SitesBLAST
Comparing BWI76_RS10695 FitnessBrowser__Koxy:BWI76_RS10695 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5iuwA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ and iaa (see paper)
59% identity, 98% coverage: 7:493/495 of query aligns to 5:495/495 of 5iuwA
- active site: N166 (= N168), K189 (= K191), E265 (= E267), C300 (= C302), E399 (= E397), D476 (= D474)
- binding 1h-indol-3-ylacetic acid: F167 (= F169), M170 (≠ L172), C300 (= C302), D457 (≠ N455), F465 (= F463)
- binding nicotinamide-adenine-dinucleotide: I162 (≠ V164), V163 (= V165), P164 (= P166), W165 (= W167), N166 (= N168), K189 (= K191), G222 (= G224), G226 (= G228), K227 (≠ Q229), F240 (= F242), T241 (= T243), G242 (= G244), S243 (= S245), I246 (≠ T248), Y253 (≠ D255), E265 (= E267), A266 (= A268), C300 (= C302), E399 (= E397), F401 (= F399)
5iuvA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ (see paper)
59% identity, 98% coverage: 7:493/495 of query aligns to 5:495/495 of 5iuvA
- active site: N166 (= N168), K189 (= K191), E265 (= E267), C300 (= C302), E399 (= E397), D476 (= D474)
- binding nicotinamide-adenine-dinucleotide: I162 (≠ V164), V163 (= V165), P164 (= P166), W165 (= W167), N166 (= N168), K189 (= K191), S191 (= S193), G222 (= G224), G226 (= G228), K227 (≠ Q229), F240 (= F242), T241 (= T243), G242 (= G244), S243 (= S245), I246 (≠ T248), Y253 (≠ D255), E265 (= E267), A266 (= A268), C300 (= C302), E399 (= E397), F401 (= F399)
7jsoA P. Syringae alda indole-3-acetaldehyde dehydrogenase c302a mutant in complex with NAD+ and iaa (see paper)
58% identity, 98% coverage: 7:493/495 of query aligns to 5:495/495 of 7jsoA
- active site: N166 (= N168), E265 (= E267), A300 (≠ C302), D476 (= D474)
- binding 1h-indol-3-ylacetic acid: F167 (= F169), W174 (= W176), V299 (= V301), A300 (≠ C302), T301 (≠ I303), D457 (≠ N455), F465 (= F463)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I162 (≠ V164), V163 (= V165), P164 (= P166), W165 (= W167), K189 (= K191), E192 (= E194), G222 (= G224), G226 (= G228), K227 (≠ Q229), F240 (= F242), G242 (= G244), S243 (= S245), I246 (≠ T248), A266 (= A268), G267 (= G269), A300 (≠ C302), E399 (= E397), F401 (= F399)
7uyyA The crystal structure of the pseudomonas aeruginosa aldehyde dehydrogenase encoded by the pa4189 gene in complex with nadh (see paper)
46% identity, 97% coverage: 13:491/495 of query aligns to 14:493/496 of 7uyyA
- binding 1,4-dihydronicotinamide adenine dinucleotide: V165 (= V164), L166 (≠ V165), P167 (= P166), W168 (= W167), K192 (= K191), G225 (= G224), G229 (= G228), F243 (= F242), G245 (= G244), S246 (= S245), T249 (= T248), L252 (≠ Q251), F253 (≠ L252), Y256 (≠ D255), C269 (≠ A268), G270 (= G269), C303 (= C302), H350 (= H349), K353 (≠ S352), F400 (= F399)
Q9HWJ2 Aminoacetaldehyde dehydrogenase; ACTAL dehydrogenase; EC 1.2.1.- from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
46% identity, 97% coverage: 13:491/495 of query aligns to 14:493/496 of Q9HWJ2
- L166 (≠ V165) binding NADH
- W168 (= W167) binding NADH
- K192 (= K191) binding NADH
- S246 (= S245) binding NADH
- T249 (= T248) binding NADH
- Y256 (≠ D255) binding NADH
- C269 (≠ A268) binding NADH
- K353 (≠ S352) binding NADH
- E398 (= E397) binding NADH
- E457 (≠ D456) Important in defining aldehyde specificity; mutation E->G,Q: High decrease in catalytic efficiency with ACTAL and APAL as substrates.
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
44% identity, 96% coverage: 20:495/495 of query aligns to 11:490/494 of 4pz2B
- active site: N159 (= N168), K182 (= K191), E258 (= E267), C292 (= C302), E392 (= E397), D469 (= D474)
- binding nicotinamide-adenine-dinucleotide: I155 (≠ V164), I156 (≠ V165), P157 (= P166), W158 (= W167), N159 (= N168), M164 (≠ L173), K182 (= K191), A184 (≠ S193), E185 (= E194), G215 (= G224), G219 (= G228), F233 (= F242), T234 (= T243), G235 (= G244), S236 (= S245), V239 (≠ T248), E258 (= E267), L259 (≠ A268), C292 (= C302), E392 (= E397), F394 (= F399)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
41% identity, 97% coverage: 16:494/495 of query aligns to 13:491/491 of 5gtlA
- active site: N165 (= N168), K188 (= K191), E263 (= E267), C297 (= C302), E394 (= E397), E471 (≠ D474)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (≠ V164), P163 (= P166), K188 (= K191), A190 (≠ S193), E191 (= E194), Q192 (≠ K195), G221 (= G224), G225 (= G228), G241 (= G244), S242 (= S245), T245 (= T248), L264 (≠ A268), C297 (= C302), E394 (= E397), F396 (= F399)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
41% identity, 97% coverage: 16:494/495 of query aligns to 13:491/491 of 5gtkA
- active site: N165 (= N168), K188 (= K191), E263 (= E267), C297 (= C302), E394 (= E397), E471 (≠ D474)
- binding nicotinamide-adenine-dinucleotide: I161 (≠ V164), I162 (≠ V165), P163 (= P166), W164 (= W167), K188 (= K191), E191 (= E194), G221 (= G224), G225 (= G228), A226 (≠ Q229), F239 (= F242), G241 (= G244), S242 (= S245), T245 (= T248), Y248 (≠ Q251), L264 (≠ A268), C297 (= C302), Q344 (≠ H349), R347 (≠ S352), E394 (= E397), F396 (= F399)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
44% identity, 96% coverage: 18:494/495 of query aligns to 2:480/489 of 4o6rA