-

F

R

H

L

I

K

E

E

H

R

L

R

R

T

D

Q

S

M

M

A

G

G

Q

T

S

M

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

I

I

A

A

R

R

A

A

L

L

M

A

S

A

E

N

P

P

V

K

L

F

L

I

M

L

L

L

D

D

E

Q

P

P

S

F

L

A

G

G

L

V

A

D

P

P

K

I

I

S

V

V

G

I

E

D

L

I

F

K

A

R

T

I

I

I

K

E

Q

H

L

L

R

R

E

D

E

S

N

G

I

L

T

G

V

V

L

L

L

I

V

T

E

D

Q
x
H

N

N

A

V

T

R

A

E

A

T

L

L

T

A

I

V

A

C

D

E

R

R

A

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

K

H

I

L

M

I

L

A

S

H

G

G

P

T

A

P

A

T

E

E

V

I

L

L

A

Q

N

D

P

E

E

H

I

V

K

K

R

R

M

V

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y13 (= Y11), R16 (≠ I14), V18 (≠ G16), N38 (= N36), G39 (= G37), G41 (= G39), K42 (= K40), T43 (= T41), T44 (≠ S42), H195 (≠ Q189)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
32% identity, 99% coverage: 2:229/231 of query aligns to 3:234/234 of 6b89A

query
sites
6b89A

L

L

S

T

A

A

R

K

E

N

L

L

K

A

V

K

F

A

Y
|
Y

G

K

V

G

I
x
R

Q

R

G
x
V

L

V

K

E

G

D

V

V

D

S

I

L

D

T

I

V

H

N

D

S

R

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

S

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

S
x
T

T

T

L

F

N

Y

G

M

I

V

V

V

N

G

L

I

V

V

-

P

R

R

S

D

T

A

G

G

R

N

V

I

N

I

F

I

L

D

N

D

E

D

D

D

I

I

S

S

R

L

S

L

Q

P

T
x
L

H
|
H

Q

A

I

R

V

A

R

R

K

R

G

G

L

I

A

G

L

Y

V

L

P
|
P

E
x
Q

G

E

R
x
A

R
x
S

I

I

F
|
F

T
x
R

N
x
R

L
|
L

T

S

I

V

E

Y

E

D

N

N

L

L

R

M

-

A

-
x
V

M

L

G

Q

A

I

Y

R

N

D

N

D

L

L

A

S

G

A

F

E

P

Q

R

R

L

-

R

E

D

D

R

R

M

A

Y

N

S

E

L

L

F

M

P

E

-

E

-

F

R

H

L

I

K

E

E

H

R

L

R

R

T

D

Q

S

M

M

A

G

G
x
Q

T

S

M

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

I

I

A

A

R
|
R

A

A

L

L

M

A

S

A

E

N

P

P

V

K

L

F

L

I

M

L

L

L

D

D

E

E

P

P

S

F

L

A

G

G

L

V

A

D

P

P

K

I

I

S

V

V

G

I

E

D

L

I

F

K

A

R

T

I

I

I

K

E

Q

H

L

L

R

R

E

D

E

S

N

G

I

L

T

G

V

V

L

L

L

I

V

T

E

D

Q

H

N

N

A

V

T

R

A

E

A

T

L

L

T

A

I

V

A

C

D

E

R

R

A

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

K

H

I

L

M

I

L

A

S

H

G

G

P

T

A

P

A

T

E

E

V

I

L

L

A

Q

N

D

P

E

E

H

I

V

K

K

R

R

M

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y11), R15 (≠ I14), V17 (≠ G16), N37 (= N36), G38 (= G37), G40 (= G39), K41 (= K40), T42 (= T41), T43 (≠ S42)
binding magnesium ion: T42 (= T41), Q84 (≠ E82)
binding novobiocin: L71 (≠ T69), H72 (= H70), P83 (= P81), A86 (≠ R84), S87 (≠ R85), F89 (= F87), R90 (≠ T88), R91 (≠ N89), L92 (= L90), V101 (vs. gap), Q135 (≠ G130), R149 (= R144)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
32% identity, 99% coverage: 2:229/231 of query aligns to 3:234/234 of 4p31A

query
sites
4p31A

L

L

S

T

A

A

R

K

E

N

L

L

K

A

V

K

F

A

Y
|
Y

G

K

V

G

I
x
R

Q

R

G
x
V

L

V

K

E

G

D

V

V

D

S

I

L

D

T

I

V

H

N

D

S

R

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

S

P

N

N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

S
x
T

T

T

L

F

N

Y

G

M

I

V

V

V

N

G

L

I

V

V

-

P

R

R

S

D

T

A

G

G

R

N

V

I

N

I

F

I

L

D

N

D

E

D

D

D

I

I

S

S

R

L

S

L

Q

P

T

L

H

H

Q

A

I

R

V

A

R

R

K

R

G

G

L

I

A

G

L

Y

V

L

P

P

E
x
Q

G

E

R

A

R

S

I

I

F

F

T

R

N

R

L

L

T

S

I

V

E

Y

E

D

N

N

L

L

R

M

-

A

-

V

M

L

G

Q

A

I

Y

R

N

D

N

D

L

L

A

S

G

A

F

E

P

Q

R

R

L

-

R

E

D

D

R

R

M

A

Y

N

S

E

L

L

F

M

P

E

-

E

-

F

R

H

L

I

K

E

E

H

R

L

R

R

T

D

Q

S

M

M

A

G

G

Q

T

S

M

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

I

I

A

A

R

R

A

A

L

L

M

A

S

A

E

N

P

P

V

K

L

F

L

I

M

L

L

L

D

D

E

E

P

P

S

F

L

A

G

G

L

V

A

D

P

P

K

I

I

S

V

V

G

I

E

D

L

I

F

K

A

R

T

I

I

I

K

E

Q

H

L

L

R

R

E

D

E

S

N

G

I

L

T

G

V

V

L

L

L

I

V

T

E

D

Q

H

N

N

A

V

T

R

A

E

A

T

L

L

T

A

I

V

A

C

D

E

R

R

A

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

K

H

I

L

M

I

L

A

S

H

G

G

P

T

A

P

A

T

E

E

V

I

L

L

A

Q

N

D

P

E

E

H

I

V

K

K

R

R

M

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y11), R15 (≠ I14), V17 (≠ G16), G38 (= G37), G40 (= G39), K41 (= K40), T42 (= T41), T43 (≠ S42)
binding magnesium ion: T42 (= T41), Q84 (≠ E82)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
32% identity, 98% coverage: 2:228/231 of query aligns to 3:233/233 of 6b8bA

query
sites
6b8bA

L

L

S

T

A

A

R

K

E

N

L

L

K

A

V

K

F

A

Y
|
Y

G

K

V

G

I
x
R

Q

R

G
x
V

L

V

K

E

G

D

V

V

D

S

I

L

D

T

I

V

H

N

D

S

R

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

S

P

N

N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

S
x
T

T

T

L

F

N

Y

G

M

I

V

V

V

N

G

L

I

V

V

-

P

R

R

S

D

T

A

G

G

R

N

V

I

N

I

F

I

L

D

N

D

E

D

D

D

I

I

S

S

R

L

S

L

Q

P

T

L

H

H

Q

A

I

R

V

A

R

R

K

R

G

G

L

I

A

G

L

Y

V

L

P

P

E

Q

G

E

R

A

R

S

I

I

F
|
F

T
x
R

N
x
R

L

L

T

S

I

V

E

Y

E

D

N

N

L

L

R

M

-

A

-

V

M

L

G

Q

A

I

Y

R

N

D

N

D

L

L

A

S

G

A

F

E

P

Q

R

R

L

-

R

E

D

D

R

R

M

A

Y

N

S

E

L

L

F

M

P

E

-

E

-

F

R

H

L

I

K

E

E

H

R

L

R

R

T

D

Q

S

M

M

A

G

G

Q

T

S

M

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

I

I

A

A

R

R

A

A

L

L

M

A

S

A

E

N

P

P

V

K

L

F

L

I

M

L

L

L

D

D

E

E

P

P

S

F

L

A

G

G

L

V

A

D

P

P

K

I

I

S

V

V

G

I

E

D

L

I

F

K

A

R

T

I

I

I

K

E

Q

H

L

L

R

R

E

D

E

S

N

G

I

L

T

G

V

V

L

L

L

I

V

T

E

D

Q

H

N

N

A

V

T

R

A

E

A

T

L

L

T

A

I

V

A

C

D

E

R

R

A

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

K

H

I

L

M

I

L

A

S

H

G

G

P

T

A

P

A

T

E

E

V

I

L

L

A

Q

N

D

P

E

E

H

I

V

K

K

R

R

M

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (= Y11), R15 (≠ I14), V17 (≠ G16), G38 (= G37), G40 (= G39), K41 (= K40), T42 (= T41), T43 (≠ S42)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (= F87), R90 (≠ T88), R91 (≠ N89)

3c4jA Abc protein artp in complex with atp-gamma-s
28% identity, 98% coverage: 1:226/231 of query aligns to 3:233/242 of 3c4jA

query
sites
3c4jA

M

M

L

I

S

D

A

V

R

H

E

Q

L

L

K

K

V

K

F

S

Y
x
F

G

G

V

S

I

L

Q

E

G
x
V

L

L

K

K

G

G

V

I

D

N

I

V

D

H

I

I

H

R

D

E

R

G

E

E

I

V

V

V

T

V

L

V

I

I

G

G

S

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

S
x
T

T

F

L

L

N

R

G

-

I

C

V

L

N

N

L

L

V

L

R

E

S

D

T

F

G

D

R

E

V

G

N

E

F

I

L

I

N

I

E

D

D

G

I

I

-

N

-

L

-

K

S

A

R

K

S

D

Q

T

T

N

H

L

Q

N

I

K

V

V

R

R

K

E

G

E

L

V

A

G

L

M

V

V

P

F

E

Q

G

R

R

F

R

N

I

L

F

F

T

P

N

H

L

M

T

T

I

V

E

L

E

N

N

N

L

I

R

T

M

L

G

-

A

A

Y

P

N

M

N

K

L

V

A

R

G

K

F

W

P

P

R

R

L

E

R

K

D

A

-

E

-

A

R

K

M

A

Y

M

S

E

L

L

F

L

P

D

R

K

-

V

-

G

L

L

K

K

E

D

R

K

R

A

T

H

Q

A

M

Y

A

P

G

D

T

S

M

L

S

S

G

G

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

I

I

A

A

R

R

A

A

L

L

M

A

S

M

E

E

P

P

V

K

L

I

L

M

M

L

L

F

D

D

E

E

P

P

S

T

L

S

G

A

L

L

A

D

P

P

K

E

I

M

V

V

G

G

E

E

L

V

F

L

A

S

T

V

I

M

K

K

Q

Q

L

L

R

A

E

N

E

E

N

G

I

M

T

T

V

M

L

V

L

V

V

V

E

T

Q

H

N

E

A

M

T

G

A

F

A

A

L

R

T

E

I

V

A

G

D

D

R

R

A

V

Y

L

V

F

L

M

E

D

N

G

G

G

K

Y

I

I

M

I

L

E

S

E

G

G

P

K

A

P

A

E

E

D

V

L

L

F

A

D

N

R

P

P

E

Q

I

H

K

E

R

R

binding phosphothiophosphoric acid-adenylate ester: F13 (≠ Y11), V18 (≠ G16), S38 (≠ N36), G39 (= G37), S40 (≠ A38), G41 (= G39), K42 (= K40), S43 (≠ T41), T44 (≠ S42)

3c41J Abc protein artp in complex with amp-pnp/mg2+
28% identity, 98% coverage: 1:226/231 of query aligns to 3:233/242 of 3c41J

query
sites
3c41J

M

M

L

I

S

D

A

V

R

H

E

Q

L

L

K

K

V

K

F

S

Y
x
F

G

G

V

S

I

L

Q

E

G
x
V

L

L

K

K

G

G

V

I

D

N

I

V

D

H

I

I

H

R

D

E

R

G

E

E

I

V

V

V

T

V

L

V

I

I

G

G

S

P

N
x
S

G
|
G

A

S

G
|
G

K
|
K

T
x
S

S
x
T

T

F

L

L

N

R

G

-

I

C

V

L

N

N

L

L

V

L

R

E

S

D

T

F

G

D

R

E

V

G

N

E

F

I

L

I

N

I

E

D

D

G

I

I

-

N

-

L

-

K

S

A

R

K

S

D

Q

T

T

N

H

L

Q

N

I

K

V

V

R

R

K

E

G

E

L

V

A

G

L

M

V

V

P

F

E

Q

G

R

R

F

R

N

I

L

F

F

T

P

N

H

L

M

T

T

I

V

E

L

E

N

N

N

L

I

R

T

M

L

G

-

A

A

Y

P

N

M

N

K

L

V

A

R

G

K

F

W

P

P

R

R

L

E

R

K

D

A

-

E

-

A

R

K

M

A

Y

M

S

E

L

L

F

L

P

D

R

K

-

V

-

G

L

L

K

K

E

D

R

K

R

A

T

H

Q

A

M

Y

A

P

G

D

T

S

M

L

S

S

G

G

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

I

I

A

A

R

R

A

A

L

L

M

A

S

M

E

E

P

P

V

K

L

I

L

M

M

L

L

F

D
|
D

E

E

P

P

S

T

L

S

G

A

L

L

A

D

P

P

K

E

I

M

V

V

G

G

E

E

L

V

F

L

A

S

T

V

I

M

K

K

Q

Q

L

L

R

A

E

N

E

E

N

G

I

M

T

T

V

M

L

V

L

V

V

V

E

T

Q

H

N

E

A

M

T

G

A

F

A

A

L

R

T

E

I

V

A

G

D

D

R

R

A

V

Y

L

V

F

L

M

E

D

N

G

G

G

K

Y

I

I

M

I

L

E

S

E

G

G

P

K

A

P

A

E

E

D

V

L

L

F

A

D

N

R

P

P

E

Q

I

H

K

E

R

R

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ Y11), V18 (≠ G16), S38 (≠ N36), G39 (= G37), G41 (= G39), K42 (= K40), S43 (≠ T41), T44 (≠ S42)
binding magnesium ion: S43 (≠ T41), D163 (= D156)

2olkA Abc protein artp in complex with adp-beta-s
28% identity, 98% coverage: 1:226/231 of query aligns to 3:233/242 of 2olkA

query
sites
2olkA

M

M

L

I

S

D

A

V

R

H

E

Q

L

L

K

K

V

K

F

S

Y
x
F

G

G

V

S

I

L

Q

E

G
x
V

L

L

K

K

G

G

V

I

D

N

I

V

D

H

I

I

H

R

D

E

R

G

E

E

I

V

V

V

T

V

L

V

I

I

G

G

S

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

S
x
T

T

F

L

L

N

R

G

-

I

C

V

L

N

N

L

L

V

L

R

E

S

D

T

F

G

D

R

E

V

G

N

E

F

I

L

I

N

I

E

D

D

G

I

I

-

N

-

L

-

K

S

A

R

K

S

D

Q

T

T

N

H

L

Q

N

I

K

V

V

R

R

K

E

G

E

L

V

A

G

L

M

V

V

P

F

E

Q

G

R

R

F

R

N

I

L

F

F

T

P

N

H

L

M

T

T

I

V

E

L

E

N

N

N

L

I

R

T

M

L

G

-

A

A

Y

P

N

M

N

K

L

V

A

R

G

K

F

W

P

P

R

R

L

E

R

K

D

A

-

E

-

A

R

K

M

A

Y

M

S

E

L

L

F

L

P

D

R

K

-

V

-

G

L

L

K

K

E

D

R

K

R

A

T

H

Q

A

M

Y

A

P

G

D

T

S

M

L

S

S

G

G

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

I

I

A

A

R

R

A

A

L

L

M

A

S

M

E

E

P

P

V

K

L

I

L

M

M

L

L

F

D

D

E

E

P

P

S

T

L

S

G

A

L

L

A

D

P

P

K

E

I

M

V

V

G

G

E

E

L

V

F

L

A

S

T

V

I

M

K

K

Q

Q

L

L

R

A

E

N

E

E

N

G

I

M

T

T

V

M

L

V

L

V

V

V

E

T

Q

H

N

E

A

M

T

G

A

F

A

A

L

R

T

E

I

V

A

G

D

D

R

R

A

V

Y

L

V

F

L

M

E

D

N

G

G

G

K

Y

I

I

M

I

L

E

S

E

G

G

P

K

A

P

A

E

E

D

V

L

L

F

A

D

N

R

P

P

E

Q

I

H

K

E

R

R

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (≠ Y11), V18 (≠ G16), S38 (≠ N36), G39 (= G37), S40 (≠ A38), G41 (= G39), K42 (= K40), S43 (≠ T41), T44 (≠ S42)

2oljA Abc protein artp in complex with adp/mg2+
28% identity, 98% coverage: 1:226/231 of query aligns to 3:233/242 of 2oljA

query
sites
2oljA

M

M

L

I

S

D

A

V

R

H

E

Q

L

L

K

K

V

K

F

S

Y
x
F

G

G

V

S

I

L

Q

E

G
x
V

L

L

K

K

G

G

V

I

D

N

I

V

D

H

I

I

H

R

D

E

R

G

E

E

I

V

V

V

T

V

L

V

I

I

G

G

S

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

S
x
T

T

F

L

L

N

R

G

-

I

C

V

L

N

N

L

L

V

L

R

E

S

D

T

F

G

D

R

E

V

G

N

E

F

I

L

I

N

I

E

D

D

G

I

I

-

N

-

L

-

K

S

A

R

K

S

D

Q

T

T

N

H

L

Q

N

I

K

V

V

R

R

K

E

G

E

L

V

A

G

L

M

V

V

P

F

E

Q

G

R

R

F

R

N

I

L

F

F

T

P

N

H

L

M

T

T

I

V

E

L

E

N

N

N

L

I

R

T

M

L

G

-

A

A

Y

P

N

M

N

K

L

V

A

R

G

K

F

W

P

P

R

R

L

E

R

K

D

A

-

E

-

A

R

K

M

A

Y

M

S

E

L

L

F

L

P

D

R

K

-

V

-

G

L

L

K

K

E

D

R

K

R

A

T

H

Q

A

M

Y

A

P

G

D

T

S

M

L

S

S

G

G

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

I

I

A

A

R

R

A

A

L

L

M

A

S

M

E

E

P

P

V

K

L

I

L

M

M

L

L

F

D

D

E

E

P

P

S

T

L

S

G

A

L

L

A

D

P

P

K

E

I

M

V

V

G

G

E

E

L

V

F

L

A

S

T

V

I

M

K

K

Q

Q

L

L

R

A

E

N

E

E

N

G

I

M

T

T

V

M

L

V

L

V

V

V

E

T

Q

H

N

E

A

M

T

G

A

F

A

A

L

R

T

E

I

V

A

G

D

D

R

R

A

V

Y

L

V

F

L

M

E

D

N

G

G

G

K

Y

I

I

M

I

L

E

S

E

G

G

P

K

A

P

A

E

E

D

V

L

L

F

A

D

N

R

P

P

E

Q

I

H

K

E

R

R

binding adenosine-5'-diphosphate: F13 (≠ Y11), V18 (≠ G16), S38 (≠ N36), G39 (= G37), S40 (≠ A38), G41 (= G39), K42 (= K40), S43 (≠ T41), T44 (≠ S42)

4yerA Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
29% identity, 90% coverage: 11:218/231 of query aligns to 14:223/285 of 4yerA

query
sites
4yerA

Y
x
F

G

G

V

D

I
x
F

Q

E

G

A

L

V

K

K

G

G

V

V

D

S

I

F

D

S

I

V

H

K

D

K

R

G

E

E

I

I

V

F

T

A

L

F

I

L

G

G

S

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

S
x
T

T

T

L

I

N

H

G

M

I

L

V

T

N

T

L

L

V

L

R

K

S

P

T

T

-

S

G

G

R

K

V

A

N

W

F

V

L

A

N

G

E

H

D

D

I

V

S

L

R

K

S

E

Q

P

T

-

H

-

Q

R

I

E

V

V

R

R

K

R

G

K

L

I

A

G

L

I

V

V

P

F

E

Q

G

D

R

Q

R

S

I

L

F

D

T

R

N

E

L

L

T

T

I

A

E

Y

E

E

N

N

L

M

R

Y

M

I

G

H

A

G

Y

K

N

I

N

Y

L

G

A

Y

G

G

F

G

P

E

R

K

L

L

R

K

D

K

R

R

M

I

Y

L

S

E

L

L

F

L

P

E

R

F

L

V

K

E

E

L

R

L

-

E

-

F

R

K

T

D

Q

K

M

P

A

V

G

K

T
|
T

M
x
F

S
|
S

G

G

G

G

E

M

Q

A

Q

R

M

R

L

L

A

E

I

I

A

A

R

R

A

S

L

L

M

I

S

H

E

E

P

P

V

E

L

V

L

L

M

F

L

L

D

D

E

E

P

P

S

T

L

I

G

G

L

L

A

D

P

P

K

H

I

T

V

R

G

A

E

H

L

M

F

W

A

E

T

Y

I

I

K

S

Q

K

L

M

R

K

E

K

E

E

-

H

N

N

I

M

T

T

V

I

L

F

L

L

V

T

E

T

Q

H

N

Y

A

M

T

D

A

E

A

A

L

E

T

Q

I

L

A

A

D

D

R

R

A

V

Y

A

V

I

L

I

E

D

N

H

G

G

K

K

I

I

M

I

L

A

S

L

G

G

P

T

A

P

A

T

E

E

V

L

binding adenosine-5'-diphosphate: F14 (≠ Y11), F17 (≠ I14), N39 (= N36), G40 (= G37), G42 (= G39), K43 (= K40), T44 (= T41), T45 (≠ S42), T135 (= T131), F136 (≠ M132), S137 (= S133)

Q8N139 ATP-binding cassette sub-family A member 6; EC 7.6.2.- from Homo sapiens (Human) (see 2 papers)
28% identity, 91% coverage: 5:215/231 of query aligns to 485:697/1617 of Q8N139

query
sites
Q8N139

R

K

E

E

L

Y

K

K

V

G

F

K

Y

S

G

G

V

K

I

V

Q

E

G

A

L

L

K

K

G

G

V

L

D

L

I

F

D

D

I

I

H

Y

D

E

R

G

E

Q

I

I

V

T

T

A

L

I

I

L

G

G

S

H

N

S

G

G

A

A

G

G

K

K

T

S

S

S

T

L

L

L

N

N

G

I

I

L

V

N

N

G

L

L

-

S

V

V

R

P

S

T

T

E

G

G

R

S

V

V

N

T

F

I

L

Y

N

N

E

K

D

N

I

L

S

S

R

E

S

M

Q

Q

T

D

H

L

Q

E

I

E

V

I

R

R

K

K

G

I

L

T

A

G

L

V

V

C

P

P

E

Q

G

F

R

N

R

V

I

Q

F

F

T

D

N

I

L

L

T

T

I

V

E

K

E

E

N

N

L

L

R

S

M

L

G

F

A

A

Y

K

N

I

N

K

L

G

A

I

G

H

F

L

P

K

R

E

L

V

R

E

D

Q

R

E

M

V

Y

Q

S

R

L

I

F

L

P

L

R

E

L

L

K

D

E

M

R

Q

R

N

T

I

Q

Q

-

D

-

N

M

L

A

A

G

K

T

H

M

L

S

S

G

E

G

G

E

Q

Q

K

Q

R

M

K

L

L

A

T

I

F

A

G

R

I

A

T

L

I

M

L

S

G

E

D

P

P

V

Q

L

I

L

L

M

L

L

L

D

D

E

E

P

P

S

T

L

T

G

G

L

L

A

D

P

P

K

F

I

S

V

R

G

D

E

Q

L

V

F

W

A

S

T

L

I

L

K

R

Q

E

L

R

R

R

E

A

E

D

N

H

I

V

T

-

V

I

L

L

L

F

V

S

E

T

Q

Q

N

S

A

M

T

D

A

E

A

A

L

D

T

I

I

L

A

A

D

D

R

R

A

K

Y

V

V

I

L

M

E

S

N

N

G

G

K

R

I

L

M

K

L

C

S

A

G

G

P

S

A

S

Sites not aligning to the query:

282 V → I: in dbSNP:rs4968839
875 M → I: in dbSNP:rs7212506
940 modified: carbohydrate, N-linked (GlcNAc...) asparagine
1322 N → S: in dbSNP:rs2302134

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
26% identity, 98% coverage: 1:226/231 of query aligns to 2:231/241 of 4u00A

query
sites
4u00A

M

I

L

I

S

R

A

I

R

R

E

N

L

L

K

H

V

K

F

W

Y
x
F

G

G

V

P

I

L

Q

H

G
x
V

L

L

K

K

G

G

V

I

D

H

I

L

D

E

I

V

H

A

D

P

R

G

E

E

I

K

V

L

T

V

L

I

I

I

G

G

S

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

S
x
T

T

-

L

-

N

-

G

-

I

-

V

-

N

-

L

L

V

I

R

R

S

T

T

I

G

N

R

R

V

L

N

E

F

D

L

F

N

Q

E

E

-

G

-

E

-

V

-

V

-

V

-

D

-

G

-

L

D

S

I

V

S

K

R

D

S

D

Q

R

T

A

H

L

Q

R

I

E

V

I

R

R

K

R

G

E

L

V

A

G

L

M

V

V

P

F

E

Q

G

Q

R

F

R

N

I

L

F

F

T

P

N

H

L

M

T

T

I

V

E

L

E

E

N

N

L

V

R

T

M

L

G

-

A

A

Y

P

N

M

N

R

L

V

A

R

G

R

F

W

P

P

R

R

L

E

R

K

-

A

-

E

D

K

R

K

M

A

Y

L

S

E

L

L

F

L

P

E

R

R

L

V

K

G

-

I

-

L

E

D

R

Q

R

A

T

R

Q

K

M

Y

A

P

G

A

T

Q

M

L

S

S

G

G

G

G

E

Q

Q

Q

Q

Q

M

R

L

V

A

A

I

I

A

A

R

R

A

A

L

L

M

A

S

M

E

E

P

P

V

K

L

I

L

M

M

L

L

F

D

D

E

E

P

P

S

T

L

S

G

A

L

L

A

D

P

P

K

E

I

M

V

V

G

G

E

E

L

V

F

L

A

D

T

V

I

M

K

R

Q

D

L

L

R

A

E

Q

E

G

N

G

I

M

T

T

V

M

L

V

L

V

V

V

E

T

Q

H

N

E

A

M

T

G

A

F

A

A

L

R

T

E

I

V

A

A

D

D

R

R

A

V

Y

V

V

F

L

M

E

D

N

G

G

G

K

Q

I

I

M

V

L

E

S

E

G

G

P

R

A

P

A

E

E

E

V

I

L

F

A

T

N

R

P

P

E

K

I

E

K

E

R

R

binding adenosine-5'-diphosphate: F12 (≠ Y11), V17 (≠ G16), S37 (≠ N36), G38 (= G37), S39 (≠ A38), G40 (= G39), K41 (= K40), S42 (≠ T41), T43 (≠ S42)

Q8IUA7 ATP-binding cassette sub-family A member 9; EC 7.6.2.- from Homo sapiens (Human) (see 2 papers)
29% identity, 87% coverage: 14:215/231 of query aligns to 497:700/1624 of Q8IUA7

query
sites
Q8IUA7

I

V

Q

E

G

A

L

L

K

K

G

G

V

V

D

V

I

F

D

D

I

I

H

Y

D

E

R

G

E

Q

I

I

V

T

T

A

L

L

I

L

G

G

S

H

N

S

G

G

A

A

G

G

K

K

T

T

S

T

T

L

L

L

N

N

G

I

I

L

V

S

N

G

L

L

-

S

V

V

R

P

S

T

T

S

G

G

R

S

V

V

N

T

F

V

L

Y

N

N

E

H

D

T

I

L

S

S

R

R

S

M

Q

A

T

D

H

I

Q

E

I

N

V

I

R

S

K

K

G

F

L

T

A

G

L

F

V

C

P

P

E

Q

G

S

R

N

R

V

I

Q

F

F

T

G

N

F

L

L

T

T

I

V

E

K

E

E

N

N

L

L

R

R

M

L

G

F

A

A

Y

-

N

-

N

-

L

-

A

-

G

-

F

-

P

-

R

-

L

-

R

-

D

-

R

K

M

I

Y

K

S

G

L

I

F

L

P

P

R

H

L

E

K

V

E

E

R

K

R

E

T

V

Q

Q

-

R

-

V

-

V

-

Q

-

E

-

L

-

E

-

M

-

E

-

N

-

I

-

Q

-

D

-

I

M

L

A

A

G

Q

T

N

M

L

S

S

G

G

G

G

E

Q

Q

N

Q

R

M

K

L

L

A

T

I

F

A

G

R

I

A

A

L

I

M

L

S

G

E

D

P

P

V

Q

L

V

L

L

M

L

L

L

D

D

E

E

P

P

S

T

L

A

G

G

L

L

A

D

P

P

K

L

I

S

V

R

G

H

E

R

L

I

F

W

A

N

T

L

I

L

K

K

Q

E

L

G

R

K

E

S

E

D

N

R

I

V

T

-

V

I

L

L

L

F

V

S

E

T

Q

Q

N

F

A

I

T

D

A

E

A

A

L

D

T

I

I

L

A

A

D

D

R

R

A

K

Y

V

V

F

L

I

E

S

N

N

G

G

K

K

I

L

M

K

L

C

S

A

G

G

P

S

A

S

Sites not aligning to the query:

353 R → H: in dbSNP:rs1860447
949 modified: carbohydrate, N-linked (GlcNAc...) asparagine
1306 K → T: in dbSNP:rs2302294

1vciA Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
29% identity, 92% coverage: 11:222/231 of query aligns to 16:220/353 of 1vciA

query
sites
1vciA

Y
x
F

G

G

V

N

I
x
F

Q

T

G

A

L

V

K

N

G

K

V

L

D

N

I

L

D

T

I

I

H

K

D

D

R

G

E

E

I

F

V

L

T

V

L

L

I

L

G

G

S

P

N
x
S

G
|
G

A

C

G
|
G

K
|
K

T
|
T

S
x
T

T

T

L

L

N

R

G

M

I

I

V

A

N

G

L

L

V

E

R

E

S

P

T

T

-

E

G

G

R

R

V

I

N

Y

F

F

L

G

N

D

E

R

D

D

I

V

S

T

R

-

S

-

Q

-

T

-

H

-

Q

-

I

-

V

-

R

-

K

-

G

-

L

-

A

Y

L

L

V

P

P

P

E

K

G

D

R

R

R

N

I

I

-

S

-

M

-

V

F

F

T

Q

N

H

L

M

T

T

I

V

E

Y

E

E

N

N

L

I

R

A

M

F

G

-

A

-

Y

-

N

-

N

P

L

L

A

K

G

K

F

F

P

P

R

K

-

D

-

E

-

I

-

D

L

K

R

R

D

V

R

R

M

W

Y

A

S

A

L

E

F

L

P

L

R

Q

L

I

K

E

E

E

R

L

R

L

T

N

Q

R

M

Y

A

P

G

A

T

Q

M

L

S

S

G

G

G

G

E

Q

Q

R

Q

Q

M

R

L

V

A

A

I

V

A

A

R

R

A

A

L

I

M

V

S

V

E

E

P

P

V

D

L

V

L

L

M

L

L

M

D

D

E

E

P

P

S

L

L

S

G

N

L

L

A

D

P

A

K

K

I

L

V

R

G

V

E

A

L

M

F

R

A

A

T

E

I

I

K

K

Q

K

L

L

R

Q

E

Q

E

K

-

L

N

K

I

V

T

T

V

T

L

I

L

Y

V

V

E

T

Q

H

N

D

A

Q

T

V

A

E

A

A

L

M

T

T

I

M

A

G

D

D

R

R

A

I

Y

A

V

V

L

M

E

N

N

R

G

G

K

Q

I

L

M

L

L

Q

S

I

G

G

P

S

A

P

A

T

E

E

V

V

L

Y

A

L

N

R

P

P

binding adenosine-5'-triphosphate: F16 (≠ Y11), F19 (≠ I14), S41 (≠ N36), G42 (= G37), G44 (= G39), K45 (= K40), T46 (= T41), T47 (≠ S42)

Query Sequence

>BWI76_RS05975 FitnessBrowser__Koxy:BWI76_RS05975
MLSARELKVFYGVIQGLKGVDIDIHDREIVTLIGSNGAGKTSTLNGIVNLVRSTGRVNFL
NEDISRSQTHQIVRKGLALVPEGRRIFTNLTIEENLRMGAYNNLAGFPRLRDRMYSLFPR
LKERRTQMAGTMSGGEQQMLAIARALMSEPVLLMLDEPSLGLAPKIVGELFATIKQLREE
NITVLLVEQNATAALTIADRAYVLENGKIMLSGPAAEVLANPEIKRMYLGG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory