Comparing BWI76_RS08765 FitnessBrowser__Koxy:BWI76_RS08765 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1djeA Crystal structure of the plp-bound form of 8-amino-7-oxonanoate synthase (see paper)
72% identity, 99% coverage: 2:384/385 of query aligns to 1:383/383 of 1djeA
1dj9A Crystal structure of 8-amino-7-oxonanoate synthase (or 7-keto- 8aminipelargonate or kapa synthase) complexed with plp and the product 8(s)-amino-7-oxonanonoate (or kapa). The enzyme of biotin biosynthetic pathway. (see paper)
72% identity, 99% coverage: 2:384/385 of query aligns to 1:383/383 of 1dj9A
P12998 8-amino-7-oxononanoate synthase; AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; EC 2.3.1.47 from Escherichia coli (strain K12) (see 2 papers)
73% identity, 100% coverage: 1:384/385 of query aligns to 1:384/384 of P12998
2g6wA Suicide inhibition of a-oxamine synthase: structures of the covalent adducts of 8-amino-7-oxonanoate synthase with trifluoroalanine (see paper)
73% identity, 99% coverage: 2:384/385 of query aligns to 1:383/383 of 2g6wA
7poaA An irreversible, promiscuous and highly thermostable claisen- condensation biocatalyst drives the synthesis of substituted pyrroles
39% identity, 91% coverage: 37:385/385 of query aligns to 42:392/398 of 7poaA
P0AB77 2-amino-3-ketobutyrate coenzyme A ligase; AKB ligase; Glycine acetyltransferase; EC 2.3.1.29 from Escherichia coli (strain K12) (see paper)
35% identity, 89% coverage: 37:380/385 of query aligns to 40:387/398 of P0AB77
1fc4A 2-amino-3-ketobutyrate coa ligase (see paper)
35% identity, 89% coverage: 37:380/385 of query aligns to 43:390/401 of 1fc4A
3tqxA Structure of the 2-amino-3-ketobutyrate coenzyme a ligase (kbl) from coxiella burnetii (see paper)
33% identity, 88% coverage: 39:378/385 of query aligns to 40:384/396 of 3tqxA
Q8GW43 8-amino-7-oxononanoate synthase; AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Biotin synthase 4; Biotin synthase F; AtbioF; EC 2.3.1.47 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
36% identity, 90% coverage: 36:380/385 of query aligns to 97:455/476 of Q8GW43
Sites not aligning to the query:
7v58B Structural insights into the substrate selectivity of acyl-coa transferase (see paper)
33% identity, 90% coverage: 38:384/385 of query aligns to 43:393/400 of 7v58B
P18079 5-aminolevulinate synthase; 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase; EC 2.3.1.37 from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) (see paper)
34% identity, 87% coverage: 47:380/385 of query aligns to 54:393/409 of P18079
Sites not aligning to the query:
Q0P5L8 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; AKB ligase; Aminoacetone synthase; Glycine acetyltransferase; EC 2.3.1.29 from Bos taurus (Bovine) (see paper)
33% identity, 98% coverage: 7:384/385 of query aligns to 31:412/419 of Q0P5L8
Sites not aligning to the query:
2bwpA 5-aminolevulinate synthase from rhodobacter capsulatus in complex with glycine (see paper)
33% identity, 87% coverage: 47:380/385 of query aligns to 54:393/398 of 2bwpA
2bwoB 5-aminolevulinate synthase from rhodobacter capsulatus in complex with succinyl-coa (see paper)
33% identity, 87% coverage: 47:380/385 of query aligns to 54:393/399 of 2bwoB
Sites not aligning to the query:
8h29A Serine palmitoyltransferase from sphingobacterium multivorum complexed with l-threonine (see paper)
30% identity, 96% coverage: 11:380/385 of query aligns to 15:385/394 of 8h29A
8h21A Serine palmitoyltransferase from sphingobacterium multivorum complexed with l-alanine (see paper)
30% identity, 96% coverage: 11:380/385 of query aligns to 15:385/394 of 8h21A
8h20A Serine palmitoyltransferase from sphingobacterium multivorum complexed with glycine (see paper)
30% identity, 96% coverage: 11:380/385 of query aligns to 15:385/394 of 8h20A
8h1yA Serine palmitoyltransferase from sphingobacterium multivorum complexed with l-homoserine (see paper)
30% identity, 96% coverage: 11:380/385 of query aligns to 15:385/394 of 8h1yA
8h1qA Serine palmitoyltransferase from sphingobacterium multivorum complexed with l-serine (see paper)
30% identity, 96% coverage: 11:380/385 of query aligns to 15:385/394 of 8h1qA
8guhA Serine palmitoyltransferase from sphingobacterium multivorum complexed with tris (see paper)
30% identity, 96% coverage: 11:380/385 of query aligns to 15:385/394 of 8guhA
>BWI76_RS08765 FitnessBrowser__Koxy:BWI76_RS08765
MSWQHRIELALEERRAADALRSRLPVTLGAGRWLSREGRRWLNFSSNDYLGLSQHPAIVK
AWQQGAERYGVGSGGSGHVSGYSEAHRALEEQLADWLGYPRALLFISGFAANQAVIAALA
GKEDRIVADRLSHASLLEAASLSPAQLRRFQHNDCRHLDELLAKPLTGQQLVVTEGIFSM
DGDSAPLAEVCQAARAAGALLLVDDAHGIGALGEEGRGSCHTQQVRPDLLIVTFGKAFGV
SGAAVLCSEALADYLLQFARHLIYSTAMPPAQAVALSAALEVIRGDEGQARRETLAGHIA
DFRRGMTRYPGELTDSGSAIQPLIVGDNARALRLAARLREEGCWATAIRPPTVPVGSARL
RLTLTAAHKSADIARLLEVLHDGGE
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory