SitesBLAST
Comparing BWI76_RS12820 FitnessBrowser__Koxy:BWI76_RS12820 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
40% identity, 99% coverage: 4:498/499 of query aligns to 1:489/491 of 5gtlA
- active site: N165 (= N174), K188 (= K197), E263 (= E272), C297 (= C306), E394 (= E403), E471 (≠ D480)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I170), P163 (= P172), K188 (= K197), A190 (≠ S199), E191 (= E200), Q192 (≠ T201), G221 (= G230), G225 (= G234), G241 (= G250), S242 (= S251), T245 (= T254), L264 (= L273), C297 (= C306), E394 (= E403), F396 (= F405)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
40% identity, 99% coverage: 4:498/499 of query aligns to 1:489/491 of 5gtkA
- active site: N165 (= N174), K188 (= K197), E263 (= E272), C297 (= C306), E394 (= E403), E471 (≠ D480)
- binding nicotinamide-adenine-dinucleotide: I161 (= I170), I162 (≠ V171), P163 (= P172), W164 (= W173), K188 (= K197), E191 (= E200), G221 (= G230), G225 (= G234), A226 (= A235), F239 (= F248), G241 (= G250), S242 (= S251), T245 (= T254), Y248 (≠ Q257), L264 (= L273), C297 (= C306), Q344 (≠ H353), R347 (≠ K356), E394 (= E403), F396 (= F405)
8rwkA Cryoem structure of the central ald4 filament determined by filamentid (see paper)
39% identity, 95% coverage: 21:495/499 of query aligns to 22:489/495 of 8rwkA
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
42% identity, 95% coverage: 22:495/499 of query aligns to 13:484/494 of 4pz2B
- active site: N159 (= N174), K182 (= K197), E258 (= E272), C292 (= C306), E392 (= E403), D469 (= D480)
- binding nicotinamide-adenine-dinucleotide: I155 (= I170), I156 (≠ V171), P157 (= P172), W158 (= W173), N159 (= N174), M164 (≠ I179), K182 (= K197), A184 (≠ S199), E185 (= E200), G215 (= G230), G219 (= G234), F233 (= F248), T234 (= T249), G235 (= G250), S236 (= S251), V239 (≠ T254), E258 (= E272), L259 (= L273), C292 (= C306), E392 (= E403), F394 (= F405)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
41% identity, 96% coverage: 19:497/499 of query aligns to 3:477/489 of 4o6rA
- active site: N150 (= N174), K173 (= K197), E248 (= E272), C282 (= C306), E383 (= E403), E460 (≠ D480)
- binding adenosine monophosphate: I146 (= I170), V147 (= V171), K173 (= K197), G206 (= G230), G210 (= G234), Q211 (≠ A235), F224 (= F248), G226 (= G250), S227 (= S251), T230 (= T254), R233 (≠ Q257)
4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
40% identity, 96% coverage: 18:496/499 of query aligns to 4:477/486 of 4pxlA
- active site: N154 (= N174), K177 (= K197), E253 (= E272), C287 (= C306), E384 (= E403), D461 (= D480)
- binding nicotinamide-adenine-dinucleotide: I150 (= I170), V151 (= V171), P152 (= P172), W153 (= W173), K177 (= K197), E180 (= E200), G210 (= G230), G214 (= G234), A215 (= A235), F228 (= F248), G230 (= G250), S231 (= S251), V234 (≠ T254), E253 (= E272), G255 (= G274), C287 (= C306), Q334 (≠ H353), K337 (= K356), E384 (= E403), F386 (= F405)
7radA Crystal structure analysis of aldh1b1
40% identity, 96% coverage: 22:498/499 of query aligns to 15:487/493 of 7radA
- binding nicotinamide-adenine-dinucleotide: I158 (= I170), I159 (≠ V171), P160 (= P172), W161 (= W173), N162 (= N174), M167 (≠ I179), K185 (= K197), E188 (= E200), G218 (= G230), G222 (= G234), A223 (= A235), T237 (= T249), G238 (= G250), S239 (= S251), V242 (≠ T254), E261 (= E272), L262 (= L273), C295 (= C306), E392 (= E403), F394 (= F405)
- binding 3-(2-methoxyphenyl)-1-(4-phenylphenyl)-6,7,8,9-tetrahydro-5~{H}-imidazo[1,2-a][1,3]diazepine: L113 (≠ F119), E117 (≠ C123), F163 (= F175), E285 (≠ T296), F289 (≠ L300), N450 (≠ T461), V452 (≠ I463)
7mjdA Crystal structure analysis of aldh1b1
40% identity, 96% coverage: 22:498/499 of query aligns to 15:487/493 of 7mjdA
- binding nicotinamide-adenine-dinucleotide: I158 (= I170), I159 (≠ V171), P160 (= P172), W161 (= W173), N162 (= N174), M167 (≠ I179), K185 (= K197), E188 (= E200), G218 (= G230), G222 (= G234), F236 (= F248), T237 (= T249), G238 (= G250), S239 (= S251), V242 (≠ T254), E261 (= E272), L262 (= L273), C295 (= C306), E392 (= E403), F394 (= F405)
- binding 8-(2-methoxyphenyl)-10-(4-phenylphenyl)-1$l^{4},8-diazabicyclo[5.3.0]deca-1(7),9-diene: E117 (≠ C123), E285 (≠ T296), F289 (≠ L300), N450 (≠ T461), V452 (≠ I463)
7mjcA Crystal structure analysis of aldh1b1
40% identity, 96% coverage: 22:498/499 of query aligns to 15:487/493 of 7mjcA
- binding nicotinamide-adenine-dinucleotide: I158 (= I170), I159 (≠ V171), P160 (= P172), W161 (= W173), N162 (= N174), K185 (= K197), E188 (= E200), G218 (= G230), G222 (= G234), T237 (= T249), G238 (= G250), S239 (= S251), V242 (≠ T254), E261 (= E272), L262 (= L273), C295 (= C306), E392 (= E403), F394 (= F405)
P20000 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Bos taurus (Bovine) (see 2 papers)
41% identity, 96% coverage: 22:498/499 of query aligns to 42:514/520 of P20000